HUP0003255A2 - Eljárás faciális fém-trikarbonil vegyületek előállítására és ezek alkalmazása biológiailag aktív szubsztrátok jelzésére - Google Patents

Eljárás faciális fém-trikarbonil vegyületek előállítására és ezek alkalmazása biológiailag aktív szubsztrátok jelzésére

Info

Publication number
HUP0003255A2
HUP0003255A2 HU0003255A HUP0003255A HUP0003255A2 HU P0003255 A2 HUP0003255 A2 HU P0003255A2 HU 0003255 A HU0003255 A HU 0003255A HU P0003255 A HUP0003255 A HU P0003255A HU P0003255 A2 HUP0003255 A2 HU P0003255A2
Authority
HU
Hungary
Prior art keywords
compounds
production
biologically active
active substrates
labelling
Prior art date
Application number
HU0003255A
Other languages
English (en)
Inventor
Roger Alberto
André Egli
Roger Schibli
Original Assignee
Mallinckrodt Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc. filed Critical Mallinckrodt Inc.
Publication of HUP0003255A2 publication Critical patent/HUP0003255A2/hu
Publication of HUP0003255A3 publication Critical patent/HUP0003255A3/hu
Publication of HU225487B1 publication Critical patent/HU225487B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G45/00—Compounds of manganese
    • C01G45/04—Carbonyls
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G99/00—Subject matter not provided for in other groups of this subclass
    • C01G99/006—Compounds containing, besides a metal not provided for elsewhere in this subclass, two or more other elements other than oxygen or hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/88—Isotope composition differing from the natural occurrence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány szerinti eljárás (I) általános képletű vegyületekelőállítására szolgál, fac-[M(CO)3(OH2)3]+ (I) ahol a képletben M jelentése Mn, 99mTc, 186Re vagy 188Re. Azeljárás során egy fémet permetallát (MO4) formában szén-monoxiddal ésegy redukálószerrel reagáltatnak, ahol egy lúg, egy vízben oldódó, delényegében nem bomló redukálószer és adott esetben valamelystabilizáló anyag keverékét szén-monoxid és adott esetben halogenidionjelenlétében a fémet permanganát, pertechnetát vagy perrenát formábanoldva tartalmazó vizes oldószerrendszerben oldják. A találmány tárgyatovábbá eljárás radioaktív izotóppal jelzett vegyületek előállításra afenti (I) általános képletű vegyületek alkalmazásával. A találmánytárgya még eljárás jelzett vegyületek közvetlen előállítására, így atalálmány biológiailag aktív szubsztrátok, például aminosavak,peptidek, proteinek, cukrok, kisebb receptorkötő molekulák vagy sejtekjelzésére vonatkozik. A találmány ezenkívül jelzett vegyületek,valamint diagnosztikai vagy terápiás gyógyszerkészítmény előállításáraalkalmas kitre vonatkozik. Ó
HU0003255A 1997-04-25 1998-04-21 Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates HU225487B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201232A EP0879606A1 (en) 1997-04-25 1997-04-25 Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates
PCT/US1998/007979 WO1998048848A1 (en) 1997-04-25 1998-04-21 Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates

Publications (3)

Publication Number Publication Date
HUP0003255A2 true HUP0003255A2 (hu) 2001-02-28
HUP0003255A3 HUP0003255A3 (en) 2003-06-30
HU225487B1 HU225487B1 (en) 2006-12-28

Family

ID=8228251

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003255A HU225487B1 (en) 1997-04-25 1998-04-21 Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates

Country Status (18)

Country Link
EP (2) EP0879606A1 (hu)
JP (1) JP4357597B2 (hu)
KR (1) KR100579168B1 (hu)
AT (1) ATE211924T1 (hu)
AU (1) AU748213B2 (hu)
BR (1) BR9809409B1 (hu)
CA (1) CA2282563C (hu)
CZ (1) CZ295214B6 (hu)
DE (1) DE69803205T2 (hu)
DK (1) DK1019095T3 (hu)
ES (1) ES2168751T3 (hu)
HU (1) HU225487B1 (hu)
IL (1) IL131658A (hu)
NO (1) NO995160L (hu)
NZ (1) NZ337303A (hu)
PL (1) PL189514B1 (hu)
PT (1) PT1019095E (hu)
WO (1) WO1998048848A1 (hu)

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DE19860289C2 (de) * 1998-12-21 2003-11-13 Schering Ag Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium
EP1021074B1 (en) 1999-01-15 2012-06-20 The Boeing Company Solid state flight deck panels and components thereof
ATE325624T1 (de) * 1999-02-24 2006-06-15 Univ Zuerich Moleküle für die behandlung und diagnose von tumoren
US6844425B1 (en) 1999-02-24 2005-01-18 Mallinckrodt Inc. Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
DE60014375T2 (de) * 1999-06-29 2005-12-01 Mallinckrodt, Inc. Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung
US6926883B1 (en) * 1999-06-29 2005-08-09 Mallinckrodt Inc Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
AUPQ262499A0 (en) 1999-09-02 1999-09-23 University Of Queensland, The Novel iron chelators
RU2256664C2 (ru) * 1999-10-05 2005-07-20 Маллинкродт Инк. Производные боранокарбоната, способ их получения и применения, набор для получения карбонильных комплексов переходных металлов
US6359119B1 (en) * 2000-05-24 2002-03-19 Mallinckrodt Inc. Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
EP1286704B1 (en) * 2000-06-02 2014-07-23 Board of Regents, The University of Texas System ETHYLENEDICYSTEINE (EC)-glucose analog CONJUGATES
CN1136921C (zh) * 2001-04-27 2004-02-04 北京师范大学 一种心肌显像剂及其制备方法
GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
JP2005519928A (ja) 2002-02-04 2005-07-07 ハース，ベルナー Ｃｏ放出能力を有する化合物の投与によって哺乳動物を治療する方法と、ｃｏ放出能力を有する化合物ならびにその医薬組成物
KR100445971B1 (ko) * 2002-04-15 2004-08-25 한국원자력연구소 수소화붕소 교환수지를 이용한 테크네튬 또는 레늄의표지방법
DE60326465D1 (de) * 2002-09-03 2009-04-16 Univ Zuerich Herstellung von m(co)3-komplexen durch festphasentechniken durch metal-unterstützte trennung vom festen träger
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
EP1644050B1 (en) 2003-04-15 2010-06-09 Mallinckrodt Inc. Bifunctional tridentate pyrazolyl containing ligands for re, tc and mn tricarbonyl complexes
US7682601B2 (en) 2003-04-15 2010-03-23 Mallinckrodt Inc. Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
DE602004024879D1 (de) * 2003-04-29 2010-02-11 Univ Zuerich AN EINEM BIOMOLEKÜL GEBUNDENEN N epsilon- UND/ODER N alpha DERIVATISIERTEM UND ORGANISCH-GESCHÜTZTEM L-HISTIDIN ZUR HOCH-EFFIZIENTER MARKIERUNG MIT (M(H2O)3(CO)3)+ MITTELS FAC KOORDINIERUNG
EP1797106A1 (en) * 2004-09-07 2007-06-20 Triumf, operating as a joint venture by the Governors of the Universities of Alberta, Synthesis of radiolabeled sugar metal complexes
JP2008037752A (ja) * 2004-11-19 2008-02-21 Nihon Medi Physics Co Ltd 新規放射性テクネチウム−ビスホスフィノアミン錯体および該錯体を含む放射性画像診断剤
KR100650506B1 (ko) * 2005-12-16 2006-11-30 한국원자력연구소 방사성 의약품용 레늄-트리카보닐 착물 및 그 전구체의제조방법
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
GB0623482D0 (en) 2006-11-24 2007-01-03 Mallinckrodt Inc Technetium-99m (l) tricarbonyl complexes with tridentate chelators for myocardium imaging
DE102010014411A1 (de) 2010-04-08 2011-10-13 Friedrich-Schiller-Universität Jena Kohlenmonoxid und Eisen freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung
DE102010014412A1 (de) 2010-04-08 2012-04-19 Friedrich-Schiller-Universität Jena Verwendung von zweikernigen Eisenkomplexen mit schwefelhaltigen Liganden als pharmakologische Wirkstoffe
JP5978291B2 (ja) 2011-04-19 2016-08-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化炭素放出分子およびその使用
ES2628634T3 (es) 2011-07-21 2017-08-03 Alfama, Inc. Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
DE102012004132A1 (de) 2012-02-29 2013-08-29 Friedrich-Schiller-Universität Jena Kohlenstoffmonoxid freisetzende Materialien und deren Verwendung
KR101200049B1 (ko) * 2012-05-14 2012-11-13 한국원자력연구원 테크네튬-99엠 트리카보닐 표지 글리신 단량체 또는 올리고머 활용 생리활성분자를 이용한 프로브의 제조방법 및 이를 포함하는 영상제 조성물
DE102014008537A1 (de) 2014-06-04 2015-12-17 Friedrich-Schiller-Universität Jena Wasserlösliche manganbasierte Kohlenstoffmonoxid freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung
RU2708076C1 (ru) * 2019-09-10 2019-12-04 федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский Томский политехнический университет» Способ получения комплекса технеция-99м с производным октреотида для диагностики нейроэндокринных опухолей

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Also Published As

Publication number Publication date
IL131658A0 (en) 2001-01-28
CA2282563C (en) 2007-12-04
CA2282563A1 (en) 1998-11-05
ES2168751T3 (es) 2002-06-16
IL131658A (en) 2004-12-15
NZ337303A (en) 2000-12-22
PL336382A1 (en) 2000-06-19
BR9809409B1 (pt) 2008-11-18
NO995160L (no) 1999-12-13
AU748213B2 (en) 2002-05-30
AU7141398A (en) 1998-11-24
BR9809409A (pt) 2000-06-13
HU225487B1 (en) 2006-12-28
HUP0003255A3 (en) 2003-06-30
PL189514B1 (pl) 2005-08-31
DE69803205D1 (de) 2002-02-21
KR20010020298A (ko) 2001-03-15
ATE211924T1 (de) 2002-02-15
JP2002512616A (ja) 2002-04-23
CZ9903751A3 (en) 2001-05-16
CZ295214B6 (cs) 2005-06-15
EP0879606A1 (en) 1998-11-25
JP4357597B2 (ja) 2009-11-04
EP1019095A1 (en) 2000-07-19
WO1998048848A1 (en) 1998-11-05
EP1019095B1 (en) 2002-01-16
DK1019095T3 (da) 2002-05-06
PT1019095E (pt) 2002-07-31
DE69803205T2 (de) 2002-09-19
KR100579168B1 (ko) 2006-05-12
NO995160D0 (no) 1999-10-22

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Owner name: MALLINCKRODT LLC, US

Free format text: FORMER OWNER(S): MALLINCKRODT INC., US

FH92 Termination of representative

Representative=s name: VARNAI ES TARSAI UEGYVEDI IRODA, HU

FH91 Appointment of a representative

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Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU