HUE060783T2 - Citotoxikus dipeptidek liofilizált készítménye - Google Patents

Citotoxikus dipeptidek liofilizált készítménye

Info

Publication number
HUE060783T2
HUE060783T2 HUE19215699A HUE19215699A HUE060783T2 HU E060783 T2 HUE060783 T2 HU E060783T2 HU E19215699 A HUE19215699 A HU E19215699A HU E19215699 A HUE19215699 A HU E19215699A HU E060783 T2 HUE060783 T2 HU E060783T2
Authority
HU
Hungary
Prior art keywords
lyophilized preparation
cytotoxic dipeptides
dipeptides
cytotoxic
lyophilized
Prior art date
Application number
HUE19215699A
Other languages
English (en)
Hungarian (hu)
Inventor
Jack Spira
Fredrik Lehmann
Original Assignee
Oncopeptides Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncopeptides Ab filed Critical Oncopeptides Ab
Publication of HUE060783T2 publication Critical patent/HUE060783T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • A61K38/105Bombesin; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HUE19215699A 2011-04-28 2012-04-25 Citotoxikus dipeptidek liofilizált készítménye HUE060783T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1150371 2011-04-28
US201161535126P 2011-09-15 2011-09-15

Publications (1)

Publication Number Publication Date
HUE060783T2 true HUE060783T2 (hu) 2023-04-28

Family

ID=47071620

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE19215699A HUE060783T2 (hu) 2011-04-28 2012-04-25 Citotoxikus dipeptidek liofilizált készítménye
HUE12718949A HUE037863T2 (hu) 2011-04-28 2012-04-25 Citotoxikus dipeptidek liofilizált készítménye
HUS2300005C HUS2300005I1 (hu) 2011-04-28 2023-01-16 Citotoxikus dipeptidek liofilizált készítménye

Family Applications After (2)

Application Number Title Priority Date Filing Date
HUE12718949A HUE037863T2 (hu) 2011-04-28 2012-04-25 Citotoxikus dipeptidek liofilizált készítménye
HUS2300005C HUS2300005I1 (hu) 2011-04-28 2023-01-16 Citotoxikus dipeptidek liofilizált készítménye

Country Status (29)

Country Link
US (8) US20140128462A1 (enExample)
EP (4) EP3228319B1 (enExample)
JP (1) JP6042412B2 (enExample)
KR (2) KR102122416B1 (enExample)
CN (2) CN108096563A (enExample)
AU (1) AU2012247545B2 (enExample)
BR (2) BR122019017088B1 (enExample)
CA (2) CA3024230C (enExample)
CY (2) CY1119453T1 (enExample)
DK (3) DK3656393T3 (enExample)
ES (2) ES2930140T3 (enExample)
FI (1) FIC20230004I1 (enExample)
FR (1) FR23C1000I2 (enExample)
HR (2) HRP20171523T1 (enExample)
HU (3) HUE060783T2 (enExample)
IL (3) IL228889A0 (enExample)
LT (3) LT3656393T (enExample)
LU (1) LUC00291I2 (enExample)
MX (1) MX345102B (enExample)
NL (1) NL301206I2 (enExample)
NO (1) NO2023004I1 (enExample)
PL (3) PL2701720T3 (enExample)
PT (2) PT2701720T (enExample)
RS (3) RS56462B1 (enExample)
RU (1) RU2597154C2 (enExample)
SI (2) SI2701720T1 (enExample)
SM (3) SMT202000447T1 (enExample)
WO (1) WO2012146625A1 (enExample)
ZA (1) ZA201308765B (enExample)

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RS56462B1 (sr) 2011-04-28 2018-01-31 Oncopeptides Ab Liofilizovani preparat citotoksičnih dipeptida
JP5827178B2 (ja) * 2012-06-05 2015-12-02 北越紀州製紙株式会社 セルロース多孔質体及びその製造方法
JP6284945B2 (ja) * 2012-10-26 2018-02-28 オンコペプティデス エービーOncopeptides AB メルファランフルフェナミドの凍結乾燥製剤
DK2928463T3 (da) * 2012-10-26 2020-02-24 Oncopeptides Ab Lyofiliserede præparater af melphalan-flufenamid
GB201507903D0 (en) 2015-05-08 2015-06-24 Oncopeptides Ab Process for preparation of nitrogen mustard derivatives
GB201521217D0 (en) 2015-12-01 2016-01-13 Oncopeptides Ab Dosage regimens
US10369077B2 (en) * 2017-05-31 2019-08-06 Adienne Pharma & Biotech Sa Multi chamber flexible bag and methods of using the same
US10507165B2 (en) 2017-05-31 2019-12-17 Adienne Pharma & Biotech Sa Multi chamber flexible bag and methods of using same
AU2019362389B2 (en) * 2018-10-18 2024-12-12 Oncopeptides Innovation Ab Compounds containing deuterium
CN114025753A (zh) 2019-04-03 2022-02-08 肿瘤多肽有限公司 用美氟芬治疗al淀粉样变性
GB201905477D0 (en) * 2019-04-17 2019-05-29 Oncopeptides Ab Novel formulations
WO2021053185A1 (en) 2019-09-20 2021-03-25 Oncopeptides Ab Melflufen formulations and their use in the treatment or prophylaxis of osteosarcoma
WO2021226566A1 (en) * 2020-05-08 2021-11-11 Cjb Applied Technologies, Llc Pesticidal compositions and related methods
AU2021327164A1 (en) * 2020-08-19 2023-03-16 Cellact Pharma Gmbh Etoposide toniribate formulation
US12077809B2 (en) 2021-04-27 2024-09-03 Enplas Corporation Freeze-dried structure and producing method thereof
GB202109895D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
EP4366721A1 (en) 2021-07-08 2024-05-15 Oncopeptides Innovation AB Melflufen for use in the treatment of multiple myeloma
GB202109896D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109894D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
KR102757193B1 (ko) * 2021-10-19 2025-01-21 단국대학교 천안캠퍼스 산학협력단 피리미딘-2,4-다이온 유도체를 유효성분으로 포함하는 근감소증의 예방 또는 치료용 조성물
GB202204171D0 (en) 2022-03-24 2022-05-11 Oncopeptides Ab Novel formulations

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SI2696848T1 (sl) * 2011-04-15 2020-10-30 Janssen Pharmaceutica N.V. Liofilizirane zdravilne nanosuspenzije
RS56462B1 (sr) 2011-04-28 2018-01-31 Oncopeptides Ab Liofilizovani preparat citotoksičnih dipeptida
JP6284945B2 (ja) 2012-10-26 2018-02-28 オンコペプティデス エービーOncopeptides AB メルファランフルフェナミドの凍結乾燥製剤

Also Published As

Publication number Publication date
LUC00291I2 (enExample) 2025-05-12
KR20170140409A (ko) 2017-12-20
US11896668B2 (en) 2024-02-13
SI3228319T1 (sl) 2020-10-30
CA3024230C (en) 2022-10-18
LT2701720T (lt) 2017-11-10
CY1123242T1 (el) 2021-10-29
CY1119453T1 (el) 2018-03-07
ES2930140T3 (es) 2022-12-07
PL3228319T3 (pl) 2021-02-08
US20170049894A1 (en) 2017-02-23
NL301206I1 (en) 2022-12-14
US10869928B2 (en) 2020-12-22
US20140128462A1 (en) 2014-05-08
RS60719B1 (sr) 2020-09-30
MX2013012545A (es) 2014-04-16
HRP20171523T1 (hr) 2017-11-17
SMT201700459T1 (it) 2017-11-15
LTC2701720I2 (enExample) 2024-09-25
IL265457A (en) 2019-05-30
PT3656393T (pt) 2022-11-03
IL272429A (en) 2020-03-31
US20200345848A1 (en) 2020-11-05
NO2023004I1 (no) 2023-01-16
RU2013152751A (ru) 2015-06-10
IL265457B (en) 2021-02-28
RS63747B1 (sr) 2022-12-30
KR102122416B1 (ko) 2020-06-12
NZ617197A (en) 2015-06-26
PL3656393T3 (pl) 2023-01-16
CA3024230A1 (en) 2012-11-01
BR112013027584B1 (pt) 2020-11-03
KR101808895B1 (ko) 2017-12-13
NL301206I2 (nl) 2023-01-24
CA2833500C (en) 2019-01-08
AU2012247545B2 (en) 2016-08-11
FR23C1000I2 (fr) 2024-03-15
FR23C1000I1 (fr) 2023-03-10
ES2642676T3 (es) 2017-11-17
JP2014512402A (ja) 2014-05-22
EP3228319B1 (en) 2020-06-03
US10322182B2 (en) 2019-06-18
BR122019017088B1 (pt) 2021-11-16
LT3656393T (lt) 2022-12-12
EP3656393B1 (en) 2022-08-24
KR20140041497A (ko) 2014-04-04
ZA201308765B (en) 2016-02-24
US20200121794A1 (en) 2020-04-23
US20190240332A1 (en) 2019-08-08
US20240358838A1 (en) 2024-10-31
US20200009252A1 (en) 2020-01-09
DK3656393T3 (da) 2022-11-14
EP4122482A1 (en) 2023-01-25
CA2833500A1 (en) 2012-11-01
HRP20221355T1 (hr) 2022-12-23
PL2701720T3 (pl) 2017-12-29
EP3656393A1 (en) 2020-05-27
CN108096563A (zh) 2018-06-01
US20220323585A1 (en) 2022-10-13
IL228889A0 (en) 2013-12-31
EP2701720B1 (en) 2017-07-12
CN103547279A (zh) 2014-01-29
RU2597154C2 (ru) 2016-09-10
WO2012146625A1 (en) 2012-11-01
BR112013027584A2 (pt) 2016-09-06
HUS2300005I1 (hu) 2023-02-28
DK2701720T3 (en) 2017-10-09
HUE037863T2 (hu) 2018-09-28
SI2701720T1 (sl) 2017-11-30
IL272429B (en) 2022-05-01
DK3228319T3 (da) 2020-09-07
MX345102B (es) 2017-01-16
PT2701720T (pt) 2017-10-20
AU2012247545A1 (en) 2013-10-31
SMT202000447T1 (it) 2020-09-10
JP6042412B2 (ja) 2016-12-14
EP2701720A1 (en) 2014-03-05
US11344622B2 (en) 2022-05-31
FIC20230004I1 (fi) 2023-01-19
US10543274B2 (en) 2020-01-28
SMT202200450T1 (it) 2023-01-13
EP3228319A1 (en) 2017-10-11
RS56462B1 (sr) 2018-01-31

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