HUE059777T2 - Lixiszenatid szintézise lánczárással - Google Patents
Lixiszenatid szintézise lánczárássalInfo
- Publication number
- HUE059777T2 HUE059777T2 HUE19715517A HUE19715517A HUE059777T2 HU E059777 T2 HUE059777 T2 HU E059777T2 HU E19715517 A HUE19715517 A HU E19715517A HU E19715517 A HUE19715517 A HU E19715517A HU E059777 T2 HUE059777 T2 HU E059777T2
- Authority
- HU
- Hungary
- Prior art keywords
- lixisenatide
- capping
- synthesis
- lixisenatide synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/066—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amido functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18166551 | 2018-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE059777T2 true HUE059777T2 (hu) | 2022-12-28 |
Family
ID=62002530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE19715517A HUE059777T2 (hu) | 2018-04-10 | 2019-04-10 | Lixiszenatid szintézise lánczárással |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11028123B2 (hu) |
| EP (1) | EP3774838B1 (hu) |
| JP (1) | JP7332620B2 (hu) |
| KR (1) | KR20200142032A (hu) |
| CN (1) | CN112218876A (hu) |
| AU (1) | AU2019250362A1 (hu) |
| BR (1) | BR112020020647A2 (hu) |
| CA (1) | CA3096495A1 (hu) |
| DK (1) | DK3774838T3 (hu) |
| ES (1) | ES2928207T3 (hu) |
| HU (1) | HUE059777T2 (hu) |
| IL (1) | IL277836A (hu) |
| MX (1) | MX2020010715A (hu) |
| SG (1) | SG11202010016QA (hu) |
| WO (1) | WO2019197469A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3774838B1 (en) | 2018-04-10 | 2022-08-10 | Sanofi-Aventis Deutschland GmbH | Lixisenatide synthesis with capping |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| JP3107488B2 (ja) | 1993-09-29 | 2000-11-06 | 株式会社資生堂 | 架橋ヒアルロン酸を用いた徐放性製剤及び塞栓剤 |
| DE69739172D1 (de) | 1996-08-08 | 2009-01-29 | Amylin Pharmaceuticals Inc | Regulation gastrointestinaler beweglichkeit |
| AR010744A1 (es) | 1996-12-09 | 2000-07-12 | Guildford Pharmaceuticals Inc | Inhibidores polipropilos de ciclofilina |
| ES2425559T5 (es) | 1997-01-07 | 2018-02-02 | Amylin Pharmaceuticals, Llc | Composiciones farmacéuticas que comprenden las exendinas y los agonistas de las mismas |
| AU749914B2 (en) | 1997-08-08 | 2002-07-04 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| JP2001523688A (ja) | 1997-11-14 | 2001-11-27 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 新規エキセンジン・アゴニスト化合物 |
| BR9815670A (pt) | 1997-11-14 | 2000-10-17 | Amylin Pharmaceuticals Inc | Compostos agonistas de exendina |
| JP2002521319A (ja) | 1998-07-23 | 2002-07-16 | メタファー・インコーポレイテッド | ポリヒドロキサメートおよびそのアナログのライブラリー |
| GB9818730D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| WO2001072412A1 (de) * | 2000-03-28 | 2001-10-04 | Laser- Und Medizin-Technologie Gmbh Berlin | Verfahren und vorrichtung zum aufbau und untersuchung von substanzbibliotheken |
| DE60327771D1 (de) | 2002-07-04 | 2009-07-09 | Zealand Pharma As | Glp-1 und behandlungsmethode für diabetes |
| MXPA05003335A (es) | 2002-10-02 | 2005-07-05 | Zealand Pharma As | Compuestos de exendina-4 estabilizados. |
| US20050106100A1 (en) | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
| US20050176079A1 (en) | 2004-02-09 | 2005-08-11 | Chu Yong L. | Polypeptide bioconjugates, methods of making the bioconjugates and assays employing the bioconjugates |
| US20080019911A1 (en) | 2005-04-20 | 2008-01-24 | Aimin Xu | Method for decreasing blood glucose and improving glucose tolerance using angiopoietin-like protein 4 |
| KR20080026117A (ko) | 2005-05-26 | 2008-03-24 | 브리스톨-마이어스 스큅 컴퍼니 | Ｎ-말단 개질된 ｇｌｐ-1 수용체 조절제 |
| DK1891105T3 (da) | 2005-06-13 | 2012-07-16 | Imp Innovations Ltd | Hidtil ukendte forbindelser og deres påvirkninger på spiseadfærd |
| RU2429018C2 (ru) | 2005-07-06 | 2011-09-20 | Сейкагаку Корпорейшн | Гель, полученный из фотосшитой гиалуроновой кислоты с введенным лекарственным средством |
| CN101357938B (zh) | 2007-07-31 | 2013-07-03 | 周逸明 | 固相多肽合成Exenatide的制备方法 |
| WO2009095479A2 (en) | 2008-02-01 | 2009-08-06 | Ascendis Pharma As | Prodrug comprising a self-cleavable linker |
| PL2300035T3 (pl) | 2008-06-17 | 2016-04-29 | Univ Indiana Res & Tech Corp | Mieszani agoniści na bazie GIP do leczenia zaburzeń metabolicznych i otyłości |
| BRPI1008039A2 (pt) | 2009-02-20 | 2016-10-04 | Ipsen Pharma Sas | composto, mistura, composição farmacêutica, e, uso de um coposto, de uma mistura ou de uma composição farmacêutica |
| KR20120087875A (ko) | 2009-06-16 | 2012-08-07 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | Ｇｉｐ 수용체-활성 글루카곤 화합물 |
| WO2011012723A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Injectable sustained release compositions comprising a pramipexole prodrug |
| AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
| US8507428B2 (en) | 2010-12-22 | 2013-08-13 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting GIP receptor activity |
| CN103282054A (zh) | 2011-01-03 | 2013-09-04 | 弗·哈夫曼-拉罗切有限公司 | 抗dig抗体和与肽缀合的地高辛配基的复合物的药物组合物 |
| US20130289241A1 (en) | 2012-04-26 | 2013-10-31 | Shanghai Ambiopharm, Inc. | Method for preparing exenatide |
| CA2877358A1 (en) | 2012-06-21 | 2013-12-27 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting gip receptor activity |
| PE20150863A1 (es) | 2012-06-21 | 2015-06-11 | Univ Indiana Res & Tech Corp | Analogos de glucagon que exhiben actividad de receptor de gip |
| CN103163233B (zh) | 2012-07-12 | 2014-06-25 | 海南合瑞制药股份有限公司 | 固相合成胸腺肽α1的28肽阶段的缺失肽及检测方法 |
| WO2014049610A2 (en) | 2012-09-26 | 2014-04-03 | Cadila Healthcare Limited | Peptides as gip, glp-1 and glucagon receptors triple-agonist |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR102215175B1 (ko) | 2012-11-06 | 2021-02-15 | 레스 오삐또 유니베르시테르 드 제네브 | 모방 펩티드 |
| HUE038748T2 (hu) | 2012-12-21 | 2018-11-28 | Sanofi Sa | Exendin-4 származékok, mint duális GLP1/GIP- vagy trigonális GLP1/GIP/glukagon-agonisták |
| MX369770B (es) | 2013-11-06 | 2019-11-21 | Zealand Pharma As | Compuestos agonistas triples de glucagón-glp-1-gip. |
| TW201609800A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 做為雙重ｇｌｐ－１／升糖素受體促效劑之艾塞那肽－４胜肽類似物 |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086732A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues |
| CN103819553A (zh) * | 2013-12-27 | 2014-05-28 | 苏贤斌 | 一种使用固相和液相组合技术制备利西拉来的方法 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| CN104211801A (zh) * | 2014-07-25 | 2014-12-17 | 杭州诺泰制药技术有限公司 | 一种制备利西拉来的方法 |
| CN104844706B (zh) | 2015-06-10 | 2018-08-03 | 成都圣诺生物科技股份有限公司 | 一种合成利西拉来的方法 |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| BR112018008681A2 (pt) * | 2015-10-28 | 2018-10-30 | Tufts Medical Center | novos polipeptídeos com estabilidade proteolítica melhorada, e métodos para preparar e usar os mesmos |
| JP6991196B2 (ja) * | 2016-03-23 | 2022-02-03 | バッヘン・ホールディング・アクチエンゲゼルシャフト | グルカゴン様ペプチドを製造するための方法 |
| WO2017189925A1 (en) | 2016-04-28 | 2017-11-02 | C S Bio Co. | Methods of preparing peptides |
| TW201821434A (zh) | 2016-10-10 | 2018-06-16 | 法商賽諾菲公司 | 製備包含親脂性修飾的離胺酸側鏈的肽的方法 |
| AR110300A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Compuestos como agonistas peptídicos trigonales de los receptores de glp1 / glucagón / gip |
| BR112020020652A2 (pt) * | 2018-04-10 | 2021-03-02 | Sanofi-Aventis Deutschland Gmbh | método para clivagem de peptídeos ligados à fase sólida a partir da fase sólida |
| EP3774838B1 (en) | 2018-04-10 | 2022-08-10 | Sanofi-Aventis Deutschland GmbH | Lixisenatide synthesis with capping |
-
2019
- 2019-04-10 EP EP19715517.9A patent/EP3774838B1/en active Active
- 2019-04-10 HU HUE19715517A patent/HUE059777T2/hu unknown
- 2019-04-10 CN CN201980037082.8A patent/CN112218876A/zh active Pending
- 2019-04-10 KR KR1020207032151A patent/KR20200142032A/ko active Search and Examination
- 2019-04-10 MX MX2020010715A patent/MX2020010715A/es unknown
- 2019-04-10 AU AU2019250362A patent/AU2019250362A1/en active Pending
- 2019-04-10 WO PCT/EP2019/059090 patent/WO2019197469A1/en active Search and Examination
- 2019-04-10 ES ES19715517T patent/ES2928207T3/es active Active
- 2019-04-10 SG SG11202010016QA patent/SG11202010016QA/en unknown
- 2019-04-10 DK DK19715517.9T patent/DK3774838T3/da active
- 2019-04-10 US US16/380,321 patent/US11028123B2/en active Active
- 2019-04-10 BR BR112020020647-4A patent/BR112020020647A2/pt unknown
- 2019-04-10 CA CA3096495A patent/CA3096495A1/en active Pending
- 2019-04-10 JP JP2020555311A patent/JP7332620B2/ja active Active
-
2020
- 2020-10-07 IL IL277836A patent/IL277836A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11028123B2 (en) | 2021-06-08 |
| IL277836A (en) | 2020-11-30 |
| US20190330263A1 (en) | 2019-10-31 |
| WO2019197469A1 (en) | 2019-10-17 |
| CN112218876A (zh) | 2021-01-12 |
| MX2020010715A (es) | 2021-01-08 |
| JP2021521144A (ja) | 2021-08-26 |
| ES2928207T3 (es) | 2022-11-16 |
| CA3096495A1 (en) | 2019-10-17 |
| SG11202010016QA (en) | 2020-11-27 |
| BR112020020647A2 (pt) | 2021-02-23 |
| JP7332620B2 (ja) | 2023-08-23 |
| EP3774838B1 (en) | 2022-08-10 |
| DK3774838T3 (da) | 2022-10-31 |
| EP3774838A1 (en) | 2021-02-17 |
| KR20200142032A (ko) | 2020-12-21 |
| AU2019250362A1 (en) | 2020-11-26 |
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