HUE055157T2 - Ellenõrzött adagolású és réteges ciklodextrinbe foglaló komplex közvetítõk - Google Patents

Ellenõrzött adagolású és réteges ciklodextrinbe foglaló komplex közvetítõk

Info

Publication number
HUE055157T2
HUE055157T2 HUE17748308A HUE17748308A HUE055157T2 HU E055157 T2 HUE055157 T2 HU E055157T2 HU E17748308 A HUE17748308 A HU E17748308A HU E17748308 A HUE17748308 A HU E17748308A HU E055157 T2 HUE055157 T2 HU E055157T2
Authority
HU
Hungary
Prior art keywords
stratified
release
controlled
inclusion complex
cyclodextrin inclusion
Prior art date
Application number
HUE17748308A
Other languages
English (en)
Inventor
Al Czap
Original Assignee
Czap Res And Development Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/232,647 external-priority patent/US20170224841A1/en
Priority claimed from US15/285,264 external-priority patent/US20170224842A1/en
Application filed by Czap Res And Development Llc filed Critical Czap Res And Development Llc
Publication of HUE055157T2 publication Critical patent/HUE055157T2/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
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    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1074—Cyclomaltodextrin glucanotransferase (2.4.1.19)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Inorganic Chemistry (AREA)
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  • Neurology (AREA)
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  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
HUE17748308A 2016-02-04 2017-02-03 Ellenõrzött adagolású és réteges ciklodextrinbe foglaló komplex közvetítõk HUE055157T2 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662291202P 2016-02-04 2016-02-04
US15/232,647 US20170224841A1 (en) 2016-02-04 2016-08-09 Controlled-release and stratified cyclodextrin inclusion complex vehicles
US15/285,264 US20170224842A1 (en) 2016-02-04 2016-10-04 Controlled-release and stratified cyclodextrin inclusion complex vehicles
US201762444036P 2017-01-09 2017-01-09

Publications (1)

Publication Number Publication Date
HUE055157T2 true HUE055157T2 (hu) 2021-11-29

Family

ID=59500049

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17748308A HUE055157T2 (hu) 2016-02-04 2017-02-03 Ellenõrzött adagolású és réteges ciklodextrinbe foglaló komplex közvetítõk

Country Status (18)

Country Link
US (2) US11633448B2 (hu)
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JP (3) JP6884420B2 (hu)
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115154619A (zh) * 2016-02-04 2022-10-11 西泽普研究与发展有限责任公司 受控释放和层状的环糊精包合物媒介物
JP7181185B2 (ja) * 2016-09-16 2022-11-30 サイデックス・ファーマシューティカルズ・インコーポレイテッド アセトアミノフェンおよびスルホアルキルエーテルシクロデキストリンを含む製剤
EP3810168A1 (en) * 2018-06-20 2021-04-28 Axcella Health Inc. Methods of manufacturing amino acid compositions
CN111183989A (zh) * 2018-11-14 2020-05-22 北京中以新农高科商务咨询有限公司 包含胶囊化挥发性精油和溶解在其中的聚合物的农用制剂
KR102200694B1 (ko) * 2018-11-29 2021-01-08 한국세라믹기술원 소수성 활성성분의 안정화 방법 및 안정화된 활성성분을 함유하는 화장료 조성물
WO2020168421A1 (en) * 2019-02-19 2020-08-27 Agrima Scientific Corp. Cyclodextrin inclusion complexes of cannabis extracts
CN110123876A (zh) * 2019-05-30 2019-08-16 汉义生物科技（北京）有限公司 一种含有非精神活性大麻素的包合物及其制备方法
CN115335040A (zh) * 2020-03-23 2022-11-11 西泽普研究与发展有限责任公司 口服萜烯环糊精包合物媒介物
CN111298108A (zh) * 2020-04-10 2020-06-19 亘元(天津)生物医药科技有限公司 一种儿童长效型复合酶消毒组合物及应用
WO2021257626A1 (en) * 2020-06-15 2021-12-23 Nanosynthons Llc Excipients providing stabilization and enhanced water solubilization and their uses
CN116437816A (zh) * 2020-11-17 2023-07-14 德乐有限公司 用于选择性分离至少一种具有至少一个非极性基团的有机物质的方法，以及所述物质在食品、享乐品、化妆品或医药产品中的用途
WO2022202904A1 (ja) 2021-03-25 2022-09-29 株式会社シクロケムバイオ 腸管機能向上剤
KR102707423B1 (ko) * 2021-11-05 2024-09-19 농업회사법인 주식회사 아그로비즈 농가의 야생동물 및 해충 퇴치를 위한 복합 기능의 방제키트
IT202200008894A1 (it) * 2022-05-03 2023-11-03 Biodue S P A Composizione nutriceutica comprendente citicolina, vitamina D3 e olio di canapa.
CN115039742B (zh) * 2022-05-24 2023-08-29 江苏宁录科技股份有限公司 一种草地贪夜蛾性信息素双重缓释诱芯及其制备方法
WO2024127024A1 (en) * 2022-12-16 2024-06-20 Kingdom Therapeutics Limited Cannabinoid based therapy
CN117771389A (zh) * 2023-12-28 2024-03-29 浙江圣达生物药业股份有限公司 L-5-甲基四氢叶酸钙-γ-环糊精包合物及其制备方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2453829C2 (de) 1974-11-13 1983-04-07 Siemens AG, 1000 Berlin und 8000 München Verfahren zur Herstellung von Additiven und ihre Verwendung als Glanzbildner
HU176215B (en) * 1978-01-27 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1
EP0056995B1 (en) 1981-01-23 1986-03-26 The Wellcome Foundation Limited Chemical complex
JPS5944318A (ja) * 1982-09-04 1984-03-12 Riken Kagaku Kogyo Kk サイクロデキストリン難脱包接物質よりの脱包接法
US4538920A (en) 1983-03-03 1985-09-03 Minnesota Mining And Manufacturing Company Static mixing device
JPH0819004B2 (ja) 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
CA1321192C (en) 1988-04-20 1993-08-10 Abdul Majid Inclusion complexes of cyclodextrins by agglomeration
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
CA2013485C (en) 1990-03-06 1997-04-22 John Michael Gardlik Solid consumer product compositions containing small particle cyclodextrin complexes
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
DE839528T1 (de) * 1996-10-29 1998-10-22 Staroil Ltd Mundlösliche Zusammensetzungen die N-Acetylcystein und Cyclodextrin enthalten
US6065645A (en) 1997-04-01 2000-05-23 Discus Dental Impressions, Inc. Double-barreled syringe with detachable locking mixing tip
CN1176784A (zh) * 1997-07-24 1998-03-25 北京路德有限责任公司 对乙酰氨基酚咀嚼片的制造方法及其产品
DE19911097A1 (de) * 1999-03-12 2000-09-14 Basf Ag Verfahren zur Herstellung von festen cyclodextrinhaltigen Dosierungsformen
WO2002044350A2 (de) * 2000-11-28 2002-06-06 Henkel Kommanditgesellschaft Auf Aktien Cyclodextrin-glucanotransferase (cg tase) aus bicillus agaradherens (dsm 9948) sowie wasch- und reinigungsmittel mit dieser neuen cyclodextrin-glucanotransferase
US6566401B2 (en) 2001-03-30 2003-05-20 The Board Of Trustees Of The Leland Stanford Junior University N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
FI113340B (fi) * 2002-02-20 2004-04-15 Tomi Jaervinen Uudet luonnon syklodekstriinin kompleksit
US7001893B2 (en) 2002-10-28 2006-02-21 Council Of Scientific And Industrial Research Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof
KR100675081B1 (ko) * 2003-03-06 2007-01-26 주식회사 서울제약 아세틸시스테인 함유 경구용 제제
WO2006058153A1 (en) 2004-11-23 2006-06-01 Smith & Nephew, Inc. Composite mixer
JP2008546386A (ja) 2005-06-13 2008-12-25 カーギル インコーポレイテッド シクロデキストリン包接複合体及びその製造方法
US20070003528A1 (en) 2005-06-29 2007-01-04 Paul Consigny Intracoronary device and method of use thereof
ATE443007T1 (de) 2005-07-22 2009-10-15 Dentaco Gmbh Mehrkammerausgabevorrichtung
US20070072146A1 (en) 2005-09-29 2007-03-29 Dentsply Research And Development Corp. Dispensing syringe having multiple barrels for discharging a dental composition
US20100204178A1 (en) 2006-10-02 2010-08-12 James Cloyd Novel parenteral carbamazepine formulation
US8100295B2 (en) 2006-03-24 2012-01-24 Medmix Systems Ag Dispensing assembly with removably attachable accessories
CN100411688C (zh) 2006-09-12 2008-08-20 南京师范大学 含有环糊精/多烯紫杉醇包合物的药物组合物及其制备方法
JP2010505938A (ja) * 2006-10-13 2010-02-25 ファイザー・リミテッド 家畜動物用の同化剤として有用な複素環式化合物
DK2178521T3 (da) 2007-07-11 2014-04-28 Fertin Pharma As Stabilt medicinsk tyggegummi omfattende cyclodextrin-inklusionskompleks
KR100929920B1 (ko) 2007-09-05 2009-12-04 주식회사 마크로케어 사이클로덱스트린 및 이의 유도체에 소수성 생리활성성분이 포접된 포접체의 제조방법 및 이로써 제조된포접체의 용도
JP2011528400A (ja) * 2008-07-17 2011-11-17 ハーキュリーズ・インコーポレーテッド 水系コーティング組成物を調整する方法
CN105687177A (zh) * 2009-07-15 2016-06-22 小利兰·斯坦福大学托管委员会 N-乙酰半胱氨酸组合物以及改善对乙酰氨基酚的治疗效能的方法
US20150217896A1 (en) 2010-02-11 2015-08-06 Clemson University Packaging materials derived from renewable resources and including a cyclodextrin inclusion complex
EP2444336B1 (de) 2010-10-21 2013-08-28 Sulzer Mixpac AG Doppel-Austragsvorrichtung
CN102058536A (zh) * 2011-01-14 2011-05-18 四川大学 槲皮素羟丙基β－环糊精包和物脂质体及其制备方法和用途
GB2492284B (en) 2011-03-27 2013-07-17 Cellresin Tech Llc Cyclodextrin compositions, articles, and methods
US20140315780A1 (en) 2011-05-05 2014-10-23 Jas Pal Singh Badyal Product
KR101794242B1 (ko) 2011-06-07 2017-11-07 임병갑 서방성 경구용 액상 제제
JP6052175B2 (ja) * 2011-08-02 2016-12-27 小野薬品工業株式会社 左室拡張機能改善剤
US9545393B2 (en) 2012-08-24 2017-01-17 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating pain
EP3656371A1 (en) 2012-10-02 2020-05-27 Allergan, Inc. Dermal filler hydrogels with vitamin a/cyclodextrin inclusion complexes
KR102411834B1 (ko) 2014-06-04 2022-06-21 프로토키네틱스 인코포레이티드 이식 결과 개선 및 췌장 세포 건강, 생존 향상을 위한 항-노화 글리코펩타이드들의 용도
US9421793B2 (en) 2014-06-26 2016-08-23 Cellresin Technologies, Llc Electrostatic printing of cyclodextrin compositions
US10098964B2 (en) * 2015-03-12 2018-10-16 The Board Of Trustees Of The University Of Illinois Inclusion complexes and methods for making the same
CN115154619A (zh) * 2016-02-04 2022-10-11 西泽普研究与发展有限责任公司 受控释放和层状的环糊精包合物媒介物
US20170224842A1 (en) 2016-02-04 2017-08-10 Czap Research And Development, Llc Controlled-release and stratified cyclodextrin inclusion complex vehicles

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