DK3411047T3 - Kontrolleret udløsning og stratificeret cyclodextrin inklusionskompleks bæremedier - Google Patents

Kontrolleret udløsning og stratificeret cyclodextrin inklusionskompleks bæremedier Download PDF

Info

Publication number
DK3411047T3
DK3411047T3 DK17748308.8T DK17748308T DK3411047T3 DK 3411047 T3 DK3411047 T3 DK 3411047T3 DK 17748308 T DK17748308 T DK 17748308T DK 3411047 T3 DK3411047 T3 DK 3411047T3
Authority
DK
Denmark
Prior art keywords
stratified
controlled release
inclusion complex
cyclodextrin inclusion
complex carriers
Prior art date
Application number
DK17748308.8T
Other languages
English (en)
Inventor
Al Czap
Original Assignee
Czap Res And Development Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/232,647 external-priority patent/US20170224841A1/en
Priority claimed from US15/285,264 external-priority patent/US20170224842A1/en
Application filed by Czap Res And Development Llc filed Critical Czap Res And Development Llc
Application granted granted Critical
Publication of DK3411047T3 publication Critical patent/DK3411047T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3482—Cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16—Cyclodextrin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1074—Cyclomaltodextrin glucanotransferase (2.4.1.19)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/50—Polysaccharides, gums
    • A23V2250/51—Polysaccharide
    • A23V2250/5112—Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01054—Cyclomaltodextrinase (3.2.1.54), i.e. cyclodextrinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
DK17748308.8T 2016-02-04 2017-02-03 Kontrolleret udløsning og stratificeret cyclodextrin inklusionskompleks bæremedier DK3411047T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662291202P 2016-02-04 2016-02-04
US15/232,647 US20170224841A1 (en) 2016-02-04 2016-08-09 Controlled-release and stratified cyclodextrin inclusion complex vehicles
US15/285,264 US20170224842A1 (en) 2016-02-04 2016-10-04 Controlled-release and stratified cyclodextrin inclusion complex vehicles
US201762444036P 2017-01-09 2017-01-09
PCT/US2017/016583 WO2017136775A1 (en) 2016-02-04 2017-02-03 Controlled-release and stratified cyclodextrin inclusion complex vehicles

Publications (1)

Publication Number Publication Date
DK3411047T3 true DK3411047T3 (da) 2021-06-28

Family

ID=59500049

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17748308.8T DK3411047T3 (da) 2016-02-04 2017-02-03 Kontrolleret udløsning og stratificeret cyclodextrin inklusionskompleks bæremedier

Country Status (19)

Country Link
US (3) US11633448B2 (da)
EP (3) EP3411047B1 (da)
JP (4) JP6884420B2 (da)
KR (1) KR20190005823A (da)
CN (2) CN115154619B (da)
AU (3) AU2017214669B2 (da)
CA (1) CA3012837A1 (da)
CY (1) CY1124822T1 (da)
DK (1) DK3411047T3 (da)
ES (1) ES2878580T3 (da)
HR (1) HRP20211086T1 (da)
HU (1) HUE055157T2 (da)
LT (1) LT3411047T (da)
PL (1) PL3411047T3 (da)
PT (1) PT3411047T (da)
RS (1) RS62097B1 (da)
SI (1) SI3411047T1 (da)
SM (1) SMT202100404T1 (da)
WO (1) WO2017136775A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3411047T3 (da) 2016-02-04 2021-06-28 Czap Res And Development Llc Kontrolleret udløsning og stratificeret cyclodextrin inklusionskompleks bæremedier
JP7181185B2 (ja) * 2016-09-16 2022-11-30 サイデックス・ファーマシューティカルズ・インコーポレイテッド アセトアミノフェンおよびスルホアルキルエーテルシクロデキストリンを含む製剤
EP3810168A1 (en) * 2018-06-20 2021-04-28 Axcella Health Inc. Methods of manufacturing amino acid compositions
CN111183989A (zh) * 2018-11-14 2020-05-22 北京中以新农高科商务咨询有限公司 包含胶囊化挥发性精油和溶解在其中的聚合物的农用制剂
KR102200694B1 (ko) * 2018-11-29 2021-01-08 한국세라믹기술원 소수성 활성성분의 안정화 방법 및 안정화된 활성성분을 함유하는 화장료 조성물
WO2020168421A1 (en) * 2019-02-19 2020-08-27 Agrima Scientific Corp. Cyclodextrin inclusion complexes of cannabis extracts
CN110123876A (zh) * 2019-05-30 2019-08-16 汉义生物科技（北京）有限公司 一种含有非精神活性大麻素的包合物及其制备方法
CA3170465A1 (en) * 2020-03-23 2021-09-30 Al Czap Oral terpene cyclodextrin inclusion complex vehicles
CN111298108A (zh) * 2020-04-10 2020-06-19 亘元(天津)生物医药科技有限公司 一种儿童长效型复合酶消毒组合物及应用
WO2021257626A1 (en) * 2020-06-15 2021-12-23 Nanosynthons Llc Excipients providing stabilization and enhanced water solubilization and their uses
WO2022002369A1 (en) * 2020-06-30 2022-01-06 Ocvirk Soeren Pharmaceutical composition comprising a combination of a guanylate cyclase c (gucy2c) agonist and a short-chain fatty acid or prodrug thereof
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
MX2023005690A (es) * 2020-11-17 2023-05-29 Doehler Gmbh Metodo para separar selectivamente al menos una sustancia organica que comprende al menos un grupo apolar, y uso de esta sustancia en un producto alimenticio, producto alimenticio de lujo, producto cosmetico o producto farmaceutico.
CN114748429A (zh) * 2020-12-29 2022-07-15 汉义生物科技（北京）有限公司 一种水溶性大麻素制剂及其制备方法
WO2022202904A1 (ja) 2021-03-25 2022-09-29 株式会社シクロケムバイオ 腸管機能向上剤
KR102707423B1 (ko) * 2021-11-05 2024-09-19 농업회사법인 주식회사 아그로비즈 농가의 야생동물 및 해충 퇴치를 위한 복합 기능의 방제키트
AU2023228890A1 (en) * 2022-03-03 2024-10-17 Thetis Pharmaceuticals Llc Cyclodextrin complexes of specialized proresolving mediators
IT202200008894A1 (it) * 2022-05-03 2023-11-03 Biodue S P A Composizione nutriceutica comprendente citicolina, vitamina D3 e olio di canapa.
CN115039742B (zh) * 2022-05-24 2023-08-29 江苏宁录科技股份有限公司 一种草地贪夜蛾性信息素双重缓释诱芯及其制备方法
EP4633623A1 (en) * 2022-12-16 2025-10-22 Kingdom Therapeutics Limited Cannabinoid based therapy
ES2990173B2 (es) * 2023-05-26 2025-04-08 Fund Gaiker Complejo de inclusion cuaternario de hidroxitirosol, triptofano, arginina y gluconato de zinc, metodo de obtencion y uso
CN117771389A (zh) * 2023-12-28 2024-03-29 浙江圣达生物药业股份有限公司 L-5-甲基四氢叶酸钙-γ-环糊精包合物及其制备方法
WO2025229618A1 (en) * 2024-05-02 2025-11-06 Czap Research And Development, Llc Blood glucose control with enzymatic cyclodextrin inclusion complex formulations
CN119797585B (zh) * 2024-12-31 2025-11-18 天津大学 一种可调节菌群结构实现短程硝化的组合物及其应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2453829C2 (de) 1974-11-13 1983-04-07 Siemens AG, 1000 Berlin und 8000 München Verfahren zur Herstellung von Additiven und ihre Verwendung als Glanzbildner
HU176215B (en) * 1978-01-27 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1
IT1147806B (it) 1981-01-23 1986-11-26 Wellcome Found Complessi di ciclodestrine e glicosidi cardiaci per uso terapeutico e procedimento di preparazione
JPS5944318A (ja) * 1982-09-04 1984-03-12 Riken Kagaku Kogyo Kk サイクロデキストリン難脱包接物質よりの脱包接法
US4538920A (en) 1983-03-03 1985-09-03 Minnesota Mining And Manufacturing Company Static mixing device
JPH0819004B2 (ja) 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
CA1321192C (en) 1988-04-20 1993-08-10 Abdul Majid Inclusion complexes of cyclodextrins by agglomeration
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
CA2013485C (en) 1990-03-06 1997-04-22 John Michael Gardlik Solid consumer product compositions containing small particle cyclodextrin complexes
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
EP0839528B1 (en) * 1996-10-29 2001-03-14 Staroil Limited Mouth-soluble compositions containing N-acetylcysteine and cyclodextrin
US6065645A (en) 1997-04-01 2000-05-23 Discus Dental Impressions, Inc. Double-barreled syringe with detachable locking mixing tip
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
CN1176784A (zh) * 1997-07-24 1998-03-25 北京路德有限责任公司 对乙酰氨基酚咀嚼片的制造方法及其产品
DE19911097A1 (de) * 1999-03-12 2000-09-14 Basf Ag Verfahren zur Herstellung von festen cyclodextrinhaltigen Dosierungsformen
US7888104B2 (en) * 2000-11-28 2011-02-15 Henkel Ag & Co. Kgaa Cyclodextrin glucanotransferase (CGTase), obtained from<I>Bacillus agaradherens<λ>(DSM 9948) and detergents and cleaning agents containing said novel cyclodextrin glucanotransferase
US6566401B2 (en) 2001-03-30 2003-05-20 The Board Of Trustees Of The Leland Stanford Junior University N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
FI113340B (fi) * 2002-02-20 2004-04-15 Tomi Jaervinen Uudet luonnon syklodekstriinin kompleksit
US7001893B2 (en) 2002-10-28 2006-02-21 Council Of Scientific And Industrial Research Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof
KR100675081B1 (ko) * 2003-03-06 2007-01-26 주식회사 서울제약 아세틸시스테인 함유 경구용 제제
WO2006058153A1 (en) 2004-11-23 2006-06-01 Smith & Nephew, Inc. Composite mixer
US20090029020A1 (en) 2005-06-13 2009-01-29 Cargill, Incorporated Cyclodextrin inclusion complexes and methods of preparing same
US20070003528A1 (en) 2005-06-29 2007-01-04 Paul Consigny Intracoronary device and method of use thereof
DE502005008144D1 (de) 2005-07-22 2009-10-29 Dentaco Gmbh Mehrkammerausgabevorrichtung
US20070072146A1 (en) 2005-09-29 2007-03-29 Dentsply Research And Development Corp. Dispensing syringe having multiple barrels for discharging a dental composition
US20100204178A1 (en) 2006-10-02 2010-08-12 James Cloyd Novel parenteral carbamazepine formulation
US8100295B2 (en) 2006-03-24 2012-01-24 Medmix Systems Ag Dispensing assembly with removably attachable accessories
CN100411688C (zh) 2006-09-12 2008-08-20 南京师范大学 含有环糊精/多烯紫杉醇包合物的药物组合物及其制备方法
CN101535315A (zh) * 2006-10-13 2009-09-16 辉瑞有限公司 用作家畜动物的同化激素类药的杂环化合物
US20100260818A1 (en) 2007-07-11 2010-10-14 Fertin Pharma A/S Stable medicated chewing gum comprising cyclodextrin inclusion complex
KR100929920B1 (ko) 2007-09-05 2009-12-04 주식회사 마크로케어 사이클로덱스트린 및 이의 유도체에 소수성 생리활성성분이 포접된 포접체의 제조방법 및 이로써 제조된포접체의 용도
JP2011528400A (ja) * 2008-07-17 2011-11-17 ハーキュリーズ・インコーポレーテッド 水系コーティング組成物を調整する方法
CA2767833C (en) * 2009-07-15 2018-10-23 Leland Stanford, The Board Of Trustees Of The Junior University N-acetyl cysteine compositions and methods to improve the therapeutic efficacy of acetaminophen
US20150217896A1 (en) 2010-02-11 2015-08-06 Clemson University Packaging materials derived from renewable resources and including a cyclodextrin inclusion complex
ES2426978T3 (es) 2010-10-21 2013-10-28 Sulzer Mixpac Ag Dispositivo de distribución doble
CN102058536A (zh) * 2011-01-14 2011-05-18 四川大学 槲皮素羟丙基β－环糊精包和物脂质体及其制备方法和用途
CA2831213C (en) 2011-03-27 2016-05-17 Cellresin Technologies, Llc Cyclodextrin compositions, articles, and methods
US20140315780A1 (en) 2011-05-05 2014-10-23 Jas Pal Singh Badyal Product
KR101794242B1 (ko) 2011-06-07 2017-11-07 임병갑 서방성 경구용 액상 제제
EP2740475A4 (en) * 2011-08-02 2015-02-25 Ono Pharmaceutical Co ACTIVE AGENT FOR IMPROVING THE LEFT-VENTRICULAR DIASTOLIC FUNCTION
EP2887968A2 (en) 2012-08-24 2015-07-01 The Board of Trustees of the Leland Stanford Junior University Methods and compositions for treating pain
ES2791180T3 (es) 2012-10-02 2020-11-03 Allergan Inc Hidrogeles de relleno dérmico con complejos de inclusión de vitamina A/ciclodextrina
WO2015184544A1 (en) 2014-06-04 2015-12-10 Protokinetix, Inc. Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome
US9421793B2 (en) 2014-06-26 2016-08-23 Cellresin Technologies, Llc Electrostatic printing of cyclodextrin compositions
US10098964B2 (en) * 2015-03-12 2018-10-16 The Board Of Trustees Of The University Of Illinois Inclusion complexes and methods for making the same
DK3411047T3 (da) * 2016-02-04 2021-06-28 Czap Res And Development Llc Kontrolleret udløsning og stratificeret cyclodextrin inklusionskompleks bæremedier
US20170224842A1 (en) 2016-02-04 2017-08-10 Czap Research And Development, Llc Controlled-release and stratified cyclodextrin inclusion complex vehicles
US20170224841A1 (en) 2016-02-04 2017-08-10 Czap Reseach And Development, Llc Controlled-release and stratified cyclodextrin inclusion complex vehicles

Also Published As

Publication number Publication date
SI3411047T1 (sl) 2021-09-30
EP3411047A1 (en) 2018-12-12
RS62097B1 (sr) 2021-08-31
EP3892303A1 (en) 2021-10-13
EP4098282A1 (en) 2022-12-07
AU2022200988B2 (en) 2024-06-20
KR20190005823A (ko) 2019-01-16
JP7144087B2 (ja) 2022-09-29
EP3411047A4 (en) 2019-08-28
CN115154619A (zh) 2022-10-11
BR112018016066A2 (pt) 2019-01-02
EP3411047B1 (en) 2021-04-14
AU2024219899A1 (en) 2024-10-10
JP2019512019A (ja) 2019-05-09
PL3411047T3 (pl) 2021-11-15
HRP20211086T1 (hr) 2021-10-15
CN108883125B (zh) 2022-08-09
CY1124822T1 (el) 2022-11-25
US20220257690A1 (en) 2022-08-18
JP2022173261A (ja) 2022-11-18
EP3892303B1 (en) 2023-06-07
US20230405074A1 (en) 2023-12-21
CA3012837A1 (en) 2017-08-10
SMT202100404T1 (it) 2021-09-14
EP3892303C0 (en) 2023-06-07
JP2021120386A (ja) 2021-08-19
ES2878580T3 (es) 2021-11-19
WO2017136775A1 (en) 2017-08-10
US12285455B2 (en) 2025-04-29
AU2022200988A1 (en) 2022-03-03
AU2017214669A1 (en) 2018-08-23
AU2017214669B2 (en) 2022-01-13
JP2025105883A (ja) 2025-07-10
PT3411047T (pt) 2021-07-06
US11633448B2 (en) 2023-04-25
HUE055157T2 (hu) 2021-11-29
JP6884420B2 (ja) 2021-06-09
CN108883125A (zh) 2018-11-23
JP7680756B2 (ja) 2025-05-21
LT3411047T (lt) 2021-07-26
US20250255920A1 (en) 2025-08-14
CN115154619B (zh) 2025-11-28

Similar Documents

Publication Publication Date Title
DK3411047T3 (da) Kontrolleret udløsning og stratificeret cyclodextrin inklusionskompleks bæremedier
IL268684A (en) Compositions and methods for immunooncology
IL262359A (en) Ex vivo bite-activated t cells
IL254959A (en) Compositions and methods for non-myeloablative conditioning
IL259530A (en) Shape changing drug delivery devices and methods
DK3229838T3 (da) Anti-C10orf54-antistoffer og anvendelser deraf
DK3149042T3 (da) PD-L1-antistoffer og anvendelser deraf
DK3126388T3 (da) Anti-EGFRvIII-antistoffer og anvendelser deraf
DK3597742T3 (da) Car-udtrykkende vektor og car-udtrykkende t-celler
EP3470035A4 (en) ABSORBENT ARTICLE
DK3452463T3 (da) Amidsubstituerede pyridinyltriazolderivater og anvendelser deraf
DK3215147T3 (da) Neurodæmpende norketamin-forbindelser og fremgangsmåder
DK3218358T3 (da) Ifluorometyl-aminopyridiner og difluorometyl-aminopyrimidiner
PL3550023T3 (pl) Oligomery i koniugaty oligomerów
DK3113797T3 (da) Antistoffer, anvendelser og fremgangsmåder
DK3532499T3 (da) ANTI-IL-33-antistoffer og anvendelser deraf
DK3321442T3 (da) Bærer og associeret klamme
DK3402821T5 (da) Psma-bindende antistof og anvendelser deraf
DK3161139T3 (da) Tlr-4-specifikke aptamerer og anvendelser heraf
EP3511407A4 (en) CHRISTENSENELLA INTESTINIHOMINIS AND APPLICATION THEREOF
IL272924B1 (en) Methods for making and using endoxifen
EP3549567A4 (en) ABSORBENT ARTICLE
IL259202A (en) Modified immune cells and uses thereof
EP3879472C0 (en) COMPARISON AND SIMULATION OF WASHES FOR CIP
DK3321279T3 (da) Exenatidmodificeringsmiddel og anvendelse deraf