HUE034374T2 - Genetically Modified Mice Expressing Chimeric Main Histocompatibility Complex (MHC) II Molecules - Google Patents
Genetically Modified Mice Expressing Chimeric Main Histocompatibility Complex (MHC) II Molecules Download PDFInfo
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- HUE034374T2 HUE034374T2 HUE12806199A HUE12806199A HUE034374T2 HU E034374 T2 HUE034374 T2 HU E034374T2 HU E12806199 A HUE12806199 A HU E12806199A HU E12806199 A HUE12806199 A HU E12806199A HU E034374 T2 HUE034374 T2 HU E034374T2
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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- C—CHEMISTRY; METALLURGY
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| EP2065730A3 (en) | 2006-04-26 | 2012-09-19 | L-3 Communications Security and Detection Systems, Inc. | Multi-source surveillance systems |
| PT2818478T (pt) | 2011-10-28 | 2017-05-12 | Regeneron Pharma | Il-6 e recetor de il-6 humanizados |
| PT3272214T (pt) | 2011-10-28 | 2020-03-04 | Regeneron Pharma | Ratinhos geneticamente modificados que expressam moléculas quiméricas de complexo principal de histocompatibilidade (mhc) ii |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SI2958938T1 (sl) * | 2013-02-20 | 2019-08-30 | Regeneron Pharmaceuticals, Inc. | Miši, ki izražajo humanizirane koreceptorje za celice T |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| RS57963B1 (sr) | 2013-02-22 | 2019-01-31 | Regeneron Pharma | Miševi koji eksprimiraju humanizovani glavni kompleks histokompatibilnosti |
| WO2014164638A1 (en) * | 2013-03-11 | 2014-10-09 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility comples (mhc) class ii molecules |
| SMT201900067T1 (it) | 2013-09-23 | 2019-02-28 | Regeneron Pharma | Animali non umani aventi un gene di proteina regolatoria del segnale umanizzato |
| WO2015057758A1 (en) * | 2013-10-15 | 2015-04-23 | Regeneron Pharmaceuticals, Inc. | Humanized il-15 animals |
| BR112016011003A2 (pt) | 2013-11-19 | 2017-12-05 | Regeneron Pharma | animal roedor geneticamente modificado, célula tronco embrionária de camundongo, embrião de camundongo, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo |
| JP6652931B2 (ja) | 2014-04-08 | 2020-02-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化Ｆｃγ受容体を有する非ヒト動物 |
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| US10390522B2 (en) | 2014-06-19 | 2019-08-27 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| EP3193592A1 (en) | 2014-09-19 | 2017-07-26 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| MA50679A (fr) | 2014-11-24 | 2021-03-17 | Regeneron Pharma | Animaux non humains exprimant un complexe cd3 humanisé |
| RU2728412C2 (ru) | 2014-12-05 | 2020-07-29 | Регенерон Фармасьютикалз, Инк. | Животные, отличные от человека, имеющие гуманизированный ген кластера дифференцировки 47 |
| CN107257624B (zh) | 2014-12-09 | 2021-07-13 | 瑞泽恩制药公司 | 具有人源化分化簇274基因的非人动物 |
| FI3280257T3 (fi) | 2015-04-06 | 2023-09-07 | Regeneron Pharma | Humanisoituja t-soluvälitteisiä immuunivasteita ei-ihmiseläimillä |
| PT3376857T (pt) | 2015-11-20 | 2021-05-27 | Regeneron Pharma | Animais não humanos com um gene humanizado 3 de ativação de linfócitos |
| EP3411392B1 (en) * | 2016-02-04 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| DK3422845T3 (da) | 2016-02-29 | 2021-08-30 | Regeneron Pharma | Gnavere med et humaniseret tmprss-gen |
| US10980221B2 (en) | 2016-06-03 | 2021-04-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| CA3093995A1 (en) | 2018-03-24 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| SG11202008620VA (en) | 2018-03-26 | 2020-10-29 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| JP7634994B2 (ja) | 2018-07-16 | 2025-02-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｄｉｔｒａの非ヒト動物モデルおよびその使用 |
| IL292406A (en) * | 2019-10-22 | 2022-06-01 | Univ Columbia | Transgenic pigs, methods for their production and use, and methods for producing mice with a human immune system |
| CN114901678A (zh) | 2019-12-02 | 2022-08-12 | 瑞泽恩制药公司 | 肽-mhc ii蛋白构建体及其用途 |
| US12376573B2 (en) | 2021-03-31 | 2025-08-05 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of TCRB repertoire |
| WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
| KR20250035053A (ko) | 2022-06-07 | 2025-03-11 | 리제너론 파아마슈티컬스, 인크. | T 세포 활성을 조절하기 위한 다중특이적 분자 및 이의 용도 |
| US20230417899A1 (en) * | 2022-06-27 | 2023-12-28 | Oshkosh Corporation | Position tracking for a lift device |
| JP2025532120A (ja) | 2022-09-22 | 2025-09-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト細胞性免疫系の構成要素を発現する遺伝子改変マウス |
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