HUE032754T2 - CSF-1R inhibitorok agytumorok kezelésére - Google Patents
CSF-1R inhibitorok agytumorok kezelésére Download PDFInfo
- Publication number
- HUE032754T2 HUE032754T2 HUE12720761A HUE12720761A HUE032754T2 HU E032754 T2 HUE032754 T2 HU E032754T2 HU E12720761 A HUE12720761 A HU E12720761A HU E12720761 A HUE12720761 A HU E12720761A HU E032754 T2 HUE032754 T2 HU E032754T2
- Authority
- HU
- Hungary
- Prior art keywords
- tumor
- csf
- blz945
- compound
- brain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
- CSIM R. mik M^rok ag>earu>rok kead evere S^sl>sáaiml igiriyporäokkêplcti ^fpgytlP|, akol IVebül IV Me vagy Égés R'5 vagy egy g\ ogyavsaúiag eökyjevfieM a éj a. esiilës alanyban. agytbmer kezelésében tëiténô alksiniaaäsie, V Vegyülni vagy gyögyä^eableg ellbgedhaté sije se I, igébygëël seerMtl alkslmseáem, aboi m (I.) képlete vegyülniX gvog>ás*;.ífc$g e; fogadható sója aa 1. Igénypont e^emm alkab^a^â$r%:àifô| (ü kcpíctií ^>8hd
- 4, V egt nie? N agy gux' S' ' aHug ·* & godamo síp a oh' »' 'genvy^m^k ' xnru V »ko s'c »nt? ikkaimaoáam ahol a* agynaner egy gnema. 4 Yegyökt vagy gyógyásratdsg eïïogw$at& #js' a 4 igÉWiMMefinù ;dkalma/.àvnv m-J. | gliön-n» glloklavteana nsuJtitefruc N \,v\ »! \λ'' -, wgN ! V W V Vu \ iV v"V ' ' 'V"' l\U" ^ X'V N>0? olkaltnaoesra, ahol a?' agytníror agy abdd aatrc»i>g»ma. (he leérne a giiohkstonnd), digedandroglkroie i.'pemlY»n»anak. vagy vaianeh Ogyee gkóma í. Vegyikí:! v agy gyégyáseaulag elfogadható sója a/ ekuo igátvpnmok bármely »ke v/eriam alkalnai/aata, ahal a vegüket eg> rgmkmv nn-apara vrohgàk» v/ermh hamm» alkakmuévre lunsulli 8 kegy oh.i vagy gy»kyas<fa»hae t’Nogaohaío vola a '! igény pom mmrmh alkalme/amte ahol m? gg^'nuey tg rágód a vamped veer antunga gen»'\g\ v,-e»\,k, N vom/an» 4» mmokwxnru! vagy antikok »? n \ek,oh*'n !"\ go ka»l t arraoie? d<< M g ghvp 'amgykotm :\kl»aí , ^ platina (ekvgpUnin),. alkha^b^ereíg például íem»v.»>k>núd uroomkmáo mhshdrok ígafltsnilí vagy etloűnlbj, I.'kuin. és cannahtnotdok kikäi váiavkvu
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161482723P | 2011-05-05 | 2011-05-05 | |
US201261624861P | 2012-04-16 | 2012-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE032754T2 true HUE032754T2 (hu) | 2017-10-30 |
Family
ID=46062775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE12720761A HUE032754T2 (hu) | 2011-05-05 | 2012-05-04 | CSF-1R inhibitorok agytumorok kezelésére |
Country Status (19)
Country | Link |
---|---|
US (3) | US20140065141A1 (hu) |
EP (1) | EP2704713B1 (hu) |
JP (1) | JP6046702B2 (hu) |
KR (1) | KR101938431B1 (hu) |
CN (1) | CN103501785B (hu) |
BR (1) | BR112013028095B1 (hu) |
CA (1) | CA2834696C (hu) |
CY (1) | CY1119642T1 (hu) |
DK (1) | DK2704713T3 (hu) |
EA (1) | EA023999B1 (hu) |
ES (1) | ES2622527T3 (hu) |
HR (1) | HRP20170593T1 (hu) |
HU (1) | HUE032754T2 (hu) |
LT (1) | LT2704713T (hu) |
MX (1) | MX347616B (hu) |
PL (1) | PL2704713T3 (hu) |
PT (1) | PT2704713T (hu) |
SI (1) | SI2704713T1 (hu) |
WO (1) | WO2012151523A1 (hu) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014147631A1 (en) * | 2013-03-22 | 2014-09-25 | Natco Pharma Limited | Formulation comprising gefitinib as oral suspension |
US10722517B2 (en) | 2015-05-08 | 2020-07-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for treatment of glioma |
US10316097B2 (en) * | 2015-05-27 | 2019-06-11 | Ucb Biopharma Sprl | Method for the treatment of epilepsy, epileptogenesis, seizures or convulsions by an anti-colony-stimulating factor 1 receptor (CSF-1R) antibody |
CN108367070B (zh) * | 2015-11-04 | 2022-10-28 | 杜克大学 | 免疫毒素与检查点抑制剂的组合治疗 |
WO2018069892A1 (en) * | 2016-10-14 | 2018-04-19 | Novartis Ag | Crystalline forms of 4-(2-((1r,2r)-2-hydroxycyclohexylamino) benzothiazol-6-yloxy)-n-methylpicolinamide |
US10537563B2 (en) | 2016-10-14 | 2020-01-21 | Novartis Ag | Methods for treating ocular disease using inhibitors of CSF-1R |
WO2018093591A1 (en) | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
AU2018275894A1 (en) | 2017-06-02 | 2019-12-12 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
AU2018275891A1 (en) | 2017-06-02 | 2019-12-12 | Juno Therapeutics, Inc. | Articles of manufacture and methods related to toxicity associated with cell therapy |
JP2020526194A (ja) | 2017-06-29 | 2020-08-31 | ジュノー セラピューティクス インコーポレイテッド | 免疫療法薬と関連する毒性を評価するためのマウスモデル |
MA50057A (fr) | 2017-09-01 | 2020-07-08 | Juno Therapeutics Inc | Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire |
US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
WO2020036987A1 (en) | 2018-08-13 | 2020-02-20 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
AU2019387497A1 (en) | 2018-11-30 | 2021-06-24 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
KR20210110811A (ko) | 2018-11-30 | 2021-09-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법에서 b 세포 악성 종양의 투약 및 치료 방법 |
CN110468210A (zh) * | 2019-09-12 | 2019-11-19 | 暨南大学 | Cdc45作为胶质母细胞瘤标志物及其作为治疗靶点的应用 |
CN115398231A (zh) | 2019-12-06 | 2022-11-25 | 朱诺治疗学股份有限公司 | 与治疗b细胞恶性肿瘤的细胞疗法相关的毒性和反应的相关方法 |
BR112023004719A2 (pt) * | 2020-09-21 | 2023-04-18 | Hutchison Medipharma Ltd | Compostos heteroaromáticos e usos dos mesmos |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100721656B1 (ko) | 2005-11-01 | 2007-05-23 | 주식회사 엘지화학 | 유기 전기 소자 |
PL2010496T3 (pl) * | 2006-04-14 | 2011-01-31 | Astrazeneca Ab | 4-Anilinochinolino-3-karboksyamidy jako inhibitory kinazy CSF-1R |
CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
LT2010528T (lt) * | 2006-04-19 | 2017-12-27 | Novartis Ag | 6-o-pakeistieji benzoksazolo junginiai bei csf-1r signalo perdavimo slopinimo būdai |
UA93085C2 (en) | 2006-04-20 | 2011-01-10 | Янссен Фармацевтика Н.В. | Inhibitors of c-fms kinase |
AU2008254425A1 (en) * | 2007-05-21 | 2008-11-27 | Novartis Ag | CSF-1R inhibitors, compositions, and methods of use |
-
2012
- 2012-05-04 ES ES12720761.1T patent/ES2622527T3/es active Active
- 2012-05-04 LT LTEP12720761.1T patent/LT2704713T/lt unknown
- 2012-05-04 SI SI201230916A patent/SI2704713T1/sl unknown
- 2012-05-04 EA EA201391629A patent/EA023999B1/ru not_active IP Right Cessation
- 2012-05-04 CN CN201280021878.2A patent/CN103501785B/zh active Active
- 2012-05-04 PT PT127207611T patent/PT2704713T/pt unknown
- 2012-05-04 DK DK12720761.1T patent/DK2704713T3/en active
- 2012-05-04 WO PCT/US2012/036589 patent/WO2012151523A1/en active Application Filing
- 2012-05-04 PL PL12720761T patent/PL2704713T3/pl unknown
- 2012-05-04 CA CA2834696A patent/CA2834696C/en active Active
- 2012-05-04 BR BR112013028095-6A patent/BR112013028095B1/pt not_active IP Right Cessation
- 2012-05-04 EP EP12720761.1A patent/EP2704713B1/en active Active
- 2012-05-04 HU HUE12720761A patent/HUE032754T2/hu unknown
- 2012-05-04 US US14/114,878 patent/US20140065141A1/en not_active Abandoned
- 2012-05-04 JP JP2014509491A patent/JP6046702B2/ja active Active
- 2012-05-04 KR KR1020137031960A patent/KR101938431B1/ko active IP Right Grant
- 2012-05-04 MX MX2013012939A patent/MX347616B/es active IP Right Grant
-
2015
- 2015-06-29 US US14/754,152 patent/US20150306085A1/en not_active Abandoned
-
2017
- 2017-04-10 CY CY20171100426T patent/CY1119642T1/el unknown
- 2017-04-12 HR HRP20170593TT patent/HRP20170593T1/hr unknown
-
2018
- 2018-06-04 US US15/996,945 patent/US10537561B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2012250574A8 (en) | 2016-07-28 |
AU2012250574A1 (en) | 2013-11-28 |
EA023999B1 (ru) | 2016-08-31 |
AU2012250574B2 (en) | 2016-07-07 |
EP2704713A1 (en) | 2014-03-12 |
CA2834696A1 (en) | 2012-11-08 |
WO2012151523A1 (en) | 2012-11-08 |
US20140065141A1 (en) | 2014-03-06 |
CN103501785A (zh) | 2014-01-08 |
EP2704713B1 (en) | 2017-01-18 |
LT2704713T (lt) | 2017-04-25 |
DK2704713T3 (en) | 2017-04-24 |
US20150306085A1 (en) | 2015-10-29 |
CA2834696C (en) | 2019-07-23 |
PL2704713T3 (pl) | 2017-08-31 |
KR20140029475A (ko) | 2014-03-10 |
SI2704713T1 (sl) | 2017-05-31 |
US10537561B2 (en) | 2020-01-21 |
MX2013012939A (es) | 2014-02-27 |
ES2622527T3 (es) | 2017-07-06 |
US20190030013A1 (en) | 2019-01-31 |
BR112013028095A2 (pt) | 2016-12-27 |
BR112013028095B1 (pt) | 2020-03-03 |
HRP20170593T1 (hr) | 2017-07-14 |
JP2014513136A (ja) | 2014-05-29 |
JP6046702B2 (ja) | 2016-12-21 |
CN103501785B (zh) | 2016-10-26 |
EA201391629A1 (ru) | 2016-01-29 |
KR101938431B1 (ko) | 2019-01-14 |
PT2704713T (pt) | 2017-04-24 |
CY1119642T1 (el) | 2018-04-04 |
MX347616B (es) | 2017-05-04 |
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