HUE032459T2 - Lipidszintézis heterociklusos modulátorai - Google Patents

Lipidszintézis heterociklusos modulátorai Download PDF

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HUE032459T2
HUE032459T2 HUE12754969A HUE12754969A HUE032459T2 HU E032459 T2 HUE032459 T2 HU E032459T2 HU E12754969 A HUE12754969 A HU E12754969A HU E12754969 A HUE12754969 A HU E12754969A HU E032459 T2 HUE032459 T2 HU E032459T2
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virus
compound
mmol
equiv
title compound
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HUE12754969A
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English (en)
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Johan D Oslob
Robert S Mcdowell
Russell Johnson
Hanbiao Yang
Marc Evanchik
Cristiana A Zaharia
Haiying Cai
Lily W Hu
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3-V Biosciences Inc
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Publication of HUE032459T2 publication Critical patent/HUE032459T2/hu

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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Claims (3)

  1. HfcTSROCitausoS MODULATOR Ai !» fta (tXj «2»rk«2SÎÙ vegyidet'.:
    vagy iííohöi gyogyskoRszehRg sRogadhatc sója, ahol R' jelentése H. -CN. halogen, C:-C4 egyenes vagy oíágoaé aíkit. -D {Cí-C;. íRRaliR), -G-{Ci-C* egyenes vagy stég&amp;aó sikít} ahG Gj-Cs íüKíoaikíf opcionálisan tartalmaz egy exigés vagy nitrogen hoteroatomct. es snot R- -Siamese nem R -CN vagy halogén. op«o.Tá<ísaf*.œàsætàüiÉ’-^ieg^ ÈSfcfe naiogérmai; mindegyik R;: Riaotése egymástól fôggaltsnüï hidrogén, halogén vagy C--C- egyenes vagy elàsaeé aîkiS; R'jsieajte H. -Oh vagy haksgén; R5' Rismiéss H, halogén. CVO* egyenes vagy aiéga.í:é adói. €.·,-€? dkioRM. ahol a Cy-Cj. okRatR opmoriâkoan egy oxigén vagy nitrogén hetaroatomoi tafiaimsa; Ru ietenté» H. halogén vagy C>-C;- síké }Ÿ'3 joseetèse R Cé-Cé egyenes vagy elágazó aSKit. -CCî-C* aiktlROR RCî-C* s?ki!ROriC:;-CR c!kk>atkti). •m^4e<.4u stkiOrORC ·.·-G- egyenes vi|y étéga-sô aM\ an«!. í á;1éka Ο vagy -S; a Cí-Cé c&amp;kîâiKii ppsonaihan egy oxigén vagy rotrogên neisrosionioi íaCaCosA L'! jeientése CR' S vagy N; L:í je tenté sa CH vagy Μ; L'; vagy r’ kosié SegaCbb a.ï egyé: ÿetemas« N; ès R o a* ese '' V AC i. sgyenve ν3ς\ ^ a 3 3*0 Cn<~^ a * "Ss :li»;Í ||éfípcv4 sasÄvggyÄ, a|ol n R'" ietan&amp;ee Ci-C* egyenes vagy e&amp;gazé siM vagy -<c,„o a&amp;ü ;-0'{CrC·! egyenes vagy «iagSïé aík-i). «nos t értéke 0 vagy 5 .il.. A 2 igényper* Süeitnü vegyiket. at;»i R^ joientése Ci-Cjs egyenes vagy eiagaïé «As 4s A3. ^ényg^i-iBs^íá-veiylillí.'iah^aa:ft*4^ian^ÜsüÜ» « S..· Aï t vagy 2 ^énypoirt sreent vegyeal «nos a? ·„' as sz l'jetentase egyatam N. € Aï 1. vagy 2. igénypont szerinti vegyétek'ahoi R*' yetenlése halogén, C<~C.< egyenes vagy etàg&amp;ïà aik* vagy C:rCs ctkioaiM. aiiei a C.-C; «etisa&amp;a ©pcteeâhsan egy exigé» vagy nitrogén heteea&amp;lomot taiistmss. f:t A 1 igénypont m&amp;nl· vegyiket, aho! R2 * |éi*nté*e Cs-C$ ciktoaikîi A 7 igénypont siSîMivsgyÊfeî,-#^:m : kf ' |3Mâ3e:#kÂÉi. t, Aï 12. vagy 5 igénypontok foérmelyáte sïaànti vágyóiéi, aboi a2 R"2 ieiesîése Hornéit vagy etä; :ΐί: A ξ» igénypont *?«nnî vegyiket abat aï R**‘ intentée« met*
  2. 11. Aï 1 vagy 2 igénypont 00:000= vegyui&amp;t, shot a.ï R2 jaientèse H vagy OaSogèn. 12, A 11 *gènynoot s.? «ónt vágyóiét. ones aa R? jeteniéee h 11, A 1 igénypont sse-ínt vegyülst. aboi safeéagyik R'" jeteoilse N.
  3. 34- As 1 , 2- vagy 4. igénypontok nértnaiyJkn sxe<tot! vsgyi»e*: ahoi as R' * hatoyén, -CN vagy G*« €> hato-aiki'l. il- A i4 igénypert «séant vegytstet, aboi a«. R1 letentéea -CN Ax 1 igénypont sæeHttg vegytriat, ah©} ftf’ Jelentése C; C? aîksi vagy Cs-C* oktoalfeH As R"- jefeotès© Cn V/ ·;^ΚϊΙ. 4¾ As 16. Igénypont szmmi vagy ©te!. ahol R'1 jelentése Cs-C% eMoatot ès R2* Jéianté&amp;e C<-Ca a» 14; A 1 ?. igénypont «aeftoji vsgyuist. ahoi R'"* je-smos© Ci-C > alk&amp; As 1 igénypont wnng vegyi*!«*- «M R' y^m’ém.-^Hï otinttogyt* R' tot^ééee H< Rv jelentése H vagy F Ri< jelentésé G' Oa {vtaoal*4 Rs denses® ?n«P{< l>' As t»‘ jesentése &amp;, és R Ä Nemese mefct* ets, miRiKHrséU metökt-fhehi <?'«**· w ©R i|0;, Αχ 1. igénypont ssenrèi vegyôtoi. amelyneic kôpfeis a kovetka*R*fcöt é»ô ceopooPéí kaiütt ksvâlesstâérs
    11; As i igénypont sxenoii vsgyOîey amelynek a képto!« « *ôve»«*o.
    Αχ 1-21. igénypontok 880dml vegyítetek bármelyikét. vateiterteagy §fé§ÿSKsréssets1a§ afegsihsté hordozót, segédanyagot.-vagy teglteaxerf tartaimazo készítmény.; -gl, Aï t»2i, igénypontok szerinti vegyítetek bármelyének terápiáson hatásost mennyisége. amely egy alanyban vayafcfKíXés kszteés« során alkalmazandó. Ä A 23 igénypont szedni afkaimazaraio vogySíetek. ahol » vírusos-fertőzés hapsltea € tettözést te|iáí magában. SS. Az í-21 igénypontok saásteíl vegyítetek bármelyikének terápiásán bslásos mennyisége, olyan állapot kezelése közben történő alkalmazásra. «mely fattemazhsM, M; Az 1-21. igénypontok szerinti vegyítetek bármelyikének terápiásán Itatásos mennyisége, amely egy glartybeit rák kezelése sétáé áfcalmazandO; ii A 26. igénypont szerint alkalmazandó vegyítetek, almi a rák. mellrák. Ϊ&amp;. a 28. Igénypontszabni alkalmazandó vegyoietek, anol a rák mellrák. yg A SS. igénypont szarná a&amp;ateiazandé vegyítetek, áltól &amp; fák tüdőrák, petefészekrák, prosztatarák, vastagbékák, végbáírák. peizsmiftgyiák. nyirokesortaSrék, nyalóesöfák, onrgsrat iák. esáígaml-rák, nyáimlngyrák vagy agyrák.
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