HUE031449T2 - Szilárd makrolid alakok - Google Patents

Szilárd makrolid alakok Download PDF

Info

Publication number
HUE031449T2
HUE031449T2 HUE08786436A HUE08786436A HUE031449T2 HU E031449 T2 HUE031449 T2 HU E031449T2 HU E08786436 A HUE08786436 A HU E08786436A HU E08786436 A HUE08786436 A HU E08786436A HU E031449 T2 HUE031449 T2 HU E031449T2
Authority
HU
Hungary
Prior art keywords
tylonolide
dipiperidinyl
mycaminosyl
polymorph
crystalline
Prior art date
Application number
HUE08786436A
Other languages
English (en)
Inventor
Fritz Blatter
Meinrad Brenner
Guixian Hu
Timo Rager
Ralf Warrass
Original Assignee
Intervet Int Bv
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv, Microbial Chem Res Found filed Critical Intervet Int Bv
Publication of HUE031449T2 publication Critical patent/HUE031449T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)

Claims (3)

  1. bxxbadáb-X ;gé:íy«íok L ..2}.!'ΛχΙφφ<-ΓΜΒΧχ.5·--\>·χι>4χχη8«;Μχ33χ:χ;χϊ §-:y5>.;·-:·:¾]X-í> sí.liskj&amp;v 8 ko-vcska-ab j&amp;Üasaskb IsgsIáMí «gyíkéw!:: 3: SbrSá abxiwiv;: vax; ribngxi; pxrddkkk-xó x;x4;trBm. sxxk)- í.srlstΐs<:\8<.-mX Sgl ίχ Xk.2} Jak 'itt: gvcogSi-x; ΐρ!|®§ !:kl«kk> ,á3'R;(sftaípsaí:®! tSXák refbaööíi) «íilávöms svxkxxxs. ahogy a 8. ábrás ábs'ásol vg Sask vágy ©Ixadáspoaí káxíbbaiöl !§2-akb körk4!k3'kl 14>'·· :< - í;> . J. Λ;·· i. |sjéí3g|>ö?8 alak. als>l á röpgás yx>r dilaakvk' \pok»oxx ahogy ϊϊλ 1. Ikrák afeákldka.vka. kk kk.23-<lp?;p5Bkikűk>-r}-í:>>:;;&amp;«-!!ri<ne-nk>riB!;d kmsSkbm slakjáaSh MixiSiXililaa. sssaiy r-xddkvsik a bdcikod) jklteaxsob láplálb axyikcvd: PT--&amp;sms:á. apoká-áss SPáiy IWkÉMk aKsar-fi-ciadaoi ágy digyáMíh Scdxax sáx íásdy ki vsa vái« szíva a kővc 1 .koaoko*i álló c::;:>j:=<'>r:í>í>ϊ: d-dyy í . ; aká.
  2. I&amp;BS, ks 'iáí c·'.· :. rösígxx· por dfhxkcd wkínux. asxdy axialoxs1 vaucrx;· éj (á ÖJykfcs;3kk vagy gyvxxbes tsljoa ráöcdo gxksxsáeá tök! rdlíaooá:) biho«;ré>. xprkinxn. as;d> tiiriálSíák absaai'gaxkdYVS cg.y v..:gy iába Sekvcs'ysás, sax-iy kivág vdava-va a k<x<-ikvv?ökból abb vaspörikor IldS, Íi3bf IMI I5>P, Í4SL S165, ;0kík 1 Ckd, 1141, HKdddS . ásd d 'db o-sJ sxtormédidJoái sa l.: IgágypáíS *á«rixh: tö&amp;'as^llíö:akfe-siMEMsi^»-áíKsi m '!< igMsypssm·msMtis knrxtdixi alak Fdyskrhiajorbd.vsd va.a dokígy .x 4. 30d3'-<bp!ppíyí|kk3-Q'-!kkiSMa4kbsi!->á!|irlIk! áköivgiáh kJkpsUbi áfaMSsák: fcbss.vxsiákha. x;s.enxíxbrrkv-x ás k adaypors arobrx; vokml álkspovö dxi: d&amp;Xb-ásara.. ahol az I. IgvsiypiXir raedaP ááljárl sikk Siiukrx^áh-B'.SáíXB! yaá áfMhlim: J λ 4 IgssygöiX s:ssFbb:l iklhrrzaálS®, sági ··- vxdvadk krl:«.idlia kyí&amp;llskSSS á kövakhOz-ök kyasabb sgyskéi: 2(k33~klikibkrkk8|-d;-Gkaryásaái3ásk4klóSökd BliSSkllt -sköikáílli kbSáíSlhá akskbx tr\2|^p^íidstóÍ-5-'Ö-eyb«i5«ib5íkHMid staaöbaaolvaiáli .SossxMta· οΐδίφχ kik 2 kijipipixxixak-a-(4--:8)(.asoao>d ulaaoki diSülkstöSsískölvSISik krivrraibn á!ak|S : 30v2J-:dlpip8Fláiskl--l-Ö-:83\r;s333Í8a!ál':ijlai3ák(i.^’f’^bisíjbisstíl-éíervssííi v&amp;iált teisdalhs alskjs; ItCiail3sráíjssíslíliísíi--5-O--írsysssmir?*ss 1'titonoIíí| takaliSöábíöFási áiöjyáiMt knvodbn a báb;.; 2b,23-sllpipembosi-:; ·( 3--53)¾ «xnaoaIk-ricsk|:|á nicí-iaced* --saoliSSsU :knkSál!I»: aiak;s; vágy 2kd3--dipsp8rMÍ8:ikId3^syegmk3ií8ikS:sk43y c-bfanaá;-aaolv:u;!H krssa;aiiig ak-kpa k:. k:>s?3|x;?i-:Sk ax-dy sar-abaaa 2Ö>23'k|spiJSdMsáíidSk-S-^O^ksry^fIdíkli>sSxilS'k 5:ί ahol x 22.2a - Ilpípesá|k3sk-kl3-x:öfüíbkks>klkiil||s>b ilSgliabl bö:>v-a a ix-xax)aici-X;a» ax 1-2. ixaxyp<x;x>k bSrBx:lyíkx áxcnx-x kxiskíSlliS Slákbol ML
  3. 3, Xk:>B'i;X1 ··.'-ΐ-';·. axivly ixVXBXX:? 2x,2 Xd?pU>CridiíXX->--<)-BXV:. angiX'HX-8Ϊ·iii-<-:. ah<S S 23.2.'-- ikpipeí!.2j8ik2':k)':Xs>föiXíM3ö5blrkSsí!Sliálx:iesSl2bb bilkk-xs lisxiaxágbas o;·: i-2:. lyényyx.';Hxk bMxndyikx ssXi'ikíi :kks.5bxslbr 'Mskbssv^m 5. Λ 6··7. spnynon-ak háííndyskv »©ΧήήΙ kn-npoau-á feaáglfea®, balls®* a-aepscar-X-l: ildiiasnaáláass gyélgyfeías' aIMIIMaki'in ssssdy écsvysny knsdcsérc sg#lgá| 7;énban. 6. A 1. ígényp;x-í sscvná Ibtsnvvnakn. áligl S bndgssg ki Vön válásaivá a káu.d;a®'kh6! áU® cnnxnUH·; naslcnnJSiváa. «vsrb-ί lágvgkayryi bdájsiág, ás sgltég iégsd.aary: baiggkig:, 16, Λ 'V sí;vnyp->;u sanb-Vs Ivlknvsn-dáv áh®l: s íiiss'kS iev/ö'·/®::'·-; bylágáág a ksiváikáaák tggálálsb cuyikv'-vS kápéysáánss.: .álgánípágg /vxífXfVyív ;. PáSieurelüi muktKiíM. ék ;ÍaU>pkih<·: ,n>«n/: és a séskés icnaásacrvs llélsgsag S ki>y«lkáaák kuaksbk ágylMé®! i-:sp<-\; Vauja: /k'<!;··/.>··: S·>:.>>.-;>.··.·/«{.:·. PéSS&amp;UíRiHa ;.».:·;6···:··:'.:/··..;. és R:-rd<:ii:-k; kx^nki-Mf/ínCü. II, Eillaás gy6gysaferééaen knnynde-6 ciaSlkaHá·«. aniniv -adal-nanaö Ínpláblí agy sssipsns !i:v®é®néÍ3->á; a 6-7, igánpnvsiök báénsalyílas, saavim-i kv-npoa-dava!, lg: < ívvav^,vasétvaí; korvpaaluv. agái a y>í-yys.--vnHi:.vi kongxvdu® sg|éaimáa PllSpölSiél.· gpikly eljárás állal -vsa kiakka vs; áisgly taml&amp;mm á 6-7, agéáygiédök: iiáimáiyské skaíisSl k®-np<>eu k-K-Tápsasa»: b.stóans mauiybégésnk a>-:ea;--pe;V:íw!á;:3í |gy|6|llb sgy aséikiáidbaak
HUE08786436A 2007-07-26 2008-07-25 Szilárd makrolid alakok HUE031449T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07113244A EP2019112A1 (en) 2007-07-26 2007-07-26 Macrolide solid-state forms

Publications (1)

Publication Number Publication Date
HUE031449T2 true HUE031449T2 (hu) 2017-07-28

Family

ID=39467287

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE08786436A HUE031449T2 (hu) 2007-07-26 2008-07-25 Szilárd makrolid alakok

Country Status (13)

Country Link
EP (3) EP2019112A1 (hu)
JP (7) JP5925989B2 (hu)
KR (2) KR20160003899A (hu)
CN (5) CN103360447B (hu)
AU (1) AU2008278969B8 (hu)
BR (1) BRPI0814318B1 (hu)
CA (1) CA2693801C (hu)
ES (2) ES2805534T3 (hu)
HU (1) HUE031449T2 (hu)
RU (1) RU2476438C2 (hu)
TW (1) TWI427083B (hu)
WO (1) WO2009013351A2 (hu)
ZA (1) ZA201000188B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms
JP5323696B2 (ja) 2006-07-28 2013-10-23 インターベツト・インターナシヨナル・ベー・ベー マクロライド合成方法
BR112014012585B1 (pt) 2011-11-25 2021-05-25 Bayer Intellectual Property Gmbh composto compreendendo derivados de tilosina, método de preparo do mesmo e composição farmacêutica ou veterinária
CN102816196A (zh) * 2012-09-10 2012-12-12 河北远征药业有限公司 泰地罗新半抗原、人工抗原及其制备方法
NO2999707T3 (hu) * 2013-05-23 2018-08-25
CN103554203A (zh) * 2013-08-17 2014-02-05 齐鲁动物保健品有限公司 一种泰地罗新无定形晶及其制备方法
CN104478974B (zh) * 2014-11-28 2016-08-17 武汉回盛生物科技有限公司 一种20，23-二哌啶基-5-o-碳霉胺糖基-泰乐内酯的合成方法
CN104447919B (zh) * 2014-11-28 2017-03-08 武汉回盛生物科技股份有限公司 一种20，23‑二哌啶基‑5‑o‑碳霉胺糖基‑泰乐内酯原料药的精制方法
CN104497082B (zh) * 2015-01-13 2017-12-12 中国兽医药品监察所 一种泰地罗新的合成方法
CN104774223A (zh) * 2015-03-26 2015-07-15 宁夏泰瑞制药股份有限公司 一种利用泰乐菌素碱生产泰地罗新的方法
CN105254693B (zh) * 2015-11-13 2017-12-22 周金华 一种泰地罗新的合成方法
CN106083958B (zh) * 2016-06-02 2019-07-23 天津大学 泰地罗新环己烷溶剂化合物及制备方法
CN106046084B (zh) * 2016-06-02 2019-08-09 天津大学 泰地罗新丙酮溶剂化合物及制备方法
CN106008629B (zh) * 2016-06-02 2019-11-22 天津大学 泰地罗新1,4-二氧六环溶剂化合物及制备方法
CN109721633A (zh) * 2017-10-31 2019-05-07 齐鲁晟华制药有限公司 一种泰地罗新晶型a及其制备方法
CN111349130A (zh) * 2018-12-21 2020-06-30 齐鲁动物保健品有限公司 一种泰地罗新晶型b及其制备方法
CA3202396A1 (en) 2020-12-03 2022-06-09 Intervet International B.V. A method of treating foot rot
CN114213484A (zh) * 2021-12-21 2022-03-22 河北远征药业有限公司 一种泰地罗新1，2-丙二醇溶剂化合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL33732A (en) * 1969-02-06 1973-05-31 Meiji Seika Kaisha The new antibiotics sf-837,sf-837-a2,sf-837-a3 and sf-837-a4 and their production
AU561147B2 (en) 1982-09-13 1987-04-30 Eli Lilly And Company 20-amino macrolide antibiotics
US4820695A (en) 1982-09-13 1989-04-11 Eli Lilly And Company C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
YU43658B (en) * 1983-07-18 1989-10-31 Pliva Pharm & Chem Works Process for preparing 7,16-dioxa-2-aza-10-0-cladinosyl-12,0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo(11.2.1)hexadeca-1(2)-ene-8
US4921947A (en) * 1986-03-31 1990-05-01 Eli Lilly And Company Process for preparing macrolide derivatives
US4920103A (en) 1986-09-29 1990-04-24 Eli Lilly And Company Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides
CA2391834C (en) * 1999-08-30 2008-08-05 Toshiaki Miyake Macrolide antibiotics and treatment of pasteurellosis
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
WO2005019226A1 (en) * 2003-08-26 2005-03-03 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
JP2007527434A (ja) * 2005-01-05 2007-09-27 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 非晶質タクロリマス及びその調製
JP5323696B2 (ja) * 2006-07-28 2013-10-23 インターベツト・インターナシヨナル・ベー・ベー マクロライド合成方法
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms
CN101506220B (zh) * 2006-07-28 2012-10-17 英特威国际有限公司 大环内酯合成方法

Also Published As

Publication number Publication date
ES2805534T3 (es) 2021-02-12
BRPI0814318B1 (pt) 2021-04-06
JP2014088394A (ja) 2014-05-15
CN103360447B (zh) 2016-04-06
EP3170833A1 (en) 2017-05-24
AU2008278969B8 (en) 2012-03-15
CN103360445B (zh) 2016-05-18
ES2608978T3 (es) 2017-04-17
JP2010534635A (ja) 2010-11-11
EP2181117A2 (en) 2010-05-05
CN103360445A (zh) 2013-10-23
EP3170833B1 (en) 2020-05-20
CN103360446A (zh) 2013-10-23
CN103467548A (zh) 2013-12-25
WO2009013351A2 (en) 2009-01-29
EP2019112A1 (en) 2009-01-28
ZA201000188B (en) 2010-09-29
KR102508115B1 (ko) 2023-03-08
JP2016147858A (ja) 2016-08-18
BRPI0814318A2 (pt) 2015-01-06
JP6343624B2 (ja) 2018-06-13
CN103360447A (zh) 2013-10-23
KR20100044864A (ko) 2010-04-30
CA2693801A1 (en) 2009-01-29
RU2010107057A (ru) 2011-09-10
JP2020172516A (ja) 2020-10-22
CA2693801C (en) 2018-08-14
TW200918547A (en) 2009-05-01
AU2008278969B2 (en) 2011-11-17
AU2008278969A1 (en) 2009-01-29
CN101778858B (zh) 2013-12-04
CN101778858A (zh) 2010-07-14
CN103360446B (zh) 2016-04-06
RU2476438C2 (ru) 2013-02-27
JP5925989B2 (ja) 2016-05-25
TWI427083B (zh) 2014-02-21
EP2181117B1 (en) 2016-11-09
JP2018104449A (ja) 2018-07-05
WO2009013351A3 (en) 2009-04-02
KR20160003899A (ko) 2016-01-11
JP2018109020A (ja) 2018-07-12
JP2020172517A (ja) 2020-10-22

Similar Documents

Publication Publication Date Title
HUE031449T2 (hu) Szilárd makrolid alakok
US8461121B2 (en) Macrolide synthesis process and solid-state forms
KR20200115661A (ko) 노르이보가인 염 무용매화물
SI9720038A (sl) Polimorfi donepezil hidroklorida in postopek izdelave
KR100892177B1 (ko) 결정형 및 무정형 형태의 베타-ｌ-2&#39;-데옥시티미딘
EP3898596B1 (en) Pharmaceutical compound, the method of its making and use as medicinal agent
TW200837067A (en) Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof