HU230160B1 - Interleukin-I inhibitort és kontrollált felszabadulású polimerként hialuronant tartalmazó készítmények - Google Patents
Interleukin-I inhibitort és kontrollált felszabadulású polimerként hialuronant tartalmazó készítmények Download PDFInfo
- Publication number
- HU230160B1 HU230160B1 HU9902612A HUP9902612A HU230160B1 HU 230160 B1 HU230160 B1 HU 230160B1 HU 9902612 A HU9902612 A HU 9902612A HU P9902612 A HUP9902612 A HU P9902612A HU 230160 B1 HU230160 B1 HU 230160B1
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- HU
- Hungary
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- sequence
- hyaluronan
- pharmaceutical composition
- use according
- seq
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1141996P | 1996-02-09 | 1996-02-09 | |
| US60/011,419 | 1996-02-09 | ||
| US3278996P | 1996-12-06 | 1996-12-06 | |
| US60/032,789 | 1996-12-06 | ||
| US3624197P | 1997-01-23 | 1997-01-23 | |
| US60/036,241 | 1997-01-23 | ||
| US08/798,414 | 1997-02-07 | ||
| US08/798,414 US6096728A (en) | 1996-02-09 | 1997-02-07 | Composition and method for treating inflammatory diseases |
| PCT/US1997/002131 WO1997028828A1 (en) | 1996-02-09 | 1997-02-10 | Composition comprising interleukin-1 inhibitor and controlled release polymer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9902612A2 HUP9902612A2 (hu) | 1999-11-29 |
| HUP9902612A3 HUP9902612A3 (en) | 2001-11-28 |
| HU230160B1 true HU230160B1 (hu) | 2015-09-28 |
Family
ID=27486083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902612A HU230160B1 (hu) | 1996-02-09 | 1997-02-10 | Interleukin-I inhibitort és kontrollált felszabadulású polimerként hialuronant tartalmazó készítmények |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0904112B1 (enExample) |
| JP (2) | JP4344404B2 (enExample) |
| KR (1) | KR20040010739A (enExample) |
| CN (1) | CN1215340A (enExample) |
| AT (1) | ATE448797T1 (enExample) |
| AU (1) | AU724960C (enExample) |
| BR (1) | BR9707325A (enExample) |
| CA (2) | CA2539273C (enExample) |
| CZ (1) | CZ299025B6 (enExample) |
| DE (1) | DE69739656D1 (enExample) |
| EA (2) | EA001792B1 (enExample) |
| ES (1) | ES2334726T3 (enExample) |
| HU (1) | HU230160B1 (enExample) |
| IL (1) | IL125552A0 (enExample) |
| MX (1) | MX9806191A (enExample) |
| NO (1) | NO983543L (enExample) |
| NZ (2) | NZ503548A (enExample) |
| SK (1) | SK288144B6 (enExample) |
| WO (1) | WO1997028828A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2273852C (en) | 1996-12-06 | 2009-09-29 | Amgen Inc. | Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| ATE348163T1 (de) | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| AT406054B (de) * | 1998-11-04 | 2000-02-25 | Andreas Bernkop-Schnuerch | Verfahren zur verbesserung der mucoadhäsion von polymeren sowie deren herstellung und verwendung |
| AU5428300A (en) * | 1999-06-21 | 2001-01-09 | Santen Pharmaceutical Co. Ltd. | Remedies for arthrosis deformans |
| CN1402642A (zh) * | 1999-07-21 | 2003-03-12 | 奥默罗斯公司 | 用于抑制疼痛,炎症和软骨退化的溶液及方法 |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| EP1278778A2 (en) * | 2000-05-03 | 2003-01-29 | Amgen Inc., | Modified peptides, comprising an fc domain, as therapeutic agents |
| US7324635B2 (en) | 2000-05-04 | 2008-01-29 | Telemaze Llc | Branch calling and caller ID based call routing telephone features |
| EP1282435A2 (en) * | 2000-05-12 | 2003-02-12 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
| DE60139944D1 (de) | 2000-10-12 | 2009-10-29 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
| US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| US7087224B2 (en) | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
| TR201809678T4 (tr) | 2001-06-26 | 2018-07-23 | Amgen Fremont Inc | Opgl ye karşi antikorlar. |
| US6818613B2 (en) | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
| WO2003061626A1 (en) * | 2002-01-18 | 2003-07-31 | Control Delivery Systems, Inc. | Polymeric gel system for the controlled delivery of codrugs |
| MXPA04011470A (es) | 2002-05-21 | 2005-02-14 | Amgen Inc | Compuestos heterociclicos sustituidos y metodos de uso. |
| MXPA05002514A (es) | 2002-09-06 | 2005-05-27 | Amgen Inc | Anticuerpo monoclonal anti-il-1r1 humano terapeutico. |
| US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
| US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| US8361467B2 (en) * | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| PL1729810T3 (pl) * | 2004-04-02 | 2019-02-28 | Swedish Orphan Biovitrum Ab (Publ) | Sposoby agregacji IL-1ra |
| CA2580796C (en) | 2004-09-24 | 2013-03-26 | Amgen Inc. | Modified fc molecules having peptides inserted in internal loop regions |
| CN103860582A (zh) * | 2004-12-30 | 2014-06-18 | 建新公司 | 用于关节内粘弹性补充的方案 |
| EP3725299A1 (en) * | 2005-06-24 | 2020-10-21 | Duke University | A direct drug delivery system based on thermally responsive biopolymers |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| AR056806A1 (es) | 2005-11-14 | 2007-10-24 | Amgen Inc | Moleculas quimericas de anticuerpo rankl- pth/ pthrp |
| US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
| GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
| US8323635B2 (en) | 2007-11-14 | 2012-12-04 | General Regeneratives, Ltd. | Methods of using interleukin-1 receptor antagonist as a myeloprotective agent |
| US8986696B2 (en) | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
| WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| KR200451958Y1 (ko) * | 2008-10-09 | 2011-01-21 | (주)에이치시티 | 모바일기기용 카드형 안테나장치 |
| PE20120359A1 (es) | 2009-03-06 | 2012-04-13 | Genentech Inc | Formulacion con anticuerpo |
| US20110052561A1 (en) * | 2009-08-27 | 2011-03-03 | Biomet Biologics,LLC | Osteolysis treatment |
| TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
| CN101690801B (zh) | 2009-10-26 | 2012-08-01 | 上海交通大学 | 白细胞介素-1受体拮抗剂的用途及其药物组合物 |
| DE202009017772U1 (de) | 2009-12-10 | 2011-04-21 | Orthogen Ag | Kombinationspräparate mit Cytokin-Antagonist und Corticosteroid |
| RU2563830C2 (ru) * | 2011-02-08 | 2015-09-20 | Эббви Инк. | Лечение остеоартрита и боли |
| BR112013020195B1 (pt) | 2011-02-11 | 2020-01-07 | Swedish Orphan Biovitrum Ab (Publ) | Composição farmacêutica livre de citrato compreendendo anakinra e uso de anakinra |
| US20140234330A1 (en) | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| WO2013030348A1 (en) | 2011-09-02 | 2013-03-07 | Novozymes Biopharma Dk A/S | Oral formulations containing hyaluronic acid for sustained drug release |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
| AU2014333953C1 (en) * | 2013-10-08 | 2020-06-25 | Ascendis Pharma A/S | Hydrogel-linked IL-1ra prodrug |
| WO2015191783A2 (en) | 2014-06-10 | 2015-12-17 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
| CZ309295B6 (cs) * | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| US10041044B2 (en) | 2016-07-29 | 2018-08-07 | Trustees Of Boston University | Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development |
| JP7216006B2 (ja) | 2017-03-22 | 2023-01-31 | ジェネンテック, インコーポレイテッド | ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法 |
| US11819536B2 (en) | 2018-06-22 | 2023-11-21 | The Trustees Of Columbia University In The City Of New York | Sustained release compositions and methods for treatment of temporomandibular joint degeneration |
| EP3836954B1 (en) | 2018-08-13 | 2025-05-07 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| US12370240B2 (en) | 2018-11-28 | 2025-07-29 | Genascence Corporation | Methods and compositions for treating osteoarthritis |
| WO2021026289A1 (en) | 2019-08-08 | 2021-02-11 | Avidence Therapeutics, Inc. | Microsphere-Based Injectible Celecoxib Formulation |
| US20250283174A1 (en) | 2022-05-16 | 2025-09-11 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation |
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| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| KR900700134A (ko) | 1988-04-15 | 1990-08-11 | 원본미기재 | Il-2 수용체-특이적 키메릭 항체 |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| DE59010941D1 (de) | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
| IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| CA2065346C (en) | 1989-09-05 | 2005-03-29 | Craig A. Smith | Tumor necrosis factor-.alpha. and-.beta. receptors |
| AU649245B2 (en) * | 1990-04-02 | 1994-05-19 | Amgen, Inc. | Methods for treating interleukin-1 mediated diseases |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
| WO1991017184A1 (en) | 1990-04-27 | 1991-11-14 | The Upjohn Company | Modified interleukin-1 inhibitors |
| AU1674292A (en) | 1991-03-15 | 1992-10-21 | Synergen, Inc. | Pegylation of polypeptides |
| CA2119090A1 (en) * | 1993-03-26 | 1994-09-27 | Wayne R. Gombotz | Compositions for controlled release of biologically active tgf-.beta. |
| JPH06321803A (ja) * | 1993-05-17 | 1994-11-22 | Kirin Brewery Co Ltd | 水溶性ペプチドホルモンの徐放性製剤 |
| US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| AU8016094A (en) | 1993-10-12 | 1995-05-04 | Mary Lake Polan | Method of contraception |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| AU698393B2 (en) | 1994-06-24 | 1998-10-29 | Immunex Corporation | Controlled release polypeptide compositions and methods of treating inflammatory bowel disease |
| IT1269989B (it) | 1994-09-21 | 1997-04-16 | Dompe Spa | Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria |
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1997
- 1997-02-10 WO PCT/US1997/002131 patent/WO1997028828A1/en not_active Ceased
- 1997-02-10 NZ NZ503548A patent/NZ503548A/en unknown
- 1997-02-10 NZ NZ331163A patent/NZ331163A/xx unknown
- 1997-02-10 KR KR10-2003-7016565A patent/KR20040010739A/ko not_active Ceased
- 1997-02-10 EA EA199800694A patent/EA001792B1/ru not_active IP Right Cessation
- 1997-02-10 CZ CZ0237398A patent/CZ299025B6/cs not_active IP Right Cessation
- 1997-02-10 CA CA2539273A patent/CA2539273C/en not_active Expired - Lifetime
- 1997-02-10 JP JP52874197A patent/JP4344404B2/ja not_active Expired - Lifetime
- 1997-02-10 AT AT97906551T patent/ATE448797T1/de not_active IP Right Cessation
- 1997-02-10 EA EA200000825A patent/EA200000825A1/ru unknown
- 1997-02-10 CA CA002244664A patent/CA2244664C/en not_active Expired - Lifetime
- 1997-02-10 AU AU21213/97A patent/AU724960C/en not_active Expired
- 1997-02-10 BR BR9707325A patent/BR9707325A/pt not_active Application Discontinuation
- 1997-02-10 DE DE69739656T patent/DE69739656D1/de not_active Expired - Lifetime
- 1997-02-10 EP EP97906551A patent/EP0904112B1/en not_active Expired - Lifetime
- 1997-02-10 HU HU9902612A patent/HU230160B1/hu unknown
- 1997-02-10 ES ES97906551T patent/ES2334726T3/es not_active Expired - Lifetime
- 1997-02-10 SK SK1036-98A patent/SK288144B6/sk not_active IP Right Cessation
- 1997-02-10 IL IL12555297A patent/IL125552A0/xx unknown
- 1997-02-10 CN CN97193632A patent/CN1215340A/zh active Pending
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1998
- 1998-07-31 MX MX9806191A patent/MX9806191A/es active IP Right Grant
- 1998-07-31 NO NO983543A patent/NO983543L/no not_active Application Discontinuation
-
2007
- 2007-05-22 JP JP2007136048A patent/JP2007211027A/ja active Pending
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|---|---|
| SK103698A3 (en) | 2001-01-18 |
| NO983543D0 (no) | 1998-07-31 |
| HUP9902612A3 (en) | 2001-11-28 |
| AU724960C (en) | 2002-08-15 |
| NZ503548A (en) | 2001-09-28 |
| WO1997028828A1 (en) | 1997-08-14 |
| AU2121397A (en) | 1997-08-28 |
| DE69739656D1 (de) | 2009-12-31 |
| ES2334726T3 (es) | 2010-03-15 |
| NZ331163A (en) | 2000-07-28 |
| EP0904112B1 (en) | 2009-11-18 |
| EA199800694A1 (ru) | 1999-02-25 |
| CA2539273A1 (en) | 1997-08-14 |
| SK288144B6 (sk) | 2013-12-02 |
| CA2244664C (en) | 2008-06-03 |
| CN1215340A (zh) | 1999-04-28 |
| AU724960B2 (en) | 2000-10-05 |
| CZ237398A3 (cs) | 1999-09-15 |
| JP2007211027A (ja) | 2007-08-23 |
| IL125552A0 (en) | 1999-03-12 |
| JP4344404B2 (ja) | 2009-10-14 |
| MX9806191A (es) | 1998-10-31 |
| BR9707325A (pt) | 1999-04-13 |
| NO983543L (no) | 1998-10-08 |
| EA001792B1 (ru) | 2001-08-27 |
| ATE448797T1 (de) | 2009-12-15 |
| EP0904112A1 (en) | 1999-03-31 |
| EA200000825A1 (ru) | 2001-02-26 |
| CA2539273C (en) | 2014-02-04 |
| JP2001500472A (ja) | 2001-01-16 |
| HUP9902612A2 (hu) | 1999-11-29 |
| CA2244664A1 (en) | 1997-08-14 |
| CZ299025B6 (cs) | 2008-04-02 |
| KR20040010739A (ko) | 2004-01-31 |
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| GB9A | Succession in title |
Owner name: SWEDISH ORPHAN BIOVITRUM AB, SE Free format text: FORMER OWNER(S): AMGEN INC., US |
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| GB9A | Succession in title |
Owner name: SWEDISH ORPHAN BIOVITRUM AB (PUBL), SE Free format text: FORMER OWNER(S): AMGEN INC., US; AMGEN INC., US; SWEDISH ORPHAN BIOVITRUM AB, SE |