JP2001500472A - インターロイキン―1インヒビターおよび制御放出ポリマーを含む組成物 - Google Patents
インターロイキン―1インヒビターおよび制御放出ポリマーを含む組成物Info
- Publication number
- JP2001500472A JP2001500472A JP09528741A JP52874197A JP2001500472A JP 2001500472 A JP2001500472 A JP 2001500472A JP 09528741 A JP09528741 A JP 09528741A JP 52874197 A JP52874197 A JP 52874197A JP 2001500472 A JP2001500472 A JP 2001500472A
- Authority
- JP
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- Prior art keywords
- composition
- hyaluronan
- inhibitor
- protein
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.IL-1媒介性疾患に罹患した患者を処置するための方法であって、該方法は、 それを必要とする患者に、治療有効量の、制御放出ポリマーおよびタンパク質性 インターロイキン-1インヒビターを含む組成物を投与する工程を包含する、方法 。 2.前記制御放出ポリマーがヒドロゲルエステルである、請求項1に記載の方法 。 3.前記ヒドロゲルエステルがヒアルロナンまたはその塩である、請求項2に記 載の方法。 4.前記ヒアルロナンがヒアルロン酸である、請求項3に記載の方法。 5.前記ヒアルロナンがヒランである、請求項3に記載の方法。 6.前記ヒアルロナンがヒアルロン酸ナトリウムである、請求項3に記載の方法 。 7.前記ヒドロゲルエステルがポリ(ビニルピロリドン)である、請求項2に記載 の方法。 8.前記ヒドロゲルエステルがセルロースである、請求項2に記載の方法。 9.前記セルロースがカルボキシメチルセルロースである、請求項8に記載の方 法。 10.前記タンパク質性インターロイキン-1インヒビターがIL-1レセプターアン タゴニスト(IL-1ra)である、請求項1に記載の方法。 11.前記IL-1raがグリコシル化されている、請求項10に記載の方法。 12.前記IL-1raがグリコシル化されていない、請求項10に記載の方法。 13.前記IL-1raがメチオニルIL-1raである、請求項10に記載の方法。 14.前記IL-1raが組換えDNA方法により産生される、請求項10に記載の方法 。 15.前記疾患が、慢性関節リウマチ、変形性関節症、および挫傷、捻挫、外傷 、感染、軟骨損傷、または整形外科手術から生じる他の炎症性状態からなる群よ り選択される関節の炎症性疾患である、請求項1に記載の方法。 16.前記組成物が関節内投与または皮下投与により投与される、請求項1に記 載の方法。 17.有効量の、制御放出ポリマーとタンパク質性インターロイキン-1インヒビ ターとの組み合わせを含む、薬学的組成物。 18.前記制御放出ポリマーがヒアルロナンまたはその塩である、請求項17に 記載の組成物。 19.前記ヒアルロナンがヒアルロン酸である、請求項18に記載の組成物。 20.前記タンパク質性インターロイキン-1インヒビターがIL-1レセプターアン タゴニスト(IL-1ra)である、請求項18に記載の組成物。 21.前記IL-1raがグリコシル化されている、請求項20に記載の組成物。 22.前記IL-1raがグリコシル化されていない、請求項20に記載の組成物。 23.前記IL-1raがメチオニルIL-1raである、請求項20に記載の組成物。 24.前記IL-1raが組換えDNA方法により産生される、請求項20に記載の組成 物。 25.関節腔中への投与のために適切な調製物形態である、請求項17に記載の 組成物。 26.前記ヒアルロナンが0.1〜5%w/vの範囲で存在する、請求項18に記載の 組成物。 27.前記IL-1raの濃度が0.1〜200mg/mlの範囲で存在する、請求項20に記載 の組成物。 28.前記ヒアルロナンが0.1〜5%w/vの範囲で存在し、そして前記IL-1raが0. 1〜200mg/mlの範囲で存在する、請求項18に記載の組成物。 29.前記ヒアルロナンが約2%w/vの濃度で存在し、そして前記IL-1raが約100 mg/mlの濃度で存在する、請求項18に記載の組成物。 30.IL-1媒介性疾患を処置するための薬物の調製における、有効量の、制御放 出ポリマーとタンパク質性インターロイキン-1インヒビターとの組み合わせを含 む、薬学的組成物の使用。 31.前記IL-1媒介性疾患が関節の炎症性疾患である、請求項30に記載の使用 。 32.前記関節の炎症性疾患が、慢性関節リウマチ、変形性関節症、および挫傷 、捻挫、外傷、感染、軟骨損傷、または整形外科手術から生じる他の炎症性状態 から選択される、請求項31に記載の使用。 33.前記薬学的組成物が関節内投与される、請求項30〜32のいずれかに記 載の使用。 34.前記制御放出ポリマーがヒアルロナンまたはその塩である、請求項30〜 33のいずれかに記載の使用。 35.前記ヒアルロナンがヒアルロン酸である、請求項34に記載の使用。 36.前記IL-1インヒビターがIL-1raである、請求項30〜35のいずれかに記 載の使用。 37.前記IL-1raが、IL-1raα、IL-1raβ、およびIL-1raxからなる群由来の少 なくとも1つの化合物を含む、請求項36に記載の使用。 38.前記IL-1インヒビターがヒト組換えIL-1raである、請求項37に記載の使 用。
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US60/036,241 | 1997-01-23 | ||
US08/798,414 US6096728A (en) | 1996-02-09 | 1997-02-07 | Composition and method for treating inflammatory diseases |
US08/798,414 | 1997-02-07 | ||
PCT/US1997/002131 WO1997028828A1 (en) | 1996-02-09 | 1997-02-10 | Composition comprising interleukin-1 inhibitor and controlled release polymer |
Related Child Applications (1)
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JP2007136048A Division JP2007211027A (ja) | 1996-02-09 | 2007-05-22 | インターロイキン−1インヒビターおよび制御放出ポリマーを含む組成物 |
Publications (3)
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JP2001500472A true JP2001500472A (ja) | 2001-01-16 |
JP2001500472A5 JP2001500472A5 (ja) | 2004-11-04 |
JP4344404B2 JP4344404B2 (ja) | 2009-10-14 |
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JP52874197A Expired - Lifetime JP4344404B2 (ja) | 1996-02-09 | 1997-02-10 | インターロイキン―1インヒビターおよび制御放出ポリマーを含む組成物 |
JP2007136048A Pending JP2007211027A (ja) | 1996-02-09 | 2007-05-22 | インターロイキン−1インヒビターおよび制御放出ポリマーを含む組成物 |
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JP2007136048A Pending JP2007211027A (ja) | 1996-02-09 | 2007-05-22 | インターロイキン−1インヒビターおよび制御放出ポリマーを含む組成物 |
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EP (1) | EP0904112B1 (ja) |
JP (2) | JP4344404B2 (ja) |
KR (1) | KR20040010739A (ja) |
CN (1) | CN1215340A (ja) |
AT (1) | ATE448797T1 (ja) |
AU (1) | AU724960C (ja) |
BR (1) | BR9707325A (ja) |
CA (2) | CA2244664C (ja) |
CZ (1) | CZ299025B6 (ja) |
DE (1) | DE69739656D1 (ja) |
EA (2) | EA001792B1 (ja) |
ES (1) | ES2334726T3 (ja) |
HU (1) | HU230160B1 (ja) |
IL (1) | IL125552A0 (ja) |
MX (1) | MX9806191A (ja) |
NO (1) | NO983543L (ja) |
NZ (2) | NZ331163A (ja) |
SK (1) | SK288144B6 (ja) |
WO (1) | WO1997028828A1 (ja) |
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CA2539273C (en) | 2014-02-04 |
CZ237398A3 (cs) | 1999-09-15 |
MX9806191A (es) | 1998-10-31 |
EA199800694A1 (ru) | 1999-02-25 |
HUP9902612A2 (hu) | 1999-11-29 |
WO1997028828A1 (en) | 1997-08-14 |
EA001792B1 (ru) | 2001-08-27 |
CA2539273A1 (en) | 1997-08-14 |
ES2334726T3 (es) | 2010-03-15 |
NZ503548A (en) | 2001-09-28 |
HUP9902612A3 (en) | 2001-11-28 |
EP0904112A1 (en) | 1999-03-31 |
BR9707325A (pt) | 1999-04-13 |
JP2007211027A (ja) | 2007-08-23 |
DE69739656D1 (de) | 2009-12-31 |
CN1215340A (zh) | 1999-04-28 |
KR20040010739A (ko) | 2004-01-31 |
CZ299025B6 (cs) | 2008-04-02 |
HU230160B1 (hu) | 2015-09-28 |
CA2244664C (en) | 2008-06-03 |
ATE448797T1 (de) | 2009-12-15 |
SK103698A3 (en) | 2001-01-18 |
IL125552A0 (en) | 1999-03-12 |
NO983543D0 (no) | 1998-07-31 |
AU2121397A (en) | 1997-08-28 |
NZ331163A (en) | 2000-07-28 |
NO983543L (no) | 1998-10-08 |
EA200000825A1 (ru) | 2001-02-26 |
CA2244664A1 (en) | 1997-08-14 |
JP4344404B2 (ja) | 2009-10-14 |
AU724960B2 (en) | 2000-10-05 |
AU724960C (en) | 2002-08-15 |
EP0904112B1 (en) | 2009-11-18 |
SK288144B6 (sk) | 2013-12-02 |
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