HU228978B1 - Use of long pentraxin ptx3 for treating female infertility - Google Patents
Use of long pentraxin ptx3 for treating female infertility Download PDFInfo
- Publication number
- HU228978B1 HU228978B1 HU0400662A HUP0400662A HU228978B1 HU 228978 B1 HU228978 B1 HU 228978B1 HU 0400662 A HU0400662 A HU 0400662A HU P0400662 A HUP0400662 A HU P0400662A HU 228978 B1 HU228978 B1 HU 228978B1
- Authority
- HU
- Hungary
- Prior art keywords
- mivel
- ftx3
- lépés
- ptx3
- lake
- Prior art date
Links
- 208000007984 Female Infertility Diseases 0.000 title 1
- 206010021928 Infertility female Diseases 0.000 title 1
- 102100027351 Pentraxin-related protein PTX3 Human genes 0.000 claims description 36
- 101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 claims description 35
- BFHAYPLBUQVNNJ-UHFFFAOYSA-N Pectenotoxin 3 Natural products OC1C(C)CCOC1(O)C1OC2C=CC(C)=CC(C)CC(C)(O3)CCC3C(O3)(O4)CCC3(C=O)CC4C(O3)C(=O)CC3(C)C(O)C(O3)CCC3(O3)CCCC3C(C)C(=O)OC2C1 BFHAYPLBUQVNNJ-UHFFFAOYSA-N 0.000 claims description 35
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 21
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 230000001850 reproductive effect Effects 0.000 claims description 13
- 238000011282 treatment Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 239000013598 vector Substances 0.000 claims description 8
- 235000013601 eggs Nutrition 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000004575 stone Substances 0.000 claims description 6
- 230000035558 fertility Effects 0.000 claims description 5
- 230000001605 fetal effect Effects 0.000 claims description 5
- 210000000287 oocyte Anatomy 0.000 claims description 5
- 210000004681 ovum Anatomy 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 108020004999 messenger RNA Proteins 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 238000013518 transcription Methods 0.000 claims description 4
- 230000035897 transcription Effects 0.000 claims description 4
- 230000003442 weekly effect Effects 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 206010042573 Superovulation Diseases 0.000 claims description 2
- 244000269722 Thea sinensis Species 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 231100000518 lethal Toxicity 0.000 claims description 2
- 230000001665 lethal effect Effects 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 230000017074 necrotic cell death Effects 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 238000009395 breeding Methods 0.000 claims 3
- 230000001488 breeding effect Effects 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000002474 experimental method Methods 0.000 claims 2
- 230000004720 fertilization Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 230000013011 mating Effects 0.000 claims 2
- 230000016087 ovulation Effects 0.000 claims 2
- 210000004508 polar body Anatomy 0.000 claims 2
- 230000002269 spontaneous effect Effects 0.000 claims 2
- 239000002023 wood Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241001136792 Alle Species 0.000 claims 1
- 241000205585 Aquilegia canadensis Species 0.000 claims 1
- 235000000832 Ayote Nutrition 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 235000000509 Chenopodium ambrosioides Nutrition 0.000 claims 1
- 244000098897 Chenopodium botrys Species 0.000 claims 1
- 235000005490 Chenopodium botrys Nutrition 0.000 claims 1
- 240000004244 Cucurbita moschata Species 0.000 claims 1
- 235000009854 Cucurbita moschata Nutrition 0.000 claims 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 claims 1
- 241000218671 Ephedra Species 0.000 claims 1
- 240000008790 Musa x paradisiaca Species 0.000 claims 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 claims 1
- 206010028851 Necrosis Diseases 0.000 claims 1
- 101710192097 Pentraxin-related protein PTX3 Proteins 0.000 claims 1
- 241000985694 Polypodiopsida Species 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 1
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 206010054094 Tumour necrosis Diseases 0.000 claims 1
- 241000256856 Vespidae Species 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 210000002459 blastocyst Anatomy 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 239000011449 brick Substances 0.000 claims 1
- 244000309466 calf Species 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 239000002826 coolant Substances 0.000 claims 1
- 235000013367 dietary fats Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 235000005583 doda Nutrition 0.000 claims 1
- 230000035622 drinking Effects 0.000 claims 1
- 238000004043 dyeing Methods 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 239000000446 fuel Substances 0.000 claims 1
- 239000010520 ghee Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 206010025482 malaise Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 210000003101 oviduct Anatomy 0.000 claims 1
- 239000011049 pearl Substances 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 238000002331 protein detection Methods 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 235000015136 pumpkin Nutrition 0.000 claims 1
- 230000036186 satiety Effects 0.000 claims 1
- 235000019627 satiety Nutrition 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000010454 slate Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 230000004797 therapeutic response Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 238000013519 translation Methods 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
- 239000006216 vaginal suppository Substances 0.000 claims 1
- 229940120293 vaginal suppository Drugs 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 241001529936 Murinae Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 108010074051 C-Reactive Protein Proteins 0.000 description 2
- 102100032752 C-reactive protein Human genes 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102100021878 Neuronal pentraxin-2 Human genes 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 108700025763 PTX3 Proteins 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 206010036618 Premenstrual syndrome Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 241001233037 catfish Species 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 210000002503 granulosa cell Anatomy 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 208000000509 infertility Diseases 0.000 description 2
- 231100000535 infertility Toxicity 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 240000003291 Armoracia rusticana Species 0.000 description 1
- 235000011330 Armoracia rusticana Nutrition 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 101001108245 Cavia porcellus Neuronal pentraxin-2 Proteins 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108091005942 ECFP Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- QTANTQQOYSUMLC-UHFFFAOYSA-O Ethidium cation Chemical compound C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 QTANTQQOYSUMLC-UHFFFAOYSA-O 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102100034176 Glutathione-specific gamma-glutamylcyclotransferase 1 Human genes 0.000 description 1
- 101710175495 Glutathione-specific gamma-glutamylcyclotransferase 1 Proteins 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 102000004858 Growth differentiation factor-9 Human genes 0.000 description 1
- 108090001086 Growth differentiation factor-9 Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001108246 Homo sapiens Neuronal pentraxin-2 Proteins 0.000 description 1
- 101100352284 Homo sapiens PITX3 gene Proteins 0.000 description 1
- 101100031710 Homo sapiens PTX3 gene Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 230000004988 N-glycosylation Effects 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 101710155147 Neuronal pentraxin-2 Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 101150095640 PTX3 gene Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 240000002871 Tectona grandis Species 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- -1 apexin (11 Natural products 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000001638 cerebellum Anatomy 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000001037 epileptic effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000004996 female reproductive system Anatomy 0.000 description 1
- 206010016531 fetishism Diseases 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 238000012224 gene deletion Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003168 insulating cell Anatomy 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 244000145841 kine Species 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Environmental Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Diabetes (AREA)
- Marine Sciences & Fisheries (AREA)
- Biodiversity & Conservation Biology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30947201P | 2001-08-03 | 2001-08-03 | |
| PCT/IT2002/000473 WO2003011326A1 (en) | 2001-08-03 | 2002-07-18 | Use of long pentraxin ptx3 for treating female infertility |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0400662A2 HUP0400662A2 (hu) | 2004-11-29 |
| HUP0400662A3 HUP0400662A3 (en) | 2010-01-28 |
| HU228978B1 true HU228978B1 (en) | 2013-07-29 |
Family
ID=23198379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400662A HU228978B1 (en) | 2001-08-03 | 2002-07-18 | Use of long pentraxin ptx3 for treating female infertility |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20040198655A1 (https=) |
| EP (1) | EP1411971B1 (https=) |
| JP (1) | JP4312599B2 (https=) |
| KR (1) | KR100890999B1 (https=) |
| CN (1) | CN1231257C (https=) |
| AT (1) | ATE321566T1 (https=) |
| AU (1) | AU2002324328B2 (https=) |
| BR (1) | BR0211619A (https=) |
| CA (1) | CA2454421C (https=) |
| DE (1) | DE60210297T2 (https=) |
| DK (1) | DK1411971T3 (https=) |
| ES (1) | ES2261714T3 (https=) |
| HU (1) | HU228978B1 (https=) |
| MX (1) | MXPA04000909A (https=) |
| PL (1) | PL205928B1 (https=) |
| PT (1) | PT1411971E (https=) |
| WO (1) | WO2003011326A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1298487B1 (it) * | 1997-12-19 | 2000-01-10 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale, |
| ITRM20020109A1 (it) * | 2002-02-28 | 2003-08-28 | Sigma Tau Ind Farmaceuti | Derivati funzionali della pentraxina lunga ptx3 per preparare un vaccino autologo per la cura dei tumori. |
| ITRM20030595A1 (it) * | 2003-12-23 | 2005-06-24 | Sigma Tau Ind Farmaceuti | Uso della ptx3 o di un suo derivato funzionale da sola o in associazione con tsg6 per il trattamento di patologie degenarative dell'osso o della cartilagine e per il trattamento della infertilita' femminile. |
| ITRM20040489A1 (it) * | 2004-10-08 | 2005-01-08 | Sigma Tau Ind Farmaceuti | Pentraxina lunga ptx3 deglicosilata o desialidata. |
| WO2006113679A2 (en) * | 2005-04-15 | 2006-10-26 | Board Of Regents, The University Of Texas System | Delivery of sirna by neutral lipid compositions |
| US9081018B2 (en) * | 2005-12-29 | 2015-07-14 | Humanitas Mirasole S.P.A. | Diagnostic test for inflammatory endothelial dysfunctions in pregnancies |
| FR2896588B1 (fr) * | 2006-01-20 | 2016-08-19 | Univ D'angers | Methode de diagnostic in vitro de reponse immunitaire autoimmune par detection d'anticorps diriges contre l'antigene pentraxine 3. |
| PT2012816E (pt) | 2006-05-02 | 2012-08-17 | Sigma Tau Ind Farmaceuti | Uso de timosina 1, isolada ou em combinação com ptx3 ou ganciclovir, para o tratamento da infeção por citomegalovírus |
| US10162800B2 (en) | 2012-10-17 | 2018-12-25 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
| US9177098B2 (en) | 2012-10-17 | 2015-11-03 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
| US9836577B2 (en) | 2012-12-14 | 2017-12-05 | Celmatix, Inc. | Methods and devices for assessing risk of female infertility |
| AU2015209126A1 (en) * | 2014-01-27 | 2016-08-04 | Celmatix, Inc. | Methods for assessing whether a genetic region is associated with infertility |
| SG11201700303UA (en) | 2014-07-17 | 2017-02-27 | Celmatix Inc | Methods and systems for assessing infertility and related pathologies |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1298487B1 (it) * | 1997-12-19 | 2000-01-10 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale, |
-
2002
- 2002-07-18 US US10/485,640 patent/US20040198655A1/en not_active Abandoned
- 2002-07-18 MX MXPA04000909A patent/MXPA04000909A/es active IP Right Grant
- 2002-07-18 DE DE60210297T patent/DE60210297T2/de not_active Expired - Lifetime
- 2002-07-18 JP JP2003516556A patent/JP4312599B2/ja not_active Expired - Fee Related
- 2002-07-18 PT PT02758773T patent/PT1411971E/pt unknown
- 2002-07-18 DK DK02758773T patent/DK1411971T3/da active
- 2002-07-18 CA CA2454421A patent/CA2454421C/en not_active Expired - Fee Related
- 2002-07-18 AT AT02758773T patent/ATE321566T1/de active
- 2002-07-18 KR KR1020047001689A patent/KR100890999B1/ko not_active Expired - Fee Related
- 2002-07-18 AU AU2002324328A patent/AU2002324328B2/en not_active Ceased
- 2002-07-18 PL PL368413A patent/PL205928B1/pl not_active IP Right Cessation
- 2002-07-18 WO PCT/IT2002/000473 patent/WO2003011326A1/en not_active Ceased
- 2002-07-18 CN CNB028152948A patent/CN1231257C/zh not_active Expired - Fee Related
- 2002-07-18 EP EP02758773A patent/EP1411971B1/en not_active Expired - Lifetime
- 2002-07-18 HU HU0400662A patent/HU228978B1/hu not_active IP Right Cessation
- 2002-07-18 ES ES02758773T patent/ES2261714T3/es not_active Expired - Lifetime
- 2002-07-18 BR BR0211619-7A patent/BR0211619A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0400662A2 (hu) | 2004-11-29 |
| MXPA04000909A (es) | 2004-03-26 |
| EP1411971A1 (en) | 2004-04-28 |
| PL368413A1 (en) | 2005-03-21 |
| HUP0400662A3 (en) | 2010-01-28 |
| CN1231257C (zh) | 2005-12-14 |
| CA2454421C (en) | 2013-03-12 |
| KR100890999B1 (ko) | 2009-03-31 |
| CA2454421A1 (en) | 2003-02-13 |
| ES2261714T3 (es) | 2006-11-16 |
| WO2003011326A1 (en) | 2003-02-13 |
| US20040198655A1 (en) | 2004-10-07 |
| DK1411971T3 (da) | 2006-08-07 |
| HK1068797A1 (en) | 2005-05-06 |
| CN1538849A (zh) | 2004-10-20 |
| JP2005502640A (ja) | 2005-01-27 |
| EP1411971B1 (en) | 2006-03-29 |
| DE60210297D1 (de) | 2006-05-18 |
| PL205928B1 (pl) | 2010-06-30 |
| PT1411971E (pt) | 2006-07-31 |
| AU2002324328B2 (en) | 2007-09-06 |
| BR0211619A (pt) | 2004-08-24 |
| JP4312599B2 (ja) | 2009-08-12 |
| KR20040019107A (ko) | 2004-03-04 |
| ATE321566T1 (de) | 2006-04-15 |
| DE60210297T2 (de) | 2007-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Letterio et al. | Maternal rescue of transforming growth factor-β 1 null mice | |
| Chang et al. | Products, genetic linkage and limb patterning activity of a murine hedgehog gene | |
| Hammer et al. | Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth | |
| Lomaga et al. | TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling | |
| De Togni et al. | Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin | |
| ES2458349T3 (es) | Polipéptidos homólogos IL-17 y usos terapéuticos de los mismos | |
| Weiner et al. | Tissue distribution and developmental expression of the messenger RNA encoding angiogenin | |
| KR100834809B1 (ko) | Baff, 관련 차단제 및 면역 반응에서 b 세포와면역글로불린을 촉진 및 억제하는데에 있어서 이들의 용도 | |
| ES2402947T3 (es) | PCA3, genes PCA3 y métodos de uso | |
| DE60028054T2 (de) | Fibroblasten-wachstumsfaktor-19 (fgf-19) nukleinsäure und polypeptide und verfahren zu deren verwendung für behandlung von fettleibigkeit | |
| ES2577532T3 (es) | Nueva composición y métodos para el tratamiento de enfermedades relacionadas con el sistema inmune | |
| HU230679B1 (en) | Mammalian interleukin-12 p40 and interleukin b30, combinations thereof, antibodies, uses in pharmaceutical compositions | |
| Hawley et al. | Transforming function of the HOX11/TCL3 homeobox gene | |
| ES2268854T3 (es) | Inhibidores de la vascularizacion. | |
| KR20010006534A (ko) | Ⅱ형 tgf-베타 수용체/면역글로불린 불변 영역 융합 단백질 | |
| EA015351B1 (ru) | Антагонисты il-17a и il-17f и способы их применения | |
| JP2000502570A (ja) | Fhitタンパク質および核酸ならびにそれに基づく方法 | |
| HU228978B1 (en) | Use of long pentraxin ptx3 for treating female infertility | |
| JP2002533058A (ja) | 97個のヒト分泌タンパク質 | |
| KR20010023325A (ko) | 함지방세포-특이적 단백질 상동체 | |
| ES2285768T3 (es) | Proteinas crsp (proteinas segregadas ricas en cisteina), moleculas de acido nucleico que codifican para las mismas y uso de las mismas. | |
| ES2291198T3 (es) | Composiciones y procedimientos para el tratamiento de enfermedades de tipo inmunologico. | |
| JP2002532092A (ja) | プロスタサイクリン刺激因子−2 | |
| JP2002526059A (ja) | 31個のヒト分泌タンパク質 | |
| JP2001503612A (ja) | 新規ヘモポイエチン受容体およびこれをコードする遺伝子配列 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |