HU217618B - Eljárás új amidinoszármazékok és ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására és eljárás ismert amidinoszármazékokat tartalmazó, nitrogénoxid szintáz inhibitor hatású gyógyszerkészítmények előállítására - Google Patents
Eljárás új amidinoszármazékok és ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására és eljárás ismert amidinoszármazékokat tartalmazó, nitrogénoxid szintáz inhibitor hatású gyógyszerkészítmények előállítására Download PDFInfo
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- HU217618B HU217618B HU9401848A HU9401848A HU217618B HU 217618 B HU217618 B HU 217618B HU 9401848 A HU9401848 A HU 9401848A HU 9401848 A HU9401848 A HU 9401848A HU 217618 B HU217618 B HU 217618B
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- nitric oxide
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919127376A GB9127376D0 (en) | 1991-12-24 | 1991-12-24 | Amidino derivatives |
| PCT/GB1992/002387 WO1993013055A1 (en) | 1991-12-24 | 1992-12-23 | Amidino derivatives and their use as nitric oxide synthase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9401848D0 HU9401848D0 (en) | 1994-09-28 |
| HUT70502A HUT70502A (en) | 1995-10-30 |
| HU217618B true HU217618B (hu) | 2000-03-28 |
Family
ID=10706815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9401848A HU217618B (hu) | 1991-12-24 | 1992-12-23 | Eljárás új amidinoszármazékok és ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására és eljárás ismert amidinoszármazékokat tartalmazó, nitrogénoxid szintáz inhibitor hatású gyógyszerkészítmények előállítására |
Country Status (20)
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
| US5424447A (en) * | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
| SK16396A3 (en) * | 1993-08-12 | 1996-09-04 | Astra Ab | Amidine derivatives with nitric oxide synthetase activities |
| CN1071746C (zh) * | 1993-08-12 | 2001-09-26 | 阿斯特拉公司 | 具有氧化氮合成酶活性的脒衍生物 |
| US6297276B1 (en) | 1993-10-04 | 2001-10-02 | Glaxosmithkline | Substituted urea and isothiourea derivatives as no synthase inhibitors |
| US6225305B1 (en) | 1993-10-04 | 2001-05-01 | Glaxo Wellcome Inc. | Substituted urea and isothiorea derivatives as no synthase inhibitors |
| AU8078394A (en) * | 1993-10-21 | 1995-05-08 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| EP0724570B1 (en) * | 1993-10-21 | 1999-03-03 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| DE4337906A1 (de) * | 1993-11-08 | 1995-05-11 | Cassella Ag | Verwendung von Cumarinderivaten |
| AU1209995A (en) * | 1993-11-17 | 1995-06-06 | Duke University Medical Center | Use of nitric oxide synthase inhibitors in the treatment of autoimmune diseases |
| GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
| GB9404400D0 (en) * | 1994-03-07 | 1994-04-20 | Wood Pauline J | Potentiation of bioreductive agents |
| WO1995024382A1 (en) * | 1994-03-10 | 1995-09-14 | G.D. Searle & Co. | L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors |
| PT751930E (pt) * | 1994-03-24 | 2000-04-28 | Searle & Co | Derivados amidino uteis como inibidores da sintetase de oxido nitrico |
| DE69511260T2 (de) * | 1994-05-07 | 2000-03-16 | Astra Ab | Bicyclische amidinderivate als no-synthetase inhibitoren |
| PT957087E (pt) * | 1994-06-15 | 2003-04-30 | Wellcome Found | Intermediarios uteis na preparacao de inibidores de enzimas |
| CA2132690A1 (en) * | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
| US6066333A (en) * | 1994-09-22 | 2000-05-23 | William Harvey Research Limited | Pharmaceutical control of inflammation |
| AU723677B2 (en) * | 1994-09-22 | 2000-08-31 | William Harvey Research Limited | Pharmaceutical control of inflammation |
| US5684008A (en) * | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
| FR2727111B1 (fr) * | 1994-11-21 | 1997-01-17 | Hoechst Lab | Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments |
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| FI832053A7 (fi) * | 1982-06-10 | 1983-12-11 | Syntex Inc | LHRH-antagonistina käyttökelpoinen LHRH:n nonapeptidi- ja dekapeptidianalogit sekä niiden valmistusmenetevalmistusmenetelmä. |
| US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
| GB8929076D0 (en) * | 1989-12-22 | 1990-02-28 | Scras | Treatment of shock by blocking agents of edrf effect or formation |
| CA2036770C (en) * | 1990-02-26 | 2003-09-09 | Jeffrey P. Whitten | Inhibitors of nitric oxide biosynthesis |
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1991
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1992
- 1992-12-23 JP JP51127393A patent/JP3171850B2/ja not_active Expired - Fee Related
- 1992-12-23 ZA ZA9210018A patent/ZA9210018B/xx unknown
- 1992-12-23 HU HU9401848A patent/HU217618B/hu not_active IP Right Cessation
- 1992-12-23 NZ NZ246202A patent/NZ246202A/xx not_active IP Right Cessation
- 1992-12-23 TW TW081110312A patent/TW255881B/zh active
- 1992-12-23 IL IL104212A patent/IL104212A/en not_active IP Right Cessation
- 1992-12-23 RU RU94031155A patent/RU2130014C1/ru not_active IP Right Cessation
- 1992-12-23 MY MYPI92002373A patent/MY109421A/en unknown
- 1992-12-23 US US08/256,032 patent/US5863931A/en not_active Expired - Lifetime
- 1992-12-23 AT AT93900357T patent/ATE178588T1/de active
- 1992-12-23 AU AU31692/93A patent/AU669345B2/en not_active Ceased
- 1992-12-23 WO PCT/GB1992/002387 patent/WO1993013055A1/en active IP Right Grant
- 1992-12-23 DK DK93900357T patent/DK0618898T3/da active
- 1992-12-23 CA CA002126327A patent/CA2126327C/en not_active Expired - Fee Related
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- 1992-12-23 EP EP93900357A patent/EP0618898B1/en not_active Expired - Lifetime
- 1992-12-23 ES ES93900357T patent/ES2130247T3/es not_active Expired - Lifetime
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1999
- 1999-06-10 GR GR990401567T patent/GR3030492T3/el unknown
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2000
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|---|---|
| DK0618898T3 (da) | 1999-10-18 |
| EP0618898B1 (en) | 1999-04-07 |
| AU3169293A (en) | 1993-07-28 |
| CA2126327C (en) | 2005-05-17 |
| GB9127376D0 (en) | 1992-02-19 |
| ES2130247T3 (es) | 1999-07-01 |
| GR3030492T3 (en) | 1999-10-29 |
| US5863931A (en) | 1999-01-26 |
| IL104212A (en) | 1998-02-22 |
| MY109421A (en) | 1997-01-31 |
| JPH07502512A (ja) | 1995-03-16 |
| DE69228879D1 (de) | 1999-05-12 |
| ZA9210018B (en) | 1994-06-23 |
| NZ246202A (en) | 1996-05-28 |
| RU2130014C1 (ru) | 1999-05-10 |
| HUT70502A (en) | 1995-10-30 |
| CY2197B1 (en) | 2002-11-08 |
| ATE178588T1 (de) | 1999-04-15 |
| JP3171850B2 (ja) | 2001-06-04 |
| WO1993013055A1 (en) | 1993-07-08 |
| HU9401848D0 (en) | 1994-09-28 |
| TW255881B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-09-01 |
| CA2126327A1 (en) | 1993-07-08 |
| DE69228879T2 (de) | 1999-08-26 |
| EP0618898A1 (en) | 1994-10-12 |
| IL104212A0 (en) | 1993-05-13 |
| AU669345B2 (en) | 1996-06-06 |
| RU94031155A (ru) | 1996-04-20 |
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