HU204894B - Process for producing polypeptides by enzymatic splitting of fusion proteins - Google Patents
Process for producing polypeptides by enzymatic splitting of fusion proteins Download PDFInfo
- Publication number
- HU204894B HU204894B HU885958A HU595888A HU204894B HU 204894 B HU204894 B HU 204894B HU 885958 A HU885958 A HU 885958A HU 595888 A HU595888 A HU 595888A HU 204894 B HU204894 B HU 204894B
- Authority
- HU
- Hungary
- Prior art keywords
- protein
- fusion protein
- gly
- cleavage
- fusion proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Fuses (AREA)
- Techniques For Improving Reliability Of Storages (AREA)
- Welding Or Cutting Using Electron Beams (AREA)
- Exhaust Gas After Treatment (AREA)
- Machines For Manufacturing Corrugated Board In Mechanical Paper-Making Processes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873739347 DE3739347A1 (de) | 1987-11-20 | 1987-11-20 | Verfahren zur selektiven spaltung von fusionsproteinen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT50514A HUT50514A (en) | 1990-02-28 |
| HU204894B true HU204894B (en) | 1992-02-28 |
Family
ID=6340882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU885958A HU204894B (en) | 1987-11-20 | 1988-11-18 | Process for producing polypeptides by enzymatic splitting of fusion proteins |
Country Status (19)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837516A (en) * | 1995-03-03 | 1998-11-17 | Genentech, Inc. | Subtilisin variants capable of cleaving substrates containing basic residues |
| US5780285A (en) * | 1995-03-03 | 1998-07-14 | Genentech, Inc. | Subtilisin variants capable of cleaving substrates containing dibasic residues |
| EP0821006B1 (de) | 1996-07-26 | 2004-04-21 | Aventis Pharma Deutschland GmbH | Insulinderivate mit erhöhter Zinkbindung |
| US6265204B1 (en) | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
| DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| JP2005528372A (ja) * | 2002-03-26 | 2005-09-22 | バイオシネクサス インコーポレイテッド | 抗菌ポリマー複合体 |
| CN101717449B (zh) * | 2008-10-09 | 2013-06-19 | 重庆富进生物医药有限公司 | 重组TRAIL-Fc融合蛋白及其制备和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3523701A1 (de) * | 1985-07-03 | 1987-01-08 | Bayer Ag | Verfahren zur herstellung von proteinen und polypeptiden |
-
1987
- 1987-11-20 DE DE19873739347 patent/DE3739347A1/de not_active Withdrawn
-
1988
- 1988-11-10 EP EP88118673A patent/EP0316748B1/de not_active Expired - Lifetime
- 1988-11-10 AT AT88118673T patent/ATE78873T1/de not_active IP Right Cessation
- 1988-11-10 ES ES88118673T patent/ES2051816T3/es not_active Expired - Lifetime
- 1988-11-10 DE DE8888118673T patent/DE3873273D1/de not_active Expired - Lifetime
- 1988-11-17 FI FI885328A patent/FI885328L/fi not_active Application Discontinuation
- 1988-11-17 PT PT89019A patent/PT89019B/pt not_active IP Right Cessation
- 1988-11-18 NZ NZ226998A patent/NZ226998A/en unknown
- 1988-11-18 DK DK645588A patent/DK645588A/da not_active Application Discontinuation
- 1988-11-18 KR KR1019880015202A patent/KR890008166A/ko not_active Ceased
- 1988-11-18 AU AU25695/88A patent/AU618035B2/en not_active Expired
- 1988-11-18 CA CA000583545A patent/CA1337283C/en not_active Expired - Lifetime
- 1988-11-18 ZA ZA888650A patent/ZA888650B/xx unknown
- 1988-11-18 IE IE346288A patent/IE62228B1/en not_active IP Right Cessation
- 1988-11-18 HU HU885958A patent/HU204894B/hu unknown
- 1988-11-18 NO NO885154A patent/NO173194C/no unknown
- 1988-11-18 JP JP63290349A patent/JPH01160496A/ja active Pending
- 1988-11-18 IL IL88413A patent/IL88413A/xx not_active IP Right Cessation
- 1988-11-19 CN CN88107955A patent/CN1033184A/zh active Pending
-
1992
- 1992-10-22 GR GR920402186T patent/GR3006045T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT50514A (en) | 1990-02-28 |
| FI885328A0 (fi) | 1988-11-17 |
| JPH01160496A (ja) | 1989-06-23 |
| CA1337283C (en) | 1995-10-10 |
| IL88413A0 (en) | 1989-06-30 |
| NZ226998A (en) | 1991-06-25 |
| AU2569588A (en) | 1989-06-29 |
| IE62228B1 (en) | 1995-01-11 |
| PT89019A (pt) | 1988-12-01 |
| KR890008166A (ko) | 1989-07-10 |
| DK645588D0 (da) | 1988-11-18 |
| ZA888650B (en) | 1989-07-26 |
| DE3739347A1 (de) | 1989-06-01 |
| PT89019B (pt) | 1993-02-26 |
| NO173194C (no) | 1993-11-10 |
| DK645588A (da) | 1989-05-21 |
| NO885154L (no) | 1989-05-22 |
| EP0316748A2 (de) | 1989-05-24 |
| FI885328A7 (fi) | 1989-05-21 |
| DE3873273D1 (de) | 1992-09-03 |
| ES2051816T3 (es) | 1994-07-01 |
| EP0316748A3 (en) | 1990-08-29 |
| IL88413A (en) | 1993-07-08 |
| EP0316748B1 (de) | 1992-07-29 |
| ATE78873T1 (de) | 1992-08-15 |
| NO173194B (no) | 1993-08-02 |
| AU618035B2 (en) | 1991-12-12 |
| IE883462L (en) | 1989-05-20 |
| FI885328L (fi) | 1989-05-21 |
| NO885154D0 (no) | 1988-11-18 |
| GR3006045T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-06-21 |
| CN1033184A (zh) | 1989-05-31 |
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