NO173194C - Fremgangsmaate for fremstilling av proinsulin - Google Patents

Fremgangsmaate for fremstilling av proinsulin

Info

Publication number
NO173194C
NO173194C NO885154A NO885154A NO173194C NO 173194 C NO173194 C NO 173194C NO 885154 A NO885154 A NO 885154A NO 885154 A NO885154 A NO 885154A NO 173194 C NO173194 C NO 173194C
Authority
NO
Norway
Prior art keywords
proinsulin
procedure
preparation
endoprotease
oligo
Prior art date
Application number
NO885154A
Other languages
English (en)
Other versions
NO885154D0 (no
NO173194B (no
NO885154L (no
Inventor
Michael Doerschug
Gerhard Seipke
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO885154D0 publication Critical patent/NO885154D0/no
Publication of NO885154L publication Critical patent/NO885154L/no
Publication of NO173194B publication Critical patent/NO173194B/no
Publication of NO173194C publication Critical patent/NO173194C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Welding Or Cutting Using Electron Beams (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Machines For Manufacturing Corrugated Board In Mechanical Paper-Making Processes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fuses (AREA)
  • Techniques For Improving Reliability Of Storages (AREA)
NO885154A 1987-11-20 1988-11-18 Fremgangsmaate for fremstilling av proinsulin NO173194C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873739347 DE3739347A1 (de) 1987-11-20 1987-11-20 Verfahren zur selektiven spaltung von fusionsproteinen

Publications (4)

Publication Number Publication Date
NO885154D0 NO885154D0 (no) 1988-11-18
NO885154L NO885154L (no) 1989-05-22
NO173194B NO173194B (no) 1993-08-02
NO173194C true NO173194C (no) 1993-11-10

Family

ID=6340882

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885154A NO173194C (no) 1987-11-20 1988-11-18 Fremgangsmaate for fremstilling av proinsulin

Country Status (19)

Country Link
EP (1) EP0316748B1 (no)
JP (1) JPH01160496A (no)
KR (1) KR890008166A (no)
CN (1) CN1033184A (no)
AT (1) ATE78873T1 (no)
AU (1) AU618035B2 (no)
CA (1) CA1337283C (no)
DE (2) DE3739347A1 (no)
DK (1) DK645588A (no)
ES (1) ES2051816T3 (no)
FI (1) FI885328A (no)
GR (1) GR3006045T3 (no)
HU (1) HU204894B (no)
IE (1) IE62228B1 (no)
IL (1) IL88413A (no)
NO (1) NO173194C (no)
NZ (1) NZ226998A (no)
PT (1) PT89019B (no)
ZA (1) ZA888650B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837516A (en) * 1995-03-03 1998-11-17 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing basic residues
US5780285A (en) * 1995-03-03 1998-07-14 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing dibasic residues
ES2218622T3 (es) 1996-07-26 2004-11-16 Aventis Pharma Deutschland Gmbh Derivados de insulina con actividad de union al zinc incrementada.
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
BR0308710A (pt) * 2002-03-26 2007-01-09 Biosynexus Inc conjugados poliméricos antimicrobianos
CN101717449B (zh) * 2008-10-09 2013-06-19 重庆富进生物医药有限公司 重组TRAIL-Fc融合蛋白及其制备和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523701A1 (de) * 1985-07-03 1987-01-08 Bayer Ag Verfahren zur herstellung von proteinen und polypeptiden

Also Published As

Publication number Publication date
DE3873273D1 (de) 1992-09-03
EP0316748A3 (en) 1990-08-29
NO885154D0 (no) 1988-11-18
ATE78873T1 (de) 1992-08-15
EP0316748B1 (de) 1992-07-29
IL88413A0 (en) 1989-06-30
IE62228B1 (en) 1995-01-11
CA1337283C (en) 1995-10-10
IE883462L (en) 1989-05-20
NO173194B (no) 1993-08-02
NZ226998A (en) 1991-06-25
PT89019B (pt) 1993-02-26
NO885154L (no) 1989-05-22
PT89019A (pt) 1988-12-01
DE3739347A1 (de) 1989-06-01
FI885328A (fi) 1989-05-21
JPH01160496A (ja) 1989-06-23
ZA888650B (en) 1989-07-26
EP0316748A2 (de) 1989-05-24
FI885328A0 (fi) 1988-11-17
CN1033184A (zh) 1989-05-31
KR890008166A (ko) 1989-07-10
ES2051816T3 (es) 1994-07-01
HU204894B (en) 1992-02-28
AU618035B2 (en) 1991-12-12
IL88413A (en) 1993-07-08
GR3006045T3 (no) 1993-06-21
HUT50514A (en) 1990-02-28
AU2569588A (en) 1989-06-29
DK645588D0 (da) 1988-11-18
DK645588A (da) 1989-05-21

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