HU203227B - Process for producing nitrate derivatives of oxazole and thiazole compounds and pharmaceutical compositions comprising same - Google Patents

Process for producing nitrate derivatives of oxazole and thiazole compounds and pharmaceutical compositions comprising same Download PDF

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Publication number
HU203227B
HU203227B HU883775A HU377588A HU203227B HU 203227 B HU203227 B HU 203227B HU 883775 A HU883775 A HU 883775A HU 377588 A HU377588 A HU 377588A HU 203227 B HU203227 B HU 203227B
Authority
HU
Hungary
Prior art keywords
nujol
thiazolecarboxamide
compound
formula
nmr
Prior art date
Application number
HU883775A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT47551A (en
Inventor
Youichi Shiokawa
Koichi Takimoto
Kohei Takenaka
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of HUT47551A publication Critical patent/HUT47551A/hu
Publication of HU203227B publication Critical patent/HU203227B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU883775A 1987-07-20 1988-07-19 Process for producing nitrate derivatives of oxazole and thiazole compounds and pharmaceutical compositions comprising same HU203227B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878717068A GB8717068D0 (en) 1987-07-20 1987-07-20 Nitric ester derivative

Publications (2)

Publication Number Publication Date
HUT47551A HUT47551A (en) 1989-03-28
HU203227B true HU203227B (en) 1991-06-28

Family

ID=10620954

Family Applications (1)

Application Number Title Priority Date Filing Date
HU883775A HU203227B (en) 1987-07-20 1988-07-19 Process for producing nitrate derivatives of oxazole and thiazole compounds and pharmaceutical compositions comprising same

Country Status (19)

Country Link
US (2) US4923886A (https=)
EP (1) EP0300400B1 (https=)
JP (1) JPH0228167A (https=)
KR (1) KR890002067A (https=)
CN (1) CN1021046C (https=)
AT (1) ATE102928T1 (https=)
AU (1) AU623858B2 (https=)
DE (1) DE3888415T2 (https=)
DK (1) DK375988A (https=)
FI (1) FI883402A7 (https=)
GB (1) GB8717068D0 (https=)
HU (1) HU203227B (https=)
IL (1) IL86959A (https=)
MX (1) MX12317A (https=)
NO (1) NO172049C (https=)
PH (1) PH24481A (https=)
PT (1) PT88019B (https=)
SU (2) SU1706388A3 (https=)
ZA (1) ZA884987B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3941438A1 (de) * 1989-12-15 1991-06-20 Hoechst Ag Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
AU647599B2 (en) * 1991-03-27 1994-03-24 Sankyo Company Limited New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
MX9704435A (es) * 1994-12-15 1997-10-31 Sankyio Company Ltd Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo.
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
WO1996026931A1 (en) * 1995-03-02 1996-09-06 Sankyo Company, Limited Optically active thiazolidinone derivatives
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
PL215901B1 (pl) 1999-04-15 2014-02-28 Bristol Myers Squibb Co Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek
DE60226063T2 (de) * 2001-11-27 2009-05-20 F. Hoffmann-La Roche Ag Benzothiazole derivative
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US6933308B2 (en) * 2002-12-20 2005-08-23 Bristol-Myers Squibb Company Aminoalkyl thiazole derivatives as KCNQ modulators
US7273866B2 (en) * 2002-12-20 2007-09-25 Bristol-Myers Squibb Company 2-aryl thiazole derivatives as KCNQ modulators
US7968575B2 (en) * 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
US8134010B2 (en) * 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
WO2005105065A2 (en) * 2004-05-05 2005-11-10 Renopharm Ltd. Thiazole-based nitric oxide donors for treating inflammatory bowel diseases
DE102009037555A1 (de) * 2009-08-13 2011-03-03 Synovo Gmbh Ein neuartiges, schonendes Verfahren zur direkten Nitrierung von Hydroxyl-, Thiol- und Aminogruppen in organischen Molekülen mittels in situ generiertem Kohlensäuredinitrat
KR101045041B1 (ko) * 2009-10-27 2011-06-28 (주)에스엠이엔지 봉합침 제조방법
EP2707354B1 (en) * 2011-10-24 2015-04-29 Nicox Science Ireland Quinone based nitric oxide donating compounds
CA2881726A1 (en) * 2012-08-23 2014-02-27 Cardiolynx Ag Extended release compositions of an aminoalkyl nitrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate

Also Published As

Publication number Publication date
EP0300400A1 (en) 1989-01-25
FI883402L (fi) 1989-01-21
IL86959A (en) 1992-12-01
SU1760984A3 (ru) 1992-09-07
DE3888415D1 (de) 1994-04-21
NO883208L (no) 1989-01-23
AU623858B2 (en) 1992-05-28
DE3888415T2 (de) 1994-07-14
AU1919988A (en) 1989-01-27
SU1706388A3 (ru) 1992-01-15
DK375988A (da) 1989-01-21
FI883402A7 (fi) 1989-01-21
ATE102928T1 (de) 1994-04-15
PT88019A (pt) 1989-06-30
US5010093A (en) 1991-04-23
ZA884987B (en) 1989-05-30
CN1031226A (zh) 1989-02-22
JPH0331709B2 (https=) 1991-05-08
PT88019B (pt) 1995-03-01
KR890002067A (ko) 1989-04-07
HUT47551A (en) 1989-03-28
GB8717068D0 (en) 1987-08-26
JPH0228167A (ja) 1990-01-30
CN1021046C (zh) 1993-06-02
NO172049B (no) 1993-02-22
IL86959A0 (en) 1988-12-30
PH24481A (en) 1990-07-18
MX12317A (es) 1993-09-01
US4923886A (en) 1990-05-08
EP0300400B1 (en) 1994-03-16
NO172049C (no) 1993-06-02
NO883208D0 (no) 1988-07-19
FI883402A0 (fi) 1988-07-18
DK375988D0 (da) 1988-07-06

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee