HU197201B - Process for producing oral pharmaceutical compositions of controlled solubility of the active components - Google Patents
Process for producing oral pharmaceutical compositions of controlled solubility of the active components Download PDFInfo
- Publication number
- HU197201B HU197201B HU864004A HU400486A HU197201B HU 197201 B HU197201 B HU 197201B HU 864004 A HU864004 A HU 864004A HU 400486 A HU400486 A HU 400486A HU 197201 B HU197201 B HU 197201B
- Authority
- HU
- Hungary
- Prior art keywords
- priority
- process according
- fatty acid
- acid ester
- weight ratio
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 35
- 239000008203 oral pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 51
- 238000013268 sustained release Methods 0.000 claims abstract description 3
- 239000012730 sustained-release form Substances 0.000 claims abstract description 3
- -1 isopropylmethyl Chemical group 0.000 claims description 40
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 35
- 238000013270 controlled release Methods 0.000 claims description 31
- 239000004480 active ingredient Substances 0.000 claims description 27
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 23
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- 229930195729 fatty acid Natural products 0.000 claims description 23
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 22
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical group NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 claims description 17
- 229940074979 cetyl palmitate Drugs 0.000 claims description 17
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims description 17
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 15
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 15
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 15
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- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
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- 239000000416 hydrocolloid Substances 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
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- GUXKBDHITFXEJG-UHFFFAOYSA-N 5-methoxycarbonylpyridine-3-carboxylic acid Chemical compound COC(=O)C1=CN=CC(C(O)=O)=C1 GUXKBDHITFXEJG-UHFFFAOYSA-N 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
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- GJAWHXHKYYXBSV-UHFFFAOYSA-L quinolinate(2-) Chemical compound [O-]C(=O)C1=CC=CN=C1C([O-])=O GJAWHXHKYYXBSV-UHFFFAOYSA-L 0.000 claims 1
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- 238000009472 formulation Methods 0.000 abstract description 14
- 239000000126 substance Substances 0.000 abstract description 4
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- RRENRMZLCFYDFO-UHFFFAOYSA-N 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydroxy-2,6-dimethylpyridine-3,5-dicarboxylic acid Chemical compound N=1ON=C2C1C=CC=C2C2(C(=C(N(C(=C2C(=O)O)C)O)C)C(=O)O)O RRENRMZLCFYDFO-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 abstract 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858524135A GB8524135D0 (en) | 1985-10-01 | 1985-10-01 | Darodipine compositions |
| GB858524653A GB8524653D0 (en) | 1985-10-07 | 1985-10-07 | Pharmaceutical formulations |
| GB858531419A GB8531419D0 (en) | 1985-12-20 | 1985-12-20 | Pindolol compositions |
| GB868603097A GB8603097D0 (en) | 1986-02-07 | 1986-02-07 | Pharmaceutical formulations |
| GB868605037A GB8605037D0 (en) | 1986-02-28 | 1986-02-28 | Oral pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT44701A HUT44701A (en) | 1988-04-28 |
| HU197201B true HU197201B (en) | 1989-03-28 |
Family
ID=27516617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU864004A HU197201B (en) | 1985-10-01 | 1986-09-19 | Process for producing oral pharmaceutical compositions of controlled solubility of the active components |
Country Status (20)
| Country | Link |
|---|---|
| KR (1) | KR920008817B1 (cs) |
| AT (1) | AT402257B (cs) |
| BE (1) | BE905516A (cs) |
| CA (1) | CA1298784C (cs) |
| CH (1) | CH669524A5 (cs) |
| DE (1) | DE3632201C2 (cs) |
| DK (1) | DK170016B1 (cs) |
| ES (1) | ES2002508A6 (cs) |
| FR (1) | FR2589732B1 (cs) |
| GR (1) | GR862457B (cs) |
| HK (1) | HK392A (cs) |
| HU (1) | HU197201B (cs) |
| IE (1) | IE59589B1 (cs) |
| IL (1) | IL80182A (cs) |
| LU (1) | LU86615A1 (cs) |
| NL (1) | NL194822C (cs) |
| NZ (1) | NZ217732A (cs) |
| PT (1) | PT83456B (cs) |
| SE (1) | SE503222C2 (cs) |
| SG (1) | SG103391G (cs) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440457B1 (en) | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
| WO2003065970A2 (en) * | 2001-02-20 | 2003-08-14 | Royal College Of Surgeons Ie | Treatment of fibromyalgia and related fatigue syndromes using pindolol |
| TW200616681A (en) * | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630257A5 (en) * | 1975-03-17 | 1982-06-15 | Hoffmann La Roche | Sustained release formulation |
| CH639659A5 (de) * | 1978-12-18 | 1983-11-30 | Sandoz Ag | Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung. |
| DD145004A3 (de) * | 1978-09-25 | 1980-11-19 | Reinhard Huettenrauch | Verfahren zur herstellung fester a zneiformen |
| CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| JPS6056122B2 (ja) * | 1980-05-21 | 1985-12-09 | 塩野義製薬株式会社 | 徐放性製剤 |
| GB2084017B (en) * | 1980-09-18 | 1984-08-22 | Sandoz Ltd | Pharmaceutical compositions effective against coronary heat disease and hypertension |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| CA1208558A (en) * | 1982-10-07 | 1986-07-29 | Kazuo Kigasawa | Soft buccal |
| GB2154874B (en) * | 1984-02-29 | 1987-11-04 | Sandoz Ltd | Bromoscriptine compositions |
| WO1985004100A1 (en) * | 1984-03-21 | 1985-09-26 | American Home Products Corporation | Sustained release pharmaceutical capsules |
| JPS6124516A (ja) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
-
1986
- 1986-09-19 HU HU864004A patent/HU197201B/hu unknown
- 1986-09-19 NL NL8602370A patent/NL194822C/nl not_active IP Right Cessation
- 1986-09-22 CH CH3780/86A patent/CH669524A5/de not_active IP Right Cessation
- 1986-09-23 DE DE3632201A patent/DE3632201C2/de not_active Expired - Lifetime
- 1986-09-29 NZ NZ217732A patent/NZ217732A/xx unknown
- 1986-09-29 IE IE256586A patent/IE59589B1/en not_active IP Right Cessation
- 1986-09-29 KR KR1019860008136A patent/KR920008817B1/ko not_active Expired
- 1986-09-29 CA CA000519302A patent/CA1298784C/en not_active Expired - Lifetime
- 1986-09-29 PT PT83456A patent/PT83456B/pt unknown
- 1986-09-29 IL IL80182A patent/IL80182A/xx not_active IP Right Cessation
- 1986-09-29 DK DK464686A patent/DK170016B1/da not_active IP Right Cessation
- 1986-09-29 SE SE8604112A patent/SE503222C2/sv not_active IP Right Cessation
- 1986-09-29 GR GR862457A patent/GR862457B/el unknown
- 1986-09-30 BE BE1/011554A patent/BE905516A/fr not_active IP Right Cessation
- 1986-09-30 AT AT0260486A patent/AT402257B/de not_active IP Right Cessation
- 1986-09-30 LU LU86615A patent/LU86615A1/fr unknown
- 1986-09-30 ES ES8602313A patent/ES2002508A6/es not_active Expired
- 1986-10-01 FR FR868613668A patent/FR2589732B1/fr not_active Expired
-
1991
- 1991-12-04 SG SG1033/91A patent/SG103391G/en unknown
-
1992
- 1992-01-02 HK HK3/92A patent/HK392A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE862565L (en) | 1987-04-01 |
| IE59589B1 (en) | 1994-03-09 |
| DK464686A (da) | 1987-04-02 |
| HK392A (en) | 1992-01-10 |
| PT83456A (en) | 1986-10-01 |
| SE503222C2 (sv) | 1996-04-22 |
| DE3632201A1 (de) | 1987-04-02 |
| NL8602370A (nl) | 1987-05-04 |
| LU86615A1 (fr) | 1987-04-02 |
| IL80182A0 (en) | 1986-12-31 |
| CH669524A5 (cs) | 1989-03-31 |
| DE3632201C2 (de) | 1997-05-07 |
| HUT44701A (en) | 1988-04-28 |
| DK170016B1 (da) | 1995-05-01 |
| SE8604112D0 (sv) | 1986-09-29 |
| AT402257B (de) | 1997-03-25 |
| NL194822B (nl) | 2002-12-02 |
| KR920008817B1 (ko) | 1992-10-09 |
| FR2589732B1 (fr) | 1989-07-13 |
| DK464686D0 (da) | 1986-09-29 |
| GR862457B (en) | 1987-01-29 |
| SG103391G (en) | 1992-01-17 |
| IL80182A (en) | 1991-01-31 |
| CA1298784C (en) | 1992-04-14 |
| ES2002508A6 (es) | 1988-08-16 |
| BE905516A (fr) | 1987-03-30 |
| KR870003777A (ko) | 1987-05-04 |
| FR2589732A1 (fr) | 1987-05-15 |
| NZ217732A (en) | 1990-07-26 |
| NL194822C (nl) | 2003-04-03 |
| PT83456B (pt) | 1989-05-12 |
| SE8604112L (sv) | 1987-04-02 |
| ATA260486A (de) | 1996-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HPC4 | Succession in title of patentee |
Owner name: NOVARTIS AG., CH |