HU189211B - Process for preparing 1,1-dioxides of 6-amnioalkyl-penam-3-carboxylic acid and derivatives thereof applied as beta-lactamase inhibitors - Google Patents

Process for preparing 1,1-dioxides of 6-amnioalkyl-penam-3-carboxylic acid and derivatives thereof applied as beta-lactamase inhibitors Download PDF

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Publication number
HU189211B
HU189211B HU8370A HU7083A HU189211B HU 189211 B HU189211 B HU 189211B HU 8370 A HU8370 A HU 8370A HU 7083 A HU7083 A HU 7083A HU 189211 B HU189211 B HU 189211B
Authority
HU
Hungary
Prior art keywords
hydrogen
formula
pharmaceutically acceptable
group
compound
Prior art date
Application number
HU8370A
Other languages
German (de)
English (en)
Hungarian (hu)
Inventor
Wayne E Barth
Original Assignee
Pfizer Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/388,323 external-priority patent/US4427678A/en
Priority claimed from US06/434,371 external-priority patent/US4452796A/en
Application filed by Pfizer Inc,Us filed Critical Pfizer Inc,Us
Publication of HU189211B publication Critical patent/HU189211B/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
HU8370A 1982-01-11 1983-01-10 Process for preparing 1,1-dioxides of 6-amnioalkyl-penam-3-carboxylic acid and derivatives thereof applied as beta-lactamase inhibitors HU189211B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33879782A 1982-01-11 1982-01-11
US38832482A 1982-06-14 1982-06-14
US06/388,323 US4427678A (en) 1982-01-11 1982-06-14 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors
US06/434,371 US4452796A (en) 1982-06-14 1982-10-21 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Publications (1)

Publication Number Publication Date
HU189211B true HU189211B (en) 1986-06-30

Family

ID=27502592

Family Applications (1)

Application Number Title Priority Date Filing Date
HU8370A HU189211B (en) 1982-01-11 1983-01-10 Process for preparing 1,1-dioxides of 6-amnioalkyl-penam-3-carboxylic acid and derivatives thereof applied as beta-lactamase inhibitors

Country Status (20)

Country Link
EP (1) EP0084925B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0689005B2 (cg-RX-API-DMAC7.html)
AU (1) AU538468B2 (cg-RX-API-DMAC7.html)
BG (1) BG42676A3 (cg-RX-API-DMAC7.html)
CA (1) CA1190921A (cg-RX-API-DMAC7.html)
DD (2) DD218365A5 (cg-RX-API-DMAC7.html)
DE (1) DE3362826D1 (cg-RX-API-DMAC7.html)
DK (1) DK166883B1 (cg-RX-API-DMAC7.html)
ES (2) ES8403489A1 (cg-RX-API-DMAC7.html)
FI (1) FI79112C (cg-RX-API-DMAC7.html)
GR (1) GR77152B (cg-RX-API-DMAC7.html)
HU (1) HU189211B (cg-RX-API-DMAC7.html)
IE (1) IE54390B1 (cg-RX-API-DMAC7.html)
IL (1) IL67647A (cg-RX-API-DMAC7.html)
NO (6) NO830046L (cg-RX-API-DMAC7.html)
NZ (1) NZ202982A (cg-RX-API-DMAC7.html)
PL (1) PL142315B1 (cg-RX-API-DMAC7.html)
PT (1) PT76077B (cg-RX-API-DMAC7.html)
RO (2) RO84910B (cg-RX-API-DMAC7.html)
YU (1) YU43646B (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499017A (en) * 1983-06-06 1985-02-12 Pfizer Inc. Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
US4502990A (en) * 1983-06-06 1985-03-05 Pfizer Inc. Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
JPS60239489A (ja) * 1984-05-15 1985-11-28 Meiji Seika Kaisha Ltd ６−エピペニシリンスルホン化合物及びその製造方法
GB2206579B (en) * 1987-07-10 1991-05-29 Erba Farmitalia 6a and 6b-(substituted methyl)-penicillanic acid derivatives
WO2008141764A1 (en) * 2007-05-21 2008-11-27 Hans Rudolf Pfaendler Bactericidal anti-mrsa active pharmaceutical composition containing carbapenems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237051A (en) * 1979-04-19 1980-12-02 Schering Corporation Stereospecific production of 6- or 7-carbon-substituted-β-lactams
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Also Published As

Publication number Publication date
GR77152B (cg-RX-API-DMAC7.html) 1984-09-07
NO841070L (no) 1983-07-12
IE830042L (en) 1983-07-11
AU1023283A (en) 1983-07-21
ES518912A0 (es) 1984-03-16
DE3362826D1 (en) 1986-05-15
PT76077B (en) 1986-01-09
RO84910B (ro) 1984-09-30
PL240108A1 (en) 1985-08-13
ES525238A0 (es) 1985-08-16
DD218365A5 (de) 1985-02-06
NO830046L (no) 1983-07-12
NO841069L (no) 1983-07-12
CA1190921A (en) 1985-07-23
FI830081L (fi) 1983-07-12
RO84910A (ro) 1984-08-17
AU538468B2 (en) 1984-08-16
IE54390B1 (en) 1989-09-13
ES8403489A1 (es) 1984-03-16
DD209462A5 (de) 1984-05-09
PL142315B1 (en) 1987-10-31
RO87705A (ro) 1985-10-31
FI79112B (fi) 1989-07-31
NO833416L (no) 1983-07-12
EP0084925B1 (en) 1986-04-09
JPH0689005B2 (ja) 1994-11-09
ES8507147A1 (es) 1985-08-16
IL67647A (en) 1986-08-31
IL67647A0 (en) 1983-05-15
RO87705B (ro) 1985-10-01
EP0084925A1 (en) 1983-08-03
DK7483A (da) 1983-07-12
FI79112C (fi) 1989-11-10
JPS58126889A (ja) 1983-07-28
FI830081A0 (fi) 1983-01-10
DK7483D0 (da) 1983-01-10
NO833415L (no) 1983-07-12
NO841068L (no) 1983-07-12
DK166883B1 (da) 1993-07-26
NZ202982A (en) 1986-04-11
YU43646B (en) 1989-10-31
YU4483A (en) 1986-02-28
BG42676A3 (en) 1988-01-15
PT76077A (en) 1983-02-01

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee