HU181959B - Process for preparing pharmaceutical compositions with hypotensive and peripherial vasodilatory effect containing racemic 3-/2-/3-tert-butylamino-2-hydroxy/-phenyl/-6-hydrazino-piperazine dihydrochloride monohydrate - Google Patents
Process for preparing pharmaceutical compositions with hypotensive and peripherial vasodilatory effect containing racemic 3-/2-/3-tert-butylamino-2-hydroxy/-phenyl/-6-hydrazino-piperazine dihydrochloride monohydrate Download PDFInfo
- Publication number
- HU181959B HU181959B HU78SI1646A HUSI001646A HU181959B HU 181959 B HU181959 B HU 181959B HU 78SI1646 A HU78SI1646 A HU 78SI1646A HU SI001646 A HUSI001646 A HU SI001646A HU 181959 B HU181959 B HU 181959B
- Authority
- HU
- Hungary
- Prior art keywords
- tert
- butylamino
- dihydrochloride monohydrate
- phenyl
- dihydrochloride
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title description 10
- 230000000304 vasodilatating effect Effects 0.000 title description 3
- 208000001953 Hypotension Diseases 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- 230000001077 hypotensive effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 34
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 150000001875 compounds Chemical class 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 239000002253 acid Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 239000003085 diluting agent Substances 0.000 claims description 6
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- 239000002798 polar solvent Substances 0.000 claims description 2
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- QGONODUKOFNSOY-UHFFFAOYSA-N 1-(tert-butylamino)-3-[2-(6-hydrazinylpyridazin-3-yl)phenoxy]propan-2-ol Chemical compound CC(C)(C)NCC(O)COC1=CC=CC=C1C1=CC=C(NN)N=N1 QGONODUKOFNSOY-UHFFFAOYSA-N 0.000 abstract description 5
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract description 2
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- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7832312 | 1978-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU181959B true HU181959B (en) | 1983-11-28 |
Family
ID=10498866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU78SI1646A HU181959B (en) | 1978-08-04 | 1978-09-01 | Process for preparing pharmaceutical compositions with hypotensive and peripherial vasodilatory effect containing racemic 3-/2-/3-tert-butylamino-2-hydroxy/-phenyl/-6-hydrazino-piperazine dihydrochloride monohydrate |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0007930B1 (Direct) |
| JP (1) | JPS6040424B2 (Direct) |
| AR (1) | AR223327A1 (Direct) |
| AT (1) | AT361001B (Direct) |
| BG (1) | BG34335A3 (Direct) |
| CA (1) | CA1098522A (Direct) |
| CS (1) | CS204035B2 (Direct) |
| DD (1) | DD138656A5 (Direct) |
| DE (1) | DE2862214D1 (Direct) |
| DK (1) | DK147761C (Direct) |
| EG (1) | EG13469A (Direct) |
| ES (1) | ES473056A1 (Direct) |
| FI (1) | FI64585C (Direct) |
| GR (1) | GR64897B (Direct) |
| HU (1) | HU181959B (Direct) |
| IE (1) | IE47555B1 (Direct) |
| IL (1) | IL55455A (Direct) |
| IN (1) | IN148775B (Direct) |
| IT (1) | IT1110169B (Direct) |
| MT (1) | MTP851B (Direct) |
| MX (1) | MX5425E (Direct) |
| NO (1) | NO783005L (Direct) |
| NZ (1) | NZ188281A (Direct) |
| OA (1) | OA06046A (Direct) |
| PL (1) | PL119444B1 (Direct) |
| SU (1) | SU897110A3 (Direct) |
| YU (1) | YU209078A (Direct) |
| ZA (1) | ZA785008B (Direct) |
| ZM (1) | ZM8078A1 (Direct) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE42214B1 (en) * | 1974-06-18 | 1980-07-02 | Smith Kline French Lab | Hydrazinopyredazines |
-
1978
- 1978-08-21 IN IN619/DEL/78A patent/IN148775B/en unknown
- 1978-08-22 IE IE1702/78A patent/IE47555B1/en unknown
- 1978-08-28 NZ NZ188281A patent/NZ188281A/xx unknown
- 1978-08-28 GR GR57100A patent/GR64897B/el unknown
- 1978-08-29 IL IL55455A patent/IL55455A/xx unknown
- 1978-08-29 JP JP53106180A patent/JPS6040424B2/ja not_active Expired
- 1978-08-30 EG EG541/78A patent/EG13469A/xx active
- 1978-08-31 IT IT27234/78A patent/IT1110169B/it active
- 1978-09-01 HU HU78SI1646A patent/HU181959B/hu unknown
- 1978-09-01 ZA ZA00785008A patent/ZA785008B/xx unknown
- 1978-09-01 CA CA310,530A patent/CA1098522A/en not_active Expired
- 1978-09-04 EP EP78300341A patent/EP0007930B1/en not_active Expired
- 1978-09-04 YU YU02090/78A patent/YU209078A/xx unknown
- 1978-09-04 PL PL1978209407A patent/PL119444B1/pl unknown
- 1978-09-04 OA OA56598A patent/OA06046A/xx unknown
- 1978-09-04 ES ES473056A patent/ES473056A1/es not_active Expired
- 1978-09-04 BG BG040811A patent/BG34335A3/xx unknown
- 1978-09-04 DD DD78207634A patent/DD138656A5/xx unknown
- 1978-09-04 DE DE7878300341T patent/DE2862214D1/de not_active Expired
- 1978-09-04 CS CS785723A patent/CS204035B2/cs unknown
- 1978-09-04 AT AT638378A patent/AT361001B/de not_active IP Right Cessation
- 1978-09-04 NO NO783005A patent/NO783005L/no unknown
- 1978-09-04 DK DK389378A patent/DK147761C/da not_active IP Right Cessation
- 1978-09-04 MX MX787372U patent/MX5425E/es unknown
- 1978-09-04 FI FI782705A patent/FI64585C/fi not_active IP Right Cessation
- 1978-09-04 SU SU782660649A patent/SU897110A3/ru active
- 1978-09-05 AR AR273573A patent/AR223327A1/es active
- 1978-09-15 ZM ZM80/78A patent/ZM8078A1/xx unknown
-
1979
- 1979-07-23 MT MT851A patent/MTP851B/xx unknown
Also Published As
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