HU181442B - Process for preparing aminosugar derivatives - Google Patents
Process for preparing aminosugar derivatives Download PDFInfo
- Publication number
- HU181442B HU181442B HU79HO2138A HUHO002138A HU181442B HU 181442 B HU181442 B HU 181442B HU 79HO2138 A HU79HO2138 A HU 79HO2138A HU HO002138 A HUHO002138 A HU HO002138A HU 181442 B HU181442 B HU 181442B
- Authority
- HU
- Hungary
- Prior art keywords
- trestatin
- water
- isp
- brown
- light
- Prior art date
Links
- 150000002336 glycosamine derivatives Chemical class 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title description 4
- WEDWQCPYKKZMDF-UHFFFAOYSA-N 2-[5-[5-[5-[3,4-dihydroxy-6-methyl-5-[[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydro Chemical compound OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC(C(C1O)O)C(CO)OC1OC(C(C1O)O)C(CO)OC1OC1OC(CO)C(O)C(O)C1O WEDWQCPYKKZMDF-UHFFFAOYSA-N 0.000 claims description 134
- 229930186167 Trestatin Natural products 0.000 claims description 105
- PYVAAPGPTLLDGV-AGKSRYJLSA-N (2r,3r,4s,5s,6r)-2-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4s,5s,6r)-5-[[(1s,4r,5r,6s)-4-[(2s,3r,4r,5s,6r)-5-[(2r,3r,4s,5s,6r)-3,4-dihydroxy-6-methyl-5-[[(1s,4r,5s,6s)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino] Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@H](C)[C@H]([C@@H]([C@H]1O)O)N[C@@H]1[C@H](O)[C@@H](O)[C@@H](C(=C1)CO)O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYVAAPGPTLLDGV-AGKSRYJLSA-N 0.000 claims description 69
- PYVAAPGPTLLDGV-UHFFFAOYSA-N Trestatin A Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC(C(=C1)CO)C(O)C(O)C1NC(C(C1O)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC(C(C1O)O)C(CO)OC1OC(C(C1O)O)C(CO)OC1OC1OC(CO)C(O)C(O)C1O PYVAAPGPTLLDGV-UHFFFAOYSA-N 0.000 claims description 69
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- 238000000034 method Methods 0.000 claims description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 17
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB583478 | 1978-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU181442B true HU181442B (en) | 1983-07-28 |
Family
ID=9803510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU79HO2138A HU181442B (en) | 1978-02-14 | 1979-02-12 | Process for preparing aminosugar derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4273765A (OSRAM) |
| EP (1) | EP0003616B1 (OSRAM) |
| JP (1) | JPS54163511A (OSRAM) |
| AR (1) | AR219150A1 (OSRAM) |
| AT (1) | AT367451B (OSRAM) |
| AU (1) | AU527318B2 (OSRAM) |
| CA (1) | CA1121290A (OSRAM) |
| DE (2) | DE2962165D1 (OSRAM) |
| DK (1) | DK149599C (OSRAM) |
| ES (1) | ES477653A1 (OSRAM) |
| FI (1) | FI63062C (OSRAM) |
| FR (1) | FR2416901A1 (OSRAM) |
| GR (1) | GR72817B (OSRAM) |
| HU (1) | HU181442B (OSRAM) |
| IE (1) | IE47916B1 (OSRAM) |
| IL (1) | IL56626A0 (OSRAM) |
| LU (1) | LU80906A1 (OSRAM) |
| MC (1) | MC1253A1 (OSRAM) |
| NL (1) | NL7901182A (OSRAM) |
| NO (1) | NO153011C (OSRAM) |
| NZ (1) | NZ189625A (OSRAM) |
| PH (1) | PH15084A (OSRAM) |
| PT (1) | PT69218A (OSRAM) |
| SE (1) | SE7901276L (OSRAM) |
| YU (1) | YU41437B (OSRAM) |
| ZA (1) | ZA79528B (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3166093D1 (en) * | 1981-01-05 | 1984-10-18 | Takeda Chemical Industries Ltd | N-substituted pseudo-aminosugars, their production and use |
| JPS57146713A (en) * | 1981-03-09 | 1982-09-10 | Akira Endo | Hypoglycemic |
| US4595678A (en) * | 1982-03-19 | 1986-06-17 | Takeda Chemical Industries, Ltd. | N-substituted pseudo-aminosugars and pharmaceutical compositions containing same |
| US4762857A (en) * | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
| US4678812A (en) * | 1986-05-30 | 1987-07-07 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
| US4885361A (en) * | 1987-07-31 | 1989-12-05 | Hoffmann-La Roche Inc. | Sulfated oligosaccharides |
| DK0559795T3 (da) * | 1990-11-30 | 1996-01-29 | Monoclonetics Int | Fremgangsmåder til diagnosticering af kroniske smerter i lænderegionen og halshvrivelsøjlen |
| CA2128044C (en) * | 1993-08-05 | 2007-02-20 | Klaus-Dieter Bremer | Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor |
| US7022684B2 (en) * | 2000-05-24 | 2006-04-04 | Pfizer Inc. | Treatment of rumen acidosis with α-amylase inhibitors |
| ES2272418T3 (es) * | 2000-05-24 | 2007-05-01 | Pfizer Inc. | Tratamiento de acidos del rumen con inhibidores de alfa-amilasa. |
| CA2546601A1 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| CA2590533C (en) * | 2004-11-23 | 2010-09-07 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2009125819A1 (ja) | 2008-04-11 | 2009-10-15 | アステラス製薬株式会社 | アミノ糖化合物及びその生産方法 |
| WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US20120046364A1 (en) | 2009-02-10 | 2012-02-23 | Metabasis Therapeutics, Inc. | Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use |
| EP2571860A1 (en) | 2010-05-21 | 2013-03-27 | Pfizer Inc | 2-phenyl benzoylamides |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US20130345392A1 (en) | 2011-03-04 | 2013-12-26 | Pfizer Inc | Edn3-like peptides and uses thereof |
| WO2013133685A1 (en) | 2012-03-09 | 2013-09-12 | Biotropics Malaysia Berhad | Extract formulations of rhodamnia cinerea and uses thereof |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CA2909442A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| DK3186242T3 (da) | 2014-08-29 | 2021-12-20 | Tes Pharma S R L | Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| AR109950A1 (es) | 2016-10-14 | 2019-02-06 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| BR112021009589A2 (pt) | 2018-11-20 | 2021-08-17 | Tes Pharma S.R.L. | inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico |
| HUE069590T2 (hu) | 2019-01-18 | 2025-03-28 | Astrazeneca Ab | PCSK9-gátló 6'-[[(1s,3s)-3-[[5-(difluormetoxi)-2-pirimidinil]amino]ciklopentil]amino][1(2h ),3'-bipiridin]-2-on és alkalmazására szolgáló eljárások |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2064092C2 (de) * | 1970-12-28 | 1983-06-01 | Bayer Ag, 5090 Leverkusen | Inhibitoren für Glykosidhydrolasen aus Actinomyceten |
| DE2347782C3 (de) * | 1973-09-22 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Aminozuckerderivate, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| US4062950A (en) * | 1973-09-22 | 1977-12-13 | Bayer Aktiengesellschaft | Amino sugar derivatives |
| US4065557A (en) * | 1974-03-21 | 1977-12-27 | Bayer Aktiengesellschaft | Amino sugars and their use in improving the meat:fat ratio in animals |
| USRE29903E (en) | 1975-03-19 | 1979-02-06 | American Cyanamid Company | Antibacterial antibiotics AM31α, AM31β and AM31γ |
| DE2614393C3 (de) * | 1976-04-02 | 1980-04-03 | Bayer Ag, 5090 Leverkusen | Aminozucker-Derivate und diese Verbindungen enthaltende Arzneimittel |
-
1979
- 1979-01-31 CA CA000320579A patent/CA1121290A/en not_active Expired
- 1979-02-07 ZA ZA79528A patent/ZA79528B/xx unknown
- 1979-02-07 AU AU44028/79A patent/AU527318B2/en not_active Ceased
- 1979-02-07 PH PH22174A patent/PH15084A/en unknown
- 1979-02-08 AR AR275445A patent/AR219150A1/es active
- 1979-02-08 IL IL56626A patent/IL56626A0/xx not_active IP Right Cessation
- 1979-02-09 US US06/011,002 patent/US4273765A/en not_active Expired - Lifetime
- 1979-02-12 FR FR7903452A patent/FR2416901A1/fr active Granted
- 1979-02-12 HU HU79HO2138A patent/HU181442B/hu not_active IP Right Cessation
- 1979-02-12 LU LU80906A patent/LU80906A1/de unknown
- 1979-02-12 NZ NZ189625A patent/NZ189625A/xx unknown
- 1979-02-13 MC MC791365A patent/MC1253A1/fr unknown
- 1979-02-13 IE IE274/79A patent/IE47916B1/en not_active IP Right Cessation
- 1979-02-13 DK DK61179A patent/DK149599C/da active
- 1979-02-13 ES ES477653A patent/ES477653A1/es not_active Expired
- 1979-02-13 AT AT0108879A patent/AT367451B/de not_active IP Right Cessation
- 1979-02-13 JP JP1443879A patent/JPS54163511A/ja active Granted
- 1979-02-13 NO NO790469A patent/NO153011C/no unknown
- 1979-02-13 SE SE7901276A patent/SE7901276L/ not_active Application Discontinuation
- 1979-02-13 GR GR58344A patent/GR72817B/el unknown
- 1979-02-13 PT PT7969218A patent/PT69218A/pt unknown
- 1979-02-14 NL NL7901182A patent/NL7901182A/xx not_active Application Discontinuation
- 1979-02-14 EP EP79100441A patent/EP0003616B1/de not_active Expired
- 1979-02-14 DE DE7979100441T patent/DE2962165D1/de not_active Expired
- 1979-02-14 YU YU348/79A patent/YU41437B/xx unknown
- 1979-02-14 FI FI790486A patent/FI63062C/fi not_active IP Right Cessation
- 1979-02-14 DE DE19792905649 patent/DE2905649A1/de not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
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| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |