HU176956B - Sposob poluchenija 2-zamehhjonnykh proizvodnykh trans-1,2,3,4,5,9b-geksagidro-5-fenil-2h-pirido!4,3-b!indola i farmacevticheskikh preparatov soderzhahhikh takie proizvodnye v kachestve aktivnogo vehhestva - Google Patents
Sposob poluchenija 2-zamehhjonnykh proizvodnykh trans-1,2,3,4,5,9b-geksagidro-5-fenil-2h-pirido!4,3-b!indola i farmacevticheskikh preparatov soderzhahhikh takie proizvodnye v kachestve aktivnogo vehhestva Download PDFInfo
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- HU176956B HU176956B HU77EO342A HUEO000342A HU176956B HU 176956 B HU176956 B HU 176956B HU 77EO342 A HU77EO342 A HU 77EO342A HU EO000342 A HUEO000342 A HU EO000342A HU 176956 B HU176956 B HU 176956B
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- methyl
- ethyl
- compounds
- hydrogen
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- 150000001875 compounds Chemical class 0.000 claims description 74
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 24
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 19
- -1 2-substituted-trans-1,3,4,4a, 5,9b-hexahydro-5-phenyl-2H-pyrido [4,3-b] indole Chemical class 0.000 claims description 18
- 150000002431 hydrogen Chemical class 0.000 claims description 18
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- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
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- 125000000068 chlorophenyl group Chemical group 0.000 description 1
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- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
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- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- AGJSNMGHAVDLRQ-HUUJSLGLSA-N methyl (2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-HUUJSLGLSA-N 0.000 description 1
- AGJSNMGHAVDLRQ-IWFBPKFRSA-N methyl (2s)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-IWFBPKFRSA-N 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical group [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 235000021395 porridge Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
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- 238000003825 pressing Methods 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
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- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
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- 206010042772 syncope Diseases 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67511276A | 1976-04-08 | 1976-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU176956B true HU176956B (hu) | 1981-06-28 |
Family
ID=24709111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU77EO342A HU176956B (hu) | 1976-04-08 | 1977-04-08 | Sposob poluchenija 2-zamehhjonnykh proizvodnykh trans-1,2,3,4,5,9b-geksagidro-5-fenil-2h-pirido!4,3-b!indola i farmacevticheskikh preparatov soderzhahhikh takie proizvodnye v kachestve aktivnogo vehhestva |
Country Status (28)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7702300L (sv) * | 1976-04-15 | 1977-10-16 | Endo Lab | Reduktionsforlopp |
| US4224329A (en) * | 1979-01-23 | 1980-09-23 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| US4252812A (en) * | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| US4267331A (en) * | 1979-01-23 | 1981-05-12 | Pfizer Inc. | Process for the production of 2-substituted pyrido[4,3-b]-indoles |
| US4432978A (en) * | 1979-07-30 | 1984-02-21 | Pfizer Inc. | Hexahydro-trans-pyridoindole |
| US4352807A (en) * | 1979-07-30 | 1982-10-05 | Pfizer Inc. | Hexahydro-trans-pyridoindole neuroleptic agents |
| US4337250A (en) * | 1979-07-30 | 1982-06-29 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US4431649A (en) * | 1979-07-30 | 1984-02-14 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US4252811A (en) * | 1979-07-30 | 1981-02-24 | Pfizer Inc. | Hexahydro-trans-pyridoindole neuroleptic agents |
| US4431646A (en) * | 1979-07-30 | 1984-02-14 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US4427679A (en) | 1981-01-16 | 1984-01-24 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US5319087A (en) * | 1987-04-16 | 1994-06-07 | Eli Lilly And Company | Piperidine opioid antagonists |
| US4992450A (en) * | 1987-04-16 | 1991-02-12 | Eli Lilly And Company | Piperidine opioid antagonists |
| US4891379A (en) * | 1987-04-16 | 1990-01-02 | Kabushiki Kaisha Kobe Seikosho | Piperidine opioid antagonists |
| US5270328A (en) * | 1991-03-29 | 1993-12-14 | Eli Lilly And Company | Peripherally selective piperidine opioid antagonists |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH303833A (de) * | 1951-04-30 | 1954-12-15 | Bayer Ag | Verfahren zur Herstellung von Derivaten des Tetrahydro-y-carbolins. |
| JPS50126699A (cg-RX-API-DMAC10.html) * | 1974-03-20 | 1975-10-04 |
-
1977
- 1977-03-02 SE SE7702301A patent/SE7702301L/xx not_active Application Discontinuation
- 1977-04-06 GR GR53175A patent/GR63666B/el unknown
- 1977-04-06 PH PH19641A patent/PH13152A/en unknown
- 1977-04-06 ES ES457665A patent/ES457665A1/es not_active Expired
- 1977-04-06 NO NO771242A patent/NO771242L/no unknown
- 1977-04-06 AU AU24012/77A patent/AU516432B2/en not_active Expired
- 1977-04-06 FI FI771088A patent/FI62304C/fi not_active IP Right Cessation
- 1977-04-06 DE DE19772715355 patent/DE2715355A1/de not_active Withdrawn
- 1977-04-06 IE IE724/77A patent/IE45189B1/en unknown
- 1977-04-06 DK DK154877A patent/DK154877A/da not_active IP Right Cessation
- 1977-04-06 PT PT66407A patent/PT66407B/pt unknown
- 1977-04-06 SU SU772468108A patent/SU719503A3/ru active
- 1977-04-06 AT AT242377A patent/AT360533B/de not_active IP Right Cessation
- 1977-04-06 CA CA275,677A patent/CA1071210A/en not_active Expired
- 1977-04-06 AR AR267148A patent/AR218246A1/es active
- 1977-04-07 FR FR7710596A patent/FR2347365A1/fr active Granted
- 1977-04-07 CH CH446877A patent/CH633795A5/de not_active IP Right Cessation
- 1977-04-07 DD DD7700198299A patent/DD132015A5/xx unknown
- 1977-04-07 ZA ZA00772166A patent/ZA772166B/xx unknown
- 1977-04-07 NL NL7703898A patent/NL7703898A/xx not_active Application Discontinuation
- 1977-04-07 NZ NZ183824A patent/NZ183824A/xx unknown
- 1977-04-07 IL IL51840A patent/IL51840A/xx unknown
- 1977-04-08 JP JP3962477A patent/JPS52125197A/ja active Pending
- 1977-04-08 BE BE176568A patent/BE853422A/xx unknown
- 1977-04-08 HU HU77EO342A patent/HU176956B/hu unknown
- 1977-04-08 LU LU77091A patent/LU77091A1/xx unknown
- 1977-04-12 GB GB15071/77A patent/GB1572057A/en not_active Expired
- 1977-12-13 US US05/860,212 patent/US4141980A/en not_active Expired - Lifetime
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