HRP980502B1 - Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments - Google Patents

Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments

Info

Publication number
HRP980502B1
HRP980502B1 HR980502A HRP980502A HRP980502B1 HR P980502 B1 HRP980502 B1 HR P980502B1 HR 980502 A HR980502 A HR 980502A HR P980502 A HRP980502 A HR P980502A HR P980502 B1 HRP980502 B1 HR P980502B1
Authority
HR
Croatia
Prior art keywords
benzazocin
oles
methano
hexahydro
medicaments
Prior art date
Application number
HR980502A
Other languages
English (en)
Inventor
Grauert Matthias
Carter Adrian
Bechtel Wolf-Dietrich
Weiser Thomas
Palluk Rainer
Paschorn Uwe
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Publication of HRP980502A2 publication Critical patent/HRP980502A2/hr
Publication of HRP980502B1 publication Critical patent/HRP980502B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR980502A 1997-09-12 1998-09-11 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments HRP980502B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19740110A DE19740110A1 (de) 1997-09-12 1997-09-12 Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
HRP980502A2 HRP980502A2 (en) 1999-06-30
HRP980502B1 true HRP980502B1 (en) 2005-02-28

Family

ID=7842134

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980502A HRP980502B1 (en) 1997-09-12 1998-09-11 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments

Country Status (38)

Country Link
US (1) US6455538B1 (cs)
EP (1) EP1015433B1 (cs)
JP (1) JP3827528B2 (cs)
KR (1) KR100601008B1 (cs)
CN (1) CN1166640C (cs)
AR (1) AR017095A1 (cs)
AT (1) ATE267811T1 (cs)
AU (1) AU751036B2 (cs)
BG (1) BG64418B1 (cs)
BR (1) BR9812443A (cs)
CA (1) CA2302347C (cs)
CO (1) CO5011117A1 (cs)
CZ (1) CZ296909B6 (cs)
DE (2) DE19740110A1 (cs)
DK (1) DK1015433T3 (cs)
EE (1) EE04398B1 (cs)
ES (1) ES2222612T3 (cs)
HR (1) HRP980502B1 (cs)
HU (1) HUP0004588A3 (cs)
ID (1) ID24173A (cs)
IL (1) IL134572A (cs)
MY (1) MY120550A (cs)
NO (1) NO315650B1 (cs)
NZ (1) NZ503710A (cs)
PE (1) PE122899A1 (cs)
PL (1) PL198486B1 (cs)
PT (1) PT1015433E (cs)
RS (1) RS49888B (cs)
RU (1) RU2218334C2 (cs)
SA (1) SA98190765B1 (cs)
SK (1) SK284670B6 (cs)
TR (1) TR200000697T2 (cs)
TW (1) TW505645B (cs)
UA (1) UA61973C2 (cs)
UY (2) UY25175A1 (cs)
WO (1) WO1999014199A1 (cs)
YU (1) YU12000A (cs)
ZA (1) ZA988285B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE19957156A1 (de) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6683089B2 (en) 2002-02-02 2004-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols
US6828311B2 (en) 2002-05-29 2004-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Formulation for the parenteral application of a sodium channel blocker
DE10223783A1 (de) * 2002-05-29 2003-12-11 Boehringer Ingelheim Pharma Neue Formulierung zur parenteralen Applikation eines Na-Kanal-Blockers
US20040019075A1 (en) * 2002-05-29 2004-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New formulation for the parenteral application of crobenetine
DE10226814A1 (de) * 2002-06-15 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung ischämischer Zustände
US20030235576A1 (en) * 2002-06-15 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of ischaemic conditions
HRP20160005T1 (hr) 2005-12-22 2016-02-12 Newron Pharmaceuticals S.P.A. 2-feniletilamono derivati kao modulatori kalcijskih i/ili natrijskih kanala
HRP20180324T8 (hr) 2007-06-15 2019-03-08 Newron Pharmaceuticals S.P.A. Supstituirani derivati 2-[2-(fenil)etilamino]alkanamida i njihova upotreba kao modulatora natrijevih i/ili kalcijevih kanala
CA2833824C (en) 2011-06-27 2017-08-29 Newron Pharmaceuticals S.P.A. Fluorinated arylalkylaminocarboxamide derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
CO5011117A1 (es) 2001-02-28
KR20010023879A (ko) 2001-03-26
CN1269790A (zh) 2000-10-11
EP1015433A1 (de) 2000-07-05
RS49888B (sr) 2008-08-07
PT1015433E (pt) 2004-08-31
BR9812443A (pt) 2000-09-26
BG104232A (bg) 2000-10-31
EE04398B1 (et) 2004-12-15
AR017095A1 (es) 2001-08-22
IL134572A0 (en) 2001-04-30
PL339061A1 (en) 2000-12-04
YU12000A (sh) 2002-11-15
PL198486B1 (pl) 2008-06-30
CA2302347A1 (en) 1999-03-25
JP3827528B2 (ja) 2006-09-27
MY120550A (en) 2005-11-30
TR200000697T2 (tr) 2001-01-22
SK284670B6 (sk) 2005-08-04
HRP980502A2 (en) 1999-06-30
TW505645B (en) 2002-10-11
JP2001516747A (ja) 2001-10-02
NZ503710A (en) 2002-04-26
CZ2000894A3 (cs) 2000-09-13
NO315650B1 (no) 2003-10-06
CZ296909B6 (cs) 2006-07-12
DE19740110A1 (de) 1999-03-18
AU9624298A (en) 1999-04-05
HUP0004588A3 (en) 2002-10-28
HUP0004588A2 (hu) 2001-07-30
ID24173A (id) 2000-07-13
EP1015433B1 (de) 2004-05-26
DK1015433T3 (da) 2004-09-27
CA2302347C (en) 2008-06-17
SK3342000A3 (en) 2000-09-12
PE122899A1 (es) 1999-12-06
SA98190765B1 (ar) 2006-06-10
US6455538B1 (en) 2002-09-24
RU2218334C2 (ru) 2003-12-10
KR100601008B1 (ko) 2006-07-19
EE200000129A (et) 2001-02-15
UY25439A1 (es) 1999-11-17
WO1999014199A1 (de) 1999-03-25
NO20001288D0 (no) 2000-03-10
ATE267811T1 (de) 2004-06-15
CN1166640C (zh) 2004-09-15
NO20001288L (no) 2000-03-13
BG64418B1 (bg) 2005-01-31
AU751036B2 (en) 2002-08-08
DE59811477D1 (de) 2004-07-01
ES2222612T3 (es) 2005-02-01
ZA988285B (en) 1999-03-12
UA61973C2 (en) 2003-12-15
IL134572A (en) 2005-05-17
UY25175A1 (es) 2000-12-29

Similar Documents

Publication Publication Date Title
NZ314419A (en) Substituted 2,4-aryl-3-hydroxyalkyl pyridines; preparation and medicaments
NZ329176A (en) 2,5-dioxo-imidazolidine derivatives and medicaments
SG87776A1 (en) Substituted isoquinoline-3-carboxamides, their preparation and their use as pharmaceuticals
HUP0001508A3 (en) 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
HUP9800138A3 (en) 8-substituted-1,3,8-triaza-spiro [4,5]-decan-4-on derivatives, process for producing them, pharmaceutical compositions containing the same and their use
IL135920A0 (en) 2-aryl -8-oxodihydropurine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
HUP0004024A3 (en) Azabenzimidazole-based compounds, process for their preparation and pharmaceutical composition thereof
IL115039A (en) Spiroazabicyclic compounds, their preparation and pharmaceutical compositions containing them
HUP9900974A3 (en) Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP0000658A3 (en) Sulphonamide derivatives, process for their preparation, and their use as medicaments
HUP9700328A3 (en) Heteroaryl-oxazolidinones, process for their preparation, pharmaceutical compositions containing the same, their use and intermediates
SI1019358T1 (en) 3,3-diarylpropylamines , their use and preparation
HUP0000426A3 (en) Novel benzonaphthyridines, pharmaceutical compositions and use thereof and process for their preparation
PL343512A1 (en) Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
HUP9800555A3 (en) 3,3-diphenylallylamine derivatives and process for their preparation
HUP0102215A3 (en) Benzoylpyridazines, pharmaceutical compositions containing the same and process for their preparation
HUP9802807A3 (en) 1,3,8-triazo-spiro[4,5]decan-4-on derivatives, their use, production thereof and medicaments containing the same
HUP9802132A3 (en) Biphenyl-sulfonyl-cyanamides, their use and pharmaceutical compositions containing them
HRP980502B1 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments
HUP9602868A3 (en) 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation
IL121969A0 (en) 10,13,15-trioxatricyclo[9.2.1.1.9.6]-pentadecanone derivatives their preparation and pharmaceutical compositions containing them
AU3011095A (en) 2,3-bridged 1,4-dihydropyridines, processes for their preparation and their use as medicaments
HUP9600665A3 (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
HRP970424B1 (en) Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
GR3035834T3 (en) Benzoxazindione derivatives, process for their preparation and their use

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG., DE

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20080911

Year of fee payment: 11

PBON Lapse due to non-payment of renewal fee

Effective date: 20090912