HRP980240B1 - A new process for the preparation of a pharmacologically ve substance - Google Patents

A new process for the preparation of a pharmacologically ve substance

Info

Publication number
HRP980240B1
HRP980240B1 HR980240A HRP980240A HRP980240B1 HR P980240 B1 HRP980240 B1 HR P980240B1 HR 980240 A HR980240 A HR 980240A HR P980240 A HRP980240 A HR P980240A HR P980240 B1 HRP980240 B1 HR P980240B1
Authority
HR
Croatia
Prior art keywords
pharmacologically
substance
preparation
new process
new
Prior art date
Application number
HR980240A
Other languages
English (en)
Inventor
Maria Bakonyi
Matianna Csatarinee Nagy
Leventene Molnar
Antal Gajary
Edit Alattyani
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of HRP980240A2 publication Critical patent/HRP980240A2/hr
Publication of HRP980240B1 publication Critical patent/HRP980240B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
HR980240A 1997-05-13 1998-05-06 A new process for the preparation of a pharmacologically ve substance HRP980240B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700885A HU222283B1 (hu) 1997-05-13 1997-05-13 Eljárás tieno[3,2-c]piridin-származékok előállítására

Publications (2)

Publication Number Publication Date
HRP980240A2 HRP980240A2 (en) 1999-02-28
HRP980240B1 true HRP980240B1 (en) 2003-02-28

Family

ID=90014236

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980240A HRP980240B1 (en) 1997-05-13 1998-05-06 A new process for the preparation of a pharmacologically ve substance

Country Status (38)

Country Link
US (1) US6180793B1 (ko)
EP (1) EP0981529B1 (ko)
KR (1) KR100428238B1 (ko)
CN (1) CN1109036C (ko)
AR (1) AR014349A1 (ko)
AT (1) ATE212025T1 (ko)
AU (1) AU735702B2 (ko)
BR (1) BR9809112B1 (ko)
CA (1) CA2289623C (ko)
CO (1) CO4950564A1 (ko)
CZ (1) CZ292820B6 (ko)
DE (1) DE69803176T2 (ko)
DK (1) DK0981529T3 (ko)
DZ (1) DZ2487A1 (ko)
EE (1) EE03925B1 (ko)
EG (1) EG21973A (ko)
ES (1) ES2172141T3 (ko)
HK (1) HK1027350A1 (ko)
HR (1) HRP980240B1 (ko)
HU (1) HU222283B1 (ko)
ID (1) ID23018A (ko)
IL (1) IL132774A0 (ko)
IS (1) IS1883B (ko)
ME (1) ME01636B (ko)
MY (1) MY121299A (ko)
NO (1) NO325419B1 (ko)
NZ (1) NZ501577A (ko)
PL (1) PL194859B1 (ko)
PT (1) PT981529E (ko)
RS (1) RS49626B (ko)
RU (1) RU2172315C1 (ko)
SA (1) SA98190583B1 (ko)
SK (1) SK283700B6 (ko)
TR (1) TR199902783T2 (ko)
TW (1) TW552263B (ko)
UA (1) UA66359C2 (ko)
WO (1) WO1998051689A1 (ko)
ZA (1) ZA983921B (ko)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
HU226421B1 (en) 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
IN191030B (ko) * 2001-01-24 2003-09-13 Cadila Healthcare Ltd
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
ITMI20020933A1 (it) * 2002-05-03 2003-11-03 Danimite Dipharma S P A Procedimento per la sintesi di clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6812363B2 (en) * 2002-10-15 2004-11-02 Usv Limited Racemization of optically active 2-substituted phenyl glycine esters
WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
US7872019B2 (en) 2003-03-12 2011-01-18 Cadila Healthcare Limited Polymorphs and amorphous form of (S)-(+)-clopidogrel bisulfate
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
WO2005063708A2 (en) 2003-11-03 2005-07-14 Cadila Healthcare Limited Processes for preparing different forms of (s)-(+)- clopidogrel bisulfate
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
KR100553398B1 (ko) 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
JP2007513889A (ja) * 2004-09-21 2007-05-31 テバ ファーマシューティカル インダストリーズ リミティド 結晶性クロピドグレル臭酸塩及びその調製方法
MX2007010267A (es) * 2005-02-24 2007-09-11 Teva Pharma Base de clopidogrel adecuada para formulacion farmaceutica y preparacion de ella.
KR100681512B1 (ko) 2005-03-08 2007-02-09 주식회사 한서켐 클로피도그렐의 신규한 제조 중간체 및 이를 이용한 클로피도그렐의 제조방법
KR101235117B1 (ko) 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
WO2007125544A2 (en) * 2006-04-27 2007-11-08 Ind-Swift Laboratories Limited Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate
KR20080055860A (ko) * 2006-08-03 2008-06-19 테바 파마슈티컬 인더스트리즈 리미티드 클로피도그렐 바이설페이트의 제조 방법
US8247558B2 (en) 2006-09-04 2012-08-21 Ranbaxy Laboratories Limited Process for the preparation of clopidogrel and its pharmaceutically acceptable salts
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
KR100990949B1 (ko) 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
US20110190502A1 (en) * 2008-10-24 2011-08-04 Sandoz Ag Process for the preparation of s-clopidogrel
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
CN101544655B (zh) * 2009-05-05 2012-07-04 上海医药集团股份有限公司 噻吩并[3，2-c]吡啶衍生物的制备方法
CN101863899B (zh) * 2010-06-21 2013-03-20 常州制药厂有限公司 一种提高氯吡格雷樟脑磺酸盐拆分收率的方法
KR20170004282A (ko) 2015-07-02 2017-01-11 류종렬 수도 지지부가 구비된 쉐이크 핸드형 탁구 라켓
KR20170004283A (ko) 2015-07-02 2017-01-11 류종렬 그립부가 개선된 쉐이크 핸드형 탁구 라켓

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr) 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) * 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.

Also Published As

Publication number Publication date
NO995533D0 (no) 1999-11-12
UA66359C2 (uk) 2004-05-17
ZA983921B (en) 1998-11-09
DZ2487A1 (fr) 2004-07-30
ES2172141T3 (es) 2002-09-16
BR9809112B1 (pt) 2010-10-05
KR20010012511A (ko) 2001-02-15
EE9900488A (et) 2000-06-15
CA2289623A1 (en) 1998-11-19
US6180793B1 (en) 2001-01-30
CN1255924A (zh) 2000-06-07
DE69803176D1 (de) 2002-02-21
EE03925B1 (et) 2002-12-16
TW552263B (en) 2003-09-11
DK0981529T3 (da) 2002-04-22
IS5244A (is) 1999-11-11
EP0981529B1 (en) 2002-01-16
ID23018A (id) 1999-12-30
CN1109036C (zh) 2003-05-21
JP4256478B2 (ja) 2009-04-22
SK151699A3 (en) 2000-07-11
CO4950564A1 (es) 2000-09-01
JP2001525819A (ja) 2001-12-11
NZ501577A (en) 2001-10-26
HK1027350A1 (en) 2001-01-12
EP0981529A1 (en) 2000-03-01
YU58799A (sh) 2002-06-19
HUP9700885A2 (hu) 1999-09-28
IS1883B (is) 2003-08-15
WO1998051689A1 (en) 1998-11-19
SA98190583B1 (ar) 2006-08-19
EG21973A (en) 2002-05-31
CZ292820B6 (cs) 2003-12-17
PL336693A1 (en) 2000-07-03
HUP9700885D0 (en) 1997-07-28
ATE212025T1 (de) 2002-02-15
KR100428238B1 (ko) 2004-04-30
PL194859B1 (pl) 2007-07-31
HU222283B1 (hu) 2003-05-28
AU735702B2 (en) 2001-07-12
DE69803176T2 (de) 2002-08-22
BR9809112A (pt) 2000-08-01
HUP9700885A3 (en) 2000-06-28
CA2289623C (en) 2007-01-30
MY121299A (en) 2006-01-28
AU7444898A (en) 1998-12-08
RS49626B (sr) 2007-08-03
ME01636B (me) 2007-08-03
SK283700B6 (sk) 2003-12-02
AR014349A1 (es) 2001-02-28
HRP980240A2 (en) 1999-02-28
RU2172315C1 (ru) 2001-08-20
NO325419B1 (no) 2008-04-21
CZ393999A3 (cs) 2000-04-12
IL132774A0 (en) 2001-03-19
NO995533L (no) 1999-12-13
TR199902783T2 (xx) 2000-04-21
PT981529E (pt) 2002-06-28

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI SYNTHELABO, FR

Owner name: SANOFI-SYNTHELABO, FR

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS, FR

Owner name: SANOFI, 40, FR

ODRP Renewal fee for the maintenance of a patent

Payment date: 20170406

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20180506