HRP980189B1 - Novel 15-membered lactams ketolides - Google Patents
Novel 15-membered lactams ketolidesInfo
- Publication number
- HRP980189B1 HRP980189B1 HR980189A HRP980189A HRP980189B1 HR P980189 B1 HRP980189 B1 HR P980189B1 HR 980189 A HR980189 A HR 980189A HR P980189 A HRP980189 A HR P980189A HR P980189 B1 HRP980189 B1 HR P980189B1
- Authority
- HR
- Croatia
- Prior art keywords
- ketolides
- novel
- membered lactams
- lactams
- membered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR980189A HRP980189B1 (en) | 1998-04-06 | 1998-04-06 | Novel 15-membered lactams ketolides |
US09/127,764 US6110965A (en) | 1998-04-06 | 1998-07-31 | Ketolides from the class of 15-membered lactams |
UA2000106059A UA70941C2 (ru) | 1998-04-06 | 1999-02-04 | Новые кетолиды из класса 15-членных лактамов |
JP2000542337A JP2002510701A (ja) | 1998-04-06 | 1999-04-02 | 15員ラクタム系からの新規なケトライド |
SK1502-2000A SK284169B6 (sk) | 1998-04-06 | 1999-04-02 | 15-členná laktámová ketolidová zlúčenina s antibakteriálnou účinnosťou, spôsob jej prípravy, farmaceutická kompozícia s jej obsahom a jej použitie |
CNB998063568A CN1141312C (zh) | 1998-04-06 | 1999-04-02 | 抗细菌活性的15元内酰胺类酮内酯 |
EP99911955A EP1070077B1 (en) | 1998-04-06 | 1999-04-02 | 15-membered lactams ketolides with antibacterial activity |
DK99911955T DK1070077T3 (da) | 1998-04-06 | 1999-04-02 | 15-Leddede ketolid-lactamer med antibakteriel virkning |
HU0101817A HUP0101817A3 (en) | 1998-04-06 | 1999-04-02 | 15-membered lactams ketolides and pharmaceutical compositions comprising them with antibacterial activity |
AU30464/99A AU3046499A (en) | 1998-04-06 | 1999-04-02 | 15-membered lactams ketolides with antibacterial activity |
PL99343441A PL193742B1 (pl) | 1998-04-06 | 1999-04-02 | Związek z klasy antybiotyków makrolidowych erytromycyty A, sposób jego wytwarzania, kompozycja farmaceutyczna i zastosowanie |
SI9930366T SI1070077T1 (en) | 1998-04-06 | 1999-04-02 | 15-membered lactams ketolides with antibacterial activity |
IL13883799A IL138837A0 (en) | 1998-04-06 | 1999-04-02 | 15-membered lactam ketolides with antibacterial activity |
RU2000128042/04A RU2211222C2 (ru) | 1998-04-06 | 1999-04-02 | Новые кетоазолиды и способ их получения |
AT99911955T ATE241638T1 (de) | 1998-04-06 | 1999-04-02 | 15-gliedrige ketolid-lactame mit antibakterieller wirkung |
EEP200000587A EE04283B1 (et) | 1998-04-06 | 1999-04-02 | 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis |
BR9910115-7A BR9910115A (pt) | 1998-04-06 | 1999-04-02 | Cetolìdeos da classe dos lactamas de 5 elementos |
ES99911955T ES2200512T3 (es) | 1998-04-06 | 1999-04-02 | Cetolidas de lactama con 15 elementos dotados de actividad antimicrobiana. |
PT99911955T PT1070077E (pt) | 1998-04-06 | 1999-04-02 | Cetolidos de lactama com 15 membros que possuem actividade antibacteriana |
CA002327775A CA2327775C (en) | 1998-04-06 | 1999-04-02 | 15-membered lactams ketolides with antibacterial activity |
DE69908338T DE69908338T2 (de) | 1998-04-06 | 1999-04-02 | 15-gliedrige ketolid-lactame mit antibakterieller wirkung |
PCT/HR1999/000004 WO1999051616A1 (en) | 1998-04-06 | 1999-04-02 | 15-membered lactams ketolides with antibacterial activity |
KR1020007011140A KR100600463B1 (ko) | 1998-04-06 | 1999-04-02 | 항균 활성을 갖는 15-원 락탐 케톨라이드 |
ARP990101519A AR019261A1 (es) | 1998-04-06 | 1999-04-05 | Cetoazalido de la clase de lactamas de 15 miembros, su uso, procedimiento para prepararlo , y una composicion farmaceutica util para el tratamiento de infecciones bacterianas en seres humanos y animales |
IL138837A IL138837A (en) | 1998-04-06 | 2000-10-03 | Derivatives of 6-O-methyl-A8-Aza-A8-homo- and 6-O-methyl-A9-aza-A9-homoarthromycin A, their preparation and antibacterial preparations containing them |
NO20005015A NO317982B1 (no) | 1998-04-06 | 2000-10-05 | 15-ring-laktamketolidforbindelse, fremgangsmate for fremstilling derav, samt anvendelse av forbindelsen for fremstilling av en farmasoytisk blanding og farmasoytisk preparat for behandling av bakterielle infeksjoner |
BG104913A BG64600B1 (bg) | 1998-04-06 | 2000-11-06 | Кетолиди от класа на 15-членни лактами с антибактериална активност |
HK01107415A HK1036457A1 (en) | 1998-04-06 | 2001-10-24 | 15-membered lactams ketolides with antibacterial activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR980189A HRP980189B1 (en) | 1998-04-06 | 1998-04-06 | Novel 15-membered lactams ketolides |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP980189A2 HRP980189A2 (en) | 2000-12-31 |
HRP980189B1 true HRP980189B1 (en) | 2004-04-30 |
Family
ID=10946724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR980189A HRP980189B1 (en) | 1998-04-06 | 1998-04-06 | Novel 15-membered lactams ketolides |
Country Status (27)
Country | Link |
---|---|
US (1) | US6110965A (ru) |
EP (1) | EP1070077B1 (ru) |
JP (1) | JP2002510701A (ru) |
KR (1) | KR100600463B1 (ru) |
CN (1) | CN1141312C (ru) |
AR (1) | AR019261A1 (ru) |
AT (1) | ATE241638T1 (ru) |
AU (1) | AU3046499A (ru) |
BG (1) | BG64600B1 (ru) |
BR (1) | BR9910115A (ru) |
CA (1) | CA2327775C (ru) |
DE (1) | DE69908338T2 (ru) |
DK (1) | DK1070077T3 (ru) |
EE (1) | EE04283B1 (ru) |
ES (1) | ES2200512T3 (ru) |
HK (1) | HK1036457A1 (ru) |
HR (1) | HRP980189B1 (ru) |
HU (1) | HUP0101817A3 (ru) |
IL (2) | IL138837A0 (ru) |
NO (1) | NO317982B1 (ru) |
PL (1) | PL193742B1 (ru) |
PT (1) | PT1070077E (ru) |
RU (1) | RU2211222C2 (ru) |
SI (1) | SI1070077T1 (ru) |
SK (1) | SK284169B6 (ru) |
UA (1) | UA70941C2 (ru) |
WO (1) | WO1999051616A1 (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP990116B1 (en) * | 1999-04-20 | 2007-10-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | NOVEL 8a AND 9a- 15-MEMBERED LACTAMES |
KR20030011797A (ko) * | 2000-03-28 | 2003-02-11 | 바이오케미 게젤샤프트 엠베하 | 맛이 차폐된 과립형 입자 |
GB0025688D0 (en) | 2000-10-19 | 2000-12-06 | Glaxo Group Ltd | Macrolides |
YU8804A (sh) * | 2001-08-21 | 2006-08-17 | Pfizer Products Inc. | Jedno-dozni azitromicin |
US20050171342A1 (en) | 2002-02-15 | 2005-08-04 | Michael Burnet | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
WO2003070173A2 (en) | 2002-02-15 | 2003-08-28 | Sympore Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
AU2003211113B2 (en) | 2002-02-15 | 2007-08-09 | Merckle Gmbh | Antibiotic conjugates |
BR0312634A (pt) | 2002-07-08 | 2005-05-10 | Pliva Istrazivacki Inst D O O | Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias |
ES2325495T3 (es) | 2002-07-08 | 2009-09-07 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas. |
HRP20020779A2 (en) | 2002-09-27 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES |
US7435805B2 (en) * | 2003-05-30 | 2008-10-14 | Glaxpsmithkline Istrazivacki | O-alkyl macrolide and azalide derivatives and regioselective process for their preparation |
US7276487B2 (en) * | 2003-09-23 | 2007-10-02 | Enanta Pharmaceuticals, Inc. | 9a, 11-3C-bicyclic 9a-azalide derivatives |
PL1851236T3 (pl) | 2005-01-13 | 2011-05-31 | Glaxo Group Ltd | Makrolidy o aktywności przeciwzapalnej |
EP1879903A1 (en) | 2005-05-10 | 2008-01-23 | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. | Ether linked macrolides useful for the treatment of microbial infections |
RU2455308C2 (ru) * | 2006-05-01 | 2012-07-10 | Тайсо Фармасьютикал Ко., Лтд. | Макролидные производные |
WO2009007988A1 (en) * | 2007-07-11 | 2009-01-15 | Alembic Limited | Process for the preparation of 6-o-methylerythromycin a 9-oxime |
UY32408A (es) | 2009-01-30 | 2010-07-30 | Glaxo Group Ltd | Macrolido anti-inflamatorio |
WO2011131749A1 (en) | 2010-04-23 | 2011-10-27 | Glaxo Group Limited | New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases |
BR112013014392B1 (pt) * | 2010-12-09 | 2021-09-21 | Wockhardt Limited | Compostos cetolídeos, seu uso e processo de preparação, bem como composição farmacêutica compreendendo os mesmos |
CA3120148A1 (en) * | 2018-11-19 | 2020-05-28 | Zikani Therapeutics, Inc. | C10-alkylene substituted 13-membered macrolides and uses thereof |
WO2021084411A1 (en) * | 2019-10-29 | 2021-05-06 | Hikal Limited | Substantially pure clarithromycin 9-oxime and its preparation thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI7910768A8 (en) * | 1979-04-02 | 1996-06-30 | Pliva Pharm & Chem Works | Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives |
US4331803A (en) * | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
JPS61103890A (ja) * | 1984-10-26 | 1986-05-22 | Taisho Pharmaceut Co Ltd | 6−0−メチルエリスロマイシンa誘導体 |
US5302705A (en) * | 1989-10-07 | 1994-04-12 | Taisho Pharmaceutical Co., Ltd. | 6-O-methylerythromycin a oxime derivatives |
IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
CA2064985A1 (en) * | 1991-04-05 | 1992-10-06 | Robert R. Wilkening | 8a-aza-8a-homoertyhromycin cyclic lactams |
US5202434A (en) * | 1991-04-05 | 1993-04-13 | Merck & Co., Inc. | 8a-aza-8a-homoerythromycin lactams |
EP0549040A1 (en) * | 1991-12-20 | 1993-06-30 | Merck & Co. Inc. | Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A |
US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
CA2162401C (en) * | 1993-05-19 | 1998-11-03 | Bingwei V. Yang | Intermediate for azithromycin |
-
1998
- 1998-04-06 HR HR980189A patent/HRP980189B1/xx not_active IP Right Cessation
- 1998-07-31 US US09/127,764 patent/US6110965A/en not_active Expired - Lifetime
-
1999
- 1999-02-04 UA UA2000106059A patent/UA70941C2/ru unknown
- 1999-04-02 DK DK99911955T patent/DK1070077T3/da active
- 1999-04-02 AT AT99911955T patent/ATE241638T1/de not_active IP Right Cessation
- 1999-04-02 EE EEP200000587A patent/EE04283B1/xx not_active IP Right Cessation
- 1999-04-02 KR KR1020007011140A patent/KR100600463B1/ko not_active IP Right Cessation
- 1999-04-02 AU AU30464/99A patent/AU3046499A/en not_active Abandoned
- 1999-04-02 HU HU0101817A patent/HUP0101817A3/hu unknown
- 1999-04-02 DE DE69908338T patent/DE69908338T2/de not_active Expired - Lifetime
- 1999-04-02 EP EP99911955A patent/EP1070077B1/en not_active Expired - Lifetime
- 1999-04-02 PL PL99343441A patent/PL193742B1/pl unknown
- 1999-04-02 BR BR9910115-7A patent/BR9910115A/pt not_active Application Discontinuation
- 1999-04-02 WO PCT/HR1999/000004 patent/WO1999051616A1/en active IP Right Grant
- 1999-04-02 SI SI9930366T patent/SI1070077T1/xx unknown
- 1999-04-02 JP JP2000542337A patent/JP2002510701A/ja active Pending
- 1999-04-02 ES ES99911955T patent/ES2200512T3/es not_active Expired - Lifetime
- 1999-04-02 CN CNB998063568A patent/CN1141312C/zh not_active Expired - Fee Related
- 1999-04-02 IL IL13883799A patent/IL138837A0/xx not_active IP Right Cessation
- 1999-04-02 CA CA002327775A patent/CA2327775C/en not_active Expired - Fee Related
- 1999-04-02 SK SK1502-2000A patent/SK284169B6/sk not_active IP Right Cessation
- 1999-04-02 PT PT99911955T patent/PT1070077E/pt unknown
- 1999-04-02 RU RU2000128042/04A patent/RU2211222C2/ru not_active IP Right Cessation
- 1999-04-05 AR ARP990101519A patent/AR019261A1/es active IP Right Grant
-
2000
- 2000-10-03 IL IL138837A patent/IL138837A/en unknown
- 2000-10-05 NO NO20005015A patent/NO317982B1/no unknown
- 2000-11-06 BG BG104913A patent/BG64600B1/bg unknown
-
2001
- 2001-10-24 HK HK01107415A patent/HK1036457A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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A1OB | Publication of a patent application | ||
AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
B1PR | Patent granted | ||
PNAN | Change of the applicant name, address/residence |
Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O., |
|
PPPP | Transfer of rights |
Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR |
|
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20080331 Year of fee payment: 11 |
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PBON | Lapse due to non-payment of renewal fee |
Effective date: 20090407 |