HRP970424B1 - Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them - Google Patents

Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Info

Publication number
HRP970424B1
HRP970424B1 HR970424A HRP970424A HRP970424B1 HR P970424 B1 HRP970424 B1 HR P970424B1 HR 970424 A HR970424 A HR 970424A HR P970424 A HRP970424 A HR P970424A HR P970424 B1 HRP970424 B1 HR P970424B1
Authority
HR
Croatia
Prior art keywords
medicaments
indanylidineacetylguanidines
substituted
preparation
diagnostic agents
Prior art date
Application number
HR970424A
Other languages
English (en)
Inventor
Nirogi Venkata Sat Ramakrishna
Arun Kumar Jain
Bansi Lal
Rao Venkata Satya Ve Vadlamudi
Anil Vasantrao Ghate
Ravindra Dattatraya Gupte
Andreas Weichert
Jan-Robert Schwark
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HRP970424A2 publication Critical patent/HRP970424A2/hr
Publication of HRP970424B1 publication Critical patent/HRP970424B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C327/54—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HR970424A 1996-07-30 1997-07-29 Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them HRP970424B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96112275A EP0837055A1 (en) 1996-07-30 1996-07-30 Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them

Publications (2)

Publication Number Publication Date
HRP970424A2 HRP970424A2 (en) 1998-06-30
HRP970424B1 true HRP970424B1 (en) 2002-06-30

Family

ID=8223055

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970424A HRP970424B1 (en) 1996-07-30 1997-07-29 Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Country Status (29)

Country Link
US (1) US5900436A (enExample)
EP (2) EP0837055A1 (enExample)
JP (1) JP4039589B2 (enExample)
KR (1) KR980009236A (enExample)
CN (1) CN1064351C (enExample)
AR (1) AR008095A1 (enExample)
AT (1) ATE207888T1 (enExample)
AU (1) AU715187B2 (enExample)
BR (1) BR9704131A (enExample)
CA (1) CA2211982C (enExample)
CZ (1) CZ241197A3 (enExample)
DE (1) DE69707777T2 (enExample)
DK (1) DK0822182T3 (enExample)
ES (1) ES2164283T3 (enExample)
HR (1) HRP970424B1 (enExample)
HU (1) HUP9701316A3 (enExample)
ID (1) ID17565A (enExample)
IL (1) IL121407A0 (enExample)
MX (1) MX9705737A (enExample)
NO (1) NO308213B1 (enExample)
NZ (1) NZ328440A (enExample)
PL (1) PL321392A1 (enExample)
PT (1) PT822182E (enExample)
RU (1) RU2176638C2 (enExample)
SI (1) SI0822182T1 (enExample)
SK (1) SK282128B6 (enExample)
TR (1) TR199700704A2 (enExample)
TW (1) TW445251B (enExample)
ZA (1) ZA976735B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN103819403B (zh) 2008-12-31 2017-01-04 阿德利克斯公司 用于治疗与体液潴留或盐超负荷有关的病症和胃肠道病症的化合物和方法
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine
CN105392483B (zh) 2013-04-12 2019-03-15 阿德利克斯公司 用于抑制磷酸盐转运的nhe3结合化合物和方法
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
KR20240090875A (ko) 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
CN116492469A (zh) * 2023-05-22 2023-07-28 遵义医科大学附属医院 一种通道阻滞剂在制备治疗和/或预防肝纤维疾病药物中的应用
CN119118881B (zh) * 2024-07-25 2026-01-02 中国农业大学 含胍基的5-氯茚满化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2135811T3 (es) * 1995-04-18 1999-11-01 Hoechst Ag Indenoil-guanidinas sustituidas antiarritmicas y cardioprotectoras.

Also Published As

Publication number Publication date
KR980009236A (ko) 1998-04-30
ZA976735B (en) 1998-01-30
TW445251B (en) 2001-07-11
NZ328440A (en) 1997-11-24
JPH1129545A (ja) 1999-02-02
EP0822182B1 (en) 2001-10-31
NO973486D0 (no) 1997-07-29
BR9704131A (pt) 1998-12-29
NO308213B1 (no) 2000-08-14
JP4039589B2 (ja) 2008-01-30
CA2211982C (en) 2007-09-18
ES2164283T3 (es) 2002-02-16
PL321392A1 (en) 1998-02-02
HUP9701316A3 (en) 1998-07-28
PT822182E (pt) 2002-03-28
CN1064351C (zh) 2001-04-11
SK282128B6 (sk) 2001-11-06
AR008095A1 (es) 1999-12-09
ID17565A (id) 1998-01-08
SK103497A3 (en) 1998-02-04
EP0837055A1 (en) 1998-04-22
AU3155497A (en) 1998-02-05
HRP970424A2 (en) 1998-06-30
HUP9701316A2 (hu) 1998-03-02
RU2176638C2 (ru) 2001-12-10
EP0822182A1 (en) 1998-02-04
DE69707777T2 (de) 2003-01-16
HU9701316D0 (en) 1997-09-29
CN1172104A (zh) 1998-02-04
AU715187B2 (en) 2000-01-20
CZ241197A3 (cs) 1998-02-18
IL121407A0 (en) 1998-01-04
ATE207888T1 (de) 2001-11-15
TR199700704A2 (xx) 1998-02-21
NO973486L (no) 1998-02-02
US5900436A (en) 1999-05-04
MX9705737A (es) 1998-02-28
CA2211982A1 (en) 1998-01-30
DK0822182T3 (da) 2002-02-25
DE69707777D1 (de) 2001-12-06
SI0822182T1 (en) 2002-04-30

Similar Documents

Publication Publication Date Title
HRP970450B1 (en) Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or diagnostic agents and drugs containing them
SI0771788T1 (en) Substituted sulphonimidamides, method for their preparation, their use as medicament or diagnostic and medicament containing them
HUP9900974A3 (en) Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP9700328A3 (en) Heteroaryl-oxazolidinones, process for their preparation, pharmaceutical compositions containing the same, their use and intermediates
GR3035126T3 (en) Substituted 2-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
AU3892593A (en) Composition for therapeutic or diagnostic use, process for its preparation and its use
HRP980502B1 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments
AU2330095A (en) Ortho-amino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
CY2220B1 (en) Substituted benzenesulfonylureas and -thioureas process for their preparation their use as medicament or diagnostic agent as well as medicaments containing them
ZA968091B (en) Substituted benzolyguanidines a process for their preparation their use as a medicament or diagnostic agent and medicament comprising them
HUP9600665A3 (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
HU9701316D0 (en) Substituted indanylideneacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them
HU9601976D0 (en) 4-fluoralkyl benzoylguanidines, process for producing them, their use for producing pharmaceutical or diagnostic compositions, and pharmaceutical compositions containing these compounds
HRP970304A2 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
HRP970294A2 (en) Substituted 1-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
GR3036122T3 (en) Substituted Thiophenylalkenylcarbonylguanidide, method for their preparation, their use as medicinal or diagnostic agent as well as medicament containing them
HU9501546D0 (en) Sulphamide-derivatives, process for their preparation and their use as insecticides
GR3032293T3 (en) Ortho-substituted benzylguanidines, process for their preparation and their use as medicament or diagnostic agent as well as medicament containing them
HRP970293A2 (en) Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
IL120093A0 (en) Substituted diaryldicarboxylic acid diguanidides processes for their preparation their use as a medicament or diagnostic and medicament containing them
FI960430L (fi) Substituoituja tiofeenisulfonyyliureoita ja tioureotit, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20030613

Year of fee payment: 7

PBON Lapse due to non-payment of renewal fee

Effective date: 20040730