AU715187B2 - Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them - Google Patents

Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them Download PDF

Info

Publication number
AU715187B2
AU715187B2 AU31554/97A AU3155497A AU715187B2 AU 715187 B2 AU715187 B2 AU 715187B2 AU 31554/97 A AU31554/97 A AU 31554/97A AU 3155497 A AU3155497 A AU 3155497A AU 715187 B2 AU715187 B2 AU 715187B2
Authority
AU
Australia
Prior art keywords
alkyl
formula
compound
treatment
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU31554/97A
Other languages
English (en)
Other versions
AU3155497A (en
Inventor
Anil Vasantrao Ghate
Arun Kumar Jain
Bansi Lal
Nirogi Venkata Satya Ramakrishna
Jan-Robert Schwark
Rao Venkata Satya Veerabhadra Vadlamudi
Ravindra Dattatraya Gupte Andreas Weichert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU3155497A publication Critical patent/AU3155497A/en
Application granted granted Critical
Publication of AU715187B2 publication Critical patent/AU715187B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C327/54—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU31554/97A 1996-07-30 1997-07-28 Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them Ceased AU715187B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96112275A EP0837055A1 (en) 1996-07-30 1996-07-30 Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them
EP96112275 1996-07-30

Publications (2)

Publication Number Publication Date
AU3155497A AU3155497A (en) 1998-02-05
AU715187B2 true AU715187B2 (en) 2000-01-20

Family

ID=8223055

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31554/97A Ceased AU715187B2 (en) 1996-07-30 1997-07-28 Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them

Country Status (29)

Country Link
US (1) US5900436A (enExample)
EP (2) EP0837055A1 (enExample)
JP (1) JP4039589B2 (enExample)
KR (1) KR980009236A (enExample)
CN (1) CN1064351C (enExample)
AR (1) AR008095A1 (enExample)
AT (1) ATE207888T1 (enExample)
AU (1) AU715187B2 (enExample)
BR (1) BR9704131A (enExample)
CA (1) CA2211982C (enExample)
CZ (1) CZ241197A3 (enExample)
DE (1) DE69707777T2 (enExample)
DK (1) DK0822182T3 (enExample)
ES (1) ES2164283T3 (enExample)
HR (1) HRP970424B1 (enExample)
HU (1) HUP9701316A3 (enExample)
ID (1) ID17565A (enExample)
IL (1) IL121407A0 (enExample)
MX (1) MX9705737A (enExample)
NO (1) NO308213B1 (enExample)
NZ (1) NZ328440A (enExample)
PL (1) PL321392A1 (enExample)
PT (1) PT822182E (enExample)
RU (1) RU2176638C2 (enExample)
SI (1) SI0822182T1 (enExample)
SK (1) SK282128B6 (enExample)
TR (1) TR199700704A2 (enExample)
TW (1) TW445251B (enExample)
ZA (1) ZA976735B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN103819403B (zh) 2008-12-31 2017-01-04 阿德利克斯公司 用于治疗与体液潴留或盐超负荷有关的病症和胃肠道病症的化合物和方法
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine
CN105392483B (zh) 2013-04-12 2019-03-15 阿德利克斯公司 用于抑制磷酸盐转运的nhe3结合化合物和方法
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
KR20240090875A (ko) 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
CN116492469A (zh) * 2023-05-22 2023-07-28 遵义医科大学附属医院 一种通道阻滞剂在制备治疗和/或预防肝纤维疾病药物中的应用
CN119118881B (zh) * 2024-07-25 2026-01-02 中国农业大学 含胍基的5-氯茚满化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2135811T3 (es) * 1995-04-18 1999-11-01 Hoechst Ag Indenoil-guanidinas sustituidas antiarritmicas y cardioprotectoras.

Also Published As

Publication number Publication date
KR980009236A (ko) 1998-04-30
ZA976735B (en) 1998-01-30
TW445251B (en) 2001-07-11
NZ328440A (en) 1997-11-24
JPH1129545A (ja) 1999-02-02
EP0822182B1 (en) 2001-10-31
NO973486D0 (no) 1997-07-29
BR9704131A (pt) 1998-12-29
NO308213B1 (no) 2000-08-14
JP4039589B2 (ja) 2008-01-30
CA2211982C (en) 2007-09-18
ES2164283T3 (es) 2002-02-16
PL321392A1 (en) 1998-02-02
HUP9701316A3 (en) 1998-07-28
PT822182E (pt) 2002-03-28
CN1064351C (zh) 2001-04-11
SK282128B6 (sk) 2001-11-06
AR008095A1 (es) 1999-12-09
ID17565A (id) 1998-01-08
SK103497A3 (en) 1998-02-04
HRP970424B1 (en) 2002-06-30
EP0837055A1 (en) 1998-04-22
AU3155497A (en) 1998-02-05
HRP970424A2 (en) 1998-06-30
HUP9701316A2 (hu) 1998-03-02
RU2176638C2 (ru) 2001-12-10
EP0822182A1 (en) 1998-02-04
DE69707777T2 (de) 2003-01-16
HU9701316D0 (en) 1997-09-29
CN1172104A (zh) 1998-02-04
CZ241197A3 (cs) 1998-02-18
IL121407A0 (en) 1998-01-04
ATE207888T1 (de) 2001-11-15
TR199700704A2 (xx) 1998-02-21
NO973486L (no) 1998-02-02
US5900436A (en) 1999-05-04
MX9705737A (es) 1998-02-28
CA2211982A1 (en) 1998-01-30
DK0822182T3 (da) 2002-02-25
DE69707777D1 (de) 2001-12-06
SI0822182T1 (en) 2002-04-30

Similar Documents

Publication Publication Date Title
US5693672A (en) 3,4,5-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them
US5965744A (en) Ortho-substituted benzoylguanidines, including composition and methods of using them
AU713664B2 (en) Phenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
AU674744B2 (en) Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them
AU683320B2 (en) Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-dioxo-2H-1,2-benzothiazinoylguanidines, a process for their preparation, their use as medicament or diagnostic agent, and also a medicament containing them
US5516805A (en) 3,5-substituted aminobenzoylguanidines, their use as a medicament or diagnostic and medicament containing them
AU683273B2 (en) Urea and thiourea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
EP0822182B1 (en) Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
AU706055B2 (en) Antiarrhythmic and cardioprotective substituted indenoylguanidines
AU704649B2 (en) 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
MXPA97005737A (en) Substitute indianilidinacylukinides, procedure for its preparation, its use as medicines or diagnostic agents and medicines containing them
AU723665B2 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
CA2197628C (en) Substituted thiophenylalkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
AU723096B2 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
MXPA96001424A (en) Indenoilguanidines replaced antiarrhythmic and cardioprotect

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)