SI0822182T1 - Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them - Google Patents

Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Info

Publication number
SI0822182T1
SI0822182T1 SI9730260T SI9730260T SI0822182T1 SI 0822182 T1 SI0822182 T1 SI 0822182T1 SI 9730260 T SI9730260 T SI 9730260T SI 9730260 T SI9730260 T SI 9730260T SI 0822182 T1 SI0822182 T1 SI 0822182T1
Authority
SI
Slovenia
Prior art keywords
medicaments
indanylidineacetylguanidines
substituted
preparation
diagnostic agents
Prior art date
Application number
SI9730260T
Other languages
English (en)
Slovenian (sl)
Inventor
Nirogi Venkata Satya Dr. Ramakrishna
Arun Kumar Jain
Bansi Dr. Lal
Rao Venkata Satya Veerabhadra Dr. Vadlamudi
Anil Vasantrao Ghate
Ravindra Dattatraya Gupte
Andreas Dr. Weichert
Jan-Robert Dr. Schwark
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of SI0822182T1 publication Critical patent/SI0822182T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C327/54—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SI9730260T 1996-07-30 1997-07-24 Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them SI0822182T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96112275A EP0837055A1 (en) 1996-07-30 1996-07-30 Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them
EP97112674A EP0822182B1 (en) 1996-07-30 1997-07-24 Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Publications (1)

Publication Number Publication Date
SI0822182T1 true SI0822182T1 (en) 2002-04-30

Family

ID=8223055

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730260T SI0822182T1 (en) 1996-07-30 1997-07-24 Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Country Status (29)

Country Link
US (1) US5900436A (enExample)
EP (2) EP0837055A1 (enExample)
JP (1) JP4039589B2 (enExample)
KR (1) KR980009236A (enExample)
CN (1) CN1064351C (enExample)
AR (1) AR008095A1 (enExample)
AT (1) ATE207888T1 (enExample)
AU (1) AU715187B2 (enExample)
BR (1) BR9704131A (enExample)
CA (1) CA2211982C (enExample)
CZ (1) CZ241197A3 (enExample)
DE (1) DE69707777T2 (enExample)
DK (1) DK0822182T3 (enExample)
ES (1) ES2164283T3 (enExample)
HR (1) HRP970424B1 (enExample)
HU (1) HUP9701316A3 (enExample)
ID (1) ID17565A (enExample)
IL (1) IL121407A0 (enExample)
MX (1) MX9705737A (enExample)
NO (1) NO308213B1 (enExample)
NZ (1) NZ328440A (enExample)
PL (1) PL321392A1 (enExample)
PT (1) PT822182E (enExample)
RU (1) RU2176638C2 (enExample)
SI (1) SI0822182T1 (enExample)
SK (1) SK282128B6 (enExample)
TR (1) TR199700704A2 (enExample)
TW (1) TW445251B (enExample)
ZA (1) ZA976735B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN103819403B (zh) 2008-12-31 2017-01-04 阿德利克斯公司 用于治疗与体液潴留或盐超负荷有关的病症和胃肠道病症的化合物和方法
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine
CN105392483B (zh) 2013-04-12 2019-03-15 阿德利克斯公司 用于抑制磷酸盐转运的nhe3结合化合物和方法
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
KR20240090875A (ko) 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
CN116492469A (zh) * 2023-05-22 2023-07-28 遵义医科大学附属医院 一种通道阻滞剂在制备治疗和/或预防肝纤维疾病药物中的应用
CN119118881B (zh) * 2024-07-25 2026-01-02 中国农业大学 含胍基的5-氯茚满化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2135811T3 (es) * 1995-04-18 1999-11-01 Hoechst Ag Indenoil-guanidinas sustituidas antiarritmicas y cardioprotectoras.

Also Published As

Publication number Publication date
KR980009236A (ko) 1998-04-30
ZA976735B (en) 1998-01-30
TW445251B (en) 2001-07-11
NZ328440A (en) 1997-11-24
JPH1129545A (ja) 1999-02-02
EP0822182B1 (en) 2001-10-31
NO973486D0 (no) 1997-07-29
BR9704131A (pt) 1998-12-29
NO308213B1 (no) 2000-08-14
JP4039589B2 (ja) 2008-01-30
CA2211982C (en) 2007-09-18
ES2164283T3 (es) 2002-02-16
PL321392A1 (en) 1998-02-02
HUP9701316A3 (en) 1998-07-28
PT822182E (pt) 2002-03-28
CN1064351C (zh) 2001-04-11
SK282128B6 (sk) 2001-11-06
AR008095A1 (es) 1999-12-09
ID17565A (id) 1998-01-08
SK103497A3 (en) 1998-02-04
HRP970424B1 (en) 2002-06-30
EP0837055A1 (en) 1998-04-22
AU3155497A (en) 1998-02-05
HRP970424A2 (en) 1998-06-30
HUP9701316A2 (hu) 1998-03-02
RU2176638C2 (ru) 2001-12-10
EP0822182A1 (en) 1998-02-04
DE69707777T2 (de) 2003-01-16
HU9701316D0 (en) 1997-09-29
CN1172104A (zh) 1998-02-04
AU715187B2 (en) 2000-01-20
CZ241197A3 (cs) 1998-02-18
IL121407A0 (en) 1998-01-04
ATE207888T1 (de) 2001-11-15
TR199700704A2 (xx) 1998-02-21
NO973486L (no) 1998-02-02
US5900436A (en) 1999-05-04
MX9705737A (es) 1998-02-28
CA2211982A1 (en) 1998-01-30
DK0822182T3 (da) 2002-02-25
DE69707777D1 (de) 2001-12-06

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