HRP950525A2 - USE OF vWF CONTAINING CONCENTRATE AS COMBINATION THERAPY WIHT ANTITHROMBOTIC AND FIBRINOLYTICS - Google Patents
USE OF vWF CONTAINING CONCENTRATE AS COMBINATION THERAPY WIHT ANTITHROMBOTIC AND FIBRINOLYTICS Download PDFInfo
- Publication number
- HRP950525A2 HRP950525A2 HRP4437544.1A HRP950525A HRP950525A2 HR P950525 A2 HRP950525 A2 HR P950525A2 HR P950525 A HRP950525 A HR P950525A HR P950525 A2 HRP950525 A2 HR P950525A2
- Authority
- HR
- Croatia
- Prior art keywords
- vwf
- bleeding
- hirudin
- fibrinolytics
- wiht
- Prior art date
Links
- 239000012141 concentrate Substances 0.000 title description 7
- 239000003146 anticoagulant agent Substances 0.000 title description 6
- 230000002785 anti-thrombosis Effects 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 108010047303 von Willebrand Factor Proteins 0.000 claims description 33
- 102100036537 von Willebrand factor Human genes 0.000 claims description 33
- 230000000740 bleeding effect Effects 0.000 claims description 26
- 230000000694 effects Effects 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000003527 fibrinolytic agent Substances 0.000 claims description 6
- 239000000729 antidote Substances 0.000 claims description 5
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 230000000702 anti-platelet effect Effects 0.000 claims description 2
- 229940127218 antiplatelet drug Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960001134 von willebrand factor Drugs 0.000 description 30
- 208000032843 Hemorrhage Diseases 0.000 description 25
- 208000034158 bleeding Diseases 0.000 description 25
- 229940006607 hirudin Drugs 0.000 description 13
- 208000007536 Thrombosis Diseases 0.000 description 10
- 238000001802 infusion Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 108010054218 Factor VIII Proteins 0.000 description 6
- 102000001690 Factor VIII Human genes 0.000 description 6
- 241000282887 Suidae Species 0.000 description 6
- 230000010100 anticoagulation Effects 0.000 description 6
- 229960000301 factor viii Drugs 0.000 description 6
- 230000003480 fibrinolytic effect Effects 0.000 description 6
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 6
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 229940122388 Thrombin inhibitor Drugs 0.000 description 5
- 229960001138 acetylsalicylic acid Drugs 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 5
- 230000015271 coagulation Effects 0.000 description 5
- 238000005345 coagulation Methods 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 239000003868 thrombin inhibitor Substances 0.000 description 5
- 108010007267 Hirudins Proteins 0.000 description 4
- 102000007625 Hirudins Human genes 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 239000013065 commercial product Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 235000002639 sodium chloride Nutrition 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 description 3
- 206010040860 Skin haemorrhages Diseases 0.000 description 3
- 108010023197 Streptokinase Proteins 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 229940075522 antidotes Drugs 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 229960004281 desmopressin Drugs 0.000 description 3
- NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 229960002897 heparin Drugs 0.000 description 3
- 229920000669 heparin Polymers 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 229960005202 streptokinase Drugs 0.000 description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 206010062713 Haemorrhagic diathesis Diseases 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 108010001014 Plasminogen Activators Proteins 0.000 description 2
- 102000001938 Plasminogen Activators Human genes 0.000 description 2
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 description 2
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 230000020764 fibrinolysis Effects 0.000 description 2
- 208000031169 hemorrhagic disease Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 description 2
- 239000003055 low molecular weight heparin Substances 0.000 description 2
- 229940127215 low-molecular weight heparin Drugs 0.000 description 2
- 229940127126 plasminogen activator Drugs 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KXNPVXPOPUZYGB-IOVMHBDKSA-N (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NCC(C)C2 KXNPVXPOPUZYGB-IOVMHBDKSA-N 0.000 description 1
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- 108010039627 Aprotinin Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 229940123583 Factor Xa inhibitor Drugs 0.000 description 1
- -1 Fenprokoumon Chemical compound 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 108010022425 Platelet Glycoprotein GPIIb-IIIa Complex Proteins 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- 229960002054 acenocoumarol Drugs 0.000 description 1
- VABCILAOYCMVPS-UHFFFAOYSA-N acenocoumarol Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=C([N+]([O-])=O)C=C1 VABCILAOYCMVPS-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- QCTBMLYLENLHLA-UHFFFAOYSA-N aminomethylbenzoic acid Chemical compound NCC1=CC=C(C(O)=O)C=C1 QCTBMLYLENLHLA-UHFFFAOYSA-N 0.000 description 1
- 229960003375 aminomethylbenzoic acid Drugs 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 230000001567 anti-fibrinolytic effect Effects 0.000 description 1
- 108010018823 anti-inhibitor coagulant complex Proteins 0.000 description 1
- 239000002506 anticoagulant protein Substances 0.000 description 1
- 229960004405 aprotinin Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 108010055460 bivalirudin Proteins 0.000 description 1
- 229960001500 bivalirudin Drugs 0.000 description 1
- OIRCOABEOLEUMC-GEJPAHFPSA-N bivalirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 OIRCOABEOLEUMC-GEJPAHFPSA-N 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 229940105778 coagulation factor viii Drugs 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940105776 factor viii inhibitor bypassing activity Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000014508 negative regulation of coagulation Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 108010039231 polyethyleneglycol-hirudin Proteins 0.000 description 1
- 239000003805 procoagulant Substances 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 108091006082 receptor inhibitors Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000012622 synthetic inhibitor Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 229940019333 vitamin k antagonists Drugs 0.000 description 1
- 108010033683 von Willebrand factor drug combination factor VIII Proteins 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4437544A DE4437544A1 (de) | 1994-10-20 | 1994-10-20 | Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP950525A2 true HRP950525A2 (en) | 1997-04-30 |
Family
ID=6531287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP4437544.1A HRP950525A2 (en) | 1994-10-20 | 1995-10-18 | USE OF vWF CONTAINING CONCENTRATE AS COMBINATION THERAPY WIHT ANTITHROMBOTIC AND FIBRINOLYTICS |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5571784A (hu) |
| EP (1) | EP0713881A3 (hu) |
| JP (1) | JPH08208504A (hu) |
| KR (1) | KR960013383A (hu) |
| CN (1) | CN1128168A (hu) |
| AU (1) | AU708670B2 (hu) |
| CA (1) | CA2160975A1 (hu) |
| CZ (1) | CZ287878B6 (hu) |
| DE (1) | DE4437544A1 (hu) |
| FI (1) | FI954964A (hu) |
| HR (1) | HRP950525A2 (hu) |
| HU (1) | HU219595B (hu) |
| IL (1) | IL115652A (hu) |
| NO (1) | NO954175L (hu) |
| NZ (1) | NZ280274A (hu) |
| PL (1) | PL183182B1 (hu) |
| SK (1) | SK129695A3 (hu) |
| TW (1) | TW398977B (hu) |
| UY (1) | UY24063A1 (hu) |
| ZA (1) | ZA958838B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5772629A (en) * | 1995-10-23 | 1998-06-30 | Localmed, Inc. | Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels |
| AT405485B (de) | 1997-05-28 | 1999-08-25 | Immuno Ag | Eine das vwf-propeptid enthaltende pharmazeutische präparation |
| AT409335B (de) * | 1998-11-10 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend einen rezeptor-antagonisten zur behandlung von blutgerinnungsstörungen |
| US6794412B1 (en) * | 1999-03-11 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin |
| EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
| JP2003284570A (ja) | 2001-04-25 | 2003-10-07 | Chemo Sero Therapeut Res Inst | フォンビルブラント因子（ｖＷＦ）切断酵素 |
| DE102008032361A1 (de) * | 2008-07-10 | 2010-01-21 | Csl Behring Gmbh | Der Einsatz von Faktor VIII und vWF bzw. vWF-enthaltenden Konzentraten zur Therapie der durch Thrombocyten-Inhibitoren induzierte Koagulopathie |
| WO2011101242A1 (en) * | 2010-02-16 | 2011-08-25 | Novo Nordisk A/S | Factor viii molecules with reduced vwf binding |
| ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
| TWI580423B (zh) * | 2013-12-24 | 2017-05-01 | 財團法人工業技術研究院 | 緩解或治療痛風之醫藥組合物及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198349A (en) * | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
| US5200510A (en) * | 1987-06-16 | 1993-04-06 | Zymogenetics, Inc. | Method for purifying factor viii:c, von willebrand factor and complexes thereof |
| US4774323A (en) * | 1987-06-29 | 1988-09-27 | Rorer Pharmaceutical Corporation | Purification of von Willebrand Factor solutions using gel permeation chromatography |
| FR2619314B1 (fr) * | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
| US5204323B1 (en) | 1988-10-06 | 1995-07-18 | Ciba Geigy Corp | Hirudin antidotal compositions and methods |
| GB8823480D0 (en) * | 1988-10-06 | 1988-11-16 | Ciba Geigy Ag | Antidote |
| FR2673632A1 (fr) * | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
| DE4115453A1 (de) * | 1991-05-11 | 1992-11-12 | Knoll Ag | Neue wirkstoffkombination |
| US5366869A (en) * | 1991-11-08 | 1994-11-22 | Sheldon Goldstein | Multiple coagulation test device and method |
| DE4203965A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Antidot fuer hirudin und synthetische thrombininhibitoren |
| CA2159508A1 (en) * | 1993-04-23 | 1994-11-10 | Leonard Garfinkel | Method of enhancing thrombolysis |
-
1994
- 1994-10-20 DE DE4437544A patent/DE4437544A1/de not_active Withdrawn
-
1995
- 1995-09-21 EP EP95114846A patent/EP0713881A3/de not_active Withdrawn
- 1995-09-29 TW TW084110150A patent/TW398977B/zh not_active IP Right Cessation
- 1995-10-16 UY UY24063A patent/UY24063A1/es unknown
- 1995-10-18 SK SK1296-95A patent/SK129695A3/sk unknown
- 1995-10-18 HR HRP4437544.1A patent/HRP950525A2/hr not_active Application Discontinuation
- 1995-10-18 NZ NZ280274A patent/NZ280274A/en unknown
- 1995-10-18 CN CN95118715A patent/CN1128168A/zh active Pending
- 1995-10-18 KR KR1019950035874A patent/KR960013383A/ko not_active Application Discontinuation
- 1995-10-18 FI FI954964A patent/FI954964A/fi unknown
- 1995-10-18 IL IL11565295A patent/IL115652A/xx not_active IP Right Cessation
- 1995-10-18 AU AU34304/95A patent/AU708670B2/en not_active Ceased
- 1995-10-18 CZ CZ19952719A patent/CZ287878B6/cs not_active IP Right Cessation
- 1995-10-18 US US08/544,867 patent/US5571784A/en not_active Expired - Fee Related
- 1995-10-19 ZA ZA958838A patent/ZA958838B/xx unknown
- 1995-10-19 NO NO954175A patent/NO954175L/no not_active Application Discontinuation
- 1995-10-19 JP JP7270785A patent/JPH08208504A/ja active Pending
- 1995-10-19 PL PL95311031A patent/PL183182B1/pl unknown
- 1995-10-19 CA CA002160975A patent/CA2160975A1/en not_active Abandoned
- 1995-10-20 HU HU9503031A patent/HU219595B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO954175L (no) | 1996-04-22 |
| SK129695A3 (en) | 1996-10-02 |
| CZ271995A3 (en) | 1996-05-15 |
| CZ287878B6 (cs) | 2001-03-14 |
| IL115652A0 (en) | 1996-01-19 |
| TW398977B (en) | 2000-07-21 |
| AU708670B2 (en) | 1999-08-12 |
| FI954964A0 (fi) | 1995-10-18 |
| IL115652A (en) | 2000-08-31 |
| AU3430495A (en) | 1996-05-02 |
| JPH08208504A (ja) | 1996-08-13 |
| EP0713881A2 (de) | 1996-05-29 |
| FI954964A (fi) | 1996-04-21 |
| HUT73762A (en) | 1996-09-30 |
| NO954175D0 (no) | 1995-10-19 |
| HU219595B (hu) | 2001-05-28 |
| PL183182B1 (pl) | 2002-06-28 |
| UY24063A1 (es) | 1995-10-24 |
| HU9503031D0 (en) | 1995-12-28 |
| EP0713881A3 (de) | 1996-08-21 |
| CA2160975A1 (en) | 1996-04-21 |
| DE4437544A1 (de) | 1996-04-25 |
| KR960013383A (ko) | 1996-05-22 |
| CN1128168A (zh) | 1996-08-07 |
| US5571784A (en) | 1996-11-05 |
| NZ280274A (en) | 1997-01-29 |
| ZA958838B (en) | 1996-05-13 |
| PL311031A1 (en) | 1996-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Horrow et al. | Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery. | |
| Woodman et al. | Bleeding complications associated with cardiopulmonary bypass | |
| Franchini | The use of desmopressin as a hemostatic agent: a concise review | |
| Horrow et al. | Prophylactic tranexamic acid decreases bleeding after cardiac operations | |
| Johnson et al. | Management of dental patients with bleeding disorders: review and update | |
| CA2730290C (en) | Von willebrand factor or factor viii and von willebrand factor for the treatment of coagulopathy induced by inhibitors of thrombocytes | |
| US20080254147A1 (en) | Method of providing hemostasis in anti-coagulated blood | |
| CA2684075A1 (en) | Providing hemostasis in anticoagulated blood by using zeolites | |
| Macik et al. | Safety and initial clinical efficacy of three dose levels of recombinant activated factor VII (rFVIIa): results of a phase I study | |
| JP3859176B2 (ja) | 抗凝血物質に対する解毒剤として用いるのに適した組成物およびそれらの使用 | |
| HRP950525A2 (en) | USE OF vWF CONTAINING CONCENTRATE AS COMBINATION THERAPY WIHT ANTITHROMBOTIC AND FIBRINOLYTICS | |
| JP2011173923A (ja) | 高分子量多量体の割合が高いｖｗｆを含有する血漿タンパク質濃縮物の使用 | |
| TWI441645B (zh) | 作為新穎之局部用止血劑的活化型因子Ｘ（ＦＸａ）刺激劑 | |
| Chen et al. | Heparin and low molecular weight heparin but not hirudin stimulate platelet aggregation in whole blood from acetylsalicylic acid treated healthy volunteers | |
| JP3838680B2 (ja) | 抗凝血物質に対する解毒剤として用いるのに適した医薬およびその使用 | |
| JP2001181204A (ja) | 血液凝固異常に基づく疾患の治療・予防用医薬組成物 | |
| Hannanb et al. | Concomitant T reatment with Factor IX Concentrates and Antifibrinolytics in Hemophilia B | |
| Moffett et al. | Hemostatic Agents and Blood Components Used to Stop Bleeding | |
| Shanthi | CLOTTING FACTOR REPLACEMENT THERAPY | |
| Gilmore et al. | and Kenneth E. Lupi Jr. | |
| Gawaz et al. | Impaired Function of Platelet Membrane Glycoprotein lIb-Illa in End-Stage Renal Disease1’2 | |
| Boccardo et al. | Coagulation problems in dialysis patients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| ODBI | Application refused |