HRP930134A2 - Novel fungal strains and the use thereof in the antibiotic production - Google Patents
Novel fungal strains and the use thereof in the antibiotic production Download PDFInfo
- Publication number
- HRP930134A2 HRP930134A2 HR930134A HRP930134A HRP930134A2 HR P930134 A2 HRP930134 A2 HR P930134A2 HR 930134 A HR930134 A HR 930134A HR P930134 A HRP930134 A HR P930134A HR P930134 A2 HRP930134 A2 HR P930134A2
- Authority
- HR
- Croatia
- Prior art keywords
- lovastatin
- aspergillus
- oryzae
- fungal
- strain
- Prior art date
Links
- 230000002538 fungal effect Effects 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title description 18
- 230000003115 biocidal effect Effects 0.000 title description 5
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims description 66
- 229960004844 lovastatin Drugs 0.000 claims description 66
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 66
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims description 64
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- ZDFOBOYQVYMVCW-IRUSZSJRSA-N monacolin J Chemical compound C([C@@H]1[C@H]2[C@@H](O)C[C@H](C=C2C=C[C@@H]1C)C)C[C@@H]1C[C@@H](O)CC(=O)O1 ZDFOBOYQVYMVCW-IRUSZSJRSA-N 0.000 description 1
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
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- 235000009566 rice Nutrition 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
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- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- VABRZWDEEDQLRD-UHFFFAOYSA-N streptomyces antibiotic uk-63052 Chemical compound CN1C(=O)C(N(C)C(=O)C(C)NC(=O)C(COC(=O)C2(C(C2)C)N(C)C2=O)NC(=O)C=3C(=CC4=CC=CC=C4N=3)O)C(SC(C)CC)SCC2N(C)C(=O)C(C)NC(=O)C(NC(=O)C=2C(=CC3=CC=CC=C3N=2)O)COC(=O)C21CC2C VABRZWDEEDQLRD-UHFFFAOYSA-N 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A20/00—Water conservation; Efficient water supply; Efficient water use
- Y02A20/40—Protecting water resources
- Y02A20/402—River restoration
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83349692A | 1992-02-10 | 1992-02-10 | |
| CA002062023A CA2062023A1 (en) | 1992-02-10 | 1992-02-27 | Novel fungal strains and use thereof in antibiotic production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP930134A2 true HRP930134A2 (en) | 1995-10-31 |
Family
ID=25674996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR930134A HRP930134A2 (en) | 1992-02-10 | 1993-02-08 | Novel fungal strains and the use thereof in the antibiotic production |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0556699A1 (cs) |
| JP (1) | JPH0622780A (cs) |
| CN (1) | CN1076965A (cs) |
| AU (1) | AU667498B2 (cs) |
| BG (1) | BG61180B1 (cs) |
| BR (1) | BR9300467A (cs) |
| CZ (1) | CZ17293A3 (cs) |
| EE (1) | EE03048B1 (cs) |
| FI (1) | FI930561A (cs) |
| HR (1) | HRP930134A2 (cs) |
| HU (1) | HUT67061A (cs) |
| IL (1) | IL104481A0 (cs) |
| LV (1) | LV10502B (cs) |
| NO (1) | NO930446L (cs) |
| NZ (1) | NZ245713A (cs) |
| PL (1) | PL297691A1 (cs) |
| SI (1) | SI9300068A (cs) |
| SK (1) | SK5593A3 (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94183A (en) | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
| US5766939A (en) * | 1989-05-05 | 1998-06-16 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| US5849881A (en) * | 1989-05-05 | 1998-12-15 | Baylor College Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms |
| US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| US6100054A (en) * | 1989-05-05 | 2000-08-08 | Baylor College Of Medicine | Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| WO1995012661A1 (en) * | 1993-11-02 | 1995-05-11 | Merck & Co., Inc. | Dna encoding triol polyketide synthase |
| CN1171400A (zh) * | 1996-03-05 | 1998-01-28 | 武田药品工业株式会社 | 呫吨衍生物,其制备和用途 |
| US6111081A (en) * | 1996-05-31 | 2000-08-29 | Baylor College Of Medicine | Lactoferrin variants and uses thereof |
| EP0970236B1 (en) * | 1997-02-20 | 2006-05-24 | DSM IP Assets B.V. | Fermentative production of valuable compounds on an industrial scale using chemically defined media |
| CA2289553C (en) * | 1998-03-20 | 2004-05-18 | Biogal Gyogyszergyar Rt. | Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid |
| US6391583B1 (en) | 1998-12-18 | 2002-05-21 | Wisconsin Alumni Research Foundation | Method of producing antihypercholesterolemic agents |
| EP1176208A1 (en) * | 2000-07-28 | 2002-01-30 | Société des Produits Nestlé S.A. | Koji molds and use thereof for preparing cholesterol-lowering products |
| CN1273608C (zh) | 2001-02-09 | 2006-09-06 | 荷兰联合利华有限公司 | 通过发酵制备一种或多种抑制素的方法 |
| KR100423892B1 (ko) * | 2001-12-03 | 2004-03-22 | 씨제이 주식회사 | 스타틴의 제조에 있어서 새로운 락톤화 방법 |
| WO2006035295A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Process for the purification of lovastatin |
| CN102533893A (zh) * | 2010-12-09 | 2012-07-04 | 浙江海正药业股份有限公司 | 一种制备莫那可林j的方法 |
| CN104277980B (zh) * | 2013-07-09 | 2020-04-21 | 丰益(上海)生物技术研发中心有限公司 | 分离纯化米曲霉转化子的方法 |
| CN105602856B (zh) * | 2015-12-16 | 2019-04-16 | 浙江师范大学 | 黑曲霉（Aspergillus niger）An-19菌株及其用于洛伐他汀的生产的用途和发酵方法 |
| CN108118042B (zh) * | 2016-11-30 | 2021-01-15 | 中国科学院青岛生物能源与过程研究所 | 2-甲基丁酸侧链水解酶和产莫纳可林j的曲霉菌株及其构建方法与应用 |
| CN111117894B (zh) * | 2019-11-26 | 2023-11-10 | 漳州大北农农牧科技有限公司 | 一株米曲霉菌株及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU535944B2 (en) * | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
| AU598516B2 (en) * | 1985-12-17 | 1990-06-28 | Lubrizol Genetics Inc. | Isolation of genes for biosynthesis of polyketide antibiotics |
| FI104984B (fi) * | 1988-08-11 | 2000-05-15 | Dsm Nv | Menetelmä biosynteettisten tai säätelygeenien identifioimiseksi ja käyttämiseksi sekundääristen metaboliittien tuoton parantamiseksi |
-
1993
- 1993-01-20 NZ NZ245713A patent/NZ245713A/en unknown
- 1993-01-22 IL IL104481A patent/IL104481A0/xx unknown
- 1993-01-28 AU AU32121/93A patent/AU667498B2/en not_active Ceased
- 1993-02-02 SK SK55-93A patent/SK5593A3/sk unknown
- 1993-02-03 BR BR9300467A patent/BR9300467A/pt not_active Application Discontinuation
- 1993-02-08 HR HR930134A patent/HRP930134A2/hr not_active Application Discontinuation
- 1993-02-09 NO NO93930446A patent/NO930446L/no unknown
- 1993-02-09 FI FI930561A patent/FI930561A/fi not_active Application Discontinuation
- 1993-02-09 BG BG97421A patent/BG61180B1/bg unknown
- 1993-02-09 EP EP93102016A patent/EP0556699A1/en not_active Withdrawn
- 1993-02-10 CZ CZ93172A patent/CZ17293A3/cs unknown
- 1993-02-10 HU HU9300330A patent/HUT67061A/hu unknown
- 1993-02-10 PL PL29769193A patent/PL297691A1/xx unknown
- 1993-02-10 CN CN93102686A patent/CN1076965A/zh active Pending
- 1993-02-10 LV LVP-93-115A patent/LV10502B/en unknown
- 1993-02-10 JP JP5061492A patent/JPH0622780A/ja active Pending
- 1993-02-10 SI SI19939300068A patent/SI9300068A/sl unknown
-
1994
- 1994-11-14 EE EE9400129A patent/EE03048B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LV10502A (lv) | 1995-02-20 |
| AU3212193A (en) | 1993-08-12 |
| HU9300330D0 (en) | 1993-04-28 |
| NO930446L (no) | 1993-08-11 |
| BG61180B1 (bg) | 1997-02-28 |
| PL297691A1 (en) | 1994-01-24 |
| HUT67061A (en) | 1995-01-30 |
| EP0556699A1 (en) | 1993-08-25 |
| SK5593A3 (en) | 1993-12-08 |
| JPH0622780A (ja) | 1994-02-01 |
| CZ17293A3 (en) | 1993-12-15 |
| NZ245713A (en) | 1994-12-22 |
| FI930561A (fi) | 1993-08-11 |
| EE03048B1 (et) | 1997-10-15 |
| BR9300467A (pt) | 1993-08-17 |
| LV10502B (en) | 1995-08-20 |
| BG97421A (bg) | 1994-03-24 |
| SI9300068A (en) | 1993-09-30 |
| NO930446D0 (no) | 1993-02-09 |
| FI930561A0 (fi) | 1993-02-09 |
| IL104481A0 (en) | 1993-05-13 |
| CN1076965A (zh) | 1993-10-06 |
| AU667498B2 (en) | 1996-03-28 |
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