HRP20241352T1 - Male molekule inhibitori kinaze koja inducira nf-kb - Google Patents
Male molekule inhibitori kinaze koja inducira nf-kb Download PDFInfo
- Publication number
- HRP20241352T1 HRP20241352T1 HRP20241352TT HRP20241352T HRP20241352T1 HR P20241352 T1 HRP20241352 T1 HR P20241352T1 HR P20241352T T HRP20241352T T HR P20241352TT HR P20241352 T HRP20241352 T HR P20241352T HR P20241352 T1 HRP20241352 T1 HR P20241352T1
- Authority
- HR
- Croatia
- Prior art keywords
- image
- formula
- ethynyl
- hydroxy
- pyrimidin
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000003384 small molecules Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- SYDSHTZOHFOVFO-WRLIODQTSA-N (3S)-3-[2-[3-(2-deuterio-4-imino-1H-pyrido[3,2-d]pyrimidin-6-yl)phenyl]ethynyl]-3-hydroxy-1-methylpyrrolidin-2-one Chemical compound NC=1C2=C(N=C(N=1)[2H])C=CC(=N2)C=1C=C(C=CC=1)C#C[C@@]1(C(N(CC1)C)=O)O SYDSHTZOHFOVFO-WRLIODQTSA-N 0.000 claims 2
- FYMBEUHVWDUXRB-QFIPXVFZSA-N NC1=NC=C(C2=C1N=C(N=C2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)CC Chemical compound NC1=NC=C(C2=C1N=C(N=C2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)CC FYMBEUHVWDUXRB-QFIPXVFZSA-N 0.000 claims 2
- FKVSVHKPLBGNQS-FQEVSTJZSA-N NC1=NC=CC2=C1N=C(N=C2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O Chemical compound NC1=NC=CC2=C1N=C(N=C2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O FKVSVHKPLBGNQS-FQEVSTJZSA-N 0.000 claims 2
- RLDYBDXGTWEFJZ-NRFANRHFSA-N NC=1C2=C(N=C(N=1)C)C=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O Chemical compound NC=1C2=C(N=C(N=1)C)C=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O RLDYBDXGTWEFJZ-NRFANRHFSA-N 0.000 claims 2
- BMGCLNUWPNEMRQ-NRFANRHFSA-N NC=1C2=C(N=CN=1)CCN(C2)C=1C=C(C=CC=1C)C#C[C@]1(C(N(CC1)C)=O)O Chemical compound NC=1C2=C(N=CN=1)CCN(C2)C=1C=C(C=CC=1C)C#C[C@]1(C(N(CC1)C)=O)O BMGCLNUWPNEMRQ-NRFANRHFSA-N 0.000 claims 2
- CXTMHGLFUDUJLE-IBGZPJMESA-N NC=1C2=C(N=CN=1)SC(=N2)C=1C=C(C=CC=1C)C#C[C@]1(C(N(CC1)C)=O)O Chemical compound NC=1C2=C(N=CN=1)SC(=N2)C=1C=C(C=CC=1C)C#C[C@]1(C(N(CC1)C)=O)O CXTMHGLFUDUJLE-IBGZPJMESA-N 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- SYDSHTZOHFOVFO-VXQWRZFRSA-N (3R)-3-[2-[3-(2-deuterio-4-imino-1H-pyrido[3,2-d]pyrimidin-6-yl)phenyl]ethynyl]-3-hydroxy-1-methylpyrrolidin-2-one Chemical compound NC=1C2=C(N=C(N=1)[2H])C=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O SYDSHTZOHFOVFO-VXQWRZFRSA-N 0.000 claims 1
- LZAUFLQEOZGLBG-WNBCCLPKSA-N (3R)-3-[2-[3-(2-deuterio-8-ethyl-4-imino-1H-pyrido[3,2-d]pyrimidin-6-yl)phenyl]ethynyl]-3-hydroxy-1-methylpyrrolidin-2-one Chemical compound NC=1C2=C(N=C(N=1)[2H])C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)CC LZAUFLQEOZGLBG-WNBCCLPKSA-N 0.000 claims 1
- DYUIILDYMFTFPP-MUPYNFCXSA-N (3R)-3-[2-[3-(8-cyclopentyl-2-deuterio-4-imino-1H-pyrido[3,2-d]pyrimidin-6-yl)phenyl]ethynyl]-3-hydroxy-1-methylpyrrolidin-2-one Chemical compound NC=1C2=C(N=C(N=1)[2H])C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)C1CCCC1 DYUIILDYMFTFPP-MUPYNFCXSA-N 0.000 claims 1
- DRSHHHLTFNAOGN-KIKSHYFBSA-N (3R,5R)-3-[2-[3-(2-deuterio-4-imino-1H-pyrido[3,2-d]pyrimidin-6-yl)phenyl]ethynyl]-3-hydroxy-1,5-dimethylpyrrolidin-2-one Chemical compound NC=1C2=C(N=C(N=1)[2H])C=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N([C@@H](C1)C)C)=O)O DRSHHHLTFNAOGN-KIKSHYFBSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- DZTZPLQFQOSNIE-FQEVSTJZSA-N NC1=NC=C(C2=C1N=C(N=C2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)Cl Chemical compound NC1=NC=C(C2=C1N=C(N=C2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)Cl DZTZPLQFQOSNIE-FQEVSTJZSA-N 0.000 claims 1
- IRWCCQNHZKTMBC-HXUWFJFHSA-N NC1=NC=NC2=C1N=C(N=C2C)C=1C=C(C=CC=1)C#C[C@@]1(C(N(CC1)C)=O)O Chemical compound NC1=NC=NC2=C1N=C(N=C2C)C=1C=C(C=CC=1)C#C[C@@]1(C(N(CC1)C)=O)O IRWCCQNHZKTMBC-HXUWFJFHSA-N 0.000 claims 1
- MFUBQMZDXKAVSA-NRFANRHFSA-N NC1=NC=NC2=CC=C(C=C12)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O Chemical compound NC1=NC=NC2=CC=C(C=C12)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O MFUBQMZDXKAVSA-NRFANRHFSA-N 0.000 claims 1
- RLDYBDXGTWEFJZ-OAQYLSRUSA-N NC=1C2=C(N=C(N=1)C)C=CC(=N2)C=1C=C(C=CC=1)C#C[C@@]1(C(N(CC1)C)=O)O Chemical compound NC=1C2=C(N=C(N=1)C)C=CC(=N2)C=1C=C(C=CC=1)C#C[C@@]1(C(N(CC1)C)=O)O RLDYBDXGTWEFJZ-OAQYLSRUSA-N 0.000 claims 1
- LJGVSTKZALQANF-NRFANRHFSA-N NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)C Chemical compound NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)C LJGVSTKZALQANF-NRFANRHFSA-N 0.000 claims 1
- LJGVSTKZALQANF-SHKVTDPKSA-N NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)C([2H])([2H])[2H] Chemical compound NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)C([2H])([2H])[2H] LJGVSTKZALQANF-SHKVTDPKSA-N 0.000 claims 1
- IJKFNPMPERZKIV-QHCPKHFHSA-N NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)C1CC1 Chemical compound NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)C1CC1 IJKFNPMPERZKIV-QHCPKHFHSA-N 0.000 claims 1
- CIRHIKZELFNGMU-NRFANRHFSA-N NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)NC Chemical compound NC=1C2=C(N=CN=1)C(=CC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O)NC CIRHIKZELFNGMU-NRFANRHFSA-N 0.000 claims 1
- PVFOYAHXMWIDAG-IBGZPJMESA-N NC=1C2=C(N=CN=1)C=NC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O Chemical compound NC=1C2=C(N=CN=1)C=NC(=N2)C=1C=C(C=CC=1)C#C[C@]1(C(N(CC1)C)=O)O PVFOYAHXMWIDAG-IBGZPJMESA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 206010037575 Pustular psoriasis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000002557 hidradenitis Diseases 0.000 claims 1
- 201000007162 hidradenitis suppurativa Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000010914 pustulosis of palm and sole Diseases 0.000 claims 1
- 208000011797 pustulosis palmaris et plantaris Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962855144P | 2019-05-31 | 2019-05-31 | |
| US201962907833P | 2019-09-30 | 2019-09-30 | |
| EP20733688.4A EP3976597B1 (en) | 2019-05-31 | 2020-05-29 | Small molecule inhibitors of nf-kb inducing kinase |
| PCT/EP2020/065024 WO2020239999A1 (en) | 2019-05-31 | 2020-05-29 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20241352T1 true HRP20241352T1 (hr) | 2024-12-20 |
Family
ID=71108552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20241352TT HRP20241352T1 (hr) | 2019-05-31 | 2020-05-29 | Male molekule inhibitori kinaze koja inducira nf-kb |
Country Status (37)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114222737B (zh) * | 2019-05-31 | 2024-07-26 | 詹森药业有限公司 | NF-κB诱导激酶的小分子抑制剂 |
| WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| KR20220030222A (ko) | 2019-05-31 | 2022-03-10 | 이케나 온콜로지, 인코포레이티드 | Tead 억제제 및 이의 용도 |
| IL316886A (en) * | 2022-05-11 | 2025-01-01 | Janssen Pharmaceutica Nv | History of pyrrolidinones as NF kappa B kinase inhibitors |
| CA3257152A1 (en) * | 2022-05-11 | 2023-11-16 | Janssen Pharmaceutica Nv | Pyrrolidine derivatives useful as NF-κB induction kinase inhibitors |
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