KR20220027871A - NF-kB 유도 키나아제의 소분자 억제제 - Google Patents
NF-kB 유도 키나아제의 소분자 억제제 Download PDFInfo
- Publication number
- KR20220027871A KR20220027871A KR1020217042635A KR20217042635A KR20220027871A KR 20220027871 A KR20220027871 A KR 20220027871A KR 1020217042635 A KR1020217042635 A KR 1020217042635A KR 20217042635 A KR20217042635 A KR 20217042635A KR 20220027871 A KR20220027871 A KR 20220027871A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- ethynyl
- pyrimidin
- hydroxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C)c1nc2c(*)nc(*)c([Rh])c2c(*)n1 Chemical compound CC(C)c1nc2c(*)nc(*)c([Rh])c2c(*)n1 0.000 description 64
- APKXTIJQLBCFKE-UHFFFAOYSA-N CC(C)c(cc1)cc2c1cnnc2N Chemical compound CC(C)c(cc1)cc2c1cnnc2N APKXTIJQLBCFKE-UHFFFAOYSA-N 0.000 description 2
- LGYFYVBTVMWCGJ-UHFFFAOYSA-N CC(C)c(cc12)cnc1ncnc2N Chemical compound CC(C)c(cc12)cnc1ncnc2N LGYFYVBTVMWCGJ-UHFFFAOYSA-N 0.000 description 2
- XFVDPTOYIQBMBX-UHFFFAOYSA-N C[n](cc12)nc1ncnc2N Chemical compound C[n](cc12)nc1ncnc2N XFVDPTOYIQBMBX-UHFFFAOYSA-N 0.000 description 2
- XYFVIZUWUPOWCH-UHFFFAOYSA-N CC(C)(C)C(CCC1(C)C)(C1=O)O Chemical compound CC(C)(C)C(CCC1(C)C)(C1=O)O XYFVIZUWUPOWCH-UHFFFAOYSA-N 0.000 description 1
- DABWGTJDDCXCBJ-SNVBAGLBSA-N CC(C)(C)[C@](CCN1C)(C(F)F)C1=O Chemical compound CC(C)(C)[C@](CCN1C)(C(F)F)C1=O DABWGTJDDCXCBJ-SNVBAGLBSA-N 0.000 description 1
- ILVCWGPHMHYZAZ-UHFFFAOYSA-N CC(C)(c1nnc(C)[o]1)O Chemical compound CC(C)(c1nnc(C)[o]1)O ILVCWGPHMHYZAZ-UHFFFAOYSA-N 0.000 description 1
- PVORTHBYWDTPOE-SECBINFHSA-N CC(C)[C@](C)(c1n[o]c(C)c1)O Chemical compound CC(C)[C@](C)(c1n[o]c(C)c1)O PVORTHBYWDTPOE-SECBINFHSA-N 0.000 description 1
- QNOAAQBRQAXVKM-UHFFFAOYSA-N CC(C)c1nc2ncnc(N)c2[s]1 Chemical compound CC(C)c1nc2ncnc(N)c2[s]1 QNOAAQBRQAXVKM-UHFFFAOYSA-N 0.000 description 1
- FILVIKOEJGORQS-UHFFFAOYSA-N CC(CC1)N(C)C1=O Chemical compound CC(CC1)N(C)C1=O FILVIKOEJGORQS-UHFFFAOYSA-N 0.000 description 1
- VQVREJAGUJGFCA-UHFFFAOYSA-N CC(CN(C)C1=O)C1O Chemical compound CC(CN(C)C1=O)C1O VQVREJAGUJGFCA-UHFFFAOYSA-N 0.000 description 1
- JOQNJBUUMSOBDS-UHFFFAOYSA-N CC(N1)=Nc(c(N)ncc2)c2C1=O Chemical compound CC(N1)=Nc(c(N)ncc2)c2C1=O JOQNJBUUMSOBDS-UHFFFAOYSA-N 0.000 description 1
- WPAPDOIRWDGLKY-UHFFFAOYSA-N CC1(c2ncc[n]2CC1)O Chemical compound CC1(c2ncc[n]2CC1)O WPAPDOIRWDGLKY-UHFFFAOYSA-N 0.000 description 1
- IHMZSFSUNLZWNX-JTQLQIEISA-N CCC(C)(C)[C@](C)(c1nnc(C)[o]1)O Chemical compound CCC(C)(C)[C@](C)(c1nnc(C)[o]1)O IHMZSFSUNLZWNX-JTQLQIEISA-N 0.000 description 1
- RERNMUGTYCXNIZ-UHFFFAOYSA-N CCC1=CN(C=C(C(C)C)NC2=O)C2=CC1 Chemical compound CCC1=CN(C=C(C(C)C)NC2=O)C2=CC1 RERNMUGTYCXNIZ-UHFFFAOYSA-N 0.000 description 1
- LCKBSQVRPUVPQD-SSDOTTSWSA-N CC[C@](C)(c1c[s]cn1)O Chemical compound CC[C@](C)(c1c[s]cn1)O LCKBSQVRPUVPQD-SSDOTTSWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962855144P | 2019-05-31 | 2019-05-31 | |
| US62/855,144 | 2019-05-31 | ||
| US201962907833P | 2019-09-30 | 2019-09-30 | |
| US62/907,833 | 2019-09-30 | ||
| PCT/EP2020/065024 WO2020239999A1 (en) | 2019-05-31 | 2020-05-29 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20220027871A true KR20220027871A (ko) | 2022-03-08 |
Family
ID=71108552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217042635A Pending KR20220027871A (ko) | 2019-05-31 | 2020-05-29 | NF-kB 유도 키나아제의 소분자 억제제 |
Country Status (37)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3141826A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3142351A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| UA130430C2 (uk) * | 2019-05-31 | 2026-02-18 | Янссен Фармацевтика Нв | НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB |
| CA3257152A1 (en) * | 2022-05-11 | 2023-11-16 | Janssen Pharmaceutica Nv | Pyrrolidine derivatives useful as NF-κB induction kinase inhibitors |
| US20250304567A1 (en) * | 2022-05-11 | 2025-10-02 | Janssen Pharmaceutica Nv | Pyrrolidione derivatives as inhibitors of nf kappa b inducing kinase |
| AU2023410324A1 (en) | 2022-12-22 | 2025-05-15 | Boehringer Ingelheim International Gmbh | Crystalline forms of a her2 inhibitor |
| WO2025020886A1 (zh) * | 2023-07-27 | 2025-01-30 | 浙江星浩澎博医药有限公司 | 氮杂喹唑啉环衍生物及其用途 |
| CN121568696A (zh) | 2023-07-28 | 2026-02-24 | 勃林格殷格翰国际有限公司 | 制备her2抑制剂的方法 |
| WO2025235874A1 (en) * | 2024-05-10 | 2025-11-13 | Schrödinger, Inc. | Heterocyclics as egfr inhibitors |
| WO2026029041A1 (ja) * | 2024-07-30 | 2026-02-05 | 日本たばこ産業株式会社 | ピラゾロピリミジン化合物及びその医薬用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US7132428B2 (en) | 2003-07-03 | 2006-11-07 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders |
| EP1773781A2 (en) * | 2004-08-03 | 2007-04-18 | Wyeth | Indazoles useful in treating cardiovascular diseases |
| WO2006053277A2 (en) | 2004-11-12 | 2006-05-18 | Chippac, Inc. | Wire bond interconnection |
| JP2011525915A (ja) | 2008-06-26 | 2011-09-29 | アムジエン・インコーポレーテツド | キナーゼ阻害薬としてのアルキニルアルコール類 |
| US20110183975A1 (en) | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| MX2013010513A (es) * | 2011-03-16 | 2013-10-07 | Hoffmann La Roche | Compuestos de alcohol 6,5-heterociclil-propargilico y usos de los mismos. |
| US9034866B2 (en) | 2012-02-17 | 2015-05-19 | Genentech, Inc. | Tricyclic compounds and methods of use therefor |
| US8859553B2 (en) | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| CN105658639A (zh) * | 2013-08-22 | 2016-06-08 | 豪夫迈·罗氏有限公司 | 炔基醇和应用方法 |
| JP2016533385A (ja) | 2013-08-22 | 2016-10-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アルキニルアルコール及び使用方法 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| EP3209654B1 (en) | 2014-10-23 | 2018-10-03 | Janssen Pharmaceutica N.V. | New pyrazole derivatives as nik inhibitors |
| CA2960336C (en) | 2014-10-23 | 2023-03-07 | Janssen Pharmaceutica Nv | Compounds as nik inhibitors |
| EA033238B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные тиенопиримидина в качестве ингибиторов nik |
| KR102523405B1 (ko) | 2014-10-23 | 2023-04-18 | 얀센 파마슈티카 엔.브이. | Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체 |
| WO2016135163A1 (en) | 2015-02-25 | 2016-09-01 | F. Hoffmann-La Roche Ag | Alkynyl alcohols and methods of use |
| JP6910359B2 (ja) | 2016-01-22 | 2021-07-28 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新たな置換されたシアノインドリン誘導体 |
| KR102720461B1 (ko) | 2016-01-22 | 2024-10-21 | 잔센파마슈티카엔.브이. | Nik 억제제로서의 신규 6원 헤테로방향족 치환된 시아노인돌린 유도체 |
| ES2805976T3 (es) | 2016-06-30 | 2021-02-16 | Janssen Pharmaceutica Nv | Derivados heteroaromáticos en calidad de inhibidores de NIK |
| WO2018002219A1 (en) | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
| JP7140751B2 (ja) | 2016-08-24 | 2022-09-21 | エフ．ホフマン－ラ ロシュ アーゲー | ２－アザビシクロ［３．１．０］ヘキサン－３－オン誘導体及び使用方法 |
| CN109863142B (zh) * | 2016-08-24 | 2022-06-10 | 豪夫迈·罗氏有限公司 | 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法 |
| KR102662373B1 (ko) | 2017-07-06 | 2024-04-29 | 얀센 파마슈티카 엔브이 | Nik 억제제로서의 신규 치환 아자인돌린 유도체 |
| CN109810110B (zh) * | 2017-11-22 | 2023-01-24 | 中国科学院上海药物研究所 | 一种具有2-氨基嘧啶结构的化合物，其制备方法和用途 |
| CA3141826A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| SG11202112391UA (en) | 2019-05-31 | 2021-12-30 | Sage Therapeutics Inc | Neuroactive steroids and compositions thereof |
| CA3142351A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| UA130430C2 (uk) * | 2019-05-31 | 2026-02-18 | Янссен Фармацевтика Нв | НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB |
| CA3139018A1 (en) | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| PE20221038A1 (es) | 2019-09-30 | 2022-06-17 | Incyte Corp | Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores |
-
2020
- 2020-05-29 UA UAA202107796A patent/UA130430C2/uk unknown
- 2020-05-29 KR KR1020217042635A patent/KR20220027871A/ko active Pending
- 2020-05-29 MD MDE20220374T patent/MD3976597T2/ro unknown
- 2020-05-29 MA MA56038A patent/MA56038B1/fr unknown
- 2020-05-29 ES ES20733688T patent/ES2989387T3/es active Active
- 2020-05-29 TW TW109118004A patent/TWI850390B/zh active
- 2020-05-29 JP JP2021570919A patent/JP7547387B2/ja active Active
- 2020-05-29 MX MX2021014679A patent/MX2021014679A/es unknown
- 2020-05-29 EP EP24188073.1A patent/EP4467199A3/en active Pending
- 2020-05-29 HR HRP20241352TT patent/HRP20241352T1/hr unknown
- 2020-05-29 TW TW113125993A patent/TWI906955B/zh active
- 2020-05-29 CN CN202410972792.2A patent/CN118908957A/zh active Pending
- 2020-05-29 IL IL288387A patent/IL288387B2/en unknown
- 2020-05-29 HU HUE20733688A patent/HUE068694T2/hu unknown
- 2020-05-29 PH PH1/2021/553011A patent/PH12021553011A1/en unknown
- 2020-05-29 UY UY0001038721A patent/UY38721A/es unknown
- 2020-05-29 PT PT207336884T patent/PT3976597T/pt unknown
- 2020-05-29 MY MYPI2021007053A patent/MY205653A/en unknown
- 2020-05-29 PL PL20733688.4T patent/PL3976597T3/pl unknown
- 2020-05-29 RS RS20241148A patent/RS66105B1/sr unknown
- 2020-05-29 SI SI202030499T patent/SI3976597T1/sl unknown
- 2020-05-29 US US16/887,889 patent/US11254673B2/en active Active
- 2020-05-29 AU AU2020282005A patent/AU2020282005B2/en active Active
- 2020-05-29 WO PCT/EP2020/065024 patent/WO2020239999A1/en not_active Ceased
- 2020-05-29 BR BR112021023796A patent/BR112021023796A2/pt unknown
- 2020-05-29 CN CN202080057418.XA patent/CN114222737B/zh active Active
- 2020-05-29 PE PE2021001987A patent/PE20220768A1/es unknown
- 2020-05-29 EP EP20733688.4A patent/EP3976597B1/en active Active
- 2020-05-29 LT LTEPPCT/EP2020/065024T patent/LT3976597T/lt unknown
- 2020-05-29 SM SM20240418T patent/SMT202400418T1/it unknown
- 2020-05-29 FI FIEP20733688.4T patent/FI3976597T3/fi active
- 2020-05-29 SG SG11202112994WA patent/SG11202112994WA/en unknown
- 2020-05-29 CR CR20210587A patent/CR20210587A/es unknown
- 2020-05-29 DK DK20733688.4T patent/DK3976597T3/da active
-
2021
- 2021-11-25 CL CL2021003142A patent/CL2021003142A1/es unknown
- 2021-11-26 DO DO2021000244A patent/DOP2021000244A/es unknown
- 2021-11-29 JO JOJO/P/2021/0318A patent/JOP20210318B1/ar active
- 2021-11-30 SA SA521430960A patent/SA521430960B1/ar unknown
- 2021-12-13 US US17/549,057 patent/US11827634B2/en active Active
- 2021-12-27 CO CONC2021/0017838A patent/CO2021017838A2/es unknown
- 2021-12-28 EC ECSENADI202193623A patent/ECSP21093623A/es unknown
-
2024
- 2024-08-28 JP JP2024146717A patent/JP2024167319A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7547387B2 (ja) | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 | |
| JP7446236B2 (ja) | ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール－ビピリジンアミン誘導体 | |
| JP2018150358A (ja) | Ｔａｎｋ結合キナーゼインヒビター化合物 | |
| KR20130094710A (ko) | Ｊａｋ 키나아제의 억제제로서 5,7-치환된-이미다조［1,2-ｃ］피리미딘 | |
| JP2011529920A (ja) | ピリミジン化合物、組成物及び使用方法 | |
| KR20170068503A (ko) | 융합된 펜타시클릭 이미다졸 유도체 | |
| WO2020223590A1 (en) | Modulators of trex1 | |
| KR20230069169A (ko) | 카제인 키나제 1 델타 조절제 | |
| US12617789B2 (en) | Small molecular inhibitors of NF-κb inducing kinase | |
| CA3143350C (en) | Small molecule inhibitors of nf-kb inducing kinase | |
| HK40119602A (en) | Small molecule inhibitors of nf-kb inducing kinase | |
| US20230416256A1 (en) | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE | |
| EA045720B1 (ru) | НИЗКОМОЛЕКУЛЯРНЫЕ ИНГИБИТОРЫ NF-κB-ИНДУЦИРУЮЩЕЙ КИНАЗЫ | |
| HK40071178A (en) | Small molecule inhibitors of nf-kb inducing kinase | |
| HK40071178B (en) | Small molecule inhibitors of nf-kb inducing kinase | |
| US20250282785A1 (en) | Pyrrolidinone derivatives as inhibitors of nf kappa b inducing kinase | |
| TW202506660A (zh) | Mrgprx2拮抗劑及其使用方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |