HRP20240078T1 - Imuno-onkolitičke terapije - Google Patents
Imuno-onkolitičke terapije Download PDFInfo
- Publication number
- HRP20240078T1 HRP20240078T1 HRP20240078TT HRP20240078T HRP20240078T1 HR P20240078 T1 HRP20240078 T1 HR P20240078T1 HR P20240078T T HRP20240078T T HR P20240078TT HR P20240078 T HRP20240078 T HR P20240078T HR P20240078 T1 HRP20240078 T1 HR P20240078T1
- Authority
- HR
- Croatia
- Prior art keywords
- vaccinia virus
- oncolytic vaccinia
- deletion
- virus according
- mutation
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 241000700618 Vaccinia virus Species 0.000 claims 15
- 230000000174 oncolytic effect Effects 0.000 claims 15
- 230000037430 deletion Effects 0.000 claims 11
- 238000012217 deletion Methods 0.000 claims 11
- 230000035772 mutation Effects 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 4
- 229960002986 dinoprostone Drugs 0.000 claims 4
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 108010051913 15-hydroxyprostaglandin dehydrogenase Proteins 0.000 claims 2
- 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 claims 2
- 101150108168 A33R gene Proteins 0.000 claims 2
- 101150076005 A36R gene Proteins 0.000 claims 2
- 101150023320 B16R gene Proteins 0.000 claims 2
- 101150074766 C12L gene Proteins 0.000 claims 2
- 102220477045 Dynein axonemal assembly factor 10_A56R_mutation Human genes 0.000 claims 2
- 101150039660 HA gene Proteins 0.000 claims 2
- 101000595548 Homo sapiens TIR domain-containing adapter molecule 1 Proteins 0.000 claims 2
- 102220508636 Liprin-beta-1_C12L_mutation Human genes 0.000 claims 2
- 101150009018 SPI-1 gene Proteins 0.000 claims 2
- 102100036073 TIR domain-containing adapter molecule 1 Human genes 0.000 claims 2
- 101100000230 Vaccinia virus (strain Copenhagen) A35R gene Proteins 0.000 claims 2
- 101100316831 Vaccinia virus (strain Copenhagen) B18R gene Proteins 0.000 claims 2
- 101100272150 Vaccinia virus (strain Copenhagen) B8R gene Proteins 0.000 claims 2
- 101100000231 Vaccinia virus (strain Western Reserve) VACWR158 gene Proteins 0.000 claims 2
- 101100000236 Vaccinia virus (strain Western Reserve) VACWR159 gene Proteins 0.000 claims 2
- 101100272151 Vaccinia virus (strain Western Reserve) VACWR190 gene Proteins 0.000 claims 2
- 101100004099 Vaccinia virus (strain Western Reserve) VACWR200 gene Proteins 0.000 claims 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 230000005907 cancer growth Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 210000004779 membrane envelope Anatomy 0.000 claims 2
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 101150039990 B13R gene Proteins 0.000 claims 1
- 101150019032 B29R gene Proteins 0.000 claims 1
- 101100232885 Cowpox virus (strain Brighton Red) CPXV209 gene Proteins 0.000 claims 1
- 101150019990 H5R gene Proteins 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 1
- 102000006601 Thymidine Kinase Human genes 0.000 claims 1
- 108020004440 Thymidine kinase Proteins 0.000 claims 1
- 101100004091 Vaccinia virus (strain Copenhagen) B15R gene Proteins 0.000 claims 1
- 101100506190 Vaccinia virus (strain Western Reserve) VACWR103 gene Proteins 0.000 claims 1
- 101100340726 Vaccinia virus (strain Western Reserve) VACWR197 gene Proteins 0.000 claims 1
- 101100391609 Variola virus (isolate Human/India/Ind3/1967) G3R gene Proteins 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960001388 interferon-beta Drugs 0.000 claims 1
- 102000014909 interleukin-1 receptor activity proteins Human genes 0.000 claims 1
- 108040006732 interleukin-1 receptor activity proteins Proteins 0.000 claims 1
- 244000309459 oncolytic virus Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24171—Demonstrated in vivo effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Claims (15)
1. Onkolitički virus vakcinije koji sadrži: nukleinsku kiselinu koja kodira protein interferona beta (TRIF) koji sadrži Toll/IL-1R domenu ili funkcionalnu domenu koja ima TRIF aktivnost.
2. Onkolitički virus vakcinije prema zahtjevu 1, nadalje sadrži:
a. mutaciju virusne okosnice koja sadrži brisanje u nukleinskoj kiselini koja kodira jedan ili više C12L, B8R, B18R, A35R, B15R, B29R, G3R, H5R, STAT1 inhibitor (H1L); dsRNA ili PKR inhibitora;
b. virusnu ovojnicu sa smanjenom glikozilacijom u odnosu na inače identičan nemodificirani virus;
c. nukleinsku kiselinu koja kodira faktor stimulacije kolonije granulocita-makrofaga (GM-CSF);
d. nukleinsku kiselinu koja kodira antagonist prostaglandina E2 (PGE2); ili
e. mutaciju odabranu iz skupine koju čine: aminokiselinska supstitucija Lys151 s Glu u A34R, potpuno ili djelomično brisanje B5R, A36R mutacija ili brisanje, A56R mutacija ili brisanje, i njihove kombinacije.
3. Onkolitički virus vakcinije prema zahtjevu 2, naznačen time što sadrži nukleinsku kiselinu koja kodira antagonist PGE2, pri čemu je antagonist PGE2 15-hidroksiprostaglandin dehidrogenaza (15-PGDH).
4. Onkolitički virus vakcinije prema zahtjevu 2 ili 3, sadrži brisanje C12L.
5. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 2-4, koji sadrži virusnu ovojnicu sa smanjenom glikozilacijom u odnosu na inače identičan nemodificirani virus.
6. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 2-5, koji sadrži mutaciju virusne okosnice odabranu iz skupine koju čine: brisanje B8R, brisanje B18R, brisanje A35R, i njihove kombinacije.
7. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 2-6, koji sadrži mutaciju odabranu iz skupine koju čine: aminokiselinska supstitucija Lys151 s Glu u A34R, potpuno ili djelomično brisanje B5R, mutaciju ili brisanje A36R, A56R mutaciju ili brisanje, i njihove kombinacije.
8. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 2-7, koji sadrži nukleinsku kiselinu koja kodira GM-CSF.
9. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 1-7, naznačen time što je onkolitički virus vakcinije negativan na timidin kinazu.
10. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 1-8, naznačen time što onkolitički virus vakcinije sadrži soj Western Reserve.
11. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 1-10, za uporabu u najmanje jednom od:
a. liječenje subjekta koji ima rak;
b stvaranje učinka protiv raka kod subjekta;
c. smanjenje rasta stanica raka; i
d. smanjenje rasta tumora.
12. Onkolitički virus vakcinije prema bilo kojem od zahtjeva 1-10, u kombinaciji sa sredstvom koje inhibira ili smanjuje razine supresorskih stanica izvedenih iz mijeloida, ili njihove kombinacije, za uporabu u najmanje jednom od:
a. liječenje subjekta koji ima rak;
b stvaranje učinka protiv raka kod subjekta;
c. smanjenje rasta stanica raka; i
d. smanjenje rasta tumora.
13. Onkolitički virus vakcinije prema zahtjevu 12, naznačen time što je sredstvo koje inhibira ili smanjuje razine supresorskih stanica izvedenih iz mijeloida neovisno odabrano iz skupine koju čine: anti-CD33 antitijelo ili njegova varijabilna regija, anti-CD11b antitijelo ili njegova varijabilna regija, ili inhibitor COX2.
14. Farmaceutski pripravak koji sadrži onkolitički virus prema bilo kojem od zahtjeva 1-10, i farmaceutski prihvatljiv nosač.
15. Farmaceutski pripravak prema zahtjevu 14, za uporabu u liječenju raka kod subjekta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868978P | 2013-08-22 | 2013-08-22 | |
| EP20189155.3A EP3778897B1 (en) | 2013-08-22 | 2014-08-22 | Immuno-oncolytic therapies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240078T1 true HRP20240078T1 (hr) | 2024-03-29 |
Family
ID=52484194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240078TT HRP20240078T1 (hr) | 2013-08-22 | 2014-08-22 | Imuno-onkolitičke terapije |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11478518B2 (hr) |
| EP (3) | EP3778897B1 (hr) |
| JP (3) | JP6912199B2 (hr) |
| KR (1) | KR102389240B1 (hr) |
| CN (1) | CN105658795B (hr) |
| AU (1) | AU2014308648B2 (hr) |
| CA (3) | CA3213683A1 (hr) |
| DK (2) | DK3778897T3 (hr) |
| EA (1) | EA037582B1 (hr) |
| ES (2) | ES2971528T3 (hr) |
| FI (1) | FI3778897T3 (hr) |
| HK (1) | HK1223402A1 (hr) |
| HR (1) | HRP20240078T1 (hr) |
| HU (1) | HUE066593T2 (hr) |
| IL (1) | IL243996A0 (hr) |
| LT (1) | LT3778897T (hr) |
| MD (2) | MD4624C1 (hr) |
| MX (1) | MX2016002257A (hr) |
| NZ (1) | NZ716825A (hr) |
| PE (1) | PE20160673A1 (hr) |
| PH (1) | PH12016500329A1 (hr) |
| PL (1) | PL3778897T3 (hr) |
| PT (1) | PT3778897T (hr) |
| RS (1) | RS65104B1 (hr) |
| SG (1) | SG11201600960PA (hr) |
| SI (1) | SI3778897T1 (hr) |
| WO (1) | WO2015027163A1 (hr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20160673A1 (es) * | 2013-08-22 | 2016-07-21 | Univ Of Pittsburgh - Of The Commonwealth System Of Higher Education | Terapias inmuno-oncoliticas |
| EP3261669B1 (en) | 2015-02-25 | 2022-08-03 | Memorial Sloan Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| CN116173193A (zh) | 2015-04-17 | 2023-05-30 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| US10370647B2 (en) * | 2015-07-22 | 2019-08-06 | National University Corporation Tottori University | Host regulatory factor that enhances replication and/or propagation of vaccinia virus |
| WO2017043815A1 (en) * | 2015-09-08 | 2017-03-16 | Sillajen, Inc. | Modified oncolytic vaccinia viruses expressing a cytokine and a car- boxylesterase and methods of use thereof |
| KR20180104597A (ko) | 2015-11-07 | 2018-09-21 | 멀티비르 인코포레이티드 | 암 치료를 위한 종양 억제 유전자 요법 및 면역관문 봉쇄를 포함하는 조성물 |
| CA3015650A1 (en) | 2016-02-25 | 2017-08-31 | Memorial Sloan Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy |
| BR112018016948A2 (pt) | 2016-02-25 | 2019-01-08 | Memorial Sloan Kettering Cancer Center | mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos |
| US20200316146A1 (en) * | 2016-03-25 | 2020-10-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Synthetically enveloped virus |
| EP3254692A1 (en) * | 2016-06-10 | 2017-12-13 | Ceva Sante Animale | Multivalent recombinant spv |
| KR102648600B1 (ko) | 2016-07-19 | 2024-03-15 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Stat3를 타겟으로 하는 종양용해성 바이러스 |
| WO2018057755A1 (en) * | 2016-09-21 | 2018-03-29 | Thorne Stephen H | High mobility group box i mutant |
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