HRP20230726T1 - Topikalna formulacija za poticanje zarastanja rana - Google Patents
Topikalna formulacija za poticanje zarastanja rana Download PDFInfo
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- HRP20230726T1 HRP20230726T1 HRP20230726TT HRP20230726T HRP20230726T1 HR P20230726 T1 HRP20230726 T1 HR P20230726T1 HR P20230726T T HRP20230726T T HR P20230726TT HR P20230726 T HRP20230726 T HR P20230726T HR P20230726 T1 HRP20230726 T1 HR P20230726T1
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- topical formulation
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- 239000012049 topical pharmaceutical composition Substances 0.000 title claims 22
- 230000001737 promoting effect Effects 0.000 title claims 2
- 230000029663 wound healing Effects 0.000 title claims 2
- 241001184136 Plectranthus amboinicus Species 0.000 claims 7
- 239000000284 extract Substances 0.000 claims 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- ZIIAJIWLQUVGHB-UHFFFAOYSA-N Circimaritin Natural products C=1C(=O)C=2C(O)=C(OC)C(OC)=CC=2OC=1C1=CC=C(O)C=C1 ZIIAJIWLQUVGHB-UHFFFAOYSA-N 0.000 claims 5
- 235000004094 Coleus amboinicus Nutrition 0.000 claims 4
- 206010052428 Wound Diseases 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- OBQMAEGCYPFNKQ-UHFFFAOYSA-N cirsimaritin Natural products COc1c(C)cc2OC(=CC(=O)c2c1O)c3ccc(O)cc3 OBQMAEGCYPFNKQ-UHFFFAOYSA-N 0.000 claims 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 4
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 230000000845 anti-microbial effect Effects 0.000 claims 3
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 claims 3
- 229940022757 asiaticoside Drugs 0.000 claims 3
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims 3
- 239000003883 ointment base Substances 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- QCDYOIZVELGOLZ-UHFFFAOYSA-N salvigenin Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(O)C(OC)=C(OC)C=C2O1 QCDYOIZVELGOLZ-UHFFFAOYSA-N 0.000 claims 3
- ZZPHAQJIENBZOF-UHFFFAOYSA-N salvigenin Natural products COc1c(C)cc2OC(=CC(=O)c2c1O)c3ccc(C)cc3 ZZPHAQJIENBZOF-UHFFFAOYSA-N 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 claims 2
- 244000146462 Centella asiatica Species 0.000 claims 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 235000019271 petrolatum Nutrition 0.000 claims 2
- 239000000419 plant extract Substances 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 241000167550 Centella Species 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 206010056340 Diabetic ulcer Diseases 0.000 claims 1
- 208000034693 Laceration Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004264 Petrolatum Substances 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 208000004210 Pressure Ulcer Diseases 0.000 claims 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 208000002847 Surgical Wound Diseases 0.000 claims 1
- 208000000558 Varicose Ulcer Diseases 0.000 claims 1
- 238000005299 abrasion Methods 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940059958 centella asiatica extract Drugs 0.000 claims 1
- 229960000541 cetyl alcohol Drugs 0.000 claims 1
- 229960002242 chlorocresol Drugs 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229940107161 cholesterol Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000004519 grease Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 229940066842 petrolatum Drugs 0.000 claims 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 1
- 229940113124 polysorbate 60 Drugs 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 229960004274 stearic acid Drugs 0.000 claims 1
- 229940012831 stearyl alcohol Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 239000003871 white petrolatum Substances 0.000 claims 1
- 229940045860 white wax Drugs 0.000 claims 1
- -1 white wax Natural products 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (15)
1. Topikalna formulacija koja sadrži:
(i) aktivni agens koji sadrži salvigenin u količini od oko 0,0001% do 0.5% (tež./tež.) i azijatikozid u količini od oko 0,05% do 5% (tež./tež.);
(ii) sredstvo koje povećava viskoznost u količini od oko 1.0-10% (tež./tež.);
(iii) podlogu za mast u količini od oko 5-30% (tež./tež.);
(iv) antimikrobni konzervans u količini od oko 0,005-0.2% (tež./tež.); i
(v) emulgator u količini od oko 0.5-10% (tež./tež.).
2. Topikalna formulacija prema patentnom zahtjevu 1, naznačena time što je aktivni agens ekstrakt biljke Plectranthus amboinicus, ekstrakt biljke Centella asiatica, ili njihova kombinacija, i pri čemu ekstrakt biljke Plectranthus amboinicus i/ili ekstrakt biljke Centella asiatica sadrži salvigenin i/ili azijatikozid.
3. Topikalna formulacija prema patentnom zahtjevu 1 ili 2, naznačena time što je aktivni agens u topikalnoj formulaciji u količini od oko 0,1-30% (tež./tež.).
4. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-3, naznačena time što topikalna formulacija sadrži salvigenin u opsegu od 0,0001% do 0,1% (tež./tež.), i/ili pri čemu topikalna formulacija sadrži azijatikozid u opsegu od 0,05% do 1% (tež./tež.).
5. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-4, naznačena time što aktivni agens dalje sadrži cirsimaritin, madekasozid, ili njihovu kombinaciju.
6. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-5, naznačena time što je u topikalnoj formulaciji podloga za mast u količini od oko 10-30% (tež./tež.), antimikrobni konzervans je oko 0,01-0,2% (tež./tež.) i emulgator je oko 0,5-6% (tež./tež.).
7. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-6, naznačena time što se Plectranthus amboinicus ekstrakt priprema dovođenjem cijele biljke Plectranthus amboinicus ili njenog dijela, u kontakt sa otapalom koje ima indeks polarnosti niži od 7, kako bi se proizvela otopina, i sušenjem otopine kako bi se proizveo Plectranthus amboinicus ekstrakt.
8. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-7, naznačena time što topikalna formulacija sadrži i ekstrakt biljke Plectranthus amboinicus i ekstrakt biljke Centella u težinskom odnosu od oko 1:10 do 10:1, poželjno oko 1:5 do 5:1.
9. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-8, naznačena time što što je sredstvo za povećanje viskoznosti cetostearil alkohol, kolesterol, stearil alkohol, klorokrezol, bijeli vosak, stearinska kiselina, cetil alkohol ili njihova kombinacija, podloga za mast sadrži jedan ili više spojeva vazelina, i/ili antimikrobni konzervans sadrži jedan ili više spojeva parabena.
10. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-9, naznačena time što podloga za mast predstavlja podlogu za kremu; poželjno pri čemu formulacija dalje sadrži jedan ili više otapala; gdje poželjno jedan ili više otapala sadrži propilen glikol.
11. Topikalna formulacija prema patentnom zahtjevu 1, naznačena time što topikalna formulacija sadrži kombinaciju Plectranthus amboinicus ekstrakta i Centella asiatica ekstrakta u količini od oko 0,1-30% (tež./tež.), cetostearil alkohol u količini od oko 1,0-10% (tež./tež.), kombinaciju bijelog vazelina i tekućeg vazelina u ukupnoj količini od oko 5-30% (tež./tež.), kombinaciju metil parabena i propil parabena u ukupnoj količini od oko 0,005-0,2% (tež./tež.) i kombinaciju sorbitan monostearata i polisorbata 60 u ukupnoj količini od oko 0,5-10% (tež./tež.);
koja poželjno dalje sadrži propilen glikol u količini od oko 2-20% (tež./tež.).
12. Topikalna formulacija prema bilo kojem od patentnih zahtjeva 1-11, za uporabu u poticanju zarastanja rana kod subjekta.
13. Topikalna formulacija za uporabu prema patentnom zahtjevu 12,
naznačena time što je formulacija za topikalnu primjenu najmanje jednom na dan, poželjno dvaput dnevno;
ili/poželjno, gdje je subjekt čovjek, pacijent sa dijabetesom, koji pati od čira na dijabetesnom stopalu.
14. Topikalna formulacija za uporabu prema bilo kojem od patentnih zahtjeva 12-13, naznačena time što je subjekt čovjek, pacijent koji ima otvorenu ranu, koja je izborno abrazija, rez, razderotina, ubod ili avulzija.
15. Topikalna formulacija za uporabu prema patentnom zahtjevu 14,
naznačena time što je subjekt čovjek, pacijent koji ima kroničnu ranu, koja je izborno kirurška rana, traumatska rana, dekubitusni čir, venski čir, dijabetesni čir ili rana uzrokovana rakom, opekotinom, dekubitusom ili atopijskim dermatitisom; ili
gdje je subjekt čovjek, pacijent koji ima akne.
Applications Claiming Priority (3)
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| US201662363284P | 2016-07-17 | 2016-07-17 | |
| EP17830439.0A EP3484457B1 (en) | 2016-07-17 | 2017-07-17 | Topical formulation for promoting wound healing |
| PCT/CN2017/093118 WO2018014805A1 (en) | 2016-07-17 | 2017-07-17 | Topical formulation for promoting wound healing |
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| HRP20230726T1 true HRP20230726T1 (hr) | 2023-10-13 |
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| HRP20230726TT HRP20230726T1 (hr) | 2016-07-17 | 2017-07-17 | Topikalna formulacija za poticanje zarastanja rana |
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| EP (1) | EP3484457B1 (hr) |
| JP (2) | JP7538599B2 (hr) |
| KR (1) | KR102362362B1 (hr) |
| CN (1) | CN108778262A (hr) |
| CA (1) | CA3030774A1 (hr) |
| DK (1) | DK3484457T3 (hr) |
| ES (1) | ES2955844T3 (hr) |
| FI (1) | FI3484457T3 (hr) |
| HR (1) | HRP20230726T1 (hr) |
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| LT (1) | LT3484457T (hr) |
| MX (1) | MX2019000769A (hr) |
| MY (1) | MY193312A (hr) |
| PH (1) | PH12019500126A1 (hr) |
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| RS (1) | RS64356B1 (hr) |
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| SA (1) | SA519400913B1 (hr) |
| SG (1) | SG11201900408RA (hr) |
| SI (1) | SI3484457T1 (hr) |
| TW (1) | TWI746597B (hr) |
| WO (1) | WO2018014805A1 (hr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP7172438B2 (ja) * | 2018-10-24 | 2022-11-16 | ライオン株式会社 | 水性眼科用組成物及び保存効力向上方法 |
| CN111297877A (zh) * | 2019-12-31 | 2020-06-19 | 中国药科大学 | 积雪草苷或其类似物的制药用途 |
| KR102583283B1 (ko) * | 2021-04-15 | 2023-09-27 | 주식회사 엘지생활건강 | 고함량의 센텔라아시아티카 정량추출물을 포함하는 안정한 화장료 조성물 |
| CN113209007B (zh) * | 2021-05-17 | 2022-11-25 | 海南普利制药股份有限公司 | 积雪苷外用制剂及其制备方法 |
| EP4362937A1 (en) | 2021-06-28 | 2024-05-08 | Oneness Biotech Co., Ltd. | Methods for preparation of plectranthus amboinicus extracts |
| US20230405070A1 (en) * | 2022-05-27 | 2023-12-21 | Oneness Biotech Co., Ltd. | Plectranthus amboinicus extract for use in inhibiting immune responses |
| US20230414558A1 (en) * | 2022-06-27 | 2023-12-28 | Oneness Biotech Co., Ltd. | Plectranthus amboinicus extract for use in alleviation of radiation-induced skin disorders |
| WO2024159451A1 (en) * | 2023-02-01 | 2024-08-08 | Oneness Biotech Co., Ltd. | Plectranthus amboinicus extract for use in scar cosmesis |
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| FR2459661A1 (fr) | 1979-06-25 | 1981-01-16 | Phybiocit Laboratoires | Nouvelle composition medicamenteuse a base de plantes, et procede de preparation |
| CN1049122C (zh) | 1993-01-11 | 2000-02-09 | 李厚清 | 复方外伤软膏 |
| CN1067976C (zh) | 1994-12-03 | 2001-07-04 | 东国制药株式会社 | 积雪草酸衍生物及其制备方法和包含该衍生物的皮科制剂 |
| TW299064U (en) | 1995-01-23 | 1997-02-21 | Hitachi Ltd | Resin molded transformer |
| US6267996B1 (en) | 1996-10-17 | 2001-07-31 | Indena S.P.A | Pharmaceutical and cosmetic formulations with antimicrobial activity |
| KR100228873B1 (ko) | 1997-03-24 | 1999-11-01 | 강재헌 | 센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물을 함유한 간세포 및 항간섬유화 치료제 |
| CN1194154A (zh) | 1997-03-24 | 1998-09-30 | 东国制药株式会社 | 自积雪草的积雪草苷和羟基的积雪草苷和羧基积雪草苷的水溶性提取物及其分离方法 |
| AU7038600A (en) * | 1999-08-27 | 2001-03-26 | Cheil Jedang Corporation | Extracts derived from pueraria mirifica, butea superba and/or mucuna collettii and extraction thereof |
| CN1137681C (zh) | 2000-11-21 | 2004-02-11 | 国家医药管理局上海医药工业研究院 | 积雪甙防粘膜及制备方法 |
| CN1127970C (zh) | 2001-03-14 | 2003-11-19 | 周华国 | 一种治疗烧伤的药膏及其制备方法 |
| US6579543B1 (en) | 2002-02-22 | 2003-06-17 | Jackie H. McClung | Composition for topical application to skin |
| JP2004059482A (ja) | 2002-07-29 | 2004-02-26 | Masahiro Sakanaka | 組織再生促進剤 |
| US20060099283A1 (en) | 2004-11-10 | 2006-05-11 | We Gene Technologies, Inc. | Leaf juice of plectranthus amboinicus for treating cancer and/or tumor |
| CN1682744A (zh) | 2005-03-15 | 2005-10-19 | 天津大学 | 制备积雪草苷巴布剂的方法 |
| TWI361074B (en) | 2005-12-22 | 2012-04-01 | Dev Center Biotechnology | Plant extracts for enhancing healing of wounds,and the preparation process and use thereof |
| TWI320714B (en) | 2006-09-15 | 2010-02-21 | Dev Center Biotechnology | Plant extracts for the treatment of rheumatoid arthritis |
| EP1925310B1 (en) * | 2006-11-24 | 2015-03-25 | Development Center For Biotechnology | Plant extracts from Plectranthus and Centella for treating skin disorders and accelerating wound healing in diabetic patients |
| ES2358306T3 (es) * | 2007-02-12 | 2011-05-09 | Indus Biotech Private Limited | Una composición para la inhibición selectiva de la reabsorción de la seretonina y los procesos correspondientes. |
| US8449924B2 (en) * | 2007-08-29 | 2013-05-28 | Development Center For Biotechnology | Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds |
| JP4853442B2 (ja) | 2007-09-27 | 2012-01-11 | パナソニック株式会社 | ミストサウナ装置 |
| KR101779999B1 (ko) * | 2010-02-19 | 2017-09-19 | 마리 케이 인코포레이티드 | 국소 피부 케어 제형 |
| CA2802154C (en) * | 2010-06-10 | 2017-02-28 | Indus Biotech Private Limited | A method for preparation of highly pure asiaticoside composition from centella asiatica and a method of use thereof |
| FR2964570A1 (fr) * | 2010-09-09 | 2012-03-16 | Burgundy | Procede de preparation d'un extrait de centella asiatica |
| TWI501772B (zh) * | 2011-11-22 | 2015-10-01 | Oneness Biotech Co | 具抗關節炎活性的到手香精萃物 |
| CN103420967A (zh) | 2013-08-19 | 2013-12-04 | 南京标科生物科技有限公司 | 一种滨蓟黄素的制备方法 |
| TWI663982B (zh) * | 2013-09-03 | 2019-07-01 | 合一生技股份有限公司 | 到手香萃取物用於製備具抗微生物功效組合物之用途 |
| US10376488B2 (en) | 2014-09-05 | 2019-08-13 | ONENESS BIOTECH CO., Ltd | Use of flavonoids in manufacturing compositions for wound healing |
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2017
- 2017-07-17 WO PCT/CN2017/093118 patent/WO2018014805A1/en unknown
- 2017-07-17 CN CN201780009172.7A patent/CN108778262A/zh active Pending
- 2017-07-17 FI FIEP17830439.0T patent/FI3484457T3/fi active
- 2017-07-17 PT PT178304390T patent/PT3484457T/pt unknown
- 2017-07-17 LT LTEPPCT/CN2017/093118T patent/LT3484457T/lt unknown
- 2017-07-17 TW TW106123820A patent/TWI746597B/zh active
- 2017-07-17 MY MYPI2019000107A patent/MY193312A/en unknown
- 2017-07-17 JP JP2019502066A patent/JP7538599B2/ja active Active
- 2017-07-17 MX MX2019000769A patent/MX2019000769A/es unknown
- 2017-07-17 DK DK17830439.0T patent/DK3484457T3/da active
- 2017-07-17 SG SG11201900408RA patent/SG11201900408RA/en unknown
- 2017-07-17 EP EP17830439.0A patent/EP3484457B1/en active Active
- 2017-07-17 RU RU2019104255A patent/RU2750286C2/ru active
- 2017-07-17 CA CA3030774A patent/CA3030774A1/en active Pending
- 2017-07-17 RS RS20230554A patent/RS64356B1/sr unknown
- 2017-07-17 PL PL17830439.0T patent/PL3484457T3/pl unknown
- 2017-07-17 HU HUE17830439A patent/HUE062184T2/hu unknown
- 2017-07-17 HR HRP20230726TT patent/HRP20230726T1/hr unknown
- 2017-07-17 SI SI201731369T patent/SI3484457T1/sl unknown
- 2017-07-17 ES ES17830439T patent/ES2955844T3/es active Active
- 2017-07-17 US US15/651,337 patent/US10758584B2/en active Active
- 2017-07-17 KR KR1020197004556A patent/KR102362362B1/ko active IP Right Grant
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2019
- 2019-01-15 SA SA519400913A patent/SA519400913B1/ar unknown
- 2019-01-17 PH PH12019500126A patent/PH12019500126A1/en unknown
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2022
- 2022-08-04 JP JP2022124798A patent/JP7469400B2/ja active Active
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