HRP20210750T1 - Ekspresijski sustavi - Google Patents
Ekspresijski sustavi Download PDFInfo
- Publication number
- HRP20210750T1 HRP20210750T1 HRP20210750TT HRP20210750T HRP20210750T1 HR P20210750 T1 HRP20210750 T1 HR P20210750T1 HR P20210750T T HRP20210750T T HR P20210750TT HR P20210750 T HRP20210750 T HR P20210750T HR P20210750 T1 HRP20210750 T1 HR P20210750T1
- Authority
- HR
- Croatia
- Prior art keywords
- polynucleotide
- peptide
- protein
- preparation according
- cleavage site
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/007995 WO2012089231A1 (en) | 2010-12-30 | 2010-12-30 | Paramyxovirus vaccines |
| PCT/EP2011/074307 WO2012089833A2 (en) | 2010-12-30 | 2011-12-30 | Expression Systems |
| EP11805889.0A EP2658573B1 (en) | 2010-12-30 | 2011-12-30 | Expression systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210750T1 true HRP20210750T1 (hr) | 2021-11-12 |
Family
ID=45464575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210750TT HRP20210750T1 (hr) | 2010-12-30 | 2011-12-30 | Ekspresijski sustavi |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US20140141042A1 (enExample) |
| EP (2) | EP2658573B1 (enExample) |
| JP (2) | JP6324725B2 (enExample) |
| KR (1) | KR102070463B1 (enExample) |
| CN (1) | CN103442731B (enExample) |
| AU (2) | AU2011351380A1 (enExample) |
| BR (1) | BR112013016823A2 (enExample) |
| CA (1) | CA2821111A1 (enExample) |
| CY (1) | CY1124146T1 (enExample) |
| DK (1) | DK2658573T3 (enExample) |
| ES (1) | ES2869199T3 (enExample) |
| HR (1) | HRP20210750T1 (enExample) |
| HU (1) | HUE053986T2 (enExample) |
| IL (1) | IL226551B (enExample) |
| LT (1) | LT2658573T (enExample) |
| MX (1) | MX352205B (enExample) |
| NZ (1) | NZ610743A (enExample) |
| PL (1) | PL2658573T3 (enExample) |
| PT (1) | PT2658573T (enExample) |
| RU (1) | RU2609645C2 (enExample) |
| SG (2) | SG190919A1 (enExample) |
| SI (1) | SI2658573T1 (enExample) |
| WO (2) | WO2012089231A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2869841B1 (en) | 2012-07-05 | 2021-08-25 | GlaxoSmithKline Biologicals SA | Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides |
| SI2879702T1 (sl) * | 2012-08-01 | 2020-02-28 | Bavarian Nordic A/S | Cepivo na osnovi rekombinantnega modificiranega virusa vakcinacije Ankara (MVA) proti respiratornemu sincitialnemu virusu (RSV) |
| ES2767324T3 (es) * | 2012-08-01 | 2020-06-17 | Bavarian Nordic As | Vacuna de virus vaccinia modificado de Ankara (MVA) recombinante para el virus sincicial respiratorio (VRS) |
| SG11201500573RA (en) | 2012-08-06 | 2015-02-27 | Glaxosmithkline Biolog Sa | Method for eliciting in infants an immune response against rsv and b. pertussis |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| RS60056B1 (sr) * | 2013-02-01 | 2020-04-30 | Medimmune Llc | Epitopi f proteina respiratornog sincicijalnog virusa |
| US20140286981A1 (en) * | 2013-03-14 | 2014-09-25 | Wisconsin Alumni Research Foundation | Broadly reactive mosaic peptide for influenza vaccine |
| HRP20200012T1 (hr) | 2013-03-15 | 2020-03-20 | The Research Foundation Of The State University Of New York | Atenuirani virusi i cjepiva gripe |
| SG11201600709TA (en) | 2013-08-05 | 2016-02-26 | Glaxosmithkline Biolog Sa | Combination immunogenic compositions |
| EP3154576A1 (en) | 2014-06-13 | 2017-04-19 | GlaxoSmithKline Biologicals S.A. | Immunogenic combinations |
| WO2016198621A1 (en) | 2015-06-12 | 2016-12-15 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
| DE20164728T1 (de) * | 2015-10-22 | 2021-09-30 | Modernatx, Inc. | Impfstoffe gegen atemwegsvirus |
| GB201614485D0 (en) | 2016-08-25 | 2016-10-12 | Univ Oxford Innovation Ltd | Immunogenic composition |
| WO2018060288A1 (en) | 2016-09-29 | 2018-04-05 | Glaxosmithkline Biologicals S.A. | Compositions and methods of treatment of persistent hpv infection |
| EP3551193A4 (en) | 2016-12-08 | 2020-08-19 | Modernatx, Inc. | NUCLEIC ACID VACCINES AGAINST RESPIRATORY VIRUSES |
| JP7118062B2 (ja) | 2016-12-09 | 2022-08-15 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | リサウイルス抗原を有するチンパンジーアデノウイルス構築物 |
| GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
| GB201701239D0 (en) | 2017-01-25 | 2017-03-08 | Glaxosmithkline Biologicals Sa | Novel formulation |
| CN107119064A (zh) * | 2017-02-21 | 2017-09-01 | 南京农业大学 | 重组枯草芽孢杆菌串联表达禽流感病毒ha抗原片段和pb1－f2蛋白 |
| US20200299651A1 (en) | 2017-10-16 | 2020-09-24 | Glaxosmithkline Biologicals Sa | Simian adenoviral vectors with two expression cassettes |
| US11859199B2 (en) | 2017-10-16 | 2024-01-02 | Glaxosmithkline Biologicals Sa | Adenoviral vectors with two expression cassettes encoding RSV antigenic proteins or fragments thereof |
| MX394509B (es) | 2017-10-16 | 2025-03-12 | Glaxosmithkline Biologicals Sa | Promotor mejorado |
| CN111386126B (zh) * | 2017-10-25 | 2024-01-30 | Nouscom股份公司 | 真核细胞系 |
| KR20200101394A (ko) | 2017-12-20 | 2020-08-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 엡스타인-바 바이러스 항원 구축물 |
| MX2020013553A (es) | 2018-06-12 | 2021-02-26 | Glaxosmithkline Biologicals Sa | Polinucleotidos y polipeptidos de adenovirus. |
| WO2020014656A1 (en) * | 2018-07-13 | 2020-01-16 | University Of Georgia Research Foundation | Broadly reactive immunogens of influenza h3 virus, compositions and methods of use thereof |
| CN109180820B (zh) * | 2018-09-19 | 2021-06-25 | 天康生物制药有限公司 | 马流感病毒h3n8亚型的融合蛋白及其制备方法、应用和疫苗 |
| US12064478B2 (en) | 2018-09-21 | 2024-08-20 | Nutech Ventures | Methods of making and using universal centralized influenza vaccine genes |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| CN112220921B (zh) * | 2020-08-25 | 2022-08-16 | 北京交通大学 | 一种针对呼吸道合胞病毒感染的组合疫苗 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135312B2 (en) * | 1993-04-15 | 2006-11-14 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| DE19651443A1 (de) * | 1996-12-11 | 1998-06-18 | Hoechst Ag | Selbstverstärkende, pharmakologisch kontrollierbare Expressionssysteme |
| US7655774B2 (en) | 2000-02-18 | 2010-02-02 | University Of Washington | Ancestral and COT viral sequences, proteins and immunogenic compositions |
| US20040096451A1 (en) * | 2002-07-25 | 2004-05-20 | Young James F. | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| WO2003028759A1 (en) | 2001-09-28 | 2003-04-10 | University Of South Florida | Rsv gene expression vaccine |
| MXPA04004876A (es) * | 2001-11-21 | 2004-07-30 | Univ Pennsylvania | Secuencias de acido nucleico y de aminoacido de adenovirus de simio, vectores que contienen los mismos y metodos de uso. |
| TWI344991B (en) * | 2002-02-21 | 2011-07-11 | Medimmune Vaccines Inc | Metapneumovirus strains as vaccine formulations and as vectors for expression of heterologous antigenic sequences |
| US20050136035A1 (en) * | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
| EP1633312A4 (en) * | 2003-06-16 | 2012-09-26 | Medimmune Llc | INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS |
| JP4814800B2 (ja) | 2004-01-23 | 2011-11-16 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | チンパンジーアデノウイルスワクチン担体 |
| WO2007126887A2 (en) * | 2006-03-27 | 2007-11-08 | The Government Of The United States Of America | Immunogenic compositions comprising polynucleotides encoding matrix protein 2 and methods of use |
| EP2023952B1 (en) * | 2006-05-18 | 2015-07-15 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
| US9422342B2 (en) * | 2006-07-13 | 2016-08-23 | Institute Of Advanced Study | Recoding method that removes inhibitory sequences and improves HIV gene expression |
| DE202007018643U1 (de) | 2006-09-05 | 2009-01-02 | BSH Bosch und Siemens Hausgeräte GmbH | Bodendüse für Hartböden |
| WO2008133663A2 (en) * | 2006-11-30 | 2008-11-06 | Government Of The United States Of America, As Represented By The Secretary, | Codon modified immunogenic compositions and methods of use |
| WO2009092113A2 (en) * | 2008-01-19 | 2009-07-23 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for the delivery of vaccines to disrupted epithelium |
| US20100040650A1 (en) * | 2008-05-30 | 2010-02-18 | Crowe Jr James E | Virus-Like paramyxovirus particles and vaccines |
| CA2726914A1 (en) * | 2008-06-03 | 2009-12-10 | Okairos Ag | A vaccine for the prevention and therapy of hcv infections |
| JP5781929B2 (ja) * | 2008-07-15 | 2015-09-24 | ノバルティス アーゲー | 免疫原性の両親媒性ペプチド組成物 |
| WO2010077712A1 (en) * | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Bovine respiratory syncytial virus virus-like particle (vlps) |
| ES2987238T3 (es) * | 2008-12-09 | 2024-11-14 | Novavax Inc | Proteínas F del RSV modificadas y métodos de su uso |
| JP2010168288A (ja) * | 2009-01-20 | 2010-08-05 | Yokohama City Univ | 最適化した抗原遺伝子の使用によるウイルスワクチンの免疫原性の増強 |
| HUE039908T2 (hu) | 2009-02-02 | 2019-02-28 | Glaxosmithkline Biologicals Sa | Majom adenovírusból származó nukleinsav- és aminosav-szekvenciák, azt tartalmazó vektorok és alkalmazásuk |
-
2010
- 2010-12-30 WO PCT/EP2010/007995 patent/WO2012089231A1/en not_active Ceased
-
2011
- 2011-12-30 JP JP2013546722A patent/JP6324725B2/ja not_active Expired - Fee Related
- 2011-12-30 ES ES11805889T patent/ES2869199T3/es active Active
- 2011-12-30 EP EP11805889.0A patent/EP2658573B1/en active Active
- 2011-12-30 BR BR112013016823A patent/BR112013016823A2/pt not_active IP Right Cessation
- 2011-12-30 RU RU2013135498A patent/RU2609645C2/ru active
- 2011-12-30 KR KR1020137017082A patent/KR102070463B1/ko not_active Expired - Fee Related
- 2011-12-30 AU AU2011351380A patent/AU2011351380A1/en not_active Abandoned
- 2011-12-30 SG SG2013041348A patent/SG190919A1/en unknown
- 2011-12-30 PL PL11805889T patent/PL2658573T3/pl unknown
- 2011-12-30 NZ NZ610743A patent/NZ610743A/en not_active IP Right Cessation
- 2011-12-30 SG SG10201510760WA patent/SG10201510760WA/en unknown
- 2011-12-30 LT LTEP11805889.0T patent/LT2658573T/lt unknown
- 2011-12-30 CA CA2821111A patent/CA2821111A1/en active Pending
- 2011-12-30 DK DK11805889.0T patent/DK2658573T3/da active
- 2011-12-30 US US13/976,873 patent/US20140141042A1/en not_active Abandoned
- 2011-12-30 SI SI201131973T patent/SI2658573T1/sl unknown
- 2011-12-30 PT PT118058890T patent/PT2658573T/pt unknown
- 2011-12-30 WO PCT/EP2011/074307 patent/WO2012089833A2/en not_active Ceased
- 2011-12-30 MX MX2013007716A patent/MX352205B/es active IP Right Grant
- 2011-12-30 EP EP21158524.5A patent/EP3868397A1/en not_active Withdrawn
- 2011-12-30 CN CN201180063466.0A patent/CN103442731B/zh not_active Expired - Fee Related
- 2011-12-30 HU HUE11805889A patent/HUE053986T2/hu unknown
- 2011-12-30 HR HRP20210750TT patent/HRP20210750T1/hr unknown
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2013
- 2013-05-23 IL IL226551A patent/IL226551B/en active IP Right Grant
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2016
- 2016-03-11 US US15/068,115 patent/US20170049879A1/en not_active Abandoned
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2017
- 2017-01-13 JP JP2017004556A patent/JP2017079787A/ja active Pending
- 2017-05-12 AU AU2017203189A patent/AU2017203189B2/en not_active Ceased
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2020
- 2020-02-25 US US16/800,384 patent/US11701422B2/en active Active
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2021
- 2021-05-17 CY CY20211100421T patent/CY1124146T1/el unknown
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2023
- 2023-05-22 US US18/200,421 patent/US20240075125A1/en not_active Abandoned
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