HRP20190966T1 - Monovalentne smjese za vezivanje sa cd28 i metode upotrebe - Google Patents
Monovalentne smjese za vezivanje sa cd28 i metode upotrebe Download PDFInfo
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- HRP20190966T1 HRP20190966T1 HRP20190966TT HRP20190966T HRP20190966T1 HR P20190966 T1 HRP20190966 T1 HR P20190966T1 HR P20190966T T HRP20190966T T HR P20190966TT HR P20190966 T HRP20190966 T HR P20190966T HR P20190966 T1 HRP20190966 T1 HR P20190966T1
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- Prior art keywords
- seq
- antibody
- variable domain
- immunoglobulin variable
- peg
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 16
- 102000018358 immunoglobulin Human genes 0.000 claims 16
- 239000002202 Polyethylene glycol Substances 0.000 claims 14
- 229920001223 polyethylene glycol Polymers 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 1
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 1
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 1
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 230000006320 pegylation Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Claims (17)
1. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom koje se vezuje za CD28, koje sadrži CDR1 sekvencu sa SEQ ID NO:636, CDR2 sekvencu sa SEQ ID NO:637, i CDR3 sekvencu sa SEQ ID NO:638.
2. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz patentnog zahtjeva 1, koje sadrži aminokiselinsku sekvencu odabranu iz grupe koja se sastoji od SEQ ID NO:476, SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541, SEQ ID NO:542, SEQ ID NO:544, SEQ ID NO:545, i SEQ ID NO:546.
3. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz patentnog zahtjeva 1 ili 2, gdje je antitijelo vezano za polietilen-glikol (PEG) reakcijom PEGilacije.
4. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz patentnog zahtjeva 3, gdje je PEG linearan.
5. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz patentnog zahtjeva 3, gdje je PEG razgranat.
6. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz bilo kojeg od patentnih zahtjeva 3-5, gdje PEG ima oko 10 do oko 50 kD.
7. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz patentnog zahtjeva 3 ili patentnog zahtjeva 4, koje sadrži aminokiselinsku sekvencu sa SEQ ID NO:543, gdje PEG je linearni PEG od 30 kD, i gdje je PEG polimer vezan za D70C cisteinski ostatak.
8. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz patentnog zahtjeva 3 ili patentnog zahtjeva 5, koje sadrži aminokiselinsku sekvencu sa SEQ ID NO:543, gdje PEG je razgranati PEG od 40 kD, i gdje je PEG polimer vezan za D70C cisteinski ostatak.
9. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz patentnog zahtjeva 3 ili patentnog zahtjeva 5, koje se sastoji od aminokiselinske sekvence sa SEQ ID NO:543, gdje PEG je razgranati PEG od 40 kD, i gdje je PEG polimer vezan za D70C cisteinski ostatak.
10. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz bilo kojeg od patentnih zahtjeva 1-9, gdje antitijelo ima najmanje dvije karakteristike odabrane iz grupe koja se sastoji od:
a) ima Kd od oko 50 nM do oko 1pM za vezivanje za CD28 u tekstu
b) ima tα poluživot od oko 15 sekundi do oko 12 sati, i
c) ima tβ poluživot od oko 12 sati do oko 336 sati.
11. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom iz bilo kojeg patentnog zahtjeva 1-10 koje sadrži aminokiselinske sekvence od FW1, FW2, FW3, i FW4, gdje se sekvence od FW1, FW2, FW3, i FW4 razlikuju od FW1, FW2, FW3, i FW4 humanog antitijela po ne više od 10 aminokiselina, poželjno gdje
a) sekvence od FW1, FW2, FW3, i FW4 su identične sa FW1, FW2, FW3, i FW4 humanog antitijela, ili
b) sekvenca od FW2 je identična sa FW2 humanog antitijela.
12. Nukleinska kiselina koja kodira antitijelo sa jednim imunoglobulinskim varijabilnim domenom prema bilo kojem od patentnih zahtjeva 1-11.
13. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom prema bilo kojem od patentnih zahtjeva 1-11 za primjenu u metodi liječenja, ublažavanja ili sprečavanja autoimune bolesti ili bolesti u vezi sa kalemom, poželjno bolesti odabrane iz grupe koja se sastoji od odbacivanja alografta, odbacivanja transplantata ksenografta, bolesti presatka protiv domaćina, sistemskog eritematoznog lupusa, Sjogrenovog sindroma, multiple skleroze, reumatoidnog artritisa, dijabetesa, psorijaze, skleroderme, ateroskleroze, upalne bolesti crijeva, Kronove bolesti, ulceroznog kolitisa, i lupus nefritisa.
14. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom prema bilo kojem od patentnih zahtjeva 1-11 za primjenu prema patentnom zahtjevu 13, gdje je bolest odabrana iz grupe koja se sastoji od sistemskog eritematoznog lupusa, Sjogrenovog sindroma, upalne bolesti crijeva, Kronove bolesti, i ulceroznog kolitisa.
15. Antitijelo sa jednim imunoglobulinskim varijabilnim domenom prema bilo kojem od patentnih zahtjeva 1-11 za primjenu prema patentnom zahtjevu 13, gdje je bolest sistemski eritematozni lupus.
16. Farmaceutska smjesa koja sadrži terapijski-efikasnu količinu antitijela sa jednim imunoglobulinskim varijabilnim domenom iz bilo kojeg od patentnih zahtjeva 1-11 i farmaceutski prihvatljiv nosač.
17. Farmaceutska smjesa iz patentnog zahtjeva 16, koja uključuje još i imunosupresivni/imunomodulatorni i/ili antiinflamatorni agens.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8207808P | 2008-07-18 | 2008-07-18 | |
US16212109P | 2009-03-20 | 2009-03-20 | |
EP13185422.6A EP2700651B1 (en) | 2008-07-18 | 2009-07-17 | Compositions monovalent for CD28 binding and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20190966T1 true HRP20190966T1 (hr) | 2019-07-26 |
Family
ID=41226147
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160329TT HRP20160329T1 (hr) | 2008-07-18 | 2016-04-01 | Monovalentne smjese za vezivanje sa cd28 i metode uporabe |
HRP20190966TT HRP20190966T1 (hr) | 2008-07-18 | 2019-05-28 | Monovalentne smjese za vezivanje sa cd28 i metode upotrebe |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160329TT HRP20160329T1 (hr) | 2008-07-18 | 2016-04-01 | Monovalentne smjese za vezivanje sa cd28 i metode uporabe |
Country Status (30)
Country | Link |
---|---|
US (6) | US8168759B2 (hr) |
EP (2) | EP2321352B1 (hr) |
JP (3) | JP5675608B2 (hr) |
KR (2) | KR101791372B1 (hr) |
CN (2) | CN105936648B (hr) |
AR (1) | AR072571A1 (hr) |
AU (1) | AU2009270726B2 (hr) |
CA (1) | CA2731220C (hr) |
CL (2) | CL2011000117A1 (hr) |
CO (1) | CO6341641A2 (hr) |
CY (1) | CY1121796T1 (hr) |
DK (2) | DK2700651T3 (hr) |
EA (1) | EA024585B1 (hr) |
ES (2) | ES2562629T3 (hr) |
HK (1) | HK1155178A1 (hr) |
HR (2) | HRP20160329T1 (hr) |
HU (2) | HUE045249T2 (hr) |
IL (2) | IL210413A (hr) |
LT (1) | LT2700651T (hr) |
ME (1) | ME02396B (hr) |
MX (1) | MX2011000501A (hr) |
NZ (1) | NZ590343A (hr) |
PE (2) | PE20140852A1 (hr) |
PL (2) | PL2321352T3 (hr) |
PT (2) | PT2700651T (hr) |
RS (2) | RS58904B1 (hr) |
SI (2) | SI2700651T1 (hr) |
SM (1) | SMT201600090B (hr) |
TW (2) | TWI450725B (hr) |
WO (1) | WO2010009391A1 (hr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1888640B1 (en) | 2005-05-18 | 2012-03-14 | Ablynx N.V. | Improved nanobodies against tumor necrosis factor-alpha |
US8168759B2 (en) | 2008-07-18 | 2012-05-01 | Bristol-Myers Squibb Company | Compositions monovalent for CD28 binding and methods of use |
US20110097339A1 (en) * | 2008-07-18 | 2011-04-28 | Domantis Limited | Compositions monovalent for CD28 binding and methods of use |
US8946128B2 (en) * | 2009-02-25 | 2015-02-03 | Nextera As | Signal sequence-independent pIX phage display |
FR2951176A1 (fr) * | 2009-10-09 | 2011-04-15 | Tcl Pharma | Ligands monovalents du recepteur cd28 humain |
EP2361935A1 (en) * | 2010-02-18 | 2011-08-31 | TcL Pharma | Anti-CD28 humanized antibodies |
CA2788544C (en) | 2010-02-18 | 2019-03-05 | Effimune | Anti-cd28 humanized antibodies |
CN114246952A (zh) * | 2010-06-08 | 2022-03-29 | 基因泰克公司 | 半胱氨酸改造的抗体和偶联物 |
JP5768022B2 (ja) * | 2012-03-19 | 2015-08-26 | 株式会社東芝 | メモリコントローラ、記憶装置、誤り訂正装置および誤り訂正方法 |
WO2014120916A1 (en) | 2013-02-01 | 2014-08-07 | Bristol-Myers Squibb Company | Pegylated domain antibodies monovalent for cd28 binding and methods of use |
US10654933B2 (en) * | 2013-12-27 | 2020-05-19 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying antibody having low isoelectric point |
MX2016011102A (es) * | 2014-03-19 | 2017-01-26 | Bristol Myers Squibb Co | Metodos para tratar rechazo al trasplante usando un anticuerpo de dominio dirigido contra cd40l. |
KR20170052600A (ko) | 2014-09-12 | 2017-05-12 | 제넨테크, 인크. | 시스테인 가공된 항체 및 콘주게이트 |
JP2017535524A (ja) * | 2014-09-30 | 2017-11-30 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Cd28を標的とするドメイン抗体を用いる全身性エリテマトーデスの処置法 |
WO2017160975A1 (en) | 2016-03-16 | 2017-09-21 | Bristol-Myers Squibb Company | Methods of diagnosing and treating lupus |
WO2018106959A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
EP4108183A1 (en) | 2017-03-30 | 2022-12-28 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
EP3619235A1 (en) | 2017-04-11 | 2020-03-11 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
CA3103629A1 (en) | 2018-06-15 | 2019-12-19 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
EP3830579A1 (en) | 2018-08-03 | 2021-06-09 | Bristol-Myers Squibb Company | Methods for detecting anti-drug antibodies |
WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
CA3130351A1 (en) * | 2019-03-14 | 2020-09-17 | Motti HAKIM | Small shedding blocking agents |
EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
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