HRP20181743T1 - Poboljšani postupci za pročišćavanje rekombinantnih aav vektora - Google Patents
Poboljšani postupci za pročišćavanje rekombinantnih aav vektoraInfo
- Publication number
- HRP20181743T1 HRP20181743T1 HRP20181743TT HRP20181743T HRP20181743T1 HR P20181743 T1 HRP20181743 T1 HR P20181743T1 HR P20181743T T HRP20181743T T HR P20181743TT HR P20181743 T HRP20181743 T HR P20181743T HR P20181743 T1 HRP20181743 T1 HR P20181743T1
- Authority
- HR
- Croatia
- Prior art keywords
- purification
- improved methods
- aav vectors
- recombinant aav
- recombinant
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18760109P | 2009-06-16 | 2009-06-16 | |
EP16166278.8A EP3067417B1 (en) | 2009-06-16 | 2010-06-16 | Improved methods for purification of recombinant aav vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20181743T1 true HRP20181743T1 (hr) | 2019-02-22 |
Family
ID=43356746
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20181743TT HRP20181743T1 (hr) | 2009-06-16 | 2018-10-23 | Poboljšani postupci za pročišćavanje rekombinantnih aav vektora |
HRP20211120TT HRP20211120T1 (hr) | 2009-06-16 | 2021-07-13 | Poboljšani postupci za pročišćavanje rekombinantnih aav vektora |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20211120TT HRP20211120T1 (hr) | 2009-06-16 | 2021-07-13 | Poboljšani postupci za pročišćavanje rekombinantnih aav vektora |
Country Status (24)
Country | Link |
---|---|
US (3) | US10017746B2 (hr) |
EP (4) | EP3444335B1 (hr) |
JP (3) | JP5956331B2 (hr) |
KR (2) | KR101812813B1 (hr) |
CN (2) | CN105861454B (hr) |
BR (1) | BRPI1015176B1 (hr) |
CA (2) | CA2764176C (hr) |
CY (3) | CY1117936T1 (hr) |
DK (2) | DK3067417T3 (hr) |
ES (3) | ES2588990T3 (hr) |
HK (1) | HK1165830A1 (hr) |
HR (2) | HRP20181743T1 (hr) |
HU (3) | HUE054940T2 (hr) |
IL (3) | IL216960A (hr) |
LT (2) | LT3444335T (hr) |
MX (2) | MX352986B (hr) |
PL (2) | PL3067417T3 (hr) |
PT (3) | PT2443233T (hr) |
RS (2) | RS62086B1 (hr) |
RU (1) | RU2016119739A (hr) |
SG (2) | SG176283A1 (hr) |
SI (2) | SI3067417T1 (hr) |
TR (1) | TR201815937T4 (hr) |
WO (1) | WO2010148143A1 (hr) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9198984B2 (en) | 2006-04-28 | 2015-12-01 | The Trustees Of The University Of Pennsylvania | Scalable production method for AAV |
BRPI1015176B1 (pt) | 2009-06-16 | 2019-10-29 | Genzyme Corp | método para isolar uma população de partículas de vírus adenoassociado recombinante (raav) de impurezas de processo em uma corrente de alimentação |
CA2787009C (en) | 2010-01-15 | 2018-04-03 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
US9592540B2 (en) | 2011-02-02 | 2017-03-14 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
SG193378A1 (en) | 2011-03-16 | 2013-10-30 | Hoffmann La Roche | Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase |
JP6007463B2 (ja) * | 2011-04-18 | 2016-10-12 | 国立研究開発法人国立精神・神経医療研究センター | 薬剤送達粒子及びその製造方法 |
DK2744895T3 (en) * | 2011-09-08 | 2016-01-04 | Uniqure Ip Bv | REMOVAL OF INFECTED VIRA FROM AAV PREPARATIONS |
WO2013180933A1 (en) * | 2012-05-30 | 2013-12-05 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
KR20150023297A (ko) * | 2012-05-31 | 2015-03-05 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 고상 우레이드에 대한 생물학적 표적의 선택적 결합 |
GB2525562B (en) * | 2013-02-15 | 2017-10-11 | T Gjerde Douglas | Methods for purification of biological cells |
US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
ES2681434T3 (es) * | 2013-03-15 | 2018-09-13 | The Children's Hospital Of Philadelphia | Procedimiento de fabricación escalable para producir vectores lentivirales recombinantes en un sistema de cultivo celular en suspensión libre de suero |
SG10201912901YA (en) | 2013-04-17 | 2020-02-27 | Genzyme Corp | Compositions and methods for treating and preventing macular degeneration |
KR102069561B1 (ko) * | 2013-07-11 | 2020-01-23 | 다카라 바이오 가부시키가이샤 | 외피 비보유 바이러스의 제조 방법 |
CA2938828A1 (en) | 2014-02-06 | 2015-08-13 | Genzyme Corporation | Compositions and methods for treating and preventing macular degeneration |
MX2016014220A (es) | 2014-05-02 | 2017-02-06 | Genzyme Corp | Vectores de aav para la terapia genica de la retina y el snc. |
WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
CN105407917B (zh) | 2014-06-23 | 2021-07-06 | 生物辐射实验室股份有限公司 | 磷灰石原位恢复 |
US9802822B2 (en) | 2014-06-23 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
US10023846B2 (en) | 2014-07-10 | 2018-07-17 | Takara Bio Inc. | Production method for non-enveloped virus particles |
CN104232687A (zh) * | 2014-09-17 | 2014-12-24 | 许瑞安 | 一种重组腺相关病毒rAAV载体的分离纯化方法 |
RU2020109343A (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
DK3218386T3 (da) | 2014-11-14 | 2021-06-07 | Voyager Therapeutics Inc | Modulatorisk polynukleotid |
EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
CN107109374B (zh) | 2015-01-09 | 2021-04-06 | 宝生物工程株式会社 | 用于生产无包膜病毒颗粒的方法 |
IL296391B2 (en) | 2015-01-20 | 2024-06-01 | Genzyme Corp | Analytical ultracentrifugation for characterization of recombinant viral particles |
EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
EP3054006A1 (en) * | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification with multiple-step anion exchange chromatography |
SG10201907399RA (en) | 2015-02-10 | 2019-09-27 | Genzyme Corp | Enhanced delivery of viral particles to the striatum and cortex |
TWI707951B (zh) | 2015-04-08 | 2020-10-21 | 美商健臻公司 | 過大腺相關載體之製造 |
CN105907729B (zh) * | 2015-05-05 | 2019-08-16 | 广东东阳光药业有限公司 | 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法 |
US20170067028A1 (en) * | 2015-05-15 | 2017-03-09 | Douglas J. Ballon | Radiolabeling of adeno associated virus |
WO2016186772A2 (en) | 2015-05-16 | 2016-11-24 | Genzyme Corporation | Gene editing of deep intronic mutations |
US9663766B2 (en) * | 2015-07-24 | 2017-05-30 | Bio-Rad Laboratories, Inc. | Methods for purifying adenovirus vectors |
EP4215605A1 (en) | 2015-12-11 | 2023-07-26 | The Trustees of The University of Pennsylvania | Scalable purification method for aav8 |
WO2017160360A2 (en) | 2015-12-11 | 2017-09-21 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav9 |
US11015173B2 (en) | 2015-12-11 | 2021-05-25 | The Trustees Of The University Of Pennsylvania | Scalable purification method for AAV1 |
WO2017100704A1 (en) | 2015-12-11 | 2017-06-15 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aavrh10 |
CA3008268A1 (en) | 2015-12-15 | 2017-06-22 | Genzyme Corporation | Adeno-associated viral vectors for treating mucolipidosis type ii |
US11208630B2 (en) | 2015-12-24 | 2021-12-28 | University Of Florida Research Foundation, Incorporated | AAV production using suspension adapted cells |
WO2017172772A1 (en) * | 2016-03-28 | 2017-10-05 | Dimension Therapeutics | Methods of heat inactivation of adenovirus |
JP7364306B2 (ja) | 2016-03-31 | 2023-10-18 | スパーク セラピューティクス インコーポレイテッド | カラムに基づく高度にスケーラブルなrAAVの製造プロセス |
US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
GB201608046D0 (en) | 2016-05-09 | 2016-06-22 | Cambridge Entpr Ltd And Syndey Children S Hospitals Network Randwick And Westmead Incorporating The | Treatment of complement-mediated disorders |
IL302748A (en) | 2016-05-18 | 2023-07-01 | Voyager Therapeutics Inc | modulatory polynucleotides |
CN109831916B (zh) | 2016-05-18 | 2023-07-21 | 沃雅戈治疗公司 | 治疗亨廷顿氏舞蹈病的组合物和方法 |
GB201612248D0 (en) | 2016-07-14 | 2016-08-31 | Puridify Ltd | New process |
TN2019000047A1 (en) | 2016-08-15 | 2020-07-15 | Genzyme Corp | Methods for detecting aav |
MY196321A (en) | 2016-08-16 | 2023-03-24 | Regeneron Pharma | Methods for Quantitating Individual Antibodies From a Mixture |
CN110225975A (zh) | 2016-08-23 | 2019-09-10 | 阿库斯股份有限公司 | 用于治疗人受试者中非年龄相关的听力损害的组合物和方法 |
EP3831281A1 (en) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
WO2018071817A1 (en) | 2016-10-14 | 2018-04-19 | Dimension Therapeutics | Use of tonicifying agents to enhance recombinant adeno-associated virus yield |
WO2018081203A1 (en) | 2016-10-25 | 2018-05-03 | Regeneron Pharmaceuticals, Inc. | Methods and systems for chromatography data analysis |
JP7071348B2 (ja) * | 2016-11-04 | 2022-05-18 | 武田薬品工業株式会社 | アデノ随伴ウイルスの精製法 |
US10626376B2 (en) * | 2016-11-14 | 2020-04-21 | St. Jude Children's Research Hospital | Method for isolating and purifying adeno-associated virus particles using salt |
JP7142643B2 (ja) | 2017-03-22 | 2022-09-27 | ウルトラジェニックス ファーマシューティカル インコーポレイテッド | Hdac阻害剤またはrepタンパク質を伴う細胞培養方法 |
CN110913866A (zh) | 2017-05-05 | 2020-03-24 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
US11752181B2 (en) | 2017-05-05 | 2023-09-12 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's disease |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
CA3068622A1 (en) * | 2017-06-30 | 2019-01-03 | Spark Therapeutics, Inc. | Aav vector column purification methods |
WO2019018342A1 (en) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | NETWORK EQUIPMENT TRACK GUIDE SYSTEM |
EP3662060A2 (en) | 2017-08-03 | 2020-06-10 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
JP7502991B2 (ja) | 2017-10-16 | 2024-06-19 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症(als)の治療 |
JP7299896B2 (ja) | 2017-12-29 | 2023-06-28 | 武田薬品工業株式会社 | アデノ随伴ウイルス精製方法 |
US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
JP7244547B2 (ja) | 2018-02-19 | 2023-03-22 | ホモロジー・メディシンズ・インコーポレイテッド | F8遺伝子機能を回復させるためのアデノ随伴ウイルス組成物及びその使用の方法 |
WO2019212921A1 (en) * | 2018-04-29 | 2019-11-07 | Regenxbio Inc. | Scalable clarification process for recombinant aav production |
TW202005694A (zh) | 2018-07-02 | 2020-02-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
US20210355454A1 (en) * | 2018-07-24 | 2021-11-18 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
JP7070238B2 (ja) * | 2018-08-22 | 2022-05-18 | 株式会社島津製作所 | 液体クロマトグラフ分析装置、移動相供給装置、液体クロマトグラフ分析方法および移動相供給方法 |
JP2022501037A (ja) * | 2018-09-21 | 2022-01-06 | ナイトスター リミテッド | 遺伝子治療用ベクターを製造するための組成物及び方法 |
CN113194982A (zh) | 2018-10-12 | 2021-07-30 | 建新公司 | 通过肝导向基因替代疗法治疗严重pku的改良的人pah的产生 |
TW202039854A (zh) | 2018-11-16 | 2020-11-01 | 美商編碼製藥公司 | 治療威爾遜氏病的組合物和方法 |
US20220280655A1 (en) | 2019-04-23 | 2022-09-08 | Institut National de la Santé et de la Recherche Médicale | New Adeno-Associated Virus (AAV) Variants and Uses Thereof for Gene Therapy |
US10801042B1 (en) | 2019-07-15 | 2020-10-13 | Vigene Biosciences, Inc. | Use of ion concentrations to increase the packaging efficiency of recombinant adeno-associated virus |
US10653731B1 (en) | 2019-07-15 | 2020-05-19 | Vigene Biosciences Inc. | Recombinantly-modified adeno-associated virus (rAAV) having improved packaging efficiency |
US10557149B1 (en) | 2019-07-15 | 2020-02-11 | Vigene Biosciences, Inc. | Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus |
TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
JP2023513004A (ja) | 2020-01-29 | 2023-03-30 | ジェンザイム・コーポレーション | 眼科遺伝子療法のための改変されたアデノ随伴ウイルスカプシドタンパク質およびその使用方法 |
WO2021168362A1 (en) | 2020-02-21 | 2021-08-26 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
EP3919613A1 (en) * | 2020-06-05 | 2021-12-08 | Bia Separations D.O.O. | Enhanced purification of adeno-associated virus to more effectively remove contaminating dna |
WO2021255835A1 (ja) * | 2020-06-16 | 2021-12-23 | HOYA Technosurgical株式会社 | アパタイトカラムを使用したウイルスの精製方法 |
CN111808828B (zh) * | 2020-09-14 | 2020-11-17 | 和元生物技术(上海)股份有限公司 | 腺相关病毒的分离纯化方法 |
TW202229559A (zh) | 2020-10-01 | 2022-08-01 | 美商健臻公司 | 藉由肝導向基因替代療法治療pku之人類pah表現匣 |
WO2022191168A1 (ja) | 2021-03-09 | 2022-09-15 | Jcrファーマ株式会社 | 組換えaav9ビリオンの製造方法 |
CN117460832A (zh) | 2021-03-22 | 2024-01-26 | 建新公司 | 空aav衣壳和完整aav衣壳的尺寸排阻色谱分析 |
US20230407255A1 (en) | 2022-04-12 | 2023-12-21 | Genzyme Corporation | Dendritic cell assay for innate immunogenicity to gene therapy agents |
WO2023201274A1 (en) | 2022-04-12 | 2023-10-19 | Genzyme Corporation | Use of an irak4 modulator for gene therapy |
TW202400250A (zh) | 2022-04-12 | 2024-01-01 | 美商健臻公司 | Irak4調節劑於基因療法之用途(一) |
US20230346977A1 (en) | 2022-04-13 | 2023-11-02 | Universitat Autònoma De Barcelona | Treatment of neuromuscular diseases via gene therapy that expresses klotho protein |
WO2023225481A1 (en) | 2022-05-16 | 2023-11-23 | Genzyme Corporation | Methods of treating metachromatic leukodystrophy |
WO2023240062A1 (en) | 2022-06-07 | 2023-12-14 | Adverum Biotechnologies, Inc. | Melanopsin variants for vision restoration |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0847442A1 (en) * | 1995-08-30 | 1998-06-17 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
CA2995542A1 (en) | 1997-09-05 | 1999-03-11 | Genzyme Corporation | Methods for generating high titer helper-free preparations of recombinant aav vectors |
US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
US7419817B2 (en) | 2002-05-17 | 2008-09-02 | The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. | Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography |
EP1841863B1 (en) * | 2005-01-14 | 2010-08-04 | Bayer HealthCare LLC | Method for purification of factor vii |
US8481693B2 (en) * | 2007-03-14 | 2013-07-09 | Takeda Vaccines (Montana), Inc. | Virus like particle purification |
GB2467320A (en) | 2009-01-28 | 2010-08-04 | Surrey Nanosystems Ltd | Two methods of forming carbon nano-materials using filtered acetylene gas |
BRPI1015176B1 (pt) * | 2009-06-16 | 2019-10-29 | Genzyme Corp | método para isolar uma população de partículas de vírus adenoassociado recombinante (raav) de impurezas de processo em uma corrente de alimentação |
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