HRP20161349T1 - 7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]piramidin-2-il]-1,7-diazaspiro[4.4]nonan-6-on - Google Patents

7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]piramidin-2-il]-1,7-diazaspiro[4.4]nonan-6-on Download PDF

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Publication number
HRP20161349T1
HRP20161349T1 HRP20161349TT HRP20161349T HRP20161349T1 HR P20161349 T1 HRP20161349 T1 HR P20161349T1 HR P20161349T T HRP20161349T T HR P20161349TT HR P20161349 T HRP20161349 T HR P20161349T HR P20161349 T1 HRP20161349 T1 HR P20161349T1
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Croatia
Prior art keywords
compound
formula
methyl
pharmaceutically acceptable
diazaspiro
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HRP20161349TT
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English (en)
Croatian (hr)
Inventor
Gerard MP Giblin
David T Macpherson
David R Witty
Steven J STANWAY
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Convergence Pharmaceuticals Limited
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Publication date
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Publication of HRP20161349T1 publication Critical patent/HRP20161349T1/hr

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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HRP20161349TT 2012-05-22 2013-05-22 7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]piramidin-2-il]-1,7-diazaspiro[4.4]nonan-6-on HRP20161349T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
US201361773710P 2013-03-06 2013-03-06
PCT/GB2013/051335 WO2013175205A1 (en) 2012-05-22 2013-05-22 Novel Compounds
EP13725438.9A EP2861602B1 (en) 2012-05-22 2013-05-22 7-Methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one

Publications (1)

Publication Number Publication Date
HRP20161349T1 true HRP20161349T1 (hr) 2017-01-27

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HRP20161349TT HRP20161349T1 (hr) 2012-05-22 2013-05-22 7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]piramidin-2-il]-1,7-diazaspiro[4.4]nonan-6-on
HRP20200580TT HRP20200580T1 (hr) 2012-05-22 2020-04-06 Novi spojevi

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20200580TT HRP20200580T1 (hr) 2012-05-22 2020-04-06 Novi spojevi

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US (7) US9376445B2 (https=)
EP (3) EP3106464B1 (https=)
JP (3) JP2015517562A (https=)
KR (2) KR102161101B1 (https=)
CN (2) CN107344942B (https=)
AU (3) AU2013265001B2 (https=)
BR (1) BR112014029280B1 (https=)
CA (1) CA2873956C (https=)
CY (2) CY1118274T1 (https=)
DK (2) DK3106464T3 (https=)
EA (1) EA025579B1 (https=)
ES (3) ES2782088T3 (https=)
GB (1) GB201209015D0 (https=)
HR (2) HRP20161349T1 (https=)
HU (2) HUE049445T2 (https=)
IL (4) IL235805A (https=)
IN (1) IN2014MN02393A (https=)
LT (2) LT2861602T (https=)
MX (1) MX355303B (https=)
PL (2) PL3106464T3 (https=)
PT (2) PT3106464T (https=)
RS (2) RS55415B1 (https=)
SG (2) SG11201407755UA (https=)
SI (2) SI2861602T1 (https=)
SM (2) SMT202000210T1 (https=)
WO (2) WO2013175206A1 (https=)
ZA (1) ZA201408253B (https=)

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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) * 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
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WO2022133097A1 (en) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthesis of compounds that modulate use-dependent voltage-gated sodium channels

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GB0520578D0 (en) * 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
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GB201209015D0 (en) * 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds

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IL235805A0 (en) 2015-02-01
AU2013265001B2 (en) 2016-12-01
PT2861602T (pt) 2016-11-14
KR20150023401A (ko) 2015-03-05
IL235805A (en) 2017-05-29
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JP6378404B2 (ja) 2018-08-22
AU2018201653B2 (en) 2019-05-02
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SMT201600421B (it) 2017-01-10
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BR112014029280B1 (pt) 2022-10-04
US9376445B2 (en) 2016-06-28
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US20150119404A1 (en) 2015-04-30
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AU2017201421A1 (en) 2017-03-23
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US10010551B2 (en) 2018-07-03
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