PL2861602T3 - 7-metylo-2-[4-metylo-6-[4-(trifluorometylo)-fenylo]pirymidyn-2-ylo]-1,7-diazaspiro[4.4]nonano-6-on - Google Patents

7-metylo-2-[4-metylo-6-[4-(trifluorometylo)-fenylo]pirymidyn-2-ylo]-1,7-diazaspiro[4.4]nonano-6-on

Info

Publication number
PL2861602T3
PL2861602T3 PL13725438T PL13725438T PL2861602T3 PL 2861602 T3 PL2861602 T3 PL 2861602T3 PL 13725438 T PL13725438 T PL 13725438T PL 13725438 T PL13725438 T PL 13725438T PL 2861602 T3 PL2861602 T3 PL 2861602T3
Authority
PL
Poland
Prior art keywords
methyl
diazaspiro
nonan
pyrimidin
trifluoromethyl
Prior art date
Application number
PL13725438T
Other languages
English (en)
Inventor
Gerard M P Giblin
David T Macpherson
David R Witty
Steven J Stanway
Original Assignee
Convergence Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Convergence Pharmaceuticals Limited filed Critical Convergence Pharmaceuticals Limited
Publication of PL2861602T3 publication Critical patent/PL2861602T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Hematology (AREA)
  • Reproductive Health (AREA)
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  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL13725438T 2012-05-22 2013-05-22 7-metylo-2-[4-metylo-6-[4-(trifluorometylo)-fenylo]pirymidyn-2-ylo]-1,7-diazaspiro[4.4]nonano-6-on PL2861602T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
US201361773710P 2013-03-06 2013-03-06
EP13725438.9A EP2861602B1 (en) 2012-05-22 2013-05-22 7-Methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one

Publications (1)

Publication Number Publication Date
PL2861602T3 true PL2861602T3 (pl) 2017-05-31

Family

ID=46546493

Family Applications (2)

Application Number Title Priority Date Filing Date
PL13725438T PL2861602T3 (pl) 2012-05-22 2013-05-22 7-metylo-2-[4-metylo-6-[4-(trifluorometylo)-fenylo]pirymidyn-2-ylo]-1,7-diazaspiro[4.4]nonano-6-on
PL16177700T PL3106464T3 (pl) 2012-05-22 2013-05-22 Nowatorskie związki

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL16177700T PL3106464T3 (pl) 2012-05-22 2013-05-22 Nowatorskie związki

Country Status (28)

Country Link
US (7) US9309254B2 (pl)
EP (3) EP2861594B1 (pl)
JP (3) JP6169687B2 (pl)
KR (2) KR102161101B1 (pl)
CN (2) CN104640867B (pl)
AU (3) AU2013265001B2 (pl)
BR (1) BR112014029280B1 (pl)
CA (1) CA2873956C (pl)
CY (2) CY1118274T1 (pl)
DK (2) DK2861602T3 (pl)
EA (1) EA025579B1 (pl)
ES (3) ES2602308T3 (pl)
GB (1) GB201209015D0 (pl)
HK (1) HK1209423A1 (pl)
HR (2) HRP20161349T1 (pl)
HU (2) HUE031664T2 (pl)
IL (4) IL235805A (pl)
IN (1) IN2014MN02393A (pl)
LT (2) LT2861602T (pl)
MX (1) MX355303B (pl)
PL (2) PL2861602T3 (pl)
PT (2) PT3106464T (pl)
RS (2) RS55415B1 (pl)
SG (2) SG11201407755UA (pl)
SI (2) SI2861602T1 (pl)
SM (1) SMT201600421B (pl)
WO (2) WO2013175206A1 (pl)
ZA (1) ZA201408253B (pl)

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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) * 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
CN111343978A (zh) * 2017-09-28 2020-06-26 生物基因公司 新型盐
EP3694510A4 (en) 2017-10-10 2021-06-30 Biogen Inc. SPIRO DERIVATIVE PREPARATION PROCESS
WO2022133097A1 (en) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthesis of compounds that modulate use-dependent voltage-gated sodium channels

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MXPA05000370A (es) * 2002-07-05 2005-04-19 Targacept Inc Compuestos n-aril diazaespiraciclicos y metodos de preparacion y usos de los mismos.
GB0520578D0 (en) * 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
EP1943216B1 (en) 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
US8143306B2 (en) 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
JP2009511599A (ja) * 2005-10-12 2009-03-19 バーテックス ファーマシューティカルズ インコーポレイテッド 電位依存性イオンチャネルの調整剤としてのビフェニル誘導体
WO2007084314A2 (en) * 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
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US20110237567A9 (en) * 2006-10-12 2011-09-29 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
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GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
KR20140139000A (ko) * 2012-03-21 2014-12-04 인터디지탈 패튼 홀딩스, 인크 무선 네트워크에서 다른 이동국에 의한 이동국 세션의 스폰서링
GB201209015D0 (en) * 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds

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JP2015517561A (ja) 2015-06-22
JP2017206534A (ja) 2017-11-24
MX355303B (es) 2018-04-12
MX2014014274A (es) 2015-06-17
PT2861602T (pt) 2016-11-14
LT3106464T (lt) 2020-04-10
IN2014MN02393A (pl) 2015-08-21
EP2861602A1 (en) 2015-04-22
US20170304303A1 (en) 2017-10-26
HUE049445T2 (hu) 2020-09-28
CY1118274T1 (el) 2017-06-28
EP3106464A1 (en) 2016-12-21
RS55415B1 (sr) 2017-04-28
ZA201408253B (en) 2015-12-23
DK3106464T3 (da) 2020-03-23
HRP20200580T1 (hr) 2020-10-02
US10010551B2 (en) 2018-07-03
AU2018201653A1 (en) 2018-03-29
LT2861602T (lt) 2016-11-10
RS60368B1 (sr) 2020-07-31
US20150166551A1 (en) 2015-06-18
KR20200113027A (ko) 2020-10-05
JP2015517562A (ja) 2015-06-22
US20200289508A1 (en) 2020-09-17
KR20150023401A (ko) 2015-03-05
US20160263115A1 (en) 2016-09-15
IL280595A (en) 2021-03-25
ES2602193T3 (es) 2017-02-20
KR102161101B1 (ko) 2020-10-20
CA2873956C (en) 2021-03-23
EP2861602B1 (en) 2016-08-10
AU2013265001B2 (en) 2016-12-01
AU2017201421A1 (en) 2017-03-23
SI2861602T1 (sl) 2017-03-31
GB201209015D0 (en) 2012-07-04
IL252033A0 (en) 2017-06-29
IL235805A (en) 2017-05-29
ES2782088T3 (es) 2020-09-10
IL271330A (en) 2020-01-30
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