KR20200113027A - 신규 화합물 - Google Patents

신규 화합물 Download PDF

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Publication number
KR20200113027A
KR20200113027A KR1020207027461A KR20207027461A KR20200113027A KR 20200113027 A KR20200113027 A KR 20200113027A KR 1020207027461 A KR1020207027461 A KR 1020207027461A KR 20207027461 A KR20207027461 A KR 20207027461A KR 20200113027 A KR20200113027 A KR 20200113027A
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KR
South Korea
Prior art keywords
acid
methyl
disorder
mmol
compounds
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KR1020207027461A
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English (en)
Korean (ko)
Inventor
제라드 엠 피 기블린
데이비드 티 맥퍼슨
데이비드 알 위티
스티븐 제이 스탠웨이
Original Assignee
컨버전스 파마슈티컬즈 리미티드
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Publication of KR20200113027A publication Critical patent/KR20200113027A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020207027461A 2012-05-22 2013-05-22 신규 화합물 Ceased KR20200113027A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
GB1209015.5 2012-05-22
US61/650,325 2012-05-22
US201361773710P 2013-03-06 2013-03-06
US61/773,710 2013-03-06
PCT/GB2013/051335 WO2013175205A1 (en) 2012-05-22 2013-05-22 Novel Compounds

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147035444A Division KR102161101B1 (ko) 2012-05-22 2013-05-22 신규 화합물

Publications (1)

Publication Number Publication Date
KR20200113027A true KR20200113027A (ko) 2020-10-05

Family

ID=46546493

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020207027461A Ceased KR20200113027A (ko) 2012-05-22 2013-05-22 신규 화합물
KR1020147035444A Expired - Fee Related KR102161101B1 (ko) 2012-05-22 2013-05-22 신규 화합물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147035444A Expired - Fee Related KR102161101B1 (ko) 2012-05-22 2013-05-22 신규 화합물

Country Status (27)

Country Link
US (7) US9376445B2 (https=)
EP (3) EP2861602B1 (https=)
JP (3) JP2015517562A (https=)
KR (2) KR20200113027A (https=)
CN (2) CN104640867B (https=)
AU (3) AU2013265001B2 (https=)
BR (1) BR112014029280B1 (https=)
CA (1) CA2873956C (https=)
CY (2) CY1118274T1 (https=)
DK (2) DK2861602T3 (https=)
EA (1) EA025579B1 (https=)
ES (3) ES2782088T3 (https=)
GB (1) GB201209015D0 (https=)
HR (2) HRP20161349T1 (https=)
HU (2) HUE049445T2 (https=)
IL (4) IL235805A (https=)
IN (1) IN2014MN02393A (https=)
LT (2) LT2861602T (https=)
MX (1) MX355303B (https=)
PL (2) PL3106464T3 (https=)
PT (2) PT2861602T (https=)
RS (2) RS60368B1 (https=)
SG (2) SG11201407755UA (https=)
SI (2) SI3106464T1 (https=)
SM (2) SMT202000210T1 (https=)
WO (2) WO2013175206A1 (https=)
ZA (1) ZA201408253B (https=)

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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
EA202090853A1 (ru) * 2017-09-28 2020-08-27 Байоджен Инк. Новые соли
US11149039B2 (en) * 2017-10-10 2021-10-19 Biogen Inc. Process for preparing spiro derivatives
WO2022133097A1 (en) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthesis of compounds that modulate use-dependent voltage-gated sodium channels

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DK1519939T5 (da) * 2002-07-05 2011-01-24 Targacept Inc N-Aryl-diazaspirocykliske forbindelser og fremgangsmåder til fremstilling og anvendelse deraf
US8143306B2 (en) 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
TW200728258A (en) * 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
GB0520578D0 (en) * 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
EP1943216B1 (en) 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
EP1934191B1 (en) * 2005-10-12 2012-03-28 Vertex Pharmaceuticals, Inc. Biphenyl derivatives as modulators of voltage gated ion channels
WO2007084314A2 (en) * 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
AU2007307635A1 (en) 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
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CN104205726B (zh) * 2012-03-21 2018-02-13 交互数字专利控股公司 在无线网络中由另一移动基站赞助的移动基站会话
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds

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AU2013265001B2 (en) 2016-12-01
LT2861602T (lt) 2016-11-10
US20150119404A1 (en) 2015-04-30
IL252033A0 (en) 2017-06-29
EP2861602A1 (en) 2015-04-22
IL235805A0 (en) 2015-02-01
JP6169687B2 (ja) 2017-07-26
AU2013265001A1 (en) 2014-12-18
US10485801B2 (en) 2019-11-26
BR112014029280A2 (pt) 2017-06-27
US10010551B2 (en) 2018-07-03
ES2602308T3 (es) 2017-02-20
JP2017206534A (ja) 2017-11-24
LT3106464T (lt) 2020-04-10
CN104640867A (zh) 2015-05-20
SI2861602T1 (sl) 2017-03-31
HK1209423A1 (en) 2016-04-01
RS60368B1 (sr) 2020-07-31
MX355303B (es) 2018-04-12
US20180360833A1 (en) 2018-12-20
HUE031664T2 (en) 2017-07-28
US9309254B2 (en) 2016-04-12
CY1118274T1 (el) 2017-06-28
BR112014029280B1 (pt) 2022-10-04
SG10201703527WA (en) 2017-06-29
PL3106464T3 (pl) 2020-11-16
IL252033B (en) 2019-12-31
ES2602193T3 (es) 2017-02-20
HRP20200580T1 (hr) 2020-10-02
KR20150023401A (ko) 2015-03-05
EP3106464A1 (en) 2016-12-21
AU2018201653A1 (en) 2018-03-29
JP2015517562A (ja) 2015-06-22
DK3106464T3 (da) 2020-03-23
HRP20161349T1 (hr) 2017-01-27
US20150166551A1 (en) 2015-06-18
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