HRP20160872T1 - Postupak za inhibiciju resorpcije kosti - Google Patents
Postupak za inhibiciju resorpcije kosti Download PDFInfo
- Publication number
- HRP20160872T1 HRP20160872T1 HRP20160872TT HRP20160872T HRP20160872T1 HR P20160872 T1 HRP20160872 T1 HR P20160872T1 HR P20160872T T HRP20160872T T HR P20160872TT HR P20160872 T HRP20160872 T HR P20160872T HR P20160872 T1 HRP20160872 T1 HR P20160872T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- bone loss
- seq
- fragment
- disease
- Prior art date
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- 238000000034 method Methods 0.000 title claims 6
- 208000006386 Bone Resorption Diseases 0.000 title claims 2
- 230000024279 bone resorption Effects 0.000 title claims 2
- 230000002401 inhibitory effect Effects 0.000 title claims 2
- 206010065687 Bone loss Diseases 0.000 claims 23
- 239000012634 fragment Substances 0.000 claims 15
- 208000001132 Osteoporosis Diseases 0.000 claims 9
- 102000019307 Sclerostin Human genes 0.000 claims 7
- 108050006698 Sclerostin Proteins 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- GIVATXIGCXFQQA-FXQIFTODSA-N Arg-Ala-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCN=C(N)N GIVATXIGCXFQQA-FXQIFTODSA-N 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 2
- 208000027414 Legg-Calve-Perthes disease Diseases 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 2
- 210000003054 facial bone Anatomy 0.000 claims 2
- 108010057952 lysyl-phenylalanyl-lysine Proteins 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- WOJJIRYPFAZEPF-YFKPBYRVSA-N 2-[[(2s)-2-[[2-[(2-azaniumylacetyl)amino]acetyl]amino]propanoyl]amino]acetate Chemical compound OC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)CN WOJJIRYPFAZEPF-YFKPBYRVSA-N 0.000 claims 1
- 206010000599 Acromegaly Diseases 0.000 claims 1
- VHEVVUZDDUCAKU-FXQIFTODSA-N Ala-Met-Asp Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(O)=O VHEVVUZDDUCAKU-FXQIFTODSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 201000000736 Amenorrhea Diseases 0.000 claims 1
- 206010001928 Amenorrhoea Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- XVVOVPFMILMHPX-ZLUOBGJFSA-N Asn-Asp-Asp Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O XVVOVPFMILMHPX-ZLUOBGJFSA-N 0.000 claims 1
- QUAWOKPCAKCHQL-SRVKXCTJSA-N Asn-His-Lys Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(=O)N)N QUAWOKPCAKCHQL-SRVKXCTJSA-N 0.000 claims 1
- PNHQRQTVBRDIEF-CIUDSAMLSA-N Asn-Leu-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)N PNHQRQTVBRDIEF-CIUDSAMLSA-N 0.000 claims 1
- SUIJFTJDTJKSRK-IHRRRGAJSA-N Asn-Pro-Tyr Chemical compound NC(=O)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 SUIJFTJDTJKSRK-IHRRRGAJSA-N 0.000 claims 1
- TVVYVAUGRHNTGT-UGYAYLCHSA-N Asp-Asp-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC(O)=O TVVYVAUGRHNTGT-UGYAYLCHSA-N 0.000 claims 1
- JSNWZMFSLIWAHS-HJGDQZAQSA-N Asp-Thr-Leu Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC(=O)O)N)O JSNWZMFSLIWAHS-HJGDQZAQSA-N 0.000 claims 1
- NJLLRXWFPQQPHV-SRVKXCTJSA-N Asp-Tyr-Asn Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(O)=O NJLLRXWFPQQPHV-SRVKXCTJSA-N 0.000 claims 1
- ALMIMUZAWTUNIO-BZSNNMDCSA-N Asp-Tyr-Tyr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O ALMIMUZAWTUNIO-BZSNNMDCSA-N 0.000 claims 1
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- CRRFJBGUGNNOCS-PEFMBERDSA-N Gln-Asp-Ile Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O CRRFJBGUGNNOCS-PEFMBERDSA-N 0.000 claims 1
- LOJYQMFIIJVETK-WDSKDSINSA-N Gln-Gln Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(O)=O LOJYQMFIIJVETK-WDSKDSINSA-N 0.000 claims 1
- NVEASDQHBRZPSU-BQBZGAKWSA-N Gln-Gln-Gly Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(O)=O NVEASDQHBRZPSU-BQBZGAKWSA-N 0.000 claims 1
- CXRWMMRLEMVSEH-PEFMBERDSA-N Glu-Ile-Asn Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(O)=O CXRWMMRLEMVSEH-PEFMBERDSA-N 0.000 claims 1
- HZISRJBYZAODRV-XQXXSGGOSA-N Glu-Thr-Ala Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O HZISRJBYZAODRV-XQXXSGGOSA-N 0.000 claims 1
- 206010056438 Growth hormone deficiency Diseases 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
- 206010020707 Hyperparathyroidism primary Diseases 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 206010058359 Hypogonadism Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 208000017670 Juvenile Paget disease Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000017924 Klinefelter Syndrome Diseases 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- UCDHVOALNXENLC-KBPBESRZSA-N Leu-Gly-Tyr Chemical compound CC(C)C[C@H]([NH3+])C(=O)NCC(=O)N[C@H](C([O-])=O)CC1=CC=C(O)C=C1 UCDHVOALNXENLC-KBPBESRZSA-N 0.000 claims 1
- RXGLHDWAZQECBI-SRVKXCTJSA-N Leu-Leu-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O RXGLHDWAZQECBI-SRVKXCTJSA-N 0.000 claims 1
- AZOFEHCPMBRNFD-BZSNNMDCSA-N Lys-Phe-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CC=CC=C1 AZOFEHCPMBRNFD-BZSNNMDCSA-N 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 208000001826 Marfan syndrome Diseases 0.000 claims 1
- 208000008948 Menkes Kinky Hair Syndrome Diseases 0.000 claims 1
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- JMEWFDUAFKVAAT-WDSKDSINSA-N Met-Asn Chemical compound CSCC[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC(N)=O JMEWFDUAFKVAAT-WDSKDSINSA-N 0.000 claims 1
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims 1
- 208000034789 Multiple hereditary exostosis Diseases 0.000 claims 1
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- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000013612 Parathyroid disease Diseases 0.000 claims 1
- AUJWXNGCAQWLEI-KBPBESRZSA-N Phe-Lys-Gly Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O AUJWXNGCAQWLEI-KBPBESRZSA-N 0.000 claims 1
- NJJBATPLUQHRBM-IHRRRGAJSA-N Phe-Pro-Ser Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=CC=C2)N)C(=O)N[C@@H](CO)C(=O)O NJJBATPLUQHRBM-IHRRRGAJSA-N 0.000 claims 1
- 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 claims 1
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- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000000981 Primary Hyperparathyroidism Diseases 0.000 claims 1
- FUVBEZJCRMHWEM-FXQIFTODSA-N Pro-Asn-Ser Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(O)=O FUVBEZJCRMHWEM-FXQIFTODSA-N 0.000 claims 1
- QKWYXRPICJEQAJ-KJEVXHAQSA-N Pro-Tyr-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2)O QKWYXRPICJEQAJ-KJEVXHAQSA-N 0.000 claims 1
- 208000002607 Pseudarthrosis Diseases 0.000 claims 1
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 claims 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
- ICHZYBVODUVUKN-SRVKXCTJSA-N Ser-Asn-Tyr Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O ICHZYBVODUVUKN-SRVKXCTJSA-N 0.000 claims 1
- VGQVAVQWKJLIRM-FXQIFTODSA-N Ser-Ser-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(O)=O VGQVAVQWKJLIRM-FXQIFTODSA-N 0.000 claims 1
- SNXUIBACCONSOH-BWBBJGPYSA-N Ser-Thr-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CO)C(O)=O SNXUIBACCONSOH-BWBBJGPYSA-N 0.000 claims 1
- 208000002903 Thalassemia Diseases 0.000 claims 1
- WPSKTVVMQCXPRO-BWBBJGPYSA-N Thr-Ser-Ser Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O WPSKTVVMQCXPRO-BWBBJGPYSA-N 0.000 claims 1
- AAZOYLQUEQRUMZ-GSSVUCPTSA-N Thr-Thr-Asn Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C(O)=O)CC(N)=O AAZOYLQUEQRUMZ-GSSVUCPTSA-N 0.000 claims 1
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- XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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Claims (13)
1. Protutijelo protiv sklerostina ili njegov fragment koji se koristi u postupku za inhibiranje resorpcije kosti kod čovjeka, postupak uključuje davanje navedenog protutijela protiv sklerostina ili njegovog fragmenta čovjeku u količini od 1 mg/kg do 5 mg/kg, naznačeno time, da protutijelo protiv sklerostina ili njegov fragment pokazuje afinitet vezanja na sklerostin SEQ ID NO: 1 koji je manji ili jednak 1 x 10-7M i poprečno blokira vezanje na sklerostin protutijela koje sadržava CDR SEQ ID br. 245, 246, 247, 78, 79 i 80 ili CDR SEQ ID br. 284, 285, 286, 296, 297 i 298, ili je poprečno blokirano protiv vezivanja na sklerostin navedenim protutijelom, pri čemu je:
- SEQ ID No:245 = Asp Tyr Asn Met His;
- SEQ ID No:246 = Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe Lys Gly;
- SEQ ID No:247 = Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val;
- SEQ ID No: 78 = Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn;
- SEQ ID No: 79 = Tyr Thr Ser Arg Leu Leu Ser; i
- SEQ ID No: 80 = Gln Gln Gly Asp Thr Leu Pro Tyr Thr; i
- SEQ ID NO: 284 = Arg Ala Ser Ser Ser Val Thr Ser Ser Tyr Leu Asn;
- SEQ ID NO: 285 = Ser Thr Ser Asn Leu Ala Ser;
- SEQ ID NO: 286 = Gln Gln Tyr Asp Phe Phe Pro Ser Thr;
- SEQ ID NO: 296 = Asp Tyr Tyr Met Asn;
- SEQ ID NO: 297 = Asp He Asn Pro Tyr Asn Asp Asp Thr Thr Tyr Asn His Lys Phe Lys Gly i
- SEQ ID NO 298 = Glu Thr Ala Val He Thr Thr Asn Ala Met Asp.
2. Protutijelo ili fragment za upotrebu u skladu s patentnim zahtjevom 1, naznačeno time, da je količina protutijela protiv sklerostina koja se primjenjuje od 1 mg/kg do 3 mg/kg.
3. Protutijelo ili fragment za upotrebu u skladu s patentnim zahtjevom 1 ili 2, naznačeno time, da je količina protutijela protiv sklerostina koja se primjenjuje oko 2 mg/kg.
4. Protutijelo ili fragment za upotrebu u skladu s patentnim zahtjevom 1 ili 2, naznačeno time, da je količina protutijela protiv sklerostina koja se primjenjuje oko 3 mg/kg.
5. Protutijelo ili fragment za upotrebu u skladu s patentnim zahtjevom 1, naznačeno time, da postupak obuhvaća davanje protutijela protiv sklerostina čovjeku u dozi od 70 do 450 mg.
6. Protutijelo ili fragment za upotrebu u skladu s patentnim zahtjevom 1, naznačeno time, da postupak obuhvaća davanja doze od oko 140 mg.
7. Protutijelo ili fragment za upotrebu u skladu s patentnim zahtjevom 1, naznačeno time, da postupak obuhvaća davanja doze od oko 210 mg.
8. Protutijelo ili fragment za upotrebu u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeno time, da se količina protutijela protiv sklerostina subjektu daje jednom svaka dva tjedna.
9. Protutijelo ili fragment za upotrebu u skladu s bilo kojim od zahtjeva 1 do 7, naznačeno time, da se protutijelo protiv sklerostina subjektu daje jednom mjesečno.
10. Protutijelo ili fragment za upotrebu u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeno time, da je protutijelo humano protutijelo, humanizirano protutijelo, monoklonalno protutijelo ili himerno protutijelo.
11. Protutijelo ili fragment za upotrebu u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeno time, da osoba pati od poremećaja povezanih s kostima odabranih iz skupine koju čine: ahondroplazija, kleidocranijalna disostoza, enhondromatoza, fibrozna displazija, Gaucherova bolest, hipofosfatemični rahitis, Marfanov sindrom, multipla nasljedna egzostoza, neurofibromatoza, osteogenesis imperfecta, osteoporoza, osteopoikilosis, sklerostične lezije, pseudoartroza, piogeni osteomijelitis, parodontna bolest, gubitak kosti induciran lijekovima protiv epilepsije, primarni i sekundarni hiperparatiroidizam, sindrom obiteljskog hiperparatiroidizma, gubitak kosti induciran bestežinskim stanjem, osteoporoza u muškaraca, gubitak koštane mase u postmenopauzi, osteoartritis, bubrežna osteodistrofija, infiltrativni poremećaji kosti, oralni gubitak kosti, osteonekroza čeljusti, juvenilna Pagetova bolest, melorheostoza, metaboličke bolesti kostiju, mastocitoza, anemija/bolest srpastih stanica, gubitak kosti povezan s presađivanjem organa, gubitak kosti uslijed transplantacije bubrega, sistemski eritemski lupus, ankilozni spondilitis, epilepsija, juvenilni artritis, talasemija, mucopolysaccharidoses, Fabrijeva bolest, Turnerov sindrom, Downov sindrom, Klinefelterov sindrom, lepra, Perthesova bolest, idiopatska skolioza adolescenata, multisistemska upalna bolest novorođenčeta, Winchester sindrom, Menkesova bolest, Wilsonova bolest, ishemijske bolesti kostiju, Legg - Calve - Perthesova bolest, regionalna migracijska osteoporoza, anemična stanja, stanja uzrokovana steroidima, gubitak koštane mase izazvan glukokortikoidima, gubitak koštane mase izazvan heparinom, poremećaj koštane srži, skorbut, pothranjenost, nedostatak kalcija, osteoporoza, osteopenija, alkoholizam, kronična bolest jetre, stanja u post-menopauzi, kronična upalna stanja, reumatoidni artritis, upalne bolesti crijeva, ulcerozni kolitis, upalni kolitis, Crohnova bolest, oligomenoreja, amenoreja, trudnoća, dijabetes melitus, hipertireoza, poremećaji štitnjače, poremećaji nusštitnjače, Cushingova bolest, akromegalija, hipogonadizam, imobilizacija ili neaktivnost, refleksna simpatička distrofija, regionalna osteoporoza, osteomalacija, gubitak kosti povezan sa instalacijom umjetnog zgloba, gubitak koštane mase povezan s HlV-om, gubitak kosti povezan sa nedostatkom hormona rasta, gubitak koštane mase povezan s cističnom fibrozom, gubitak koštane mase povezan s kemoterapijom, gubitak kosti uslijed tumora, gubitak koštane mase povezan s rakom, gubitak kosti povezan sa uklanjanjem organa koji izlučuju hormone, multipli mijelom, gubitak kosti induciran lijekovima, anoreksijska nervoza, bolesti povezane s gubitkom kosti lica, bolesti povezane s gubitkom kranijalnih kosti, bolesti povezane s gubitkom čeljustnih kosti, gubitak koštane mase povezan s bolestima lubanje, gubitak koštane mase povezan sa starenjem, gubitak kosti lica povezan sa starenjem, gubitak kranijalnih kosti povezan sa starenjem, gubitak kosti čeljusti povezan sa starenjem, gubitak kosti povezan sa starenjem lubanje i gubitak kosti povezan sa svemirskim putovanjima.
12. Protutijelo ili fragment za upotrebu u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeno time, da je osoba žena nakon menopauze.
13. Protutijelo ili fragment za upotrebu u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeno time, da osoba pati od osteoporoze.
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| US97302407P | 2007-09-17 | 2007-09-17 | |
| EP12180292.0A EP2556841B9 (en) | 2007-09-17 | 2008-09-17 | Method for inhibiting bone resorption |
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| HRP20140153AT HRP20140153T1 (hr) | 2007-09-17 | 2014-02-18 | Anti-sklerostin antitijela |
| HRP20160872TT HRP20160872T1 (hr) | 2007-09-17 | 2016-07-14 | Postupak za inhibiciju resorpcije kosti |
| HRP20201438TT HRP20201438T1 (hr) | 2007-09-17 | 2020-09-09 | Metoda inhibiranja resorpcije kosti |
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| HRP20140153AT HRP20140153T1 (hr) | 2007-09-17 | 2014-02-18 | Anti-sklerostin antitijela |
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| HRP20201438TT HRP20201438T1 (hr) | 2007-09-17 | 2020-09-09 | Metoda inhibiranja resorpcije kosti |
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