HRP20160558T1 - Određivanje efikasnosti živog rekombinantnog anti-mikobakterijskog cijepljenja - Google Patents
Određivanje efikasnosti živog rekombinantnog anti-mikobakterijskog cijepljenja Download PDFInfo
- Publication number
- HRP20160558T1 HRP20160558T1 HRP20160558TT HRP20160558T HRP20160558T1 HR P20160558 T1 HRP20160558 T1 HR P20160558T1 HR P20160558T T HRP20160558T T HR P20160558TT HR P20160558 T HRP20160558 T HR P20160558T HR P20160558 T1 HRP20160558 T1 HR P20160558T1
- Authority
- HR
- Croatia
- Prior art keywords
- immune response
- vaccine
- determination
- mycobacterial
- efficacy
- Prior art date
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- 238000002255 vaccination Methods 0.000 title claims 2
- 230000001355 anti-mycobacterial effect Effects 0.000 title 1
- 239000003926 antimycobacterial agent Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 12
- 229960005486 vaccine Drugs 0.000 claims 8
- 230000030429 T-helper 17 type immune response Effects 0.000 claims 6
- 241000186359 Mycobacterium Species 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 206010062207 Mycobacterial infection Diseases 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 2
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 claims 1
- 102100033461 Interleukin-17A Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108010046334 Urease Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000000680 phagosome Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Physiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (11)
1. Postupak za određivanje efikasnosti rekombinantnog mikobakterijskog živog cjepiva, koje sadrži određivanje T pomoćnog tipa 17 (Th17) imunog odgovora u cijepljenom subjektu, pri čemu je detektabilni Th17 imuni odgovor indikativan za zaštitni imunitet kod navedenog subjekta.
2. Postupak prema patentnom zahtjevu 1, naznačen time što je cjepivo rekombinantni Mycobacterium koje sadrži rekombinantnu molekulu nukleinske kiseline koja kodira fuzijski polipeptid koji sadrži (a) domenu sposobnu da izazove imuni odgovor i (b) domenu izbegavanja fagolizozoma.
3. Postupak prema patentnom zahtjevu 2, naznačen time što je Mycobacterium deficijentan za ureazu.
4. Postupak prema patentnom zahtjevu 3, naznačen time što Mycobacterium je rBCGΔUreC :: Holy* :: Hyg+.
5. Postupak prema patentnom zahtjevu 1, naznačen time što cjepivo je pojedinično cjepivo.
6. Postupak prema bilo kojem od patentnih zahtjeva 1-5, naznačen time što cjepivo je cjepivo protiv mikobakterijske infekcije, posebno pulmonarnih mikobakterijskih infekcija, posebno tuberkuloze.
7. Postupak prema bilo kojem od patentnih zahjteva 1-6, naznačen time što određivanje Th17 imunog odgovora sadrži podvrgavanje uzorka koji sadrži imune stanice iz navedenog cijepljenog subjekta restimulaciji sa imunogenom koji odgovara imunogenu u navedenom cjepivu i određivanje prisustva i/ili količine stanica povezanih sa Th17 imunim odgovorom u navedenom uzorku.
8. Postupak prema bilo kojem od patentnih zahtjeva 1-6, naznačen time što određivanje Th17 imunog odgovora sadrži određivanje IL17, npr. pomoću imunoloških postupaka.
9. Postupak prema bilo kojem od patentnih zahtjeva 1-8, naznačen time što subjekt je sisavac, npr. čovjek.
10. Postupak prema bilo kojem od patentnih zahtjeva 1-9, naznačen time što Th17 imuni odgovor je određen 20-50 dana poslije cijepljenja.
11. Uporaba reagens kita u postupku prema bilo kojem od patentnih zahtjeva 1-10 za određivanje efikasnosti rekombinantnog mikobakterijskog živog cjepiva, koje sadrži (a) reagens za restimulaciju imunih stanica iz prethodno cijepljenog subjekta i (b) reagens za detekciju Th17 imunog odgovora.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061425442P | 2010-12-21 | 2010-12-21 | |
| EP11805020.2A EP2656070B9 (en) | 2010-12-21 | 2011-12-21 | Determination of the efficacy of a live recombinant anti-mycobacterial vaccination |
| PCT/EP2011/073609 WO2012085099A1 (en) | 2010-12-21 | 2011-12-21 | Determination of the efficacy of an anti-mycobacterial vaccination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160558T1 true HRP20160558T1 (hr) | 2016-06-17 |
Family
ID=45446021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160558TT HRP20160558T1 (hr) | 2010-12-21 | 2016-05-24 | Određivanje efikasnosti živog rekombinantnog anti-mikobakterijskog cijepljenja |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8906389B2 (hr) |
| EP (1) | EP2656070B9 (hr) |
| JP (1) | JP6055780B2 (hr) |
| KR (1) | KR101882040B1 (hr) |
| CN (1) | CN103492877B (hr) |
| AU (1) | AU2011347266B2 (hr) |
| BR (1) | BR112013015878B1 (hr) |
| CA (1) | CA2822715C (hr) |
| CU (1) | CU20130084A7 (hr) |
| CY (1) | CY1117412T1 (hr) |
| DK (1) | DK2656070T3 (hr) |
| EA (1) | EA029833B9 (hr) |
| ES (1) | ES2569035T3 (hr) |
| HK (1) | HK1192322A1 (hr) |
| HR (1) | HRP20160558T1 (hr) |
| HU (1) | HUE027781T2 (hr) |
| MX (1) | MX345961B (hr) |
| PL (1) | PL2656070T3 (hr) |
| PT (1) | PT2656070E (hr) |
| RS (1) | RS54770B1 (hr) |
| SG (1) | SG191331A1 (hr) |
| SI (1) | SI2656070T1 (hr) |
| SM (1) | SMT201600149B (hr) |
| UA (2) | UA112067C2 (hr) |
| WO (1) | WO2012085099A1 (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3543698A1 (en) * | 2018-03-20 | 2019-09-25 | Helmholtz-Zentrum für Infektionsforschung GmbH | Method for determining vaccine efficacy in an individual and means therefore |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0902086A1 (en) * | 1997-08-22 | 1999-03-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tuberculosis vaccine |
| EP1137769B1 (en) * | 1998-11-10 | 2008-09-03 | University Of Rochester | Methods for the generation of dna libraries |
| GB9923309D0 (en) * | 1999-10-01 | 1999-12-08 | Glaxo Group Ltd | Assay |
| JP2001215224A (ja) * | 1999-11-25 | 2001-08-10 | Hitachi Chem Co Ltd | 免疫反応のアッセイ法、免疫学的判定法及びアッセイキット |
| BRPI0409789B8 (pt) | 2003-04-23 | 2021-05-25 | Max Planck Gesellschaft | célula bacteriana, seus processos de preparação e seu uso, composição, e processo para a preparação de uma vacina viva |
| AU2006214473A1 (en) * | 2005-02-14 | 2006-08-24 | Wyeth | Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor |
| AU2007261019A1 (en) * | 2006-06-19 | 2007-12-27 | Wyeth | Methods of modulating IL-22 and IL-17 |
| CN101329230B (zh) * | 2008-07-14 | 2010-10-20 | 中国人民解放军第三军医大学 | 改进的免疫荧光细胞染色方法 |
| JP2010051307A (ja) * | 2008-07-28 | 2010-03-11 | Eisai R & D Management Co Ltd | Ｔｈ１７細胞およびＴｒｅｇ細胞の分化誘導を調節する物質のスクリーニング方法 |
| WO2010046039A1 (en) | 2008-10-20 | 2010-04-29 | University Of Zurich | Mycobacterium tuberculosis vaccine |
| JP5931724B2 (ja) * | 2009-06-29 | 2016-06-08 | ジェノセア バイオサイエンシーズ， インコーポレイテッド | ＳｔｒｅｐｔｏｃｏｃｃｕｓＰｎｅｕｍｏｎｉａｅに対するワクチンおよび組成物 |
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2011
- 2011-12-21 EA EA201300738A patent/EA029833B9/ru not_active IP Right Cessation
- 2011-12-21 CA CA2822715A patent/CA2822715C/en active Active
- 2011-12-21 CN CN201180066448.8A patent/CN103492877B/zh active Active
- 2011-12-21 HU HUE11805020A patent/HUE027781T2/en unknown
- 2011-12-21 PL PL11805020T patent/PL2656070T3/pl unknown
- 2011-12-21 EP EP11805020.2A patent/EP2656070B9/en active Active
- 2011-12-21 ES ES11805020.2T patent/ES2569035T3/es active Active
- 2011-12-21 US US13/996,832 patent/US8906389B2/en active Active
- 2011-12-21 RS RS20160350A patent/RS54770B1/sr unknown
- 2011-12-21 JP JP2013545368A patent/JP6055780B2/ja active Active
- 2011-12-21 BR BR112013015878-6A patent/BR112013015878B1/pt active IP Right Grant
- 2011-12-21 DK DK11805020.2T patent/DK2656070T3/en active
- 2011-12-21 MX MX2013007244A patent/MX345961B/es active IP Right Grant
- 2011-12-21 SG SG2013048756A patent/SG191331A1/en unknown
- 2011-12-21 WO PCT/EP2011/073609 patent/WO2012085099A1/en active Application Filing
- 2011-12-21 SI SI201130785A patent/SI2656070T1/sl unknown
- 2011-12-21 AU AU2011347266A patent/AU2011347266B2/en active Active
- 2011-12-21 UA UAA201308660A patent/UA112067C2/uk unknown
- 2011-12-21 KR KR1020137019197A patent/KR101882040B1/ko active IP Right Grant
- 2011-12-21 PT PT118050202T patent/PT2656070E/pt unknown
- 2011-12-21 UA UAA201308661A patent/UA113282C2/uk unknown
-
2013
- 2013-06-21 CU CU2013000084A patent/CU20130084A7/es unknown
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2014
- 2014-06-13 HK HK14105616.7A patent/HK1192322A1/xx unknown
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2016
- 2016-04-25 CY CY20161100335T patent/CY1117412T1/el unknown
- 2016-05-24 HR HRP20160558TT patent/HRP20160558T1/hr unknown
- 2016-05-31 SM SM201600149T patent/SMT201600149B/it unknown
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