HRP20160475T1 - Disulfidnom vezom stabilizirani funkcionalni topivi heterodimeri mhc klase ii - Google Patents
Disulfidnom vezom stabilizirani funkcionalni topivi heterodimeri mhc klase ii Download PDFInfo
- Publication number
- HRP20160475T1 HRP20160475T1 HRP20160475TT HRP20160475T HRP20160475T1 HR P20160475 T1 HRP20160475 T1 HR P20160475T1 HR P20160475T T HRP20160475T T HR P20160475TT HR P20160475 T HRP20160475 T HR P20160475T HR P20160475 T1 HRP20160475 T1 HR P20160475T1
- Authority
- HR
- Croatia
- Prior art keywords
- mhc class
- molecule
- recombinant
- chain
- cysteine residues
- Prior art date
Links
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 20
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 20
- 102000043131 MHC class II family Human genes 0.000 claims 13
- 108091054438 MHC class II family Proteins 0.000 claims 13
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 11
- 238000000034 method Methods 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241001529936 Murinae Species 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 241000724791 Filamentous phage Species 0.000 claims 1
- 101500028288 Homo sapiens Melanin-concentrating hormone Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30572810P | 2010-02-18 | 2010-02-18 | |
| GBGB1002730.8A GB201002730D0 (en) | 2010-02-18 | 2010-02-18 | Product |
| US31657610P | 2010-03-23 | 2010-03-23 | |
| EP11730044.2A EP2536746B1 (en) | 2010-02-18 | 2011-02-18 | Disulphide bond-stabilized functional soluble mhc class ii heterodimers |
| PCT/GB2011/050325 WO2011101681A2 (en) | 2010-02-18 | 2011-02-18 | Disulphide bond-stabilized functional soluble mhc class ii heterodimers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160475T1 true HRP20160475T1 (hr) | 2016-06-03 |
Family
ID=42113985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160475TT HRP20160475T1 (hr) | 2010-02-18 | 2016-05-04 | Disulfidnom vezom stabilizirani funkcionalni topivi heterodimeri mhc klase ii |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8828379B2 (ja) |
| EP (1) | EP2536746B1 (ja) |
| JP (1) | JP5537675B2 (ja) |
| KR (1) | KR101647176B1 (ja) |
| CN (1) | CN102947330B (ja) |
| AU (1) | AU2011217027B2 (ja) |
| CA (1) | CA2789492C (ja) |
| CY (1) | CY1117697T1 (ja) |
| DK (1) | DK2536746T3 (ja) |
| ES (1) | ES2572388T3 (ja) |
| GB (1) | GB201002730D0 (ja) |
| HR (1) | HRP20160475T1 (ja) |
| HU (1) | HUE027952T2 (ja) |
| PL (1) | PL2536746T3 (ja) |
| RS (1) | RS54744B1 (ja) |
| RU (1) | RU2604813C2 (ja) |
| SI (1) | SI2536746T1 (ja) |
| WO (1) | WO2011101681A2 (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| EP2909337B1 (en) | 2012-10-17 | 2019-01-09 | Spatial Transcriptomics AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| PT3167065T (pt) * | 2014-07-09 | 2020-07-01 | Lupin Ltd | Sistema de expressão bacteriana dual cistrónica |
| WO2017004252A1 (en) | 2015-06-30 | 2017-01-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with mhc chimeric receptors and methods of use in immunotherapy |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| CN110291111A (zh) * | 2016-11-09 | 2019-09-27 | 优迪有限合伙公司 | 重组pMHC II类分子 |
| WO2018197949A1 (en) | 2017-04-27 | 2018-11-01 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| DE102018122546B3 (de) | 2018-09-14 | 2019-12-05 | Immatics Biotechnologies Gmbh | Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden |
| US20230147726A1 (en) * | 2018-09-28 | 2023-05-11 | Danmarks Tekniske Universitet | High throughput epitope identification and t cell receptor specificity determination using loadable detection molecules |
| CN113573729A (zh) | 2019-01-10 | 2021-10-29 | 詹森生物科技公司 | 前列腺新抗原及其用途 |
| EP3719033A1 (en) * | 2019-04-02 | 2020-10-07 | imusyn GmbH & Co. KG | Stabilized mhc i |
| WO2021035049A1 (en) * | 2019-08-21 | 2021-02-25 | Uti Limited Partnership | Improved recombinant pmhc molecules |
| US20210155670A1 (en) * | 2019-09-13 | 2021-05-27 | The Regents Of The University Of California | Systems and methods for the preparation of peptide-mhc-i complexes with native glycan modifications |
| CA3163549A1 (en) * | 2019-12-02 | 2021-06-10 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| DE102020109447A1 (de) | 2020-04-03 | 2021-10-07 | Jacobs University Bremen Ggmbh | Synthetisches mhc-klasse-ii-protein |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990010457A1 (en) | 1989-03-14 | 1990-09-20 | New York University | Method of treating hiv infections using immunotoxins |
| NZ333915A (en) | 1996-08-16 | 2000-11-24 | Harvard College | Soluble monovalent and multivalent MHC class II fusion proteins |
| AU741130B2 (en) * | 1997-09-16 | 2001-11-22 | Oregon Health Sciences University | Recombinant MHC molecules useful for manipulation of antigen-specific T-cells |
| JP2002515244A (ja) * | 1998-05-19 | 2002-05-28 | アヴィデックス リミテッド | 可溶性ｔ細胞受容体 |
| RU2303264C2 (ru) * | 2001-02-19 | 2007-07-20 | Мерк Патент Гмбх | Способ идентификации эпитопов т-клеток и его применение для получения молекул со сниженной иммуногенностью |
| GB2392158B (en) * | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
| AU2004288157B2 (en) * | 2003-09-05 | 2011-03-17 | Oregon Health & Science University | Monomeric recombinant MHC molecules useful for manipulation of antigen-specific T cells |
| EP1877440A4 (en) * | 2005-03-18 | 2009-07-29 | Univ Oregon Health & Science | RECOMBINANT MHC MOLECULES FOR USE IN THE MANIPULATION OF ANTIGEN-SPECIFIC T CELLS |
| ES2709176T3 (es) | 2006-08-11 | 2019-04-15 | Life Sciences Res Partners Vzw | Péptidos inmunogénicos y su uso en trastornos inmunitarios |
| JP5154564B2 (ja) * | 2006-12-01 | 2013-02-27 | カール・ツァイス・エスエムティー・ゲーエムベーハー | 像収差を低減するための交換可能で操作可能な補正構成を有する光学システム |
| DK2193199T3 (da) | 2007-08-20 | 2014-01-13 | Nextera As | Pvii fag-display |
-
2010
- 2010-02-18 GB GBGB1002730.8A patent/GB201002730D0/en not_active Ceased
-
2011
- 2011-02-18 JP JP2012553409A patent/JP5537675B2/ja active Active
- 2011-02-18 AU AU2011217027A patent/AU2011217027B2/en active Active
- 2011-02-18 CN CN201180011237.4A patent/CN102947330B/zh active Active
- 2011-02-18 WO PCT/GB2011/050325 patent/WO2011101681A2/en active Application Filing
- 2011-02-18 RS RS20160323A patent/RS54744B1/sr unknown
- 2011-02-18 PL PL11730044T patent/PL2536746T3/pl unknown
- 2011-02-18 EP EP11730044.2A patent/EP2536746B1/en active Active
- 2011-02-18 US US13/579,887 patent/US8828379B2/en active Active
- 2011-02-18 KR KR1020127024287A patent/KR101647176B1/ko active IP Right Grant
- 2011-02-18 DK DK11730044.2T patent/DK2536746T3/en active
- 2011-02-18 RU RU2012138302/10A patent/RU2604813C2/ru active
- 2011-02-18 ES ES11730044T patent/ES2572388T3/es active Active
- 2011-02-18 CA CA2789492A patent/CA2789492C/en active Active
- 2011-02-18 HU HUE11730044A patent/HUE027952T2/en unknown
- 2011-02-18 SI SI201130815A patent/SI2536746T1/sl unknown
-
2014
- 2014-07-14 US US14/331,014 patent/US9056920B2/en active Active
-
2016
- 2016-05-04 HR HRP20160475TT patent/HRP20160475T1/hr unknown
- 2016-05-11 CY CY20161100397T patent/CY1117697T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011217027B2 (en) | 2015-02-05 |
| US8828379B2 (en) | 2014-09-09 |
| SI2536746T1 (sl) | 2016-09-30 |
| CN102947330A (zh) | 2013-02-27 |
| CY1117697T1 (el) | 2017-05-17 |
| RU2604813C2 (ru) | 2016-12-10 |
| US20140349315A1 (en) | 2014-11-27 |
| EP2536746B1 (en) | 2016-04-20 |
| CA2789492C (en) | 2017-04-18 |
| ES2572388T3 (es) | 2016-05-31 |
| AU2011217027A1 (en) | 2012-09-06 |
| RU2012138302A (ru) | 2014-03-27 |
| WO2011101681A2 (en) | 2011-08-25 |
| KR101647176B1 (ko) | 2016-08-09 |
| US20130171668A1 (en) | 2013-07-04 |
| JP2013519721A (ja) | 2013-05-30 |
| CN102947330B (zh) | 2015-09-16 |
| DK2536746T3 (en) | 2016-05-30 |
| US9056920B2 (en) | 2015-06-16 |
| RS54744B1 (sr) | 2016-10-31 |
| GB201002730D0 (en) | 2010-04-07 |
| EP2536746A2 (en) | 2012-12-26 |
| KR20130009782A (ko) | 2013-01-23 |
| WO2011101681A3 (en) | 2011-12-08 |
| HUE027952T2 (en) | 2016-11-28 |
| JP5537675B2 (ja) | 2014-07-02 |
| CA2789492A1 (en) | 2011-08-25 |
| PL2536746T3 (pl) | 2016-08-31 |
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