HRP20160403T1 - Liječenje lipodistrofije - Google Patents
Liječenje lipodistrofije Download PDFInfo
- Publication number
- HRP20160403T1 HRP20160403T1 HRP20160403TT HRP20160403T HRP20160403T1 HR P20160403 T1 HRP20160403 T1 HR P20160403T1 HR P20160403T T HRP20160403T T HR P20160403TT HR P20160403 T HRP20160403 T HR P20160403T HR P20160403 T1 HRP20160403 T1 HR P20160403T1
- Authority
- HR
- Croatia
- Prior art keywords
- lipodystrophy
- compound
- treatment
- thioalkyl
- hiv
- Prior art date
Links
- 206010049287 Lipodystrophy acquired Diseases 0.000 title claims 7
- 208000006132 lipodystrophy Diseases 0.000 title claims 7
- 150000001875 compounds Chemical class 0.000 claims 11
- 206010062315 Lipohypertrophy Diseases 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 125000004001 thioalkyl group Chemical group 0.000 claims 4
- 208000005968 HIV-Associated Lipodystrophy Syndrome Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 2
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 2
- 206010024604 Lipoatrophy Diseases 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 108010062497 VLDL Lipoproteins Proteins 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 235000011114 ammonium hydroxide Nutrition 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 1
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
- 239000001361 adipic acid Substances 0.000 claims 1
- 235000011037 adipic acid Nutrition 0.000 claims 1
- 239000001099 ammonium carbonate Substances 0.000 claims 1
- 235000012501 ammonium carbonate Nutrition 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000000883 anti-obesity agent Substances 0.000 claims 1
- 229940125710 antiobesity agent Drugs 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 239000002830 appetite depressant Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 229910021538 borax Inorganic materials 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims 1
- 239000004223 monosodium glutamate Substances 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960000540 polacrilin potassium Drugs 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 229960002816 potassium chloride Drugs 0.000 claims 1
- WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical group [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 claims 1
- 239000006041 probiotic Substances 0.000 claims 1
- 235000018291 probiotics Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000001632 sodium acetate Substances 0.000 claims 1
- 235000017281 sodium acetate Nutrition 0.000 claims 1
- 235000010339 sodium tetraborate Nutrition 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Ceramic Products (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (15)
1. Spoj formule (I)
[image]
za uporabu u liječenju lipodistrofije, lipohipertrofije, lipoatropije ili metaboličkih poremećaja povezanih s lipodistrofijom, gdje se ’R’ izabire između hidroksi, hidroksialkil, acil, alkoksi, alkiltio, tioalkil, ariloksi, ariltio i M+ predstavlja priklame metalne katione izabrane između Na+, K+, Ca+2, Mg+2, poželjno Mg2+.
2. Spoj za uporabu prema zahtjevu 1, gdje ’R’ predstavlja tioalkil, alkoksi ili hidroksialkil skupinu, poželjno -SCH3 ili -OCH3 skupinu.
3. Spoj prema zahtjevu 1 gdje lipodistrofija jest s HIV-om povezana lipodistrofija, poželjno gdje s HIV-om povezana lipodistrofija uzrokuje lipohipertrofiju ili lipoatrofiju ili metabolički poremećaj.
4. Spoj za uporabu prema bilo kojem od prethodnih zahtjeva gdje se spoj primjenjuje u dnevnoj dozi izabranoj u rasponu od 1 mg do 500 mg bilo u pojedinačnoj dozi ili u više podijeljenih doza, poželjno u rasponu od 4 mg do 250 mg bilo u pojedinačnoj dozi ili u više podijeljenih doza, posebno u rasponu od 4 mg do 50 mg.
5. Spoj prema prethodnim zahtjevima koji se primjenjuje u kombinaciji s drugim prikladnim terapijskim sredstvom.
6. Spoj prema bilo kojem od prethodnih zahtjeva koji snižava koncentraciju triglicerida, razinu Apo B lipoproteina vrlo niske gustoće (VLDL, engl. very low density lipoprotein) i/ili povećava razinu Apo A1 lipoproteina visoke gustoće (HDL, engl. high density lipoprotein).
7. Farmaceutski pripravak za liječenje lipodistrofije, lipohipertrofije, lipoatropije ili metaboličkih poremećaja povezanih s lipodistrofijom, koji sadrži
a) spoj formule (I) ili njegovu sol prema zahtjevu 1;
b) prikladan stabilizator;
c) prikladan pufer;
d) po izboru, jednu ili više farmaceutski prikladnih pomoćnih tvari.
8. Farmaceutski pripravak za uporabu prema zahtjevu 7 gdje se prikladan stabilizator izabire između polakrilin kalija, kalijevog klorida i natrijevog stearil fumarata, poželjno je natrijev stearil fumarat.
9. Farmaceutski pripravak za uporabu prema zahtjevu 7 gdje se prikladan pufer izabire između natrijevog acetata, otopine amonijaka, amonijevog karbonata, natrijevog borata, adipinske kiseline, glicina, mononatrijevog glutamata, poželjno je otopina amonijaka.
10. Farmaceutski pripravak prema zahtjevu 7 za liječenje s HIV-om povezane lipodistrofije u bolesnika kojemu je potrebno takvo liječenje.
11. Farmaceutski pripravak prema zahtjevu 10 gdje s HIV-om povezana lipodistrofija uzrokuje lipohipertrofiju ili lipoatrofiju ili metabolički poremećaj.
12. Farmaceutski pripravak za uporabu prema zahtjevima 7 do 11 u kombinaciji s drugim prikladnim sredstvom izabranim između sredstva koje se koristi za kontrolu razine glukoze u krvi, sredstva koje se koristi za kontrol razine lipida, sredstva koje se koristi za snižavanje ili kontrolu kolesterola,k antioksidansa, sredstva koje suprimira apetit, sredstva protiv pretilosti, probiotika ili protuupalnog sredstva.
13. Spoj formule (Ia)
[image]
gdje se ’R’ izabire između hidroksi, hidroksialkil, acil, alkoksi, alkiltio, tioalkil, ariloksi, ariltio i M+ predstavlja prikladne metalne katione izabrane između K+, Mg+2, poželjno Mg2+.
14. Spoj prema zahtjevu 13, gdje ’R’ predstavlja tioalkil, alkoksi ili hidroksialkil skupinu, poželjno -SCH3 ili -OCH3 skupinu.
15. Farmaceutski pripravak koji sadrži spoj prema zahtjevu 13 ili 14.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN257MU2011 | 2011-01-31 | ||
| PCT/IN2012/000069 WO2012104869A1 (en) | 2011-01-31 | 2012-01-30 | Treatment for lipodystrophy |
| EP12710562.5A EP2670486B1 (en) | 2011-01-31 | 2012-01-30 | Treatment for lipodystrophy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160403T1 true HRP20160403T1 (hr) | 2016-06-03 |
Family
ID=54192841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160403TT HRP20160403T1 (hr) | 2011-01-31 | 2016-04-18 | Liječenje lipodistrofije |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10017470B2 (hr) |
| EP (2) | EP3009136A1 (hr) |
| JP (2) | JP2014504610A (hr) |
| KR (3) | KR101733414B1 (hr) |
| CN (2) | CN107056671A (hr) |
| AP (1) | AP3920A (hr) |
| AU (2) | AU2012212992B2 (hr) |
| BR (1) | BR112013019352A2 (hr) |
| CA (1) | CA2825456C (hr) |
| CL (1) | CL2013002166A1 (hr) |
| CO (1) | CO6781497A2 (hr) |
| CY (1) | CY1117564T1 (hr) |
| DK (1) | DK2670486T3 (hr) |
| EA (1) | EA025421B1 (hr) |
| ES (1) | ES2569248T3 (hr) |
| HR (1) | HRP20160403T1 (hr) |
| HU (1) | HUE027512T2 (hr) |
| IL (2) | IL227266B (hr) |
| ME (1) | ME02392B (hr) |
| MX (1) | MX350611B (hr) |
| MY (1) | MY191100A (hr) |
| NZ (1) | NZ612804A (hr) |
| PL (1) | PL2670486T3 (hr) |
| RS (1) | RS54735B1 (hr) |
| SG (1) | SG191772A1 (hr) |
| SI (1) | SI2670486T1 (hr) |
| SM (1) | SMT201600129B (hr) |
| UA (1) | UA110813C2 (hr) |
| WO (1) | WO2012104869A1 (hr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107056671A (zh) | 2011-01-31 | 2017-08-18 | 卡迪拉保健有限公司 | 脂肪代谢障碍的治疗 |
| US9897565B1 (en) | 2012-09-11 | 2018-02-20 | Aseko, Inc. | System and method for optimizing insulin dosages for diabetic subjects |
| US9171343B1 (en) | 2012-09-11 | 2015-10-27 | Aseko, Inc. | Means and method for improved glycemic control for diabetic patients |
| EA201592020A1 (ru) | 2013-04-22 | 2016-05-31 | Кадила Хелзкэр Лимитед | Новая композиция для неалкогольной жировой болезни печени (нажбп) |
| ES2889916T3 (es) * | 2013-05-30 | 2022-01-14 | Cadila Healthcare Ltd | Un procedimiento para la preparación de pirroles con actividades hipolipidémicas e hipocolesterémicas |
| TW201513857A (zh) * | 2013-07-05 | 2015-04-16 | Cadila Healthcare Ltd | 協同性組成物 |
| IN2013MU02470A (hr) * | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
| IN2013MU02828A (hr) * | 2013-08-29 | 2015-07-03 | Cadila Healthcare Ltd | |
| WO2015033357A2 (en) | 2013-09-06 | 2015-03-12 | Cadila Healthcare Limited | An improved process for the preparation of pyrrole derivatives |
| US9898585B2 (en) | 2014-01-31 | 2018-02-20 | Aseko, Inc. | Method and system for insulin management |
| US9486580B2 (en) | 2014-01-31 | 2016-11-08 | Aseko, Inc. | Insulin management |
| AU2015339576B2 (en) | 2014-10-27 | 2020-02-06 | Glytec, Llc | Subcutaneous outpatient management |
| US11081226B2 (en) | 2014-10-27 | 2021-08-03 | Aseko, Inc. | Method and controller for administering recommended insulin dosages to a patient |
| BR112017015307A2 (pt) * | 2015-02-27 | 2018-01-16 | Ionis Pharmaceuticals Inc | modulação de expressão de apolipoproteína c-iii (apociii) em populações de lipodistrofia |
| WO2017031440A1 (en) | 2015-08-20 | 2017-02-23 | Aseko, Inc. | Diabetes management therapy advisor |
| WO2017064635A2 (en) | 2015-10-14 | 2017-04-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
| WO2017089980A1 (en) | 2015-11-26 | 2017-06-01 | Cadila Healthcare Limited | Dual ppar modulators for the treatment of diabetic retinopathy and diabetic eye diseases |
| WO2017089979A1 (en) | 2015-11-26 | 2017-06-01 | Cadila Healthcare Limited | Dual ppar modulators for the treatment of diabetic nephropathy and related diseases |
| WO2018104916A1 (en) | 2016-12-09 | 2018-06-14 | Cadila Healthcare Limited | Treatment for primary biliary cholangitis |
| US20220071954A1 (en) | 2018-12-18 | 2022-03-10 | Cadila Healthcare Limited | Saroglitazar for the treatment of hepatocellular carcinoma |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| EP0648212B1 (en) | 1992-07-03 | 2001-10-24 | Smithkline Beecham Plc | Benzoxazole and benzothiazole derivatives as pharmaceutical |
| GB9225386D0 (en) | 1992-12-04 | 1993-01-27 | Smithkline Beecham Plc | Novel compounds |
| US5387613A (en) | 1993-07-23 | 1995-02-07 | Ribogene, Inc. | Treatment of tachyarrhythmias of supraventricular origin |
| GB9326171D0 (en) | 1993-12-22 | 1994-02-23 | Smithkline Beecham Plc | Novel compounds |
| BR9508468A (pt) | 1994-07-29 | 1997-11-25 | Smithkline Beecham Plc | Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário |
| PT826688E (pt) | 1995-04-28 | 2002-02-28 | Daiichi Seiyaku Co | Composto pentaciclico |
| GB9600464D0 (en) | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| US6039033A (en) | 1996-12-24 | 2000-03-21 | Daewoo Motor Co., Ltd. | Apparatus of exhaust gas recirculation valve for an internal combustion engine |
| WO1999019313A1 (en) | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
| US6130214A (en) | 1997-10-27 | 2000-10-10 | Dr. Reddy's Research Foundation | Benzothiazin and benzoxazin derivatives; their preparation and uses |
| DE69828445D1 (de) | 1998-04-23 | 2005-02-03 | Reddys Lab Ltd Dr | Heterozyklische verbindungen,und deren verwendung in arzneimittel,verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen |
| CN100357281C (zh) | 1998-05-27 | 2007-12-26 | 雷迪实验室有限公司 | 双环化合物、其制备方法和包含它们的药物组合物 |
| JP2002527503A (ja) | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物類、それらの調製及び使用 |
| WO2000023445A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
| JP2002527520A (ja) | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、その製造及び使用 |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| EE05082B1 (et) | 2000-01-19 | 2008-10-15 | Cadila Healthcare Ltd. | Pürroolirea ühend, selle valmistamine ja kasutamine lipiidi- ja kolesteroolitaset alandava ravimi valmistamiseks ning seda sisaldav farmatseutiline kompositsioon |
| US6395767B2 (en) | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| AU2001286163A1 (en) | 2000-09-22 | 2002-04-02 | Dr. Reddy's Research Foundation | An improved process for the preparation of 3-aryl-2-hydroxy propanoic acid derivatives |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| US6987123B2 (en) | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| WO2005031335A1 (ja) | 2003-09-26 | 2005-04-07 | Mitsubishi Rayon Co., Ltd. | 電気泳動装置および電気泳動法並びにそれを用いた生体関連物質の検出方法 |
| CN102134230B (zh) | 2004-03-15 | 2019-06-28 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| EP2018157A2 (en) * | 2006-04-26 | 2009-01-28 | Astron Research Limited | Controlled release formulation comprising anti-epileptic drugs |
| CA2781451C (en) | 2009-11-26 | 2019-04-16 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| CN103347506A (zh) | 2010-10-12 | 2013-10-09 | 约翰.霍普金斯大学 | 包含美金刚的镇咳组合物 |
| CN107056671A (zh) | 2011-01-31 | 2017-08-18 | 卡迪拉保健有限公司 | 脂肪代谢障碍的治疗 |
| EA201592020A1 (ru) | 2013-04-22 | 2016-05-31 | Кадила Хелзкэр Лимитед | Новая композиция для неалкогольной жировой болезни печени (нажбп) |
| ES2889916T3 (es) | 2013-05-30 | 2022-01-14 | Cadila Healthcare Ltd | Un procedimiento para la preparación de pirroles con actividades hipolipidémicas e hipocolesterémicas |
| TW201513857A (zh) | 2013-07-05 | 2015-04-16 | Cadila Healthcare Ltd | 協同性組成物 |
| IN2013MU02470A (hr) | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
| IN2013MU02828A (hr) | 2013-08-29 | 2015-07-03 | Cadila Healthcare Ltd | |
| WO2015033357A2 (en) | 2013-09-06 | 2015-03-12 | Cadila Healthcare Limited | An improved process for the preparation of pyrrole derivatives |
-
2012
- 2012-01-30 CN CN201610875009.6A patent/CN107056671A/zh active Pending
- 2012-01-30 WO PCT/IN2012/000069 patent/WO2012104869A1/en active Application Filing
- 2012-01-30 AU AU2012212992A patent/AU2012212992B2/en active Active
- 2012-01-30 SI SI201230540A patent/SI2670486T1/sl unknown
- 2012-01-30 ME MEP-2016-73A patent/ME02392B/me unknown
- 2012-01-30 DK DK12710562.5T patent/DK2670486T3/en active
- 2012-01-30 EA EA201391108A patent/EA025421B1/ru unknown
- 2012-01-30 PL PL12710562T patent/PL2670486T3/pl unknown
- 2012-01-30 EP EP15197741.0A patent/EP3009136A1/en not_active Withdrawn
- 2012-01-30 BR BR112013019352-2A patent/BR112013019352A2/pt not_active Application Discontinuation
- 2012-01-30 EP EP12710562.5A patent/EP2670486B1/en active Active
- 2012-01-30 HU HUE12710562A patent/HUE027512T2/en unknown
- 2012-01-30 SG SG2013050430A patent/SG191772A1/en unknown
- 2012-01-30 RS RS20160295A patent/RS54735B1/sr unknown
- 2012-01-30 ES ES12710562.5T patent/ES2569248T3/es active Active
- 2012-01-30 MX MX2013008012A patent/MX350611B/es active IP Right Grant
- 2012-01-30 KR KR1020167007592A patent/KR101733414B1/ko active IP Right Grant
- 2012-01-30 JP JP2013551015A patent/JP2014504610A/ja active Pending
- 2012-01-30 US US13/978,791 patent/US10017470B2/en active Active
- 2012-01-30 CA CA2825456A patent/CA2825456C/en active Active
- 2012-01-30 MY MYPI2013701165A patent/MY191100A/en unknown
- 2012-01-30 KR KR1020137021703A patent/KR20130128451A/ko active Application Filing
- 2012-01-30 UA UAA201309497A patent/UA110813C2/uk unknown
- 2012-01-30 KR KR1020157022081A patent/KR101633720B1/ko active IP Right Grant
- 2012-01-30 NZ NZ612804A patent/NZ612804A/en unknown
- 2012-01-30 CN CN2012800067602A patent/CN103354757A/zh active Pending
- 2012-01-30 AP AP2013006988A patent/AP3920A/en active
-
2013
- 2013-06-30 IL IL22726613A patent/IL227266B/en active IP Right Grant
- 2013-07-26 CO CO13177319A patent/CO6781497A2/es not_active Application Discontinuation
- 2013-07-29 CL CL2013002166A patent/CL2013002166A1/es unknown
-
2015
- 2015-09-08 JP JP2015176597A patent/JP5956664B2/ja active Active
- 2015-10-28 AU AU2015249076A patent/AU2015249076A1/en not_active Abandoned
-
2016
- 2016-04-18 HR HRP20160403TT patent/HRP20160403T1/hr unknown
- 2016-05-04 SM SM201600129T patent/SMT201600129B/it unknown
- 2016-05-09 CY CY20161100384T patent/CY1117564T1/el unknown
- 2016-11-07 US US15/345,035 patent/US9783495B2/en active Active
-
2018
- 2018-05-30 US US15/992,957 patent/US20190100492A1/en not_active Abandoned
- 2018-10-25 IL IL262611A patent/IL262611A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20160403T1 (hr) | Liječenje lipodistrofije | |
| ES2607476T3 (es) | Composición tópica que contiene ibuprofeno | |
| HRP20191777T1 (hr) | Vodena farmaceutska formulacija tapentadola za oralnu primjenu | |
| Fuller et al. | Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt | |
| HRP20151444T4 (hr) | Sredstva za liječenje i postupci liječenja dlbcl | |
| US20200375927A1 (en) | R-beta-hydroxybutyrate, s-beta-hydroxybutyrate, and rs-beta-hydroxybutyrate mixed salt compositions | |
| HRP20221325T1 (hr) | Pripravci i postupci transmukozne apsorpcije | |
| PE20081578A1 (es) | Formulacion en polvo de valganciclovir | |
| MA32692B1 (fr) | Procede de liberation d'une composition pharmaceutique a un patient qui en a besoin | |
| BRPI0516718A (pt) | forma de dosagem de ibuprofeno de liberação modificada | |
| RU2013123457A (ru) | Непрерывное введение l-допа, ингибиторов допа-декарбоксилазы, ингибиторов катехол-о-метилтрансферазы и предназначенные для этого композиции | |
| HRP20130544T4 (hr) | Dugoročno liječenje hiv-infekcije sa tcm278 | |
| BR112015012460B1 (pt) | Formulação estabilizada de pemetrexede | |
| TW201417806A (zh) | 用於改善兒童的線性生長反應之方法 | |
| US11185518B2 (en) | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer | |
| JP2017503761A5 (hr) | ||
| HRP20230929T1 (hr) | Stabilni pripravci semaglutida i njihova upotreba | |
| ES2373838T3 (es) | Medicamento así como su preparación y su utilización en el tratamiento de neuropatías dolorosas. | |
| RU2015119603A (ru) | Стабильная фармацевтическая композиция на основе слитого белка tnfr:fc | |
| BR112012028055A2 (pt) | composto, uso do mesmo, composição farmacêutica, e, métodos de tratar uma doença mediada | |
| JP2005068010A5 (hr) | ||
| BRPI0914086A2 (pt) | uso de paracetamol e ibuprofeno na preparação de um medicamento para o tratamento de osteoartrite moderada ou severa ou artrite reumatoide moderada ou severa e método de tratamento de osteoartrite moderada ou severa ou artrite reumatoide moderada ou severa | |
| RU2013150024A (ru) | Способы контроля и лечения хронической боли с применением hcg | |
| DE602007014193D1 (de) | Behandlung psychiatrischer patienten mit schlafstörungen und/oder übermässiger tagesschläfrigkeit mit paliperidon | |
| US20150224136A1 (en) | Performance-Enhancing Nasal Irrigation |