HRP20151210T1 - Postupak za lijeäśenje multiple skleroze inhibicijom aktivnosti il-17 - Google Patents

Postupak za lijeäśenje multiple skleroze inhibicijom aktivnosti il-17 Download PDF

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Publication number
HRP20151210T1
HRP20151210T1 HRP20151210TT HRP20151210T HRP20151210T1 HR P20151210 T1 HRP20151210 T1 HR P20151210T1 HR P20151210T T HRP20151210T T HR P20151210TT HR P20151210 T HRP20151210 T HR P20151210T HR P20151210 T1 HRP20151210 T1 HR P20151210T1
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HR
Croatia
Prior art keywords
inhibitor
antibody
activity
treatment
multiple sclerosis
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HRP20151210TT
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English (en)
Inventor
Mark Ian Christie
Richard James Mead
Martyn Kim Robinson
Stephen Edward Rapecki
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Ucb Biopharma Sprl
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34635441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20151210(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0327181A external-priority patent/GB0327181D0/en
Priority claimed from GB0417115A external-priority patent/GB0417115D0/en
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of HRP20151210T1 publication Critical patent/HRP20151210T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (4)

1. Inhibitor IL-17 aktivnosti za uporabu u postupku liječenja i/ili profilakse relapsno-remitirajućeg oblika multiple skleroze (MS), naznačen time da inhibitor je IL-17R:Fc fuzijski protein ili je protutijelo ili funkcionalno aktivni fragment protutijela koji se veže na IL-17 ili IL-17R.
2. Inhibitor za uporabu prema zahtjevu 1, naznačen time da protutijelo ili fragment protutijela je monoklonski, poliklonski, kimerni, humanizirani ili bispecifični.
3. Inhibitor za uporabu prema zahtjevu 1 ili zahtjevu 2, naznačen time da fragment protutijela je Fab, Fab', F(ab')2, scFv, ili njihov fragment koji veže epitop.
4. Inhibitor za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time da je protutijelo ili fragment protutijela konjugiran na polietilen glikol (PEG).
HRP20151210TT 2003-11-21 2015-11-11 Postupak za lijeäśenje multiple skleroze inhibicijom aktivnosti il-17 HRP20151210T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0327181A GB0327181D0 (en) 2003-11-21 2003-11-21 Biological products
GB0417115A GB0417115D0 (en) 2004-07-30 2004-07-30 Biological products
EP08008814.9A EP1983000B1 (en) 2003-11-21 2004-11-16 Method for the treatment of multiple sclerosis by inhibiting IL-17 activity

Publications (1)

Publication Number Publication Date
HRP20151210T1 true HRP20151210T1 (hr) 2015-12-04

Family

ID=34635441

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20151210TT HRP20151210T1 (hr) 2003-11-21 2015-11-11 Postupak za lijeäśenje multiple skleroze inhibicijom aktivnosti il-17

Country Status (16)

Country Link
US (2) US20070269428A1 (hr)
EP (3) EP1687026B1 (hr)
JP (1) JP4833850B2 (hr)
AT (1) ATE395083T1 (hr)
AU (1) AU2004292393C1 (hr)
CA (1) CA2544920C (hr)
CY (1) CY1116992T1 (hr)
DE (1) DE602004013825D1 (hr)
DK (1) DK1983000T3 (hr)
ES (2) ES2305879T3 (hr)
HR (1) HRP20151210T1 (hr)
HU (1) HUE026260T2 (hr)
PL (1) PL1983000T3 (hr)
PT (1) PT1983000E (hr)
SI (1) SI1983000T1 (hr)
WO (1) WO2005051422A1 (hr)

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Also Published As

Publication number Publication date
WO2005051422A1 (en) 2005-06-09
EP1983000A3 (en) 2011-07-27
US20070269428A1 (en) 2007-11-22
US20090191200A1 (en) 2009-07-30
JP2007511593A (ja) 2007-05-10
EP1687026A1 (en) 2006-08-09
PT1983000E (pt) 2015-12-30
CA2544920A1 (en) 2005-06-09
EP1687026B1 (en) 2008-05-14
US7931900B2 (en) 2011-04-26
AU2004292393A1 (en) 2005-06-09
AU2004292393C1 (en) 2011-08-04
EP1983000A2 (en) 2008-10-22
AU2004292393B2 (en) 2009-10-08
EP1983000B1 (en) 2015-09-02
JP4833850B2 (ja) 2011-12-07
PL1983000T3 (pl) 2016-02-29
EP2974742A1 (en) 2016-01-20
HUE026260T2 (en) 2016-06-28
ES2554645T3 (es) 2015-12-22
DK1983000T3 (en) 2015-12-07
ATE395083T1 (de) 2008-05-15
CY1116992T1 (el) 2017-04-05
DE602004013825D1 (de) 2008-06-26
ES2305879T3 (es) 2008-11-01
SI1983000T1 (sl) 2015-12-31
CA2544920C (en) 2012-09-11

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