HRP20150658T1 - Postupak za pripremu amida pirazol karboksilne kiseline - Google Patents
Postupak za pripremu amida pirazol karboksilne kiseline Download PDFInfo
- Publication number
- HRP20150658T1 HRP20150658T1 HRP20150658TT HRP20150658T HRP20150658T1 HR P20150658 T1 HRP20150658 T1 HR P20150658T1 HR P20150658T T HRP20150658T T HR P20150658TT HR P20150658 T HRP20150658 T HR P20150658T HR P20150658 T1 HRP20150658 T1 HR P20150658T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- oxygen
- compound
- sulfur
- image
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 8
- BNYCHCAYYYRJSH-UHFFFAOYSA-N 1h-pyrazole-5-carboxamide Chemical compound NC(=O)C1=CC=NN1 BNYCHCAYYYRJSH-UHFFFAOYSA-N 0.000 title 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- 239000001301 oxygen Substances 0.000 claims 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
- 229910052717 sulfur Chemical group 0.000 claims 8
- 239000011593 sulfur Chemical group 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 5
- 125000004784 trichloromethoxy group Chemical group ClC(O*)(Cl)Cl 0.000 claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical group CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- -1 methoxy, ethoxy, isopropoxy, isopropenyloxy Chemical group 0.000 claims 1
- 150000002923 oximes Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/56—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
- C07C251/64—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (8)
1. Postupak za pripremu spoja s formulom I
[image]
te navedeni postupak sadrži
aciliranje oksima kisika spoja s formulom VIII
[image]
u prisutnosti otapala i sredstva za aciliranje s formulom XI
R1-C(X)-Cl (XI),
pri čemu X je kisik ili sumpor;
R1 je kloro ako X je kisik ili sumpor; ili
R1 je C1-C6alkoksi, CH3-C(=CH2)-O-, fenoksi ili triklorometoksi ako X je kisik;
i
a) ako R1 je kloro i spoj s formulom XI je bio dodan u spoj s formulom VIII; reakciju tako dobivenog produkta s formulom XIIa
[image]
pri čemu X je kisik ili sumpor;
sa spojem s formulom IX
[image]
ili
b) ako R1 je kloro i spoj s formulom VIII je bio dodan u spoj s formulom XI; ili R1 je C1-C6alkoksi, CH3-C(=CH2)-O-, fenoksi ili triklorometoksi ako X je kisik;
reakciju tako dobivenog produkta s formulom XII
[image]
pri čemu X je kisik ili sumpor;
R1 je kloro ako X je kisik ili sumpor; ili
R1 je C1-C6alkoksi, CH3-C(=CH2)-O-, fenoksi ili triklorometoksi ako X je kisik; sa spojem s formulom IX
[image]
2. Postupak prema zahtjevu 1, naznačen time da je sredstvo za aciliranje odabrano od spoja s formulom XI, pri čemu R1 je metoksi, etoksi, izopropoksi, izopropeniloksi ili fenoksi i X je kisik.
3. Postupak prema zahtjevu 2, naznačen time da sredstvo za aciliranje je etil-kloroformat.
4. Postupak prema zahtjevu 1, naznačen time da sredstvo za aciliranje reagira sa spojem s formulom IX u prisutnosti kiseline.
5. Postupak prema zahtjevu 1, naznačen time da sredstvo za aciliranje reagira sa spojem s formulom IX u prisutnosti CH3SO3H.
6. Postupak prema zahtjevu 1, naznačen time da sredstvo za aciliranje je etil-kloroformat i acilirani derivat reagira sa spojem s formulom IX u prisutnosti CH3SO3H.
7. Spoj s formulom XII
[image]
naznačen time da X je kisik ili sumpor;
R1 je kloro ako X je kisik ili sumpor; ili
R1 je C1-C6alkoksi, CH3-C(=CH2)-O-, fenoksi ili triklorometoksi ako X je kisik.
8. Spoj s formulom XIIa
[image]
naznačen time da X je kisik ili sumpor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151965 | 2011-01-25 | ||
| EP12700859.7A EP2668166B1 (en) | 2011-01-25 | 2012-01-25 | Process for the preparation of a pyrazole carboxylic acid amide |
| PCT/EP2012/051075 WO2012101139A1 (en) | 2011-01-25 | 2012-01-25 | Process for the preparation of pyrazole carboxylic acid amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150658T1 true HRP20150658T1 (hr) | 2015-07-31 |
Family
ID=45524566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150658TT HRP20150658T1 (hr) | 2011-01-25 | 2015-06-17 | Postupak za pripremu amida pirazol karboksilne kiseline |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8895757B2 (hr) |
| EP (1) | EP2668166B1 (hr) |
| JP (2) | JP6133788B2 (hr) |
| KR (1) | KR101851781B1 (hr) |
| CN (1) | CN103339113B (hr) |
| AR (1) | AR084915A1 (hr) |
| AU (1) | AU2012210547B2 (hr) |
| BR (1) | BR112013018533A2 (hr) |
| CA (1) | CA2824730C (hr) |
| CO (1) | CO6751253A2 (hr) |
| ES (1) | ES2540211T3 (hr) |
| HR (1) | HRP20150658T1 (hr) |
| IL (1) | IL227317A (hr) |
| MX (1) | MX352697B (hr) |
| PL (1) | PL2668166T3 (hr) |
| PT (1) | PT2668166E (hr) |
| TW (1) | TWI534126B (hr) |
| UY (1) | UY33879A (hr) |
| WO (1) | WO2012101139A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI534126B (zh) * | 2011-01-25 | 2016-05-21 | 先正達合夥公司 | 用於製備吡唑羧酸醯胺之方法 |
| TWI510472B (zh) | 2012-02-15 | 2015-12-01 | Syngenta Participations Ag | 立體選擇性製備吡唑羧醯胺之方法 |
| WO2018179632A1 (ja) | 2017-03-31 | 2018-10-04 | 日本精工株式会社 | レーザ溶接装置、レーザ加工装置、レーザ溶接方法、軸受の製造方法、機械の製造方法、車両の製造方法、軸受、機械、及び車両 |
| WO2024017788A1 (en) | 2022-07-22 | 2024-01-25 | Syngenta Crop Protection Ag | Solid form of a heterocyclic amide derivative |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58194853A (ja) * | 1982-05-11 | 1983-11-12 | Showa Denko Kk | シクロヘキセン−アセチルオキシム誘導体 |
| US5093347A (en) | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| GT200600468A (es) * | 2005-10-25 | 2007-06-08 | Nuevos microbiocidas | |
| MX2010011790A (es) * | 2008-05-14 | 2010-11-25 | Syngenta Ltd | Proceso para la preparacion de amidas. |
| CN102264705A (zh) * | 2008-12-24 | 2011-11-30 | 辛根塔有限公司 | 制备芳基酰胺的方法 |
| EP2462108B1 (en) | 2009-08-06 | 2013-04-17 | Syngenta Participations AG | Process for the preparation of pyrazole carboxylic acid amides |
| US8524915B2 (en) * | 2010-04-20 | 2013-09-03 | Syngenta Crop Protection Llc | Process for the preparation of pyrazole carboxylic acid amides |
| ES2513540T3 (es) * | 2010-04-20 | 2014-10-27 | Syngenta Participations Ag | Proceso para preparar amidas de ácidos carboxílicos pirazólicos |
| CN102844306B (zh) * | 2010-04-20 | 2015-01-14 | 先正达参股股份有限公司 | 吡唑羧酸酰胺的制备方法 |
| TWI534126B (zh) * | 2011-01-25 | 2016-05-21 | 先正達合夥公司 | 用於製備吡唑羧酸醯胺之方法 |
-
2012
- 2012-01-20 TW TW101102374A patent/TWI534126B/zh active
- 2012-01-23 AR ARP120100211A patent/AR084915A1/es active IP Right Grant
- 2012-01-25 AU AU2012210547A patent/AU2012210547B2/en active Active
- 2012-01-25 UY UY0001033879A patent/UY33879A/es active IP Right Grant
- 2012-01-25 EP EP12700859.7A patent/EP2668166B1/en active Active
- 2012-01-25 CN CN201280006384.7A patent/CN103339113B/zh active Active
- 2012-01-25 WO PCT/EP2012/051075 patent/WO2012101139A1/en active Application Filing
- 2012-01-25 PL PL12700859T patent/PL2668166T3/pl unknown
- 2012-01-25 MX MX2013007914A patent/MX352697B/es active IP Right Grant
- 2012-01-25 PT PT127008597T patent/PT2668166E/pt unknown
- 2012-01-25 KR KR1020137022399A patent/KR101851781B1/ko active IP Right Grant
- 2012-01-25 US US13/981,913 patent/US8895757B2/en active Active
- 2012-01-25 CA CA2824730A patent/CA2824730C/en active Active
- 2012-01-25 JP JP2013549849A patent/JP6133788B2/ja active Active
- 2012-01-25 ES ES12700859.7T patent/ES2540211T3/es active Active
- 2012-01-25 BR BR112013018533A patent/BR112013018533A2/pt active IP Right Grant
-
2013
- 2013-07-04 IL IL227317A patent/IL227317A/en active IP Right Grant
- 2013-07-23 CO CO13173578A patent/CO6751253A2/es unknown
-
2015
- 2015-06-17 HR HRP20150658TT patent/HRP20150658T1/hr unknown
-
2016
- 2016-11-07 JP JP2016217091A patent/JP6419131B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI534126B (zh) | 2016-05-21 |
| PT2668166E (pt) | 2015-08-27 |
| PL2668166T3 (pl) | 2015-09-30 |
| JP6133788B2 (ja) | 2017-05-24 |
| ES2540211T3 (es) | 2015-07-09 |
| TW201245114A (en) | 2012-11-16 |
| AU2012210547A1 (en) | 2013-08-01 |
| IL227317A (en) | 2014-11-30 |
| MX2013007914A (es) | 2013-08-29 |
| KR101851781B1 (ko) | 2018-04-24 |
| JP2017071614A (ja) | 2017-04-13 |
| IL227317A0 (en) | 2013-09-30 |
| AU2012210547B2 (en) | 2016-04-14 |
| UY33879A (es) | 2012-08-31 |
| EP2668166A1 (en) | 2013-12-04 |
| BR112013018533A2 (pt) | 2016-07-12 |
| CO6751253A2 (es) | 2013-09-16 |
| US20130310592A1 (en) | 2013-11-21 |
| CA2824730A1 (en) | 2012-08-02 |
| JP6419131B2 (ja) | 2018-11-07 |
| WO2012101139A1 (en) | 2012-08-02 |
| MX352697B (es) | 2017-12-05 |
| JP2014504596A (ja) | 2014-02-24 |
| CN103339113A (zh) | 2013-10-02 |
| CA2824730C (en) | 2018-10-23 |
| EP2668166B1 (en) | 2015-05-13 |
| US8895757B2 (en) | 2014-11-25 |
| CN103339113B (zh) | 2015-07-22 |
| AR084915A1 (es) | 2013-07-10 |
| KR20140019333A (ko) | 2014-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20150658T1 (hr) | Postupak za pripremu amida pirazol karboksilne kiseline | |
| IN2014CN02497A (hr) | ||
| EA201070235A1 (ru) | Новые производные 6-триазолпиридинсульфанил-бензотиазола и -бензимидазола, способ их получения, применение их в качестве лекарственных средств, фармацевтические композиции и новое применение, а именно в качестве ингибиторов met | |
| GB0601744D0 (en) | Organic compounds | |
| ME00040B (me) | Biciklično cinamidno jedinjenje | |
| TN2012000399A1 (en) | Dihydrofuran derivatives as insecticidal compounds | |
| SG195118A1 (en) | Process for the production of estetrol intermediates | |
| MY162033A (en) | New process for the synthesis of agomelatine | |
| AR066107A1 (es) | Derivados de triazolopiridin - carboxamidas y triazolopirimidin-carboxamidas, su preparacion y su aplicacion en terapeutica como inhibidores de la enzimamonoacil glicerol lipasa y composiciones qu los contienen. | |
| SA114350251B1 (ar) | تحضير مشتقات مكرر اميد باعتبارها مبيدات حشرات او مبيدات قراديات او مبيدات خيطيات | |
| DE602008001872D1 (de) | Verfahren zur synthese von saccharose-6-estern | |
| JO2818B1 (en) | A new process for the installation of agililatine | |
| IN2014DN01993A (hr) | ||
| ATE461198T1 (de) | 6,7-dihydrobenzimidazoä1,2-cüchinazolin-6- oncarbonsäuren, ihre ester und verfahren zu ihrer synthese | |
| PE20120223A1 (es) | Compuestos heterociclicos como inhibidores del transportador de glicina-1 (glyt-1) | |
| WO2009127949A8 (en) | 4- [3- (aryloxy) benzylidene] -3-methyl piperidine aryl carboxamide compounds useful as faah inhibitors | |
| RS53785B1 (en) | PIRAZOL UNITS AS CRTH2 ANTAGONISTS | |
| IN2014MN00850A (hr) | ||
| DE502007003531D1 (de) | Verfahren zum herstellen von alkylaniliden aus halogenbenzolderivaten | |
| MY144746A (en) | Process for the preparation of agomelatine | |
| DE502005008252D1 (de) | Verfahren zur herstellung von harnstoff aus erdgas | |
| EP2571857A4 (en) | NEW PROCESSES | |
| HRP20170776T1 (hr) | Postupak za pripravu modulatora histaminskog h3 receptora | |
| AU2013293943B2 (en) | Solid detergent composition | |
| DE602008004124D1 (de) | Verfahren zur Herstellung eines polylaktischen Säurestereokomplex-Pulvers |