HRP20150418T1 - Derivat kolestanola za kombiniranu uporabu - Google Patents

Derivat kolestanola za kombiniranu uporabu Download PDF

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Publication number
HRP20150418T1
HRP20150418T1 HRP20150418TT HRP20150418T HRP20150418T1 HR P20150418 T1 HRP20150418 T1 HR P20150418T1 HR P20150418T T HRP20150418T T HR P20150418TT HR P20150418 T HRP20150418 T HR P20150418T HR P20150418 T1 HRP20150418 T1 HR P20150418T1
Authority
HR
Croatia
Prior art keywords
antitumor
agent
cholestanol
derivative
glcnac
Prior art date
Application number
HRP20150418TT
Other languages
English (en)
Inventor
Shin Yazawa
Toyo Nishimura
Takayuki Asao
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
National University Corporation Gunma University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2009/004353 external-priority patent/WO2010100686A1/ja
Application filed by Otsuka Pharmaceutical Co., Ltd., National University Corporation Gunma University filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of HRP20150418T1 publication Critical patent/HRP20150418T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides

Claims (5)

1. Protutumorsko kemoterapijsko sredstvo, naznačeno time, da sadrži, u kombinaciji, derivat kolestanola, prikazan formulom (1): [image] (pri čemu G predstavlja GlcNAc- ili GlcNAc-Gal-) ili njihov inkluzijski spoj ciklodekstrina, i irinotekan kao protutumorsko sredstvo.
2. Protutumorsko kemoterapijsko sredstvo u skladu s patentnim zahtjevom 1, naznačeno time, da je to kombinacijsko sredstvo.
3. Protutumorsko kemoterapijsko sredstvo u skladu s patentnim zahtjevom 1, naznačeno time, da je u obliku kompleta uključujući lijek koji sadrži derivat kolestanola i lijek koji sadrži protutumorsko sredstvo.
4. Protutumorsko kemoterapijsko sredstvo u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačeno time, da je lijek koji sadrži derivat kolestanola liposomski pripravak.
5. Upotreba, u kombinaciji, derivata kolestanola, naznačena time, da je predstavljen formulom (1): [image] (pri čemu G predstavlja GlcNAc- ili GlcNAc-Gal-) ili njihov inkluzijski spoj ciklodekstrina, i irinotekan kao protutumorsko sredstvo.
HRP20150418TT 2008-03-05 2015-04-14 Derivat kolestanola za kombiniranu uporabu HRP20150418T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2008055284 2008-03-05
PCT/JP2009/000985 WO2009110235A1 (ja) 2008-03-05 2009-03-04 コレスタノール誘導体の併用用途
PCT/JP2009/004353 WO2010100686A1 (ja) 2009-03-04 2009-09-03 コレスタノール誘導体の併用用途
EP09841052.5A EP2404608B1 (en) 2009-03-04 2009-09-03 Cholestanol derivative for combined use

Publications (1)

Publication Number Publication Date
HRP20150418T1 true HRP20150418T1 (hr) 2015-05-08

Family

ID=41055800

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20140154AT HRP20140154T1 (hr) 2008-03-05 2014-02-18 Kombinacija protutumorskog sredstva i derivata kolestanola
HRP20150418TT HRP20150418T1 (hr) 2008-03-05 2015-04-14 Derivat kolestanola za kombiniranu uporabu

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20140154AT HRP20140154T1 (hr) 2008-03-05 2014-02-18 Kombinacija protutumorskog sredstva i derivata kolestanola

Country Status (27)

Country Link
US (6) US8088744B2 (hr)
EP (1) EP2251014B8 (hr)
JP (1) JP5336466B2 (hr)
KR (1) KR20100120674A (hr)
CN (2) CN101678037B (hr)
AR (1) AR070857A1 (hr)
AU (1) AU2009220699C1 (hr)
BR (2) BRPI0908756A2 (hr)
CA (1) CA2717135A1 (hr)
CO (2) CO6311080A2 (hr)
CY (1) CY1115217T1 (hr)
DK (1) DK2251014T3 (hr)
ES (1) ES2437640T3 (hr)
HK (1) HK1145455A1 (hr)
HR (2) HRP20140154T1 (hr)
IL (1) IL207874A (hr)
MX (1) MX2010009794A (hr)
NZ (2) NZ587729A (hr)
PL (1) PL2251014T3 (hr)
PT (1) PT2251014E (hr)
RU (1) RU2492865C2 (hr)
SG (2) SG188805A1 (hr)
SI (1) SI2251014T1 (hr)
TW (1) TWI492759B (hr)
UA (2) UA101831C2 (hr)
WO (1) WO2009110235A1 (hr)
ZA (1) ZA201006228B (hr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ548195A (en) * 2004-01-14 2011-01-28 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
PT2404608E (pt) * 2009-03-04 2015-07-21 Otsuka Pharma Co Ltd Derivado de colestanol para utilização combinada
JP5480241B2 (ja) * 2009-03-04 2014-04-23 大塚製薬株式会社 コレスタノール誘導体の併用用途
WO2013179310A1 (en) * 2012-05-31 2013-12-05 Mylan Laboratories Limited Stable aqueous compositions of pemetrexed
WO2024018412A1 (en) * 2022-07-20 2024-01-25 University Of The Witwatersrand, Johannesburg 2-hydroxypropyl-beta-cyclodextrin as a cancer therapy neoadjuvant or adjuvant

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5782310A (en) 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
JPS6012127A (ja) 1983-06-30 1985-01-22 Dai Ichi Seiyaku Co Ltd リポソ−ムの製法
JPS6058915A (ja) 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd 薬物含有脂質小胞体製剤
JPH0610131B2 (ja) 1987-10-30 1994-02-09 テルモ株式会社 リポソームの製法
JPH01167218A (ja) 1987-12-22 1989-06-30 Sumitomo Electric Ind Ltd 超電導薄膜の作製方法
JPH082780B2 (ja) 1990-05-28 1996-01-17 テルモ株式会社 リポソームの製法
JP3831958B2 (ja) 1995-09-20 2006-10-11 日本油脂株式会社 リポソーム用混合脂質及びリポソーム分散液
JP4105258B2 (ja) * 1997-08-19 2008-06-25 大塚製薬株式会社 コレスタノール化合物及びこれを含有する医薬
JP4351314B2 (ja) 1998-12-24 2009-10-28 大塚製薬株式会社 コレスタノール化合物及びこれを含有する医薬
EE200200565A (et) * 2000-03-31 2004-06-15 Angiogene Pharmaceuticals Ltd. Vaskulaarse kahjustava toimega kombinatsioonravi
AU2004257509B2 (en) 2003-07-17 2008-12-18 Otsuka Pharmaceutical Co., Ltd. Glycoside-containing liposome
MXPA06006291A (es) * 2003-12-08 2006-08-23 Univ Arizona Composiciones anti-cancer sinergisticas.
EP1753512B1 (en) * 2004-05-28 2008-07-09 Nycomed GmbH Tetrahydropyridothiophenes
TWI373473B (en) * 2005-09-02 2012-10-01 Otsuka Pharma Co Ltd Anticancer agent

Also Published As

Publication number Publication date
BRPI0908756A2 (pt) 2015-07-21
US20100062053A1 (en) 2010-03-11
JPWO2009110235A1 (ja) 2011-07-14
NZ587729A (en) 2012-03-30
US20150374730A1 (en) 2015-12-31
PT2251014E (pt) 2014-02-14
US20120015025A1 (en) 2012-01-19
CN101678037A (zh) 2010-03-24
SI2251014T1 (sl) 2014-02-28
US20140178464A1 (en) 2014-06-26
NZ595615A (en) 2013-06-28
HK1145455A1 (en) 2011-04-21
CO6311080A2 (es) 2011-08-22
US8088744B2 (en) 2012-01-03
CN101678037B (zh) 2012-07-25
EP2251014B1 (en) 2013-11-20
CN101969961B (zh) 2013-01-16
CY1115217T1 (el) 2017-01-04
US20130101679A1 (en) 2013-04-25
UA101884C2 (uk) 2013-05-13
CN101969961A (zh) 2011-02-09
SG188805A1 (en) 2013-04-30
KR20100120674A (ko) 2010-11-16
HRP20140154T1 (hr) 2014-03-14
RU2492865C2 (ru) 2013-09-20
TW200940097A (en) 2009-10-01
JP5336466B2 (ja) 2013-11-06
MX2010009794A (es) 2010-12-21
CO6361931A2 (es) 2012-01-20
IL207874A (en) 2014-05-28
BRPI0924525A2 (pt) 2016-03-01
US20120009251A1 (en) 2012-01-12
AR070857A1 (es) 2010-05-12
TWI492759B (zh) 2015-07-21
EP2251014A4 (en) 2012-05-23
EP2251014A1 (en) 2010-11-17
DK2251014T3 (da) 2013-12-02
AU2009220699A1 (en) 2009-09-11
IL207874A0 (en) 2010-12-30
PL2251014T3 (pl) 2014-04-30
ES2437640T3 (es) 2014-01-13
ZA201006228B (en) 2011-11-30
UA101831C2 (uk) 2013-05-13
CA2717135A1 (en) 2009-09-11
AU2009220699B2 (en) 2013-06-20
EP2251014B8 (en) 2014-01-08
WO2009110235A1 (ja) 2009-09-11
RU2010140611A (ru) 2012-04-10
SG10201400171PA (en) 2014-06-27
AU2009220699C1 (en) 2014-01-16

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