HRP20141174T1 - Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a - Google Patents

Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a Download PDF

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Publication number
HRP20141174T1
HRP20141174T1 HRP20141174AT HRP20141174T HRP20141174T1 HR P20141174 T1 HRP20141174 T1 HR P20141174T1 HR P20141174A T HRP20141174A T HR P20141174AT HR P20141174 T HRP20141174 T HR P20141174T HR P20141174 T1 HRP20141174 T1 HR P20141174T1
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Croatia
Prior art keywords
alkyl
cyclopropyl
amino
alkoxy
heterocycloalkyl
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HRP20141174AT
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English (en)
Croatian (hr)
Inventor
Stephen Brough
Richard Evans
Timothy Jon Luker
Piotr Raubo
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Astrazeneca Ab
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Publication of HRP20141174T1 publication Critical patent/HRP20141174T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
HRP20141174AT 2007-06-27 2008-06-25 Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a HRP20141174T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94641507P 2007-06-27 2007-06-27
US97816707P 2007-10-08 2007-10-08
US2944408P 2008-02-18 2008-02-18
EP08776162.3A EP2170848B1 (en) 2007-06-27 2008-06-25 Pyrazinone derivatives and their use in the treatment of lung diseases
PCT/GB2008/050491 WO2009001132A1 (en) 2007-06-27 2008-06-25 Pyrazinone derivatives and their use in the treatment of lung diseases

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HRP20141174T1 true HRP20141174T1 (hr) 2015-02-13

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HRP20141174AT HRP20141174T1 (hr) 2007-06-27 2008-06-25 Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a

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US (4) US8163905B2 (Direct)
EP (1) EP2170848B1 (Direct)
JP (2) JP5140154B2 (Direct)
KR (1) KR101541203B1 (Direct)
CN (1) CN101842361B (Direct)
AR (1) AR067444A1 (Direct)
AU (1) AU2008269516B2 (Direct)
BR (1) BRPI0813244B8 (Direct)
CA (1) CA2691215C (Direct)
CL (1) CL2008001898A1 (Direct)
CO (1) CO6251251A2 (Direct)
CY (1) CY1115836T1 (Direct)
DK (1) DK2170848T3 (Direct)
EC (1) ECSP109903A (Direct)
ES (1) ES2525716T3 (Direct)
HR (1) HRP20141174T1 (Direct)
IL (1) IL202826A (Direct)
MY (1) MY153258A (Direct)
NZ (1) NZ581942A (Direct)
PE (1) PE20090547A1 (Direct)
PL (1) PL2170848T3 (Direct)
PT (1) PT2170848E (Direct)
RS (1) RS53682B1 (Direct)
RU (1) RU2479580C2 (Direct)
SG (1) SG182958A1 (Direct)
SI (1) SI2170848T1 (Direct)
TW (1) TWI448288B (Direct)
UA (1) UA98961C2 (Direct)
UY (1) UY31183A1 (Direct)
WO (1) WO2009001132A1 (Direct)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2170848T1 (sl) * 2007-06-27 2015-01-30 Astrazeneca Ab Derivati pirazinona in njihova uporaba pri zdravljenju bolezni pljuč
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
AR073711A1 (es) 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
EP2379174A4 (en) * 2008-12-18 2012-11-14 Astrazeneca Ab PHARMACEUTICAL PRODUCT USING A P38 KINASE INHIBITOR AND A SECOND ACTIVE SUBSTANCE
EP2389362B1 (en) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
CN102639496B (zh) 2009-09-25 2014-10-29 奥瑞泽恩基因组学股份有限公司 赖氨酸特异性脱甲基酶-1抑制剂及其应用
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
WO2011082218A1 (en) 2009-12-31 2011-07-07 Ira Milton Trachtman Compositions and method for treatment and prophylaxis of inflammatory bowel disease
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
WO2011106105A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
CN102947265B (zh) 2010-04-19 2015-07-29 奥瑞泽恩基因组学股份有限公司 赖氨酸特异性脱甲基酶-1抑制剂及其应用
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
EP2598482B1 (en) 2010-07-29 2018-04-04 Oryzon Genomics, S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
TWI535712B (zh) * 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
WO2012107498A1 (en) 2011-02-08 2012-08-16 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative disorders
EP2741741A2 (en) * 2011-05-19 2014-06-18 Oryzon Genomics, S.A. Lysine demethylase inhibitors for inflammatory diseases or conditions
BR112014009306B1 (pt) 2011-10-20 2021-07-20 Oryzon Genomics S.A. Compostos de (hetero)aril ciclopropilamina como inibidores de lsd1
US9469597B2 (en) 2011-10-20 2016-10-18 Oryzon Genomics S.A. (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
MX2014012236A (es) 2012-04-10 2014-11-25 Sumitomo Dainippon Pharma Co Ltd Derivado novedoso de indazol 1-sustituido.
US9434695B2 (en) 2012-07-18 2016-09-06 Sunshine Lake Pharma Co., Ltd Nitrogenous heterocyclic derivatives and their application in drugs
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
US20140302819A1 (en) * 2013-04-05 2014-10-09 Microsoft Corporation Techniques for selecting a proximity card of a mobile device for access
MX383590B (es) 2013-08-06 2025-03-11 Imago Biosciences Inc Inhibidores de kdm1a para el tratamiento de enfermedades.
EA030946B1 (ru) 2014-06-27 2018-10-31 Селджен Квонтисел Рисёрч, Инк. Ингибиторы лизин-специфической деметилазы-1
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
PT3256218T (pt) 2015-02-12 2025-01-29 Imago Biosciences Inc Um inibidor de kdm1a e a sua utilização na terapia
CN108884057A (zh) * 2016-03-24 2018-11-23 阿斯利康(瑞典)有限公司 结晶形式
US10934272B2 (en) 2016-04-07 2021-03-02 Glaxosmithkline Intellectual Property (No. 2) Limited Pyridyl derivatives as bromodomain inhibitors
CN111194306B (zh) 2016-08-16 2023-05-16 伊美格生物科学公司 用于制备kdm1a抑制剂的方法和过程
CN109715163B (zh) 2016-09-19 2022-11-22 诺华股份有限公司 包含raf抑制剂和erk抑制剂的治疗组合
CN109843870A (zh) * 2016-10-19 2019-06-04 星座制药公司 Ezh2抑制剂的合成
CN106674029B (zh) * 2016-12-23 2018-08-21 四川久凌制药科技有限公司 一种他喷他多中间体的制备方法
JP7309614B2 (ja) 2017-05-02 2023-07-18 ノバルティス アーゲー 組み合わせ療法
CN112513020B (zh) * 2018-05-11 2024-02-23 伊美格生物科学公司 用于治疗疾病的kdm1a抑制剂
WO2020193419A1 (en) * 2019-03-22 2020-10-01 Saniona A/S Novel potassium channel inhibitors
CN113795490A (zh) 2019-05-13 2021-12-14 诺华股份有限公司 N-(3-(2-(2-羟基乙氧基)-6-吗啉代吡啶-4-基)-4-甲基苯基)-2(三氟甲基)异烟酰胺的新结晶形式作为Raf抑制剂治疗癌症
RS66997B1 (sr) * 2021-04-14 2025-08-29 Shionogi & Co Derivati triazina koji imaju inhibitorno delovanje na replikaciju virusa i farmaceutska kompozicija koja sadrži iste
CN113999129B (zh) * 2021-11-23 2023-09-01 长沙普济生物科技股份有限公司 一种含酚羟基氨基酸表面活性剂的合成方法
WO2025122555A1 (en) * 2023-12-05 2025-06-12 Valo Health, Inc. S1p 1 receptor agonists and uses thereof
CN119350255B (zh) * 2024-10-21 2025-12-09 海南大学 一种酮衍生物及其合成方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU723234B2 (en) * 1996-09-06 2000-08-24 Nippon Kayaku Kabushiki Kaisha Novel acetamide derivatives and protease inhibitors
TWI328007B (en) 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
JP2005526068A (ja) 2002-03-14 2005-09-02 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗炎症剤としての単環式アロイルピリジノン類
PT1534391E (pt) 2002-07-19 2007-05-31 Biovitrum Ab Novos derivados e piperazinilo-pirazinona para o tratamento de desordens relacionadas com o receptor 5-ht
CA2540640A1 (en) 2003-09-30 2005-04-14 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1678164B1 (en) * 2003-10-14 2007-04-11 Pharmacia Corporation Substituted pyrazinone compounds for the treatment of inflammation
ES2578254T3 (es) * 2003-12-03 2016-07-22 Ym Biosciences Australia Pty Ltd Inhibidores de cinasas basados en azol
GB0402812D0 (en) * 2004-02-09 2004-03-10 Tanabe Seiyaku Co Novel compounds
BRPI0512915A (pt) 2004-06-29 2008-04-15 Warner Lambert Co terapias de combinação utilizando inibidores benzamida do receptor p2x7
JP4496092B2 (ja) 2005-01-12 2010-07-07 信越化学工業株式会社 光ファイバ母材の製造方法及び装置
US8329704B2 (en) 2005-12-21 2012-12-11 Janssen Pharmaceutica, N.V. Substituted pyrazinone derivatives for use in MCH-1 mediated diseases
GB0608837D0 (en) 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of MAP kinase
AU2007246869B2 (en) 2006-05-04 2012-10-18 Macrophage Pharma Limited p38 MAP kinase inhibitors
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
MX2008014921A (es) * 2006-05-22 2008-12-09 Janssen Pharmaceutica Nv Derivados de piracinona sustituidos para uso como un medicamento.
TW200924754A (en) * 2006-06-21 2009-06-16 Du Pont Pyrazinones as cellular proliferation inhibitors
US20090186907A1 (en) * 2006-06-21 2009-07-23 E.I. Dupont De Nemours And Company Pyrazinones As Cellular Proliferation Inhibitors
SI2170848T1 (sl) * 2007-06-27 2015-01-30 Astrazeneca Ab Derivati pirazinona in njihova uporaba pri zdravljenju bolezni pljuč

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