HRP20130023T1 - Cjepivo koje sadrži emulziju ulje u vodi kao adjuvans - Google Patents
Cjepivo koje sadrži emulziju ulje u vodi kao adjuvans Download PDFInfo
- Publication number
- HRP20130023T1 HRP20130023T1 HRP20130023TT HRP20130023T HRP20130023T1 HR P20130023 T1 HRP20130023 T1 HR P20130023T1 HR P20130023T T HRP20130023T T HR P20130023TT HR P20130023 T HRP20130023 T HR P20130023T HR P20130023 T1 HRP20130023 T1 HR P20130023T1
- Authority
- HR
- Croatia
- Prior art keywords
- immunogenic preparation
- oil
- accordance
- immunogenic
- dose volume
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 title claims 2
- 239000007764 o/w emulsion Substances 0.000 title claims 2
- 229960005486 vaccine Drugs 0.000 title 1
- 230000002163 immunogen Effects 0.000 claims 11
- DFUSDJMZWQVQSF-XLGIIRLISA-N (2r)-2-methyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 DFUSDJMZWQVQSF-XLGIIRLISA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 238000009117 preventive therapy Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Claims (10)
1. Imunogeni pripravak, naznačen time što sadrži antigen ili antigenski pripravak i adjuvans, koji se sastoji od emulzija ulje u vodi, gdje navedena emulzija ulje u vodi sadrži 1 do 6 mg skvalena, 1 do 7 mg tokola i 0,4 do 3 mg emulgatora, po dozi za čovjeka.
2. Imunogeni pripravak u skladu s patentnim zahtjevom 1, naznačen time što je tokol α-tokoferol.
3. Imunogeni pripravak u skladu s patentnim zahtjevima 1 ili 2, naznačen time što je emulgator polioksietilensorbitan-monooleat.
4. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je volumen doze za čovjeka između 0,4 i 1,5 ml.
5. Imunogeni pripravak u skladu s patentnim zahtjevom 4, naznačen time što je navedeni volumen doze za čovjeka 0,5 ml.
6. Imunogeni pripravak u skladu s patentnim zahtjevom 4, naznačen time što je navedeni volumen doze za čovjeka 0,7 ml.
7. Imunogeni pripravak u skladu s patentnim zahtjevom 4, naznačen time što je navedeni volumen doze 1,0 ml.
8. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što se antigen ili antigeni pripravak pripravlja iz virusa influence.
9. Imunogeni pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačen time što je namijenjen upotrebi u profilaktičnoj terapiji ili terapiji stanja ili bolesti.
10. Upotreba imunogenog pripravka u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačena time što je navedeni imunogeni pripravak namijenjen proizvodnji medikamenta namijenjenog upotrebi u profilaktičnoj terapiji ili terapiji stanja ili bolesti.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0620337A GB0620337D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GBGB0620336.8A GB0620336D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GB0620816A GB0620816D0 (en) | 2006-10-19 | 2006-10-19 | vaccine |
GB0620815A GB0620815D0 (en) | 2006-10-19 | 2006-10-19 | Vaccine |
PCT/EP2006/069979 WO2007071711A2 (en) | 2005-12-22 | 2006-12-20 | Vaccine |
PCT/EP2006/069977 WO2007071710A2 (en) | 2005-12-22 | 2006-12-20 | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
GB0707697A GB0707697D0 (en) | 2007-04-20 | 2007-04-20 | Vaccine |
GB0711357A GB0711357D0 (en) | 2007-06-12 | 2007-06-12 | Vaccine |
GB0712062A GB0712062D0 (en) | 2007-06-21 | 2007-06-21 | Vaccine |
PCT/EP2007/060743 WO2008043774A1 (en) | 2006-10-12 | 2007-10-10 | Vaccine comprising an oil in water emulsion adjuvant |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20130023T1 true HRP20130023T1 (hr) | 2013-02-28 |
Family
ID=40551582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20130023TT HRP20130023T1 (hr) | 2006-10-12 | 2013-01-14 | Cjepivo koje sadrži emulziju ulje u vodi kao adjuvans |
Country Status (18)
Country | Link |
---|---|
US (2) | US20100183667A1 (hr) |
JP (2) | JP5230632B2 (hr) |
KR (1) | KR101151202B1 (hr) |
CN (1) | CN101522218B (hr) |
AU (1) | AU2007306381B2 (hr) |
BR (1) | BRPI0717219B8 (hr) |
CA (1) | CA2664619C (hr) |
CR (1) | CR10726A (hr) |
DK (1) | DK2086582T3 (hr) |
EA (1) | EA015817B1 (hr) |
ES (1) | ES2397714T3 (hr) |
HR (1) | HRP20130023T1 (hr) |
IL (1) | IL197512A (hr) |
MA (1) | MA30866B1 (hr) |
MX (1) | MX2009003325A (hr) |
NO (1) | NO20091022L (hr) |
PT (1) | PT2086582E (hr) |
WO (1) | WO2008043774A1 (hr) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2457100A (en) * | 1999-02-26 | 2000-09-14 | Chiron S.P.A. | Enhancement of bactericidal activity of neisseria antigens with oligonucleotidescontaining cg motifs |
DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
US20090081253A1 (en) * | 2005-03-23 | 2009-03-26 | Glaxosmithkline Biologicals S.A. | Composition |
MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
MX2009003325A (es) | 2006-10-12 | 2009-04-09 | Glaxosmithkline Biolog Sa | Vacuna que comprende un adyuvante de emulsion de aceite en agua. |
KR101192127B1 (ko) | 2006-11-03 | 2012-10-17 | 쉐링-프라우 리미티드 | 개 라임병 백신 |
TW200908994A (en) | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
EP2889042A3 (en) | 2008-03-18 | 2015-10-14 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
WO2009127676A1 (en) * | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
KR20110009158A (ko) * | 2008-04-16 | 2011-01-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
EP2369003B1 (en) | 2008-08-28 | 2019-10-16 | Novartis AG | Process for preparing an oil-in-water emulsion containing squalene from yeasts |
AU2009294318B2 (en) | 2008-09-18 | 2014-04-24 | Novartis Ag | Vaccine adjuvant combinations |
WO2010092476A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
ES2608841T3 (es) | 2009-02-10 | 2017-04-17 | Seqirus UK Limited | Vacunas contra la gripe con cantidades reducidas de escualeno |
WO2010092477A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
BRPI1011224A2 (pt) | 2009-02-17 | 2016-03-15 | Glaxosmithkline Biolog Sa | vacina contra vírus da dengue inativado com adjuvante livre de alumínio |
WO2010109324A1 (en) | 2009-03-24 | 2010-09-30 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
BRPI1013780B8 (pt) | 2009-04-14 | 2022-10-04 | Novartis Ag | Composição imunogênica útil para imunização contra staphylococcus aureus, seu método de preparação e composição farmacêutica |
WO2010133964A1 (en) | 2009-05-21 | 2010-11-25 | Novartis Ag | Reverse genetics using non-endogenous pol i promoters |
KR20120039047A (ko) | 2009-07-31 | 2012-04-24 | 노파르티스 아게 | 역유전학 시스템 |
US8883481B2 (en) | 2009-10-20 | 2014-11-11 | Novartis Ag | Reverse genetics methods for virus rescue |
GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
SI2528621T1 (sl) | 2010-01-27 | 2017-01-31 | Glaxosmithkline Biologicals S.A., | Modificirani tuberkolozni antigeni |
JP2013522287A (ja) | 2010-03-18 | 2013-06-13 | ノバルティス アーゲー | 血清群b髄膜炎菌のためのアジュバント添加ワクチン |
PL3489211T3 (pl) | 2010-05-12 | 2020-12-14 | Novartis Ag | Ulepszone sposoby otrzymywania skwalenu |
EP2571520B1 (en) | 2010-05-21 | 2018-04-04 | Seqirus UK Limited | Influenza virus reassortment method |
GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
ES2681698T3 (es) | 2011-03-02 | 2018-09-14 | Glaxosmithkline Biologicals Sa | Vacunas de combinación con menores dosis de antígeno y/o adyuvante |
US20140248320A1 (en) | 2011-10-20 | 2014-09-04 | Novartis Ag | Adjuvanted influenza b virus vaccines for pediatric priming |
US20140335507A1 (en) | 2011-12-12 | 2014-11-13 | Novartis Ag | Assays for influenza virus hemagglutinins |
EP2793939A1 (en) | 2011-12-23 | 2014-10-29 | Novartis AG | Stable compositions for immunising against staphylococcus aureus |
EP2820126B1 (en) | 2012-03-02 | 2017-05-17 | Seqirus UK Limited | Influenza virus reassortment |
RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
US20150203543A1 (en) | 2012-08-31 | 2015-07-23 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
US9926344B2 (en) | 2012-08-31 | 2018-03-27 | Glaxosmithkline Biologicals Sa | Stabilised proteins for immunising against Staphylococcus aureus |
EP2892553A1 (en) | 2012-09-06 | 2015-07-15 | Novartis AG | Combination vaccines with serogroup b meningococcus and d/t/p |
GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
SG11201502599TA (en) | 2012-10-12 | 2015-05-28 | Glaxosmithkline Biolog Sa | Non-cross-linked acellular pertussis antigens for use in combination vaccines |
RU2018137673A (ru) | 2012-11-30 | 2019-03-22 | Глаксосмитклайн Байолоджикалс Са | Антигены и комбинации антигенов pseudomonas |
CN105120893B (zh) | 2012-12-03 | 2018-11-13 | 诺华股份有限公司 | 流感病毒重配 |
PT3513806T (pt) * | 2012-12-05 | 2023-03-02 | Glaxosmithkline Biologicals Sa | Composição imunogénica |
EP2934574A1 (en) | 2012-12-18 | 2015-10-28 | GlaxoSmithKline Biologicals SA | Conjugates for protecting against diphtheria and/or tetanus |
EP2968512A2 (en) | 2013-03-13 | 2016-01-20 | Novartis AG | Influenza b virus reassortment |
CA2903345A1 (en) * | 2013-03-19 | 2014-09-25 | Biotech Tools S.A. | Allergen preparation |
SG11201509265SA (en) | 2013-05-10 | 2015-12-30 | Novartis Ag | Avoiding narcolepsy risk in influenza vaccines |
BR112015028748A2 (pt) * | 2013-05-14 | 2017-09-19 | Zoetis Services Llc | Composições de vacina compreendendo oligonucleotídeos imunoestimulantes |
DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
WO2014195920A2 (en) | 2013-06-06 | 2014-12-11 | Novartis Ag | Influenza virus reassortment |
CN105934251A (zh) * | 2014-01-21 | 2016-09-07 | 辉瑞大药厂 | 肺炎链球菌荚膜多糖及其缀合物 |
ES2769647T3 (es) | 2014-03-26 | 2020-06-26 | Glaxosmithkline Biologicals Sa | Antígenos estafilocócicos mutantes |
CN106413782A (zh) * | 2014-05-26 | 2017-02-15 | 贝克顿迪金森法国公司 | 在润滑的医用注射装置中储存乳化佐剂疫苗的方法 |
EP3511020B1 (en) | 2014-12-02 | 2021-01-20 | Novartis AG | Manufacture of surfactant-containing compositions |
KR20230132628A (ko) | 2015-07-07 | 2023-09-15 | 세퀴러스 유케이 리미티드 | 인플루엔자 효능 검정 |
WO2017109698A1 (en) | 2015-12-22 | 2017-06-29 | Glaxosmithkline Biologicals Sa | Immunogenic formulation |
JP7125197B2 (ja) * | 2016-09-27 | 2022-08-24 | イミューノヴァクシーン テクノロジーズ インコーポレイテッド | ヒト対象において抗体免疫応答を誘導するために低投与体積b細胞エピトープ組成物を使用する方法 |
CN106511996B (zh) * | 2016-11-04 | 2019-09-10 | 江苏省农业科学院 | 用于口蹄疫疫苗的复乳型佐剂及其制备方法 |
EP3576759A4 (en) | 2017-01-31 | 2020-11-11 | Merck Sharp & Dohme Corp. | PROCESS FOR THE PREPARATION OF CAPSULE POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F |
CN109652384B (zh) * | 2019-02-21 | 2021-10-26 | 昆明理工大学 | 一种体外培养戊型肝炎病毒的方法 |
US20230000971A1 (en) | 2019-11-18 | 2023-01-05 | Seqirus Pty Ltd. | Method for producing reassortant influenza viruses |
KR20210117832A (ko) * | 2020-03-20 | 2021-09-29 | 강원대학교산학협력단 | Gla-se를 포함하는 수족구병 백신 조성물 |
EP4171629A1 (en) | 2020-06-29 | 2023-05-03 | GlaxoSmithKline Biologicals S.A. | Adjuvants |
BR112023002804A2 (pt) | 2020-08-24 | 2023-03-14 | Sanofi Pasteur Inc | Vacinas para covid-19 com adjuvantes em emulsão de esqualeno contendo tocoferol |
US20240165224A1 (en) | 2021-03-26 | 2024-05-23 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
KR20240033309A (ko) * | 2022-09-05 | 2024-03-12 | 주식회사 차백신연구소 | 에멀전 제형의 면역증강제 조성물 및 이의 제조 방법 |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2905287A1 (de) | 1979-02-12 | 1980-08-21 | Siemens Ag | Verfahren zur automatischen elektrochemischen endpunktsbestimmung einer titration |
US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
US4454119A (en) | 1981-06-29 | 1984-06-12 | Mitsubishi Chemical Industries Limited | Therapeutic agents |
FI69639C (fi) * | 1982-07-02 | 1986-03-10 | Orion Yhtymae Oy | Preparat foer anvaendning vid klamydia-diagnostik |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
FI861417A0 (fi) | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
WO1988009797A1 (en) | 1987-06-05 | 1988-12-15 | The United States Of America, As Represented By Th | Autocrine motility factors in cancer diagnosis and management |
US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
EP1088830A3 (en) | 1987-06-22 | 2004-04-07 | Medeva Holdings B.V. | Hepatitis b surface antigen particles |
US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
GB8819209D0 (en) | 1988-08-12 | 1988-09-14 | Research Corp Ltd | Polypeptide & dna encoding same |
US4999403A (en) | 1988-10-28 | 1991-03-12 | Exxon Chemical Patents Inc. | Graft polymers of functionalized ethylene-alpha-olefin copolymer with polypropylene, methods of preparation, and use in polypropylene compositions |
RU2121481C1 (ru) | 1988-12-16 | 1998-11-10 | Де Стат Дер Недерланден Вертегенвордигд Дор де Министр Ван Велзейн, Волксгезондхейд эн Кюлтюр | Модифицированный пневмолизин, рекомбинантная плазмида, способ получения модифицированного пневмолизина, вакцина |
ES2068989T3 (es) | 1989-02-04 | 1995-05-01 | Akzo Nobel Nv | Tocoles como adyuvante en vacunas. |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
DE69031556T2 (de) | 1989-07-25 | 1998-05-14 | Smithkline Beecham Biolog | Antigene sowie Verfahren zu deren Herstellung |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
KR100251505B1 (ko) | 1991-11-16 | 2000-05-01 | 장 스테판느 | 말라리아원충으로부터의 cs 및 hbsag 사이의 혼성 단백질(hybrid protein between cs from plasmodium and hbsag) |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
EP1175912A1 (en) | 1993-03-23 | 2002-01-30 | SmithKline Beecham Biologics SA | Vaccine compositions containing 3-O deacylated monophosphoryl lipid A |
GB9326253D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
AU4727296A (en) | 1995-02-24 | 1996-09-11 | Cantab Pharmaceuticals Research Limited | Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
US5666153A (en) | 1995-10-03 | 1997-09-09 | Virtual Shopping, Inc. | Retractable teleconferencing apparatus |
US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
ES2195151T3 (es) | 1996-06-18 | 2003-12-01 | Alza Corp | Dispositivo de mejora de aporte o de muestreo de agentes transdermicos. |
US20030133944A1 (en) * | 2001-04-05 | 2003-07-17 | Smithkline Beecham Biologicals S.A. | Vaccine composition against malaria |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
CN1133472C (zh) | 1996-12-20 | 2004-01-07 | 阿尔萨公司 | 增加经皮样剂流量的装置 |
WO1998050567A1 (en) | 1997-05-02 | 1998-11-12 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
AU740956B2 (en) | 1997-07-21 | 2001-11-15 | Baxter Healthcare Sa | Modified immunogenic pneumolysin compositions as vaccines |
GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
CA2302554C (en) | 1997-09-05 | 2007-04-10 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
GB9718901D0 (en) * | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
US7459524B1 (en) | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
JP2002517179A (ja) | 1997-11-28 | 2002-06-18 | ジェンセット | Chlamydiatrachomatisゲノム配列およびポリペプチド、それらのフラグメント、ならびに特に感染症の診断、予防および治療のためのそれらの使用 |
AU756828B2 (en) | 1997-12-02 | 2003-01-23 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
AU753995B2 (en) | 1998-04-07 | 2002-10-31 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
US6319224B1 (en) | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
JP2001316251A (ja) * | 2000-02-24 | 2001-11-13 | Fuairudo Kk | 炭素燃焼残査の超微粒子を含むスクワラン及びその製造方法 |
GB0025577D0 (en) * | 2000-10-18 | 2000-12-06 | Smithkline Beecham Biolog | Vaccine |
JP2005513021A (ja) | 2001-11-16 | 2005-05-12 | スリーエム イノベイティブ プロパティズ カンパニー | Irm化合物およびトール様受容体経路に関する方法および組成物 |
US20090081253A1 (en) * | 2005-03-23 | 2009-03-26 | Glaxosmithkline Biologicals S.A. | Composition |
NZ567978A (en) * | 2005-11-04 | 2011-09-30 | Novartis Vaccines & Diagnostic | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
MX2009003325A (es) | 2006-10-12 | 2009-04-09 | Glaxosmithkline Biolog Sa | Vacuna que comprende un adyuvante de emulsion de aceite en agua. |
TW200908994A (en) * | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
-
2007
- 2007-10-10 MX MX2009003325A patent/MX2009003325A/es active IP Right Grant
- 2007-10-10 KR KR1020097009716A patent/KR101151202B1/ko active IP Right Grant
- 2007-10-10 ES ES07821111T patent/ES2397714T3/es active Active
- 2007-10-10 AU AU2007306381A patent/AU2007306381B2/en active Active
- 2007-10-10 US US12/445,090 patent/US20100183667A1/en not_active Abandoned
- 2007-10-10 WO PCT/EP2007/060743 patent/WO2008043774A1/en active Application Filing
- 2007-10-10 CN CN200780038231XA patent/CN101522218B/zh active Active
- 2007-10-10 CA CA2664619A patent/CA2664619C/en active Active
- 2007-10-10 EA EA200900350A patent/EA015817B1/ru not_active IP Right Cessation
- 2007-10-10 JP JP2009531831A patent/JP5230632B2/ja active Active
- 2007-10-10 BR BRPI0717219A patent/BRPI0717219B8/pt active IP Right Grant
- 2007-10-10 PT PT78211117T patent/PT2086582E/pt unknown
- 2007-10-10 DK DK07821111.7T patent/DK2086582T3/da active
-
2009
- 2009-03-10 NO NO20091022A patent/NO20091022L/no not_active Application Discontinuation
- 2009-03-10 IL IL197512A patent/IL197512A/en active IP Right Grant
- 2009-04-17 CR CR10726A patent/CR10726A/es not_active Application Discontinuation
- 2009-05-06 MA MA31843A patent/MA30866B1/fr unknown
-
2012
- 2012-12-13 JP JP2012272452A patent/JP5767201B2/ja active Active
-
2013
- 2013-01-14 HR HRP20130023TT patent/HRP20130023T1/hr unknown
-
2015
- 2015-01-09 US US14/593,911 patent/US9700605B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR101151202B1 (ko) | 2012-06-11 |
WO2008043774A1 (en) | 2008-04-17 |
CR10726A (es) | 2009-05-25 |
AU2007306381A1 (en) | 2008-04-17 |
IL197512A0 (en) | 2011-08-01 |
JP2010505907A (ja) | 2010-02-25 |
BRPI0717219A2 (pt) | 2015-05-26 |
BRPI0717219B8 (pt) | 2021-05-25 |
EA200900350A1 (ru) | 2009-10-30 |
EA015817B1 (ru) | 2011-12-30 |
IL197512A (en) | 2013-10-31 |
JP2013067646A (ja) | 2013-04-18 |
JP5767201B2 (ja) | 2015-08-19 |
MX2009003325A (es) | 2009-04-09 |
DK2086582T3 (da) | 2013-02-04 |
KR20090066323A (ko) | 2009-06-23 |
ES2397714T3 (es) | 2013-03-08 |
CA2664619A1 (en) | 2008-04-17 |
AU2007306381B2 (en) | 2011-12-08 |
JP5230632B2 (ja) | 2013-07-10 |
CA2664619C (en) | 2012-12-11 |
US20150359863A1 (en) | 2015-12-17 |
PT2086582E (pt) | 2013-01-25 |
MA30866B1 (fr) | 2009-11-02 |
NO20091022L (no) | 2009-04-27 |
US20100183667A1 (en) | 2010-07-22 |
CN101522218A (zh) | 2009-09-02 |
CN101522218B (zh) | 2012-09-26 |
BRPI0717219B1 (pt) | 2021-01-19 |
US9700605B2 (en) | 2017-07-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20130023T1 (hr) | Cjepivo koje sadrži emulziju ulje u vodi kao adjuvans | |
EP2455101A3 (en) | Influenza vaccine with oil-in-water emulsion adjuvant | |
NZ568210A (en) | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines | |
EA200900024A1 (ru) | Противогриппозная вакцина | |
JP2011518170A5 (hr) | ||
RS54306B1 (en) | THE VACCINE | |
IL185897A (en) | Use of influenza virus or antigenic agent derived from the first influenza virus strain and adjuvant of water emulsion for the preparation of a vaccine for the protection against influenza strain caused by a variant influenza when the water emulsion contains squalene, alpha-tocopherol and emulsifier | |
EP2377551A3 (en) | Adjuvanted influenza vaccines including cytokine-inducing agents | |
BR112013005427A2 (pt) | composição imunogênica, vacina, método para tratamento ou prevenção de doença, e para preparar a composição imunogênica ou vacina, uso da vacina,e, composição farmacêutica. | |
RU2013119946A (ru) | Быстрорастворяющаяся лекарственная форма пероральной вакцины, в которой используют крахмал | |
WO2005049074A3 (en) | Methods for modulating the th2 immuneresponse to an antigen by adding or removing activated carbonyl groups from the antigen | |
EA201500910A1 (ru) | Вакцины против гриппа со сниженным количеством сквалена | |
RU2017101091A (ru) | Композиции вакцин с двойным адъювантом, получение и применения | |
EA201001478A1 (ru) | Вакцина | |
AR065765A1 (es) | Composicion de vacuna para el tratamiento de enfermedades infecciosas respiratorias | |
BR112014023283A8 (pt) | Composição imunogênica, segunda composição imunogênica, e, método para prevenção e/ou tratamento contra doença influenza | |
RU2017140856A (ru) | Стратегия вакцинации против вируса свиного гриппа вакциной на основе наночастиц | |
WO2008099908A1 (ja) | 脈絡膜新生血管のワクチン療法 | |
MX2009010963A (es) | Vacuna de influenza de emulsion de aceite en agua. | |
CY1113746T1 (el) | Εμβολιο που περιλαμβανει ανοσοενισχυτικο γαλακτωμα ελαιου σε υδωρ | |
DOP2009000068A (es) | Vacuna que comprende un adyuvante de emulsión de aceite en agua | |
JP2013001686A5 (hr) | ||
UA95646C2 (ru) | Вакцина, которая включает адъювант на основе эмульсии масло-в-воде | |
SG139618A1 (en) | Influenza vaccine | |
WO2005072679A3 (es) | Formulación adyuvante conteniendo una emulsión oleosa con aceite de jojoba |