HRP20120877T1 - Derivati sulfonil-kinolina - Google Patents

Derivati sulfonil-kinolina Download PDF

Info

Publication number
HRP20120877T1
HRP20120877T1 HRP20120877AT HRP20120877T HRP20120877T1 HR P20120877 T1 HRP20120877 T1 HR P20120877T1 HR P20120877A T HRP20120877A T HR P20120877AT HR P20120877 T HRP20120877 T HR P20120877T HR P20120877 T1 HRP20120877 T1 HR P20120877T1
Authority
HR
Croatia
Prior art keywords
fluoro
phenyl
quinoline
benzenesulfonyl
chloro
Prior art date
Application number
HRP20120877AT
Other languages
English (en)
Inventor
János Galambos
György Keseru
Krisztina GÁL
Amrita Ágnes Bobok
Csaba WÉBER
Ibolya Prauda
Gábor András Wágner
Mónika VASTAG
Original Assignee
Richter Gedeon Nyrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0700417A external-priority patent/HU0700417D0/hu
Priority claimed from HU0800376A external-priority patent/HUP0800376A2/hu
Application filed by Richter Gedeon Nyrt. filed Critical Richter Gedeon Nyrt.
Publication of HRP20120877T1 publication Critical patent/HRP20120877T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Claims (6)

1. Spoj, naznačen time, da ima formulu (I): [image] gdje Ar1predstavlja fenil- ili tienil-skupinu, opcijski supstituiranu s jednim ili više supstituenata odabranih od sljedećih: vodik, fluor, klor, cijano, metil, metoksi; Ar2 predstavlja fenil, supstituiran s jednim ili više supstituenata odabranih od sljedećih: fluor, klor, cijano, metil, metoksi; R1, R2, R3i R4 međusobno neovisno predstavljaju jedan supstituent odabran od sljedećih: vodik, fluor, klor, cijano, metil, metoksi, hidroksi, trifluorometil, amino, metilamino, dimetilamino, aminometil, metilaminometil, dimetilaminometil, i/ili njegove soli i/ili njegovi hidrati i/ili solvati.
2. Spoj prema zahtjevu 1, naznačen time, da je odabran iz skupine koju čine: 4-(4-kloro-fenil)-3-(4-metil-benzensulfonil)-kinolin, 7-kloro-3-(4-kloro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 8-kloro-4-(3-kloro-fenil)-3-(3,4-dikloro-benzensulfonil)-kinolin, 7-fluoro-3-(4-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 4-(4-kloro-fenil)-7-fluoro-3-(4-metoksi-benzensulfonil)-kinolin, 7-fluoro-3-(4-metoksi-benzensulfonil)-4-(4-metoksi-fenil)-kinolin, 7-fluoro-3-(3-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 7-fluoro-3-(3-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3,4-dimetil-benzensulfonil)-7-fluoro-kinolin, 3-(3,4-dimetil-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,4-dimetil-benzensulfonil)-7-fluoro-4-(3-metoksi-fenil)-kinolin, 4-(3-kloro-fenil)-8-fluoro-3-(4-fluoro-benzensulfonil)-kinolin, 4-(4-kloro-fenil)-8-fluoro-3-(4-fluoro-benzensulfonil)-kinolin, 8-fluoro-3-(4-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 8-fluoro-3-(4-fluoro-benzensulfonil)-4-(3-metoksi-fenil)-kinolin, 4-(4-kloro-fenil)-6-fluoro-3-(4-metoksi-benzensulfonil)-kinolin, 4-(4-kloro-fenil)-3-(3,4-dimetil-benzensulfonil)-6-fluoro-kinolin, 4-(4-kloro-fenil)-3-(3,5-difluoro-benzensulfonil)-7-fluoro-kinolin, 3-(3,5-difluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(4-kloro-fenil)-3-(3-cijano-benzensulfonil)-7-fluoro-kinolin, 3-(3-cijano-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 7-fluoro-3-(4-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 4-(4-kloro-fenil)-7-fluoro-3-(3-fluoro-benzensulfonil)-kinolin, 4-(3-kloro-fenil)-7-fluoro-3-(3-metoksi-benzensulfonil)-kinolin, 7-fluoro-4-(4-fluoro-fenil)-3-(3-metoksi-benzensulfonil)-kinolin, 4-(4-kloro-fenil)-3-(3,4-dimetil-benzensulfonil)-7-fluoro-kinolin, 3-(3,4-dimetil-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3-kloro-4-metoksi-benzensulfonil)-7-fluoro-kinolin, 3-(3-kloro-4-metoksi-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-kloro-4-metoksi-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-8-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3,5-difluoro-benzensulfonil)-8-fluoro-4-(3-fluoro-fenil)-kinolin, 8-fluoro-3-(4-fluoro-benzensulfonil)-4-(4-metoksi-fenil)-kinolin, 4-(3-kloro-fenil)-8-fluoro-3-(4-metoksi-benzensulfonil)-kinolin, 4-(4-kloro-fenil)-8-fluoro-3-(4-metoksi-benzensulfonil)-kinolin, 8-fluoro-4-(4-fluoro-fenil)-3-(4-metoksi-benzensulfonil)-kinolin, 8-fluoro-3-(4-metoksi-benzensulfonil)-4-(4-metoksi-fenil)-kinolin, 8-fluoro-3-(4-metoksi-benzensulfonil)-4-(3-metoksi-fenil)-kinolin, 4-(3-kloro-fenil)-8-fluoro-3-(3-fluoro-benzensulfonil)-kinolin, 4-(4-kloro-fenil)-8-fluoro-3-(3-fluoro-benzensulfonil)-kinolin, 8-fluoro-3-(3-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 8-fluoro-3-(3-fluoro-benzensulfonil)-4-(4-metoksi-fenil)-kinolin, 8-fluoro-3-(3-fluoro-benzensulfonil)-4-(3-metoksi-fenil)-kinolin, 8-fluoro-3-(3-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-6-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-6-fluoro-4-(3-metoksi-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-6-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-6-fluoro-3-(3-metoksi-benzensulfonil)-kinolin, 6-fluoro-4-(4-fluoro-fenil)-3-(3-metoksi-benzensulfonil)-kinolin, 3-(3-kloro-4-metoksi-benzensulfonil)-6-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3-kloro-4-metoksi-benzensulfonil)-6-fluoro-4-(3-metoksi-fenil)-kinolin, 4-(4-kloro-fenil)-7-fluoro-3-(4-fluoro-benzensulfonil)-kinolin, 3-(3,4-dimetil-benzensulfonil)-7-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3-kloro-4-metoksi-benzensulfonil)-4-(4-kloro-fenil)-6-fluoro-kinolin, 3-(3-kloro-4-metoksi-benzensulfonil)-6-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-7-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-7-fluoro-4-(3-metoksi-fenil)-kinolin, 3-(3,5-difluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-7-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-kinolin, 7-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 7-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 3-(3,5-difluoro-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,5-difluoro-benzensulfonil)-7-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,5-difluoro-benzensulfonil)-7-fluoro-4-(3-metoksi-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-benzensulfonil)-7-fluoro-kinolin, 3-(3-cijano-benzensulfonil)-7-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-7-fluoro-4-(3-metoksi-fenil)-kinolin, 3-(3-kloro-4-metil-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-7-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-7-fluoro-4-(3-metoksi-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-kloro-fenil)-7-fluoro-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-7-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-8-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-8-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-8-fluoro-4-(3-metoksi-fenil)-kinolin, 4-(3-kloro-fenil)-8-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-kinolin, 4-(4-kloro-fenil)-8-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-kinolin, 8-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 8-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(4-metoksi-fenil)-kinolin, 8-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(3-metoksi-fenil)-kinolin, 8-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3,5-difluoro-benzensulfonil)-8-fluoro-kinolin, 4-(4-kloro-fenil)-3-(3,5-difluoro-benzensulfonil)-8-fluoro-kinolin, 3-(3,5-difluoro-benzensulfonil)-8-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,5-difluoro-benzensulfonil)-8-fluoro-4-(3-metoksi-fenil)-kinolin, 3-(3,5-difluoro-benzensulfonil)-8-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(4-kloro-fenil)-3-(3,4-difluoro-benzensulfonil)-8-fluoro-kinolin, 3-(3,4-difluoro-benzensulfonil)-8-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-8-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-8-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-6-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-6-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-6-fluoro-4-(3-metoksi-fenil)-kinolin, 4-(3-kloro-fenil)-6-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-kinolin, 6-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 6-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(4-metoksi-fenil)-kinolin, 6-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(3-metoksi-fenil)-kinolin, 6-fluoro-3-(3-fluoro-4-metil-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-benzensulfonil)-6-fluoro-kinolin, 4-(4-kloro-fenil)-3-(3-cijano-benzensulfonil)-6-fluoro-kinolin, 3-(3-cijano-benzensulfonil)-6-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3-kloro-4-metil-benzensulfonil)-4-(3-kloro-fenil)-6-fluoro-kinolin, 3-(3-kloro-4-metil-benzensulfonil)-4-(4-kloro-fenil)-6-fluoro-kinolin, 3-(3-kloro-4-metil-benzensulfonil)-6-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-kloro-4-metil-benzensulfonil)-6-fluoro-4-(3-metoksi-fenil)-kinolin, 3-(3-kloro-4-metil-benzensulfonil)-6-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(4-kloro-fenil)-6-fluoro-3-(3-metoksi-benzensulfonil)-kinolin, 6-fluoro-3-(3-metoksi-benzensulfonil)-4-(3-metoksi-fenil)-kinolin, 3-(3,4-dimetil-benzensulfonil)-6-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,4-dimetil-benzensulfonil)-6-fluoro-4-(4-metoksi-fenil)-kinolin, 3-(3,4-dimetil-benzensulfonil)-6-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-6-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-6-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-kloro-fenil)-6-fluoro-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-6-fluoro-4-(3-metoksi-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-6-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3,5-dikloro-benzensulfonil)-7-fluoro-kinolin, 4-(4-kloro-fenil)-3-(3,5-dikloro-benzensulfonil)-7-fluoro-kinolin, 4-(3-kloro-fenil)-3-(3,5-dikloro-benzensulfonil)-8-fluoro-kinolin, 4-(4-kloro-fenil)-3-(3, 5-dikloro-benzensulfonil)-8-fluoro-kinolin, 4-(3-kloro-fenil)-3-(3,5-dikloro-benzensulfonil)-6-fluoro-kinolin, 4-(4-kloro-fenil)-3-(3,5-dikloro-benzensulfonil)-6-fluoro-kinolin, 6-fluoro-3-(4-metoksi-benzensulfonil)-4-(4-metoksi-fenil)-kinolin, 7-kloro-4-(4-kloro-fenil)-3-(3,5-difluoro-benzensulfonil)-kinolin, 7-kloro-4-(4-kloro-fenil)-3-(3,4-difluoro-benzensulfonil)-kinolin, 7-kloro-4-(4-kloro-fenil)-3-(3-cijano-benzensulfonil)-kinolin, 7-kloro-3-(3,5-dikloro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(4-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(3-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(3,4-difluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, i 7-kloro-3-(3-cijano-5-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 6-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-kloro-fenil)-7-fluoro-kinolin, 6-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-7-cijano-4-(2-fluoro-fenil)-kinolin, 7-kloro-3-(3,4-difluoro-benzensulfonil)-8-fluoro-4-(3-fluoro-fenil)-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-8-fluoro-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-8-fluoro-4-(3-fluoro-fenil)-kinolin, 7-kloro-4-(4-kloro-fenil)-3-(3,4-difluoro-benzensulfonil)-8-fluoro-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-8-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3-cijano-4-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 3-(3-cijano-5-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-kloro-fenil)-8-fluoro-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-8-fluoro-4-(2-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-8-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-cijano-4-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-8-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-8-fluoro-4-(2-fluoro-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-8-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-cijano-4-fluoro-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-4-fluoro-benzensulfonil)-kinolin, 3-(3-cijano-5-fluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(3-cijano-4-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-4-(3,4-difluoro-fenil)-8-fluoro-kinolin, 7-kloro-3-(3-cijano-5-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 3-(3-cijano-benzensulfonil)-8-fluoro-4-(4-fluoro-fenil)-kinolin, 3-(3,5-dikloro-benzensulfonil)-8-fluoro-4-(2-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-7-fluoro-4-(2-fluoro-fenil)-kinolin, 4-(4-kloro-fenil)-3-(3-cijano-benzensulfonil)-8-fluoro-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-S-fluoro-benzensulfonil)-kinolin, 7-kloro-3-(3-cijano-benzensulfonil)-4-(2-fluoro-fenil)-kinolin, 3-(3-cijano-5-fluoro-benzensulfonil)-7-fluoro-4-(3-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-4-(3-kloro-fenil)-8-fluoro-kinolin, 3-(3-cijano-benzensulfonil)-7-fluoro-4-(2-fluoro-fenil)-kinolin, 3-(3-cijano-5-fluoro-benzensulfonil)-4-(3,4-difluoro-fenil)-7-fluoro-kinolin, 3-(3-cijano-4-fluoro-benzensulfonil)-4-(3,4-dikloro-fenil)-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-4-(2-fluoro-fenil)-kinolin, 7-kloro-3-(3-cijano-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-4-fluoro-benzensulfonil)-7-fluoro-kinolin, 3-(3,4-difluoro-benzensulfonil)-4-(3,5-difluoro-fenil)-8-fluoro-kinolin, 3-(3,4-difluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-4-(3,4-difluoro-fenil)-8-fluoro-kinolin, 3-(3,5-dikloro-benzensulfonil)-4-(3,4-difluoro-fenil)-7-fluoro-kinolin, 3-(3,4-difluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 7-kloro-3-(3-cijano-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 7-kloro-4-(3-kloro-fenil)-3-(3-cijano-4-fluoro-benzensulfonil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-8-fluoro-4-(2-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-5-fluoro-benzensulfonil)-7-fluoro-kinolin, 3-(3-cijano-benzensulfonil)-4-(3,5-difluoro-fenil)-7-fluoro-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-benzensulfonil)-8-fluoro-kinolin, 4-(4-kloro-fenil)-3-(3,4-difluoro-benzensulfonil)-7-fluoro-kinolin, 7-kloro-3-(3,4-dikloro-benzensulfonil)-4-(3,4-difluoro-fenil)-kinolin, 3-(3,5-dicijano-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(3-kloro-5-fluoro-benzensulfonil)-4-(3-kloro-fenil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-4-(3,4-difluoro-fenil)-7-fluoro-kinolin, 7-kloro-4-(3-kloro-fenil)-3-(3,5-dikloro-benzensulfonil)-8-fluoro-kinolin, 7-kloro-4-(3-kloro-fenil)-3-(3-cijano-benzensulfonil)-8-fluoro-kinolin, 7-kloro-4-(3-kloro-fenil)-3-(3-cijano-benzensulfonil)-kinolin, 7-kloro-3-(3,5-dikloro-benzensulfonil)-4-(2-fluoro-fenil)-kinolin, 3-(3,5-dicijano-benzensulfonil)-4-(3,4-difluoro-fenil)-7-fluoro-kinolin, 3-(3,5-dikloro-benzensulfonil)-7-fluoro-4-(2-fluoro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-4-(3-kloro-fenil)-7-fluoro-kinolin, 4-(3-kloro-fenil)-3-(3,4-difluoro-benzensulfonil)-8-fluoro-kinolin, 4-(3,4-dikloro-fenil)-3-(3,4-difluoro-benzensulfonil)-kinolin, 3-(3,4-difluoro-benzensulfonil)-7-fluoro-4-(2-fluoro-fenil)-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-4-(3,5-difluoro-fenil)-kinolin, 7-kloro-4-(3-kloro-fenil)-3-(3,5-dikloro-benzensulfonil)-kinolin, 7-amino-3-(3,4-difluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, 4-(3-kloro-fenil)-3-(3-cijano-benzensulfonil)-kinolin, 3-(3-cijano-5-fluoro-benzensulfonil)-4-(3,4-difluoro-fenil)-kinolin, 3-(3-cijano-S-fluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 4-(4-kloro-fenil)-3-(3-cijano-5-fluoro-benzensulfonil)-7-fluoro-kinolin, 7-kloro-3-(3-kloro-5-fluoro-benzensulfonil)-4-(4-kloro-fenil)-kinolin, 7-kloro-3-(3-kloro-5-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 3-(3-kloro-5-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 3-(3-kloro-5-fluoro-benzensulfonil)-4-(4-kloro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-kloro-fenil)-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-kloro-fenil)-7-fluoro-kinolin, 3-(3-kloro-4-fluoro-benzensulfonil)-7-fluoro-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 7-kloro-3-(3-kloro-4-fluoro-benzensulfonil)-4-(4-kloro-fenil)-kinolin, 7-amino-3-(3-kloro-5-fluoro-benzensulfonil)-4-(4-fluoro-fenil)-kinolin, 7-amino-3-(3-kloro-5-fluoro-benzensulfonil)-4-(3-fluoro-fenil)-kinolin, i/ili njegove soli i/ili njegovi hidrati i/ili solvati.
3. Postupak pripravljanja spoja formule (I): [image] gdje su Ar1, Ar2, R1, R2, R3 i R4određeni u zahtjevu 1, i/ili njegovih soli i/ili hidrata i/ili solvata, naznačen time, da obuhvaća sljedeće korake: a. a1. reakcija spoja formule (II): [image] gdje su R1, R2, R3 i R4 određeni kao gore za spoj formule (I), sa spojem formule (III): Ar1-S-M+(III) gdje je Ar1određen kao gore za spojeve formule (I), M je odabran od alkalijskih metala ili zemno-alkalijskih metala, kako bi se dobio spoj formule (IV): [image] gdje su Ar1, R1, R2, R3 i R4određeni kao gore za spojeve formule (I), nakon toga oksidiranje spoja formule (IV) za dobivanje spoja formule (V): [image] gdje su Ar1, R1, R2, R3 i R4 određeni kao gore za spojeve formule (I), nakon toga oksidiranje spoja formule (V) za dobivanje spoja formule (VI): [image] gdje su Ar1, R1, R2, R3 i R4 određeni kao gore za spojeve formule (I), ili a2. reakcija spoja formule (IX): Ar1-SO2Na (IX) gdje je Ar1 određen kao gore za spojeve formule (I), s esterima α-halogen-octene kiseline formule (X): Hlg-CH2-COOR5(X) gdje Hlg je halogen, a R5 je etil- ili metil-skupina, za dobivanje spoja formule (XI): Ar1-SO2-CH2-COOR5(XI) gdje Ar1 je određen kao gore za spoj formule (I), a R5je određen kao gore za spojeve formule (X), nakon toga reakcija spoja formule (XI) s trialkil ortoformiatom formule (XII): CH(OR6)3(XII) gdje R6 je etil- ili metil-skupina, za dobivanje spoja formule (XIII): [image] gdje Ar1 je određen kao gore za spoj formule (I), R5je određen kao gore za spojeve formule (X), a R6je određen kao gore za spojeve formule (XII), nakon toga reakcija spoja formule (XIII) s derivatom anilina formule (XIV): [image] gdje su R1, R2, R3 i R4 određeni kao gore za spoj formule (I), za dobivanje spoja formule (VI): [image] gdje su Ar1, R1, R2, R3 i R4 određeni kao gore za spoj formule (I), nakon toga pretvaranje spoja formule (VI) u spoj formule (VII): [image] gdje su Ar1, R1, R2, R3 i R4 određeni kao gore za spojeve formule (I), X je odabran od sljedećih skupina: kloro, bromo, benzensulfoniloksi, 4-fluoro-benzensulfoniloksi, 4-metil-benzensulfoniloksi, metansulfoniloksi ili trifluorometansulfoniloksi, nakon toga reakcija dobivenog spoja formule (VII) s derivatom borne kiseline formule (VIII): Ar2-B(OH)2(VIII) gdje je Ar2 određen kao gore za spoj formule (I), u prisutnosti baze i katalizatora u otapalu, te nakon toga opcijski tvorba soli i/ili hidrata i/ili solvata spojeva formule (I), ili b. pretvaranje spoja formule formule (I), gdje su Ar1, Ar2, R1, R2, R3 i R4 određeni gore za spoj formule (I), u različite spojeve formule (I), gdje su Ar1, Ar2, R1, R2, R3 i R4određeni gore za spoj formule (I), te nakon toga opcijski tvorba soli i/ili hidrata i/ili solvata spojeva formule (I).
4. Farmaceutska formulacija, naznačena time, da sadrži terapeutski učinkovitu količnu spoja formule (I) određenog u zahtjevu 1, i/ili njegovih fiziološki prihvatljivih soli i/ili hidrata i/ili solvata u sastavu s jednim ili više fiziološki prihvatljivih razrjeđivača, pomoćnih sredstava i/ili inertnih nosača.
5. Farmaceutska formulacija prema zahtjevu 4, naznačena time, da se upotrebljava u postupku prevencije i/ili liječenja poremećaja odabranog od sljedećih: psihijatrijski poremećaji, neurološki poremećaji, kronični i akutni bolovi, neuromuskularna disfunkcija donjeg urinarnog trakta, gastrointestinalna refluksna bolest, sindrom osjetljivog mjehura, zlouporaba loših tvari i odvikavanje od uzimanja loših tvari.
6. Spoj formule (I) prema zahtjevima 1 ili 2 i/ili njegove fiziološki prihvatljive soli i/ili hidrati i/ili solvati, naznačen time, da se upotrebljava u postupku prevencije i/ili liječenja poremećaja odabranog od sljedećih: psihijatrijski poremećaji, neurološki poremećaji, kronični i akutni bolovi, neuromuskularna disfunkcija donjeg urinarnog trakta, gastrointestinalna refluksna bolest, sindrom osjetljivih crijeva, zlouporaba loših tvari i odvikavanje od uzimanja loših tvari.
HRP20120877AT 2007-06-18 2012-10-30 Derivati sulfonil-kinolina HRP20120877T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0700417A HU0700417D0 (en) 2007-06-18 2007-06-18 Sulfonyl-quinoline derivatives
HU0800376A HUP0800376A2 (en) 2008-06-12 2008-06-12 Sulfonyl-quinoline derivatives
PCT/HU2008/000068 WO2008155588A1 (en) 2007-06-18 2008-06-17 Sulfonyl-quinoline derivatives

Publications (1)

Publication Number Publication Date
HRP20120877T1 true HRP20120877T1 (hr) 2012-11-30

Family

ID=89988338

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20120877AT HRP20120877T1 (hr) 2007-06-18 2012-10-30 Derivati sulfonil-kinolina

Country Status (28)

Country Link
EP (1) EP2167469B1 (hr)
JP (1) JP5543917B2 (hr)
KR (1) KR101532101B1 (hr)
CN (1) CN101730684B (hr)
AU (1) AU2008264999B8 (hr)
BR (1) BRPI0812816B8 (hr)
CA (1) CA2690079C (hr)
CO (1) CO6311082A2 (hr)
CU (1) CU23822A3 (hr)
CY (1) CY1113251T1 (hr)
DK (1) DK2167469T3 (hr)
EA (1) EA016691B1 (hr)
EC (1) ECSP109884A (hr)
ES (1) ES2392905T3 (hr)
GE (1) GEP20125524B (hr)
HK (1) HK1141009A1 (hr)
HR (1) HRP20120877T1 (hr)
IL (1) IL202463A (hr)
MX (1) MX2009013959A (hr)
MY (1) MY146992A (hr)
NI (1) NI200900217A (hr)
NZ (1) NZ581853A (hr)
PL (1) PL2167469T3 (hr)
PT (1) PT2167469E (hr)
RS (1) RS52495B (hr)
SI (1) SI2167469T1 (hr)
TN (1) TN2009000511A1 (hr)
WO (1) WO2008155588A1 (hr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9173864B2 (en) 2008-10-22 2015-11-03 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
US9278960B2 (en) * 2011-11-03 2016-03-08 Merck Sharp & Dohme Corp. Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
RU2500672C1 (ru) * 2012-10-25 2013-12-10 Андрей Александрович Иващенко (3-арилсульфонилхинолин-8-ил)-диалкил-амины - селективные антагонисты серотониновых 5-ht6 рецепторов, способы их получения и применения
AR106515A1 (es) 2015-10-29 2018-01-24 Bayer Cropscience Ag Sililfenoxiheterociclos trisustituidos y análogos
US9932310B2 (en) 2016-02-08 2018-04-03 City Of Hope DNA2 inhibitors for cancer treatment
KR101893515B1 (ko) * 2017-06-09 2018-08-30 영남대학교 산학협력단 구리 촉매를 이용한 4-하이드록시-3-설파닐쿠마린 유도체 또는 4-하이드록시-3-설파닐퀴놀리논 유도체의 신규 제조방법 및 이로 제조된 유도체 화합물과 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1165542B1 (en) * 1999-03-29 2003-08-20 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
US6339093B1 (en) * 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives
AU2001293847B2 (en) * 2000-10-02 2007-05-24 Janssen Pharmaceutica N.V. Metabotropic glutamate receptor antagonists
WO2003080580A2 (en) 2002-03-27 2003-10-02 Glaxo Group Limited Quinoline derivatives and their use as 5-ht6 ligands
CA2537141A1 (en) * 2003-09-02 2005-03-10 Merck And Co., Inc. Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5
BRPI0417543A (pt) * 2003-12-12 2007-03-27 Wyeth Corp quinolinas úteis no tratamento de doença cardiovascular
GB0519765D0 (en) * 2005-09-28 2005-11-09 Glaxo Group Ltd Novel compounds
US20090270371A1 (en) * 2005-12-20 2009-10-29 Gyorgy Keseru Quinoline derivatives useful in the treatment of mglur5 receptor-mediated disorders

Also Published As

Publication number Publication date
HK1141009A1 (en) 2010-10-29
KR101532101B1 (ko) 2015-06-26
AU2008264999A1 (en) 2008-12-24
CU23822A3 (es) 2012-06-21
JP5543917B2 (ja) 2014-07-09
AU2008264999B2 (en) 2013-09-26
AU2008264999B8 (en) 2013-10-31
GEP20125524B (en) 2012-05-25
BRPI0812816B1 (pt) 2020-09-15
SI2167469T1 (sl) 2012-10-30
CU20090219A7 (es) 2011-10-14
PL2167469T3 (pl) 2013-01-31
BRPI0812816B8 (pt) 2021-05-25
RS52495B (en) 2013-02-28
BRPI0812816A2 (pt) 2014-12-23
TN2009000511A1 (en) 2011-03-31
CA2690079A1 (en) 2008-12-24
DK2167469T3 (da) 2012-11-12
CO6311082A2 (es) 2011-08-22
IL202463A (en) 2013-08-29
CY1113251T1 (el) 2016-04-13
KR20100021434A (ko) 2010-02-24
NZ581853A (en) 2012-11-30
CN101730684A (zh) 2010-06-09
EA201070025A1 (ru) 2010-04-30
NI200900217A (es) 2010-10-04
EA016691B1 (ru) 2012-06-29
WO2008155588A1 (en) 2008-12-24
IL202463A0 (en) 2010-06-30
EP2167469A1 (en) 2010-03-31
MY146992A (en) 2012-10-15
MX2009013959A (es) 2010-03-09
ES2392905T3 (es) 2012-12-14
CA2690079C (en) 2016-01-26
EP2167469B1 (en) 2012-08-15
WO2008155588A8 (en) 2009-12-30
JP2010530407A (ja) 2010-09-09
ECSP109884A (es) 2010-02-26
CN101730684B (zh) 2013-07-24
PT2167469E (pt) 2012-11-20

Similar Documents

Publication Publication Date Title
HRP20120877T1 (hr) Derivati sulfonil-kinolina
JP4593929B2 (ja) キノリン及びイソキノリン誘導体類、それらの生成方法及び炎症インヒビターとしてのそれらの使用
AU2008255733B2 (en) Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein and has glucocorticoid receptor-binding activity
CN101171238B (zh) 对5-ht受体具有活性的(3,4-二氢-喹唑啉-2-基)-(2-芳氧基-乙基)胺
CA2651573A1 (en) Pyridopyrimidinone derivatives
JPH0219112B2 (hr)
CN1013114B (zh) 5-氨基和5-羟基-6，8-二氟喹诺酮类抗菌药组合物制备方法
JP2008543782A (ja) ５−ｈｔ１ａ受容体のピペラジン−ピペリジンアンタゴニストおよびアゴニスト
JP2016512256A5 (hr)
CN106211770A (zh) 作为γ‑分泌酶调节剂的色烯和1,1A,2,7B‑四氢环丙烷并[c]色烯吡啶并吡嗪二酮
FI113174B (fi) Menetelmä ja välituote 5-amino-8-metyyli-7-pyrrolidinyylikinoliini-3-karboksyylihappojohdannaisten valmistamiseksi
JPS611683A (ja) ７‐（３‐アリール‐１‐ピペラジニル）‐及び７‐（３‐シクロヘキシル‐１‐ピペラジニル）‐３‐キノロンカルボン酸類
CN1013865B (zh) 喹啉衍生物的制备方法
KR20080112233A (ko) 테트라히드로나프탈렌 유도체, 이들의 제조 방법 및 소염제로서의 이들의 용도
JP2001506981A (ja) α―２アドレナリン受容体作動薬として有用な２―イミダゾリニルアミノインドール化合物
RU2013142364A (ru) Замещенные производные 6,7-диалкокси-3-изохинолинола в качестве ингибиторов фосфодиэстеразы 10 (фдэ10а)
WO2007146115A2 (en) 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
CN87100298A (zh) 制备喹啉-3-羧酸抗菌剂的改进方法
CN1211569A (zh) 取代的喹诺酮衍生物及含有它的药物
CN1878761A (zh) 芳基茚并吡啶和芳基茚并嘧啶及其作为腺苷A2a受体拮抗剂的用途
JP5927071B2 (ja) Ｐａｒｐ阻害活性を有する新規化合物
JP2011190238A (ja) 新規環状スクアリン酸アミド誘導体
CA2126076A1 (en) Nitroquinolone derivatives as nmda antagonists
CN100422170C (zh) 喹诺酮羧酸衍生物的制备方法
CN101967123B (zh) 2-环丙基-4-(n-甲基取代苯胺基)喹啉类化合物及其中间体、制备方法和应用