HRP20120857T1 - Derivati 4-(n-azacikloalkil) anilida kao modulatori kalijevog kanala - Google Patents

Derivati 4-(n-azacikloalkil) anilida kao modulatori kalijevog kanala Download PDF

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Publication number
HRP20120857T1
HRP20120857T1 HRP20120857AT HRP20120857T HRP20120857T1 HR P20120857 T1 HRP20120857 T1 HR P20120857T1 HR P20120857A T HRP20120857A T HR P20120857AT HR P20120857 T HRP20120857 T HR P20120857T HR P20120857 T1 HRP20120857 T1 HR P20120857T1
Authority
HR
Croatia
Prior art keywords
alkyl
cycloalkyl
compound according
image
groups
Prior art date
Application number
HRP20120857AT
Other languages
English (en)
Croatian (hr)
Inventor
Jean-Michel Vernier
Samedy Ouk
Martha Alicia De La Rosa
Original Assignee
Valeant Pharmaceuticals International
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Pharmaceuticals International filed Critical Valeant Pharmaceuticals International
Publication of HRP20120857T1 publication Critical patent/HRP20120857T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20120857AT 2007-06-13 2008-06-13 Derivati 4-(n-azacikloalkil) anilida kao modulatori kalijevog kanala HRP20120857T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93439607P 2007-06-13 2007-06-13
US12/138,251 US8367684B2 (en) 2007-06-13 2008-06-12 Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
PCT/US2008/066984 WO2008157404A2 (en) 2007-06-13 2008-06-13 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators

Publications (1)

Publication Number Publication Date
HRP20120857T1 true HRP20120857T1 (hr) 2012-11-30

Family

ID=40137141

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20120857AT HRP20120857T1 (hr) 2007-06-13 2008-06-13 Derivati 4-(n-azacikloalkil) anilida kao modulatori kalijevog kanala

Country Status (18)

Country Link
US (1) US8367684B2 (online.php)
EP (1) EP2170861B1 (online.php)
JP (1) JP2010530002A (online.php)
KR (1) KR20100018618A (online.php)
CN (1) CN101868451A (online.php)
AU (1) AU2008266009B2 (online.php)
BR (1) BRPI0812564A2 (online.php)
CA (1) CA2689208A1 (online.php)
DK (1) DK2170861T3 (online.php)
ES (1) ES2392774T3 (online.php)
HR (1) HRP20120857T1 (online.php)
MX (1) MX2009013581A (online.php)
PL (1) PL2170861T3 (online.php)
PT (1) PT2170861E (online.php)
RU (1) RU2010100893A (online.php)
SI (1) SI2170861T1 (online.php)
TW (1) TW200914452A (online.php)
WO (1) WO2008157404A2 (online.php)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
EP2421863A1 (en) 2009-04-21 2012-02-29 NeuroSearch AS Substituted naphthyridine derivatives and their medical use
JP5763758B2 (ja) * 2010-07-08 2015-08-12 ファイザー・インク Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド
BR112014025201A2 (pt) 2012-04-10 2017-07-11 Sumitomo Dainippon Pharma Co Ltd derivado de indazol 1-substituído
CN108250128A (zh) * 2012-09-27 2018-07-06 江苏先声药业有限公司 作为钾通道调节剂的化合物
CN107835649B (zh) 2015-07-07 2021-03-23 高露洁-棕榄公司 口腔护理器具和用于口腔护理器具的单丝刷毛
CN110511220B (zh) 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用
WO2023125935A1 (zh) * 2021-12-31 2023-07-06 上海翰森生物医药科技有限公司 苯并哌啶衍生物调节剂、其制备方法和应用
CN116535353A (zh) * 2022-01-25 2023-08-04 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用

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Also Published As

Publication number Publication date
CA2689208A1 (en) 2008-12-24
US8367684B2 (en) 2013-02-05
ES2392774T3 (es) 2012-12-13
MX2009013581A (es) 2010-01-26
PT2170861E (pt) 2012-09-06
BRPI0812564A2 (pt) 2015-02-10
PL2170861T3 (pl) 2013-01-31
AU2008266009A1 (en) 2008-12-24
DK2170861T3 (da) 2012-11-26
SI2170861T1 (sl) 2012-12-31
CN101868451A (zh) 2010-10-20
EP2170861A2 (en) 2010-04-07
TW200914452A (en) 2009-04-01
RU2010100893A (ru) 2011-07-20
EP2170861B1 (en) 2012-08-29
KR20100018618A (ko) 2010-02-17
US20080318979A1 (en) 2008-12-25
JP2010530002A (ja) 2010-09-02
WO2008157404A3 (en) 2009-02-19
AU2008266009B2 (en) 2013-06-06
WO2008157404A2 (en) 2008-12-24

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